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Design, synthesis, and antitumor activity evaluation of steroidal oximes.

Bioorganic & medicinal chemistry

Gomes AR, Pires AS, Abrantes AM, Gonçalves AC, Costa SC, Varela CL, Silva ET, Botelho MF, Roleira FMF.
PMID: 34425478
Bioorg Med Chem. 2021 Sep 15;46:116360. doi: 10.1016/j.bmc.2021.116360. Epub 2021 Aug 08.

Steroidal compounds were proven to be efficient drugs against several types of cancer. Oximes are also chemical structures frequently associated with anticancer activity. The main goal of this work was to combine the two referred structures by synthesizing steroidal...

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Gomes AR, Pires AS, Abrantes AM, et al. Design, synthesis, and antitumor activity evaluation of steroidal oximes. Bioorg Med Chem. 2021;46:116360doi: 10.1016/j.bmc.2021.116360.
Gomes, A. R., Pires, A. S., Abrantes, A. M., Gonçalves, A. C., Costa, S. C., Varela, C. L., Silva, E. T., Botelho, M. F., & Roleira, F. M. F. (2021). Design, synthesis, and antitumor activity evaluation of steroidal oximes. Bioorganic & medicinal chemistry, 46116360. https://doi.org/10.1016/j.bmc.2021.116360
Gomes, Ana R, et al. "Design, synthesis, and antitumor activity evaluation of steroidal oximes." Bioorganic & medicinal chemistry vol. 46 (2021): 116360. doi: https://doi.org/10.1016/j.bmc.2021.116360
Gomes AR, Pires AS, Abrantes AM, Gonçalves AC, Costa SC, Varela CL, Silva ET, Botelho MF, Roleira FMF. Design, synthesis, and antitumor activity evaluation of steroidal oximes. Bioorg Med Chem. 2021 Sep 15;46:116360. doi: 10.1016/j.bmc.2021.116360. Epub 2021 Aug 08. PMID: 34425478.
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Donor-derived vasculature is required to support neocortical cell grafts after stroke.

Stem cell research

Krzyspiak J, Yan J, Ghosh HS, Galinski B, Lituma PJ, Alvina K, Quezada A, Kee S, Grońska-Pęski M, Tai Y, McDermott K, Gonçalves JT, Zukin RS, Weiser DA, Castillo PE, Khodakhah K, Hébert JM.
PMID: 34971934
Stem Cell Res. 2021 Dec 24;59:102642. doi: 10.1016/j.scr.2021.102642. Epub 2021 Dec 24.

Neural precursor cells (NPCs) transplanted into the adult neocortex generate neurons that synaptically integrate with host neurons, supporting the possibility of achieving functional tissue repair. However, poor survival and functional neuronal recovery of transplanted NPCs greatly limits engraftment. Here,...

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Krzyspiak J, Yan J, Ghosh HS, et al. Donor-derived vasculature is required to support neocortical cell grafts after stroke. Stem Cell Res. 2021;59:102642doi: 10.1016/j.scr.2021.102642.
Krzyspiak, J., Yan, J., Ghosh, H. S., Galinski, B., Lituma, P. J., Alvina, K., Quezada, A., Kee, S., Grońska-Pęski, M., Tai, Y., McDermott, K., Gonçalves, J. T., Zukin, R. S., Weiser, D. A., Castillo, P. E., Khodakhah, K., & Hébert, J. M. (2021). Donor-derived vasculature is required to support neocortical cell grafts after stroke. Stem cell research, 59102642. https://doi.org/10.1016/j.scr.2021.102642
Krzyspiak, Joanna, et al. "Donor-derived vasculature is required to support neocortical cell grafts after stroke." Stem cell research vol. 59 (2021): 102642. doi: https://doi.org/10.1016/j.scr.2021.102642
Krzyspiak J, Yan J, Ghosh HS, Galinski B, Lituma PJ, Alvina K, Quezada A, Kee S, Grońska-Pęski M, Tai Y, McDermott K, Gonçalves JT, Zukin RS, Weiser DA, Castillo PE, Khodakhah K, Hébert JM. Donor-derived vasculature is required to support neocortical cell grafts after stroke. Stem Cell Res. 2021 Dec 24;59:102642. doi: 10.1016/j.scr.2021.102642. Epub 2021 Dec 24. PMID: 34971934.
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Does Probiotic Consumption Enhance Wound Healing? A Systematic Review.

Nutrients

Togo C, Zidorio AP, Gonçalves V, Botelho P, de Carvalho K, Dutra E.
PMID: 35010987
Nutrients. 2021 Dec 27;14(1). doi: 10.3390/nu14010111.

