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Showing 13 to 24 of 77 entries
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DISCO: a database of Deeply Integrated human Single-Cell Omics data.

Nucleic acids research

Li M, Zhang X, Ang KS, Ling J, Sethi R, Lee NYS, Ginhoux F, Chen J.
PMID: 34791375
Nucleic Acids Res. 2021 Nov 17; doi: 10.1093/nar/gkab1020. Epub 2021 Nov 17.

The ability to study cellular heterogeneity at single cell resolution is making single-cell sequencing increasingly popular. However, there is no publicly available resource that offers an integrated cell atlas with harmonized metadata that users can integrate new data with....

MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche.

Nature

Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B.
PMID: 33658717
Nature. 2021 Apr;592(7855):606-610. doi: 10.1038/s41586-021-03283-y. Epub 2021 Mar 03.

Intestinal stromal cells are known to modulate the propagation and differentiation of intestinal stem cells

Epithelial-Macrophage Crosstalk Initiates Sterile Inflammation in Embryonic Skin.

Frontiers in immunology

Bhattacharjee O, Ayyangar U, Kurbet AS, Lakshmanan V, Palakodeti D, Ginhoux F, Raghavan S.
PMID: 34721382
Front Immunol. 2021 Oct 14;12:718005. doi: 10.3389/fimmu.2021.718005. eCollection 2021.

Macrophages are highly responsive to the environmental cues and are the primary responders to tissue stress and damage. While much is known about the role of macrophages during inflammatory disease progression; the initial series of events that set up...

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model.

Molecular therapy. Methods & clinical development

Do TM, Capdevila C, Pradier L, Blanchard V, Lopez-Grancha M, Schussler N, Steinmetz A, Beninga J, Boulay D, Dugay P, Verdier P, Aubin N, Dargazanli G, Chaves C, Genet E, Lossouarn Y, Loux C, Michoux F, Moindrot N, Chanut F, Gury T, Eyquem S, Valente D, Bergis O, Rao E, Lesuisse D.
PMID: 33005703
Mol Ther Methods Clin Dev. 2020 Aug 21;19:58-77. doi: 10.1016/j.omtm.2020.08.014. eCollection 2020 Dec 11.

Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of bispecific constructs....

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma.

Oncoimmunology

Penny HL, Sieow JL, Adriani G, Yeap WH, See Chi Ee P, San Luis B, Lee B, Lee T, Mak SY, Ho YS, Lam KP, Ong CK, Huang RY, Ginhoux F, Rotzschke O, Kamm RD, Wong SC.
PMID: 27622062
Oncoimmunology. 2016 Jun 21;5(8):e1191731. doi: 10.1080/2162402X.2016.1191731. eCollection 2016 Aug.

Patients with pancreatic ductal adenocarcinoma (PDAC) face a clinically intractable disease with poor survival rates, attributed to exceptionally high levels of metastasis. Epithelial-to-mesenchymal transition (EMT) is pronounced at inflammatory foci within the tumor; however, the immunological mechanisms promoting tumor...

Author Correction: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma.

Nature communications

Nguyen PHD, Ma S, Phua CZJ, Kaya NA, Lai HLH, Lim CJ, Lim JQ, Wasser M, Lai L, Tam WL, Lim TKH, Wan WK, Loh T, Leow WQ, Pang YH, Chan CY, Lee SY, Cheow PC, Toh HC, Ginhoux F, Iyer S, Kow AWC, Young Dan Y, Chung A, Bonney GK, Goh BKP, Albani S, Chow PKH, Zhai W, Chew V.
PMID: 33623020
Nat Commun. 2021 Feb 23;12(1):1372. doi: 10.1038/s41467-021-21556-y.

No abstract available.

Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis.

Cell death and differentiation

Goubet AG, Dubuisson A, Geraud A, Danlos FX, Terrisse S, Silva CAC, Drubay D, Touri L, Picard M, Mazzenga M, Silvin A, Dunsmore G, Haddad Y, Pizzato E, Ly P, Flament C, Melenotte C, Solary E, Fontenay M, Garcia G, Balleyguier C, Lassau N, Maeurer M, Grajeda-Iglesias C, Nirmalathasan N, Aprahamian F, Durand S, Kepp O, Ferrere G, Thelemaque C, Lahmar I, Fahrner JE, Meziani L, Ahmed-Belkacem A, Saïdani N, La Scola B, Raoult D, Gentile S, Cortaredona S, Ippolito G, Lelouvier B, Roulet A, Andre F, Barlesi F, Soria JC, Pradon C, Gallois E, Pommeret F, Colomba E, Ginhoux F, Kazandjian S, Elkrief A, Routy B, Miyara M, Gorochov G, Deutsch E, Albiges L, Stoclin A, Gachot B, Florin A, Merad M, Scotte F, Assaad S, Kroemer G, Blay JY, Marabelle A, Griscelli F, Zitvogel L, Derosa L.
PMID: 34230615
Cell Death Differ. 2021 Dec;28(12):3297-3315. doi: 10.1038/s41418-021-00817-9. Epub 2021 Jul 06.

Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus-host interactions during cancer therapies remain elusive. When comparing nasopharyngeal swabs from cancer and noncancer patients for RT-qPCR cycle thresholds measuring...

Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment.

Science immunology

Heidkamp GF, Sander J, Lehmann CHK, Heger L, Eissing N, Baranska A, Lühr JJ, Hoffmann A, Reimer KC, Lux A, Söder S, Hartmann A, Zenk J, Ulas T, McGovern N, Alexiou C, Spriewald B, Mackensen A, Schuler G, Schauf B, Forster A, Repp R, Fasching PA, Purbojo A, Cesnjevar R, Ullrich E, Ginhoux F, Schlitzer A, Nimmerjahn F, Schultze JL, Dudziak D.
PMID: 28783692
Sci Immunol. 2016 Dec 16;1(6). doi: 10.1126/sciimmunol.aai7677. Epub 2016 Dec 16.

In mice, conventional and plasmacytoid dendritic cells (DCs) derive from separate hematopoietic precursors before they migrate to peripheral tissues. Moreover, two classes of conventional DCs (cDC1 and cDC2 DCs) and one class of plasmacytoid DCs (pDCs) have been shown...

Towards the better understanding of myelopoiesis using single-cell technologies.

Molecular immunology

Dress RJ, Liu Z, Ginhoux F.
PMID: 32388073
Mol Immunol. 2020 May 06;122:186-192. doi: 10.1016/j.molimm.2020.04.020. Epub 2020 May 06.

Myeloid cells and their progenitors have historically been characterized based on their expression of a well-defined set of surface proteins, transcription factors and cytokines they depend on. These traditional analyses on "bulk" myeloid cell populations led to valuable early...

Safety of right heart catheterization for pulmonary hypertension in very elderly patients.

Pulmonary circulation

Ginoux M, Cottin V, Glérant JC, Traclet J, Philit F, Sénéchal A, Mornex JF, Turquier S.
PMID: 30124132
Pulm Circ. 2018 Oct-Dec;8(4):2045894018799272. doi: 10.1177/2045894018799272. Epub 2018 Aug 20.

Right heart catheterization (RHC) is the reference test in diagnosing pulmonary hypertension (PH). The increasing age of patients at the time of diagnosis raises the issue of the morbidity of this invasive test in elderly individuals. We hypothesized that...

Global air quality and climate.

Chemical Society reviews

Fiore AM, Naik V, Spracklen DV, Steiner A, Unger N, Prather M, Bergmann D, Cameron-Smith PJ, Cionni I, Collins WJ, Dalsøren S, Eyring V, Folberth GA, Ginoux P, Horowitz LW, Josse B, Lamarque JF, MacKenzie IA, Nagashima T, O'Connor FM, Righi M, Rumbold ST, Shindell DT, Skeie RB, Sudo K, Szopa S, Takemura T, Zeng G.
PMID: 22868337
Chem Soc Rev. 2012 Oct 07;41(19):6663-83. doi: 10.1039/c2cs35095e. Epub 2012 Aug 06.

Emissions of air pollutants and their precursors determine regional air quality and can alter climate. Climate change can perturb the long-range transport, chemical processing, and local meteorology that influence air pollution. We review the implications of projected changes in...

T-lymphoblastic lymphoma with cutaneous involvement.

World journal of clinical cases

Ginoux E, Julia F, Balme B, Thomas L, Dalle S.
PMID: 26301233
World J Clin Cases. 2015 Aug 16;3(8):727-31. doi: 10.12998/wjcc.v3.i8.727.

To study dermatological manifestation of T-lymphoblastic lymphoma and to help clinicians in the diagnosis, we report here the case of a 75-year-old patient who presented with violaceous nodules acquired during the last 4 wk and affecting the scalp and...

Showing 13 to 24 of 77 entries