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Showing 25 to 36 of 177 entries
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Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor.

Journal for immunotherapy of cancer

You D, Hillerman S, Locke G, Chaudhry C, Stromko C, Murtaza A, Fan Y, Koenitzer J, Chen Y, Briceno S, Bhadra R, Duperret E, Gullo-Brown J, Gao C, Zhao D, Feder J, Curtin J, Degnan AP, Kumi G, Wittman M, Johnson BM, Parrish KE, Gokulrangan G, Morrison J, Quigley M, Hunt JT, Salter-Cid L, Lees E, Sanjuan MA, Liu J.
PMID: 33408094
J Immunother Cancer. 2021 Jan;9(1). doi: 10.1136/jitc-2020-001402.

BACKGROUND: Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) has been demonstrated as a negative intracellular immune checkpoint in mediating antitumor immunity in studies with HPK1 knockout and kinase dead mice. Pharmacological inhibition of HPK1 is desirable to investigate the...

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You D, Hillerman S, Locke G, et al. Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor. J Immunother Cancer. 2021;9(1)doi: 10.1136/jitc-2020-001402.
You, D., Hillerman, S., Locke, G., Chaudhry, C., Stromko, C., Murtaza, A., Fan, Y., Koenitzer, J., Chen, Y., Briceno, S., Bhadra, R., Duperret, E., Gullo-Brown, J., Gao, C., Zhao, D., Feder, J., Curtin, J., Degnan, A. P., Kumi, G., Wittman, M., Johnson, B. M., Parrish, K. E., Gokulrangan, G., Morrison, J., Quigley, M., Hunt, J. T., Salter-Cid, L., Lees, E., Sanjuan, M. A., & Liu, J. (2021). Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor. Journal for immunotherapy of cancer, 9(1), . https://doi.org/10.1136/jitc-2020-001402
You, Dan, et al. "Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor." Journal for immunotherapy of cancer vol. 9,1 (2021). doi: https://doi.org/10.1136/jitc-2020-001402
You D, Hillerman S, Locke G, Chaudhry C, Stromko C, Murtaza A, Fan Y, Koenitzer J, Chen Y, Briceno S, Bhadra R, Duperret E, Gullo-Brown J, Gao C, Zhao D, Feder J, Curtin J, Degnan AP, Kumi G, Wittman M, Johnson BM, Parrish KE, Gokulrangan G, Morrison J, Quigley M, Hunt JT, Salter-Cid L, Lees E, Sanjuan MA, Liu J. Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor. J Immunother Cancer. 2021 Jan;9(1). doi: 10.1136/jitc-2020-001402. PMID: 33408094; PMCID: PMC7789447.
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Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study.

Frontiers in physiology

Wang Y, Wang J, Peng J, Huo M, Yang Z, Giridharan GA, Luan Y, Qin K.
PMID: 34621186
Front Physiol. 2021 Sep 21;12:733464. doi: 10.3389/fphys.2021.733464. eCollection 2021.

Patients with heart failure (HF) or undergoing cardiogenic shock and percutaneous coronary intervention require short-term cardiac support. Short-term cardiac support using a left ventricular assist device (LVAD) alters the pressure and flows of the vasculature by enhancing perfusion and...

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Wang Y, Wang J, Peng J, et al. Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study. Front Physiol. 2021;12:733464doi: 10.3389/fphys.2021.733464.
Wang, Y., Wang, J., Peng, J., Huo, M., Yang, Z., Giridharan, G. A., Luan, Y., & Qin, K. (2021). Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study. Frontiers in physiology, 12733464. https://doi.org/10.3389/fphys.2021.733464
Wang, Yu, et al. "Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study." Frontiers in physiology vol. 12 (2021): 733464. doi: https://doi.org/10.3389/fphys.2021.733464
Wang Y, Wang J, Peng J, Huo M, Yang Z, Giridharan GA, Luan Y, Qin K. Effects of a Short-Term Left Ventricular Assist Device on Hemodynamics in a Heart Failure Patient-Specific Aorta Model: A CFD Study. Front Physiol. 2021 Sep 21;12:733464. doi: 10.3389/fphys.2021.733464. eCollection 2021. PMID: 34621186; PMCID: PMC8491745.
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Assessment of Pulmonary Artery Pressures by Various Doppler Echocardiographic Parameters and its Correlation with Cardiac Catheterization in Patients with Pulmonary Hypertension.

Heart views : the official journal of the Gulf Heart Association

Aashish A, Giridharan S, Karthikeyan S, Ganesh BA, Prasath PA.
PMID: 33986925
Heart Views. 2020 Oct-Dec;21(4):263-268. doi: 10.4103/HEARTVIEWS.HEARTVIEWS_133_20. Epub 2021 Jan 14.

BACKGROUND: Measuring pulmonary artery pressures is a routine index in Doppler echocardiography to diagnose, risk stratify, and prognosticate patients with pulmonary hypertension (PH). There are numerous methods in use to measure it in routine clinical practice.OBJECTIVE: The objective of...

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Aashish A, Giridharan S, Karthikeyan S, et al. Assessment of Pulmonary Artery Pressures by Various Doppler Echocardiographic Parameters and its Correlation with Cardiac Catheterization in Patients with Pulmonary Hypertension. Heart Views. 2021;21(4):263-268doi: 10.4103/HEARTVIEWS.HEARTVIEWS_133_20.
Aashish, A., Giridharan, S., Karthikeyan, S., Ganesh, B. A., & Prasath, P. A. (2020). Assessment of Pulmonary Artery Pressures by Various Doppler Echocardiographic Parameters and its Correlation with Cardiac Catheterization in Patients with Pulmonary Hypertension. Heart views : the official journal of the Gulf Heart Association, 21(4), 263-268. https://doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_133_20
Aashish, Arumugam, et al. "Assessment of Pulmonary Artery Pressures by Various Doppler Echocardiographic Parameters and its Correlation with Cardiac Catheterization in Patients with Pulmonary Hypertension." Heart views : the official journal of the Gulf Heart Association vol. 21,4 (2020): 263-268. doi: https://doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_133_20
Aashish A, Giridharan S, Karthikeyan S, Ganesh BA, Prasath PA. Assessment of Pulmonary Artery Pressures by Various Doppler Echocardiographic Parameters and its Correlation with Cardiac Catheterization in Patients with Pulmonary Hypertension. Heart Views. 2020 Oct-Dec;21(4):263-268. doi: 10.4103/HEARTVIEWS.HEARTVIEWS_133_20. Epub 2021 Jan 14. PMID: 33986925; PMCID: PMC8104318.
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Evaluation of anti-cancer effect of zerumbone and cisplatin on .

Natural product research

Srimathi Devi J, Haripriya D, Arul S, Saravanan KM, Bupesh G.
PMID: 34886734
Nat Prod Res. 2021 Dec 09;1-5. doi: 10.1080/14786419.2021.2012672. Epub 2021 Dec 09.

Cancer is the uncontrolled proliferation of abnormal cells in the body. There is a foreseeable need for an effective anti-carcinogenic drug. In this regard, zerumbone (ZER) is identified as one such therapeutic herbal compound that has been shown to...

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Srimathi Devi J, Haripriya D, Arul S, et al. Evaluation of anti-cancer effect of zerumbone and cisplatin on . Nat Prod Res. 2021;1-5doi: 10.1080/14786419.2021.2012672.
Srimathi Devi, J., Haripriya, D., Arul, S., Saravanan, K. M., & Bupesh, G. (2021). Evaluation of anti-cancer effect of zerumbone and cisplatin on . Natural product research, 1-5. https://doi.org/10.1080/14786419.2021.2012672
Srimathi Devi, Jegannathan, et al. "Evaluation of anti-cancer effect of zerumbone and cisplatin on ." Natural product research vol. (2021): 1-5. doi: https://doi.org/10.1080/14786419.2021.2012672
Srimathi Devi J, Haripriya D, Arul S, Saravanan KM, Bupesh G. Evaluation of anti-cancer effect of zerumbone and cisplatin on . Nat Prod Res. 2021 Dec 09;1-5. doi: 10.1080/14786419.2021.2012672. Epub 2021 Dec 09. PMID: 34886734.
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Effect of Pulsatility on Shear-induced Extensional Behavior of Von Willebrand Factor.

Artificial organs

Wang Y, Nguyen KT, Ismail E, Donoghue L, Giridharan GA, Sethu P, Cheng X.
PMID: 34866200
Artif Organs. 2021 Dec 06; doi: 10.1111/aor.14133. Epub 2021 Dec 06.

BACKGROUND: Patients with continuous flow ventricular assist devices (CF-VADs) are at high risk for non-surgical bleeding, speculated to associate with the loss of pulsatility following CF-VAD placement. It has been hypothesized that continuous shear stress causes elongation and increased...

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Wang Y, Nguyen KT, Ismail E, et al. Effect of Pulsatility on Shear-induced Extensional Behavior of Von Willebrand Factor. Artif Organs. 2021;doi: 10.1111/aor.14133.
Wang, Y., Nguyen, K. T., Ismail, E., Donoghue, L., Giridharan, G. A., Sethu, P., & Cheng, X. (2021). Effect of Pulsatility on Shear-induced Extensional Behavior of Von Willebrand Factor. Artificial organs, . https://doi.org/10.1111/aor.14133
Wang, Yi, et al. "Effect of Pulsatility on Shear-induced Extensional Behavior of Von Willebrand Factor." Artificial organs vol. (2021). doi: https://doi.org/10.1111/aor.14133
Wang Y, Nguyen KT, Ismail E, Donoghue L, Giridharan GA, Sethu P, Cheng X. Effect of Pulsatility on Shear-induced Extensional Behavior of Von Willebrand Factor. Artif Organs. 2021 Dec 06; doi: 10.1111/aor.14133. Epub 2021 Dec 06. PMID: 34866200.
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Initial experience with the Ellipsys Vascular Access System for percutaneous arteriovenous fistula creation in adolescents: A case report.

Radiology case reports

Koo KSH, Monroe EJ, Reis J, Shivaram GM, Munshi R.
PMID: 33363679
Radiol Case Rep. 2020 Dec 17;16(3):441-447. doi: 10.1016/j.radcr.2020.12.026. eCollection 2021 Mar.

This retrospective, single center, case report describes the first use of the Ellipsys Vascular Access System for percutaneous arteriovenous fistula (pAVF) creation in children. Two adolescent (

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Koo KSH, Monroe EJ, Reis J, et al. Initial experience with the Ellipsys Vascular Access System for percutaneous arteriovenous fistula creation in adolescents: A case report. Radiol Case Rep. 2020;16(3):441-447doi: 10.1016/j.radcr.2020.12.026.
Koo, K. S. H., Monroe, E. J., Reis, J., Shivaram, G. M., & Munshi, R. (2021). Initial experience with the Ellipsys Vascular Access System for percutaneous arteriovenous fistula creation in adolescents: A case report. Radiology case reports, 16(3), 441-447. https://doi.org/10.1016/j.radcr.2020.12.026
Koo, Kevin S H, et al. "Initial experience with the Ellipsys Vascular Access System for percutaneous arteriovenous fistula creation in adolescents: A case report." Radiology case reports vol. 16,3 (2021): 441-447. doi: https://doi.org/10.1016/j.radcr.2020.12.026
Koo KSH, Monroe EJ, Reis J, Shivaram GM, Munshi R. Initial experience with the Ellipsys Vascular Access System for percutaneous arteriovenous fistula creation in adolescents: A case report. Radiol Case Rep. 2020 Dec 17;16(3):441-447. doi: 10.1016/j.radcr.2020.12.026. eCollection 2021 Mar. PMID: 33363679; PMCID: PMC7753092.
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Methylome of human senescent hematopoietic progenitors.

Experimental hematology & oncology

Capone S, Colombo AR, Johnson BK, Triche TJ, Ramsingh G.
PMID: 30598855
Exp Hematol Oncol. 2018 Dec 21;7:32. doi: 10.1186/s40164-018-0123-8. eCollection 2018.

Senescence, a state of permanent cell cycle arrest, can be induced by DNA damage. This process, which was initially described in fibroblasts, is now recognized to occur in stem cells. It has been well characterized in cell lines, but...

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Capone S, Colombo AR, Johnson BK, et al. Methylome of human senescent hematopoietic progenitors. Exp Hematol Oncol. 2018;7:32doi: 10.1186/s40164-018-0123-8.
Capone, S., Colombo, A. R., Johnson, B. K., Triche, T. J., & Ramsingh, G. (2018). Methylome of human senescent hematopoietic progenitors. Experimental hematology & oncology, 732. https://doi.org/10.1186/s40164-018-0123-8
Capone, Stephen, et al. "Methylome of human senescent hematopoietic progenitors." Experimental hematology & oncology vol. 7 (2018): 32. doi: https://doi.org/10.1186/s40164-018-0123-8
Capone S, Colombo AR, Johnson BK, Triche TJ, Ramsingh G. Methylome of human senescent hematopoietic progenitors. Exp Hematol Oncol. 2018 Dec 21;7:32. doi: 10.1186/s40164-018-0123-8. eCollection 2018. PMID: 30598855; PMCID: PMC6302458.
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Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives.

Bioinformation

Meenakumari K, Bupesh G.
PMID: 32884210
Bioinformation. 2020 Jun 30;16(6):462-467. doi: 10.6026/97320630016462. eCollection 2020.

It is of interest to document the molecular docking of C-Jun-N-Terminal Kinase (Jnk) (known structure with PDB ID: 1PMN) with amino-pyrimidine derivatives in the context of Alzheimer's Disease (AD). We report the optimal binding features (binding energy, interacting residues,...

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Meenakumari K, Bupesh G. Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives. Bioinformation. 2020;16(6):462-467doi: 10.6026/97320630016462.
Meenakumari, K., & Bupesh, G. (2020). Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives. Bioinformation, 16(6), 462-467. https://doi.org/10.6026/97320630016462
Meenakumari, Krishnamoorthy, and Bupesh, Giridharan. "Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives." Bioinformation vol. 16,6 (2020): 462-467. doi: https://doi.org/10.6026/97320630016462
Meenakumari K, Bupesh G. Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives. Bioinformation. 2020 Jun 30;16(6):462-467. doi: 10.6026/97320630016462. eCollection 2020. PMID: 32884210; PMCID: PMC7452742.
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β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies.

Organic and medicinal chemistry letters

Ragavan RV, Kumar KM, Vijayakumar V, Sarveswari S, Ramaiah S, Anbarasu A, Karthikeyan S, Giridharan P, Kumari NS.
PMID: 23870758
Org Med Chem Lett. 2013 Jul 19;3(1):6. doi: 10.1186/2191-2858-3-6.

BACKGROUND: Pyrazolones are traditionally synthesized by the reaction of β-keto esters with hydrazine and its derivatives. There are methods to synthesize β-keto esters from esters and aldehydes, but these methods have main limitation in varying the substituents. Often, there...

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Ragavan RV, Kumar KM, Vijayakumar V, et al. β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies. Org Med Chem Lett. 2013;3(1):6doi: 10.1186/2191-2858-3-6.
Ragavan, R. V., Kumar, K. M., Vijayakumar, V., Sarveswari, S., Ramaiah, S., Anbarasu, A., Karthikeyan, S., Giridharan, P., & Kumari, N. S. (2013). β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies. Organic and medicinal chemistry letters, 3(1), 6. https://doi.org/10.1186/2191-2858-3-6
Ragavan, Ramasamy Venkat, et al. "β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies." Organic and medicinal chemistry letters vol. 3,1 (2013): 6. doi: https://doi.org/10.1186/2191-2858-3-6
Ragavan RV, Kumar KM, Vijayakumar V, Sarveswari S, Ramaiah S, Anbarasu A, Karthikeyan S, Giridharan P, Kumari NS. β-Keto esters from ketones and ethyl chloroformate: a rapid, general, efficient synthesis of pyrazolones and their antimicrobial, in silico and in vitro cytotoxicity studies. Org Med Chem Lett. 2013 Jul 19;3(1):6. doi: 10.1186/2191-2858-3-6. PMID: 23870758; PMCID: PMC3726461.
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2,2,10-Trimethyl-2,3-dihydro-pyrano[2,3-a]carbazol-4(11H)-one.

Acta crystallographica. Section E, Structure reports online

Sridharan M, Prasad KJ, Ngendahimana A, Zeller M.
PMID: 21581017
Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 22;64:o2157. doi: 10.1107/S1600536808033862.

The title compound, C(18)H(17)NO(2), was prepared from 1-hydr-oxy-8-methyl-carbazole and 3,3-dimethyl-acrylic acid with trifluoro-acetic acid as the cyclization catalyst. Due to the -CMe(2)- group, the mol-ecule is not quite planar. The packing is dominated by the strong N-H⋯O hydrogen bonds...

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Sridharan M, Prasad KJ, Ngendahimana A, et al. 2,2,10-Trimethyl-2,3-dihydro-pyrano[2,3-a]carbazol-4(11H)-one. Acta Crystallogr Sect E Struct Rep Online. 2008;64:o2157doi: 10.1107/S1600536808033862.
Sridharan, M., Prasad, K. J., Ngendahimana, A., & Zeller, M. (2008). 2,2,10-Trimethyl-2,3-dihydro-pyrano[2,3-a]carbazol-4(11H)-one. Acta crystallographica. Section E, Structure reports online, 64o2157. https://doi.org/10.1107/S1600536808033862
Sridharan, Makuteswaran, et al. "2,2,10-Trimethyl-2,3-dihydro-pyrano[2,3-a]carbazol-4(11H)-one." Acta crystallographica. Section E, Structure reports online vol. 64 (2008): o2157. doi: https://doi.org/10.1107/S1600536808033862
Sridharan M, Prasad KJ, Ngendahimana A, Zeller M. 2,2,10-Trimethyl-2,3-dihydro-pyrano[2,3-a]carbazol-4(11H)-one. Acta Crystallogr Sect E Struct Rep Online. 2008 Oct 22;64:o2157. doi: 10.1107/S1600536808033862. PMID: 21581017; PMCID: PMC2959518.
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9-Chloro-1-methyl-7-phenyl-5,6-dihydro-13H-indolo[3,2-c]acridine.

Acta crystallographica. Section E, Structure reports online

Sridharan M, Rajendra Prasad KJ, Zeller M.
PMID: 21583880
Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 18;65:o1064. doi: 10.1107/S1600536809013737.

The title compound, C(26)H(19)ClN(2), is a 5,6-dihydro-13H-indolo[3,2-c]acridine prepared by condensation of a 2,3,4,9-tetra-hydro-1H-carbazol-1-one with 2-amino-benzophenone. The crystals undergo a destructive phase change upon cooling at varying temperatures between 270 and 200 K, depending on cooling rate and disturbance by...

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Sridharan M, Rajendra Prasad KJ, Zeller M. 9-Chloro-1-methyl-7-phenyl-5,6-dihydro-13H-indolo[3,2-c]acridine. Acta Crystallogr Sect E Struct Rep Online. 2009;65:o1064doi: 10.1107/S1600536809013737.
Sridharan, M., Rajendra Prasad, K. J., & Zeller, M. (2009). 9-Chloro-1-methyl-7-phenyl-5,6-dihydro-13H-indolo[3,2-c]acridine. Acta crystallographica. Section E, Structure reports online, 65o1064. https://doi.org/10.1107/S1600536809013737
Sridharan, Makuteswaran, et al. "9-Chloro-1-methyl-7-phenyl-5,6-dihydro-13H-indolo[3,2-c]acridine." Acta crystallographica. Section E, Structure reports online vol. 65 (2009): o1064. doi: https://doi.org/10.1107/S1600536809013737
Sridharan M, Rajendra Prasad KJ, Zeller M. 9-Chloro-1-methyl-7-phenyl-5,6-dihydro-13H-indolo[3,2-c]acridine. Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 18;65:o1064. doi: 10.1107/S1600536809013737. PMID: 21583880; PMCID: PMC2977744.
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Important relationships between Rab and MICAL proteins in endocytic trafficking.

World journal of biological chemistry

Rahajeng J, Giridharan SS, Cai B, Naslavsky N, Caplan S.
PMID: 21537482
World J Biol Chem. 2010 Aug 26;1(8):254-64. doi: 10.4331/wjbc.v1.i8.254.

The internalization of essential nutrients, lipids and receptors is a crucial process for all eukaryotic cells. Accordingly, endocytosis is highly conserved across cell types and species. Once internalized, small cargo-containing vesicles fuse with early endosomes (also known as sorting...

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Rahajeng J, Giridharan SS, Cai B, et al. Important relationships between Rab and MICAL proteins in endocytic trafficking. World J Biol Chem. 2010;1(8):254-64doi: 10.4331/wjbc.v1.i8.254.
Rahajeng, J., Giridharan, S. S., Cai, B., Naslavsky, N., & Caplan, S. (2010). Important relationships between Rab and MICAL proteins in endocytic trafficking. World journal of biological chemistry, 1(8), 254-64. https://doi.org/10.4331/wjbc.v1.i8.254
Rahajeng, Juliati, et al. "Important relationships between Rab and MICAL proteins in endocytic trafficking." World journal of biological chemistry vol. 1,8 (2010): 254-64. doi: https://doi.org/10.4331/wjbc.v1.i8.254
Rahajeng J, Giridharan SS, Cai B, Naslavsky N, Caplan S. Important relationships between Rab and MICAL proteins in endocytic trafficking. World J Biol Chem. 2010 Aug 26;1(8):254-64. doi: 10.4331/wjbc.v1.i8.254. PMID: 21537482; PMCID: PMC3083971.
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