The use of probiotics is one of the emerging lines of treatment for wound healing. This systematic review aimed to summarize currently available evidence on the effect of oral or enteral probiotic therapy on skin or oral mucosal wound...

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Togo C, Zidorio AP, Gonçalves V, et al. Does Probiotic Consumption Enhance Wound Healing? A Systematic Review. Nutrients. 2021;14(1)doi: 10.3390/nu14010111.
Togo, C., Zidorio, A. P., Gonçalves, V., Botelho, P., de Carvalho, K., & Dutra, E. (2021). Does Probiotic Consumption Enhance Wound Healing? A Systematic Review. Nutrients, 14(1), . https://doi.org/10.3390/nu14010111
Togo, Camille, et al. "Does Probiotic Consumption Enhance Wound Healing? A Systematic Review." Nutrients vol. 14,1 (2021). doi: https://doi.org/10.3390/nu14010111
Togo C, Zidorio AP, Gonçalves V, Botelho P, de Carvalho K, Dutra E. Does Probiotic Consumption Enhance Wound Healing? A Systematic Review. Nutrients. 2021 Dec 27;14(1). doi: 10.3390/nu14010111. PMID: 35010987; PMCID: PMC8746682.
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Latitude dictates plant diversity effects on instream decomposition.

Science advances

Boyero L, Pérez J, López-Rojo N, Tonin AM, Correa-Araneda F, Pearson RG, Bosch J, Albariño RJ, Anbalagan S, Barmuta LA, Beesley L, Burdon FJ, Caliman A, Callisto M, Campbell IC, Cardinale BJ, Casas JJ, Chará-Serna AM, Ciapała S, Chauvet E, Colón-Gaud C, Cornejo A, Davis AM, Degebrodt M, Dias ES, Díaz ME, Douglas MM, Elosegi A, Encalada AC, de Eyto E, Figueroa R, Flecker AS, Fleituch T, Frainer A, França JS, García EA, García G, García P, Gessner MO, Giller PS, Gómez JE, Gómez S, Gonçalves JF, Graça MAS, Hall RO, Hamada N, Hepp LU, Hui C, Imazawa D, Iwata T, Junior ESA, Kariuki S, Landeira-Dabarca A, Leal M, Lehosmaa K, M'Erimba C, Marchant R, Martins RT, Masese FO, Camden M, McKie BG, Medeiros AO, Middleton JA, Muotka T, Negishi JN, Pozo J, Ramírez A, Rezende RS, Richardson JS, Rincón J, Rubio-Ríos J, Serrano C, Shaffer AR, Sheldon F, Swan CM, Tenkiano NSD, Tiegs SD, Tolod JR, Vernasky M, Watson A, Yegon MJ, Yule CM.
PMID: 33771867
Sci Adv. 2021 Mar 26;7(13). doi: 10.1126/sciadv.abe7860. Print 2021 Mar.

Running waters contribute substantially to global carbon fluxes through decomposition of terrestrial plant litter by aquatic microorganisms and detritivores. Diversity of this litter may influence instream decomposition globally in ways that are not yet understood. We investigated latitudinal differences...

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Boyero L, Pérez J, López-Rojo N, et al. Latitude dictates plant diversity effects on instream decomposition. Sci Adv. 2021;7(13)doi: 10.1126/sciadv.abe7860.
Boyero, L., Pérez, J., López-Rojo, N., Tonin, A. M., Correa-Araneda, F., Pearson, R. G., Bosch, J., Albariño, R. J., Anbalagan, S., Barmuta, L. A., Beesley, L., Burdon, F. J., Caliman, A., Callisto, M., Campbell, I. C., Cardinale, B. J., Casas, J. J., Chará-Serna, A. M., Ciapała, S., Chauvet, E., Colón-Gaud, C., Cornejo, A., Davis, A. M., Degebrodt, M., Dias, E. S., Díaz, M. E., Douglas, M. M., Elosegi, A., Encalada, A. C., de Eyto, E., Figueroa, R., Flecker, A. S., Fleituch, T., Frainer, A., França, J. S., García, E. A., García, G., García, P., Gessner, M. O., Giller, P. S., Gómez, J. E., Gómez, S., Gonçalves, J. F., Graça, M. A. S., Hall, R. O., Hamada, N., Hepp, L. U., Hui, C., Imazawa, D., Iwata, T., Junior, E. S. A., Kariuki, S., Landeira-Dabarca, A., Leal, M., Lehosmaa, K., M'Erimba, C., Marchant, R., Martins, R. T., Masese, F. O., Camden, M., McKie, B. G., Medeiros, A. O., Middleton, J. A., Muotka, T., Negishi, J. N., Pozo, J., Ramírez, A., Rezende, R. S., Richardson, J. S., Rincón, J., Rubio-Ríos, J., Serrano, C., Shaffer, A. R., Sheldon, F., Swan, C. M., Tenkiano, N. S. D., Tiegs, S. D., Tolod, J. R., Vernasky, M., Watson, A., Yegon, M. J., & Yule, C. M. (2021). Latitude dictates plant diversity effects on instream decomposition. Science advances, 7(13), . https://doi.org/10.1126/sciadv.abe7860
Boyero, Luz, et al. "Latitude dictates plant diversity effects on instream decomposition." Science advances vol. 7,13 (2021). doi: https://doi.org/10.1126/sciadv.abe7860
Boyero L, Pérez J, López-Rojo N, Tonin AM, Correa-Araneda F, Pearson RG, Bosch J, Albariño RJ, Anbalagan S, Barmuta LA, Beesley L, Burdon FJ, Caliman A, Callisto M, Campbell IC, Cardinale BJ, Casas JJ, Chará-Serna AM, Ciapała S, Chauvet E, Colón-Gaud C, Cornejo A, Davis AM, Degebrodt M, Dias ES, Díaz ME, Douglas MM, Elosegi A, Encalada AC, de Eyto E, Figueroa R, Flecker AS, Fleituch T, Frainer A, França JS, García EA, García G, García P, Gessner MO, Giller PS, Gómez JE, Gómez S, Gonçalves JF, Graça MAS, Hall RO, Hamada N, Hepp LU, Hui C, Imazawa D, Iwata T, Junior ESA, Kariuki S, Landeira-Dabarca A, Leal M, Lehosmaa K, M'Erimba C, Marchant R, Martins RT, Masese FO, Camden M, McKie BG, Medeiros AO, Middleton JA, Muotka T, Negishi JN, Pozo J, Ramírez A, Rezende RS, Richardson JS, Rincón J, Rubio-Ríos J, Serrano C, Shaffer AR, Sheldon F, Swan CM, Tenkiano NSD, Tiegs SD, Tolod JR, Vernasky M, Watson A, Yegon MJ, Yule CM. Latitude dictates plant diversity effects on instream decomposition. Sci Adv. 2021 Mar 26;7(13). doi: 10.1126/sciadv.abe7860. Print 2021 Mar. PMID: 33771867; PMCID: PMC7997509.
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Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal.

Frontiers in behavioral neuroscience

Fuerte-Hortigón A, Gonçalves J, Zeballos L, Masa R, Gómez-Nieto R, López DE.
PMID: 33841106
Front Behav Neurosci. 2021 Mar 24;15:613798. doi: 10.3389/fnbeh.2021.613798. eCollection 2021.

The endocannabinoid system modulates epileptic seizures by regulating neuronal excitability. It has become clear that agonist activation of central type I cannabinoid receptors (CB1R) reduces epileptogenesis in pre-clinical animal models of epilepsy. The audiogenic seizure-prone hamster GASH/Sal is a...

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Fuerte-Hortigón A, Gonçalves J, Zeballos L, et al. Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Front Behav Neurosci. 2021;15:613798doi: 10.3389/fnbeh.2021.613798.
Fuerte-Hortigón, A., Gonçalves, J., Zeballos, L., Masa, R., Gómez-Nieto, R., & López, D. E. (2021). Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Frontiers in behavioral neuroscience, 15613798. https://doi.org/10.3389/fnbeh.2021.613798
Fuerte-Hortigón, Alejando, et al. "Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal." Frontiers in behavioral neuroscience vol. 15 (2021): 613798. doi: https://doi.org/10.3389/fnbeh.2021.613798
Fuerte-Hortigón A, Gonçalves J, Zeballos L, Masa R, Gómez-Nieto R, López DE. Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Front Behav Neurosci. 2021 Mar 24;15:613798. doi: 10.3389/fnbeh.2021.613798. eCollection 2021. PMID: 33841106; PMCID: PMC8024637.
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Treadmill-based task for assessing spatial memory in head-fixed mice.

STAR protocols

Jordan JT, McDermott KD, Frechou MA, Shtrahman M, Gonçalves JT.
PMID: 34471907
STAR Protoc. 2021 Aug 21;2(3):100770. doi: 10.1016/j.xpro.2021.100770. eCollection 2021 Sep 17.

Several mouse

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Jordan JT, McDermott KD, Frechou MA, et al. Treadmill-based task for assessing spatial memory in head-fixed mice. STAR Protoc. 2021;2(3):100770doi: 10.1016/j.xpro.2021.100770.
Jordan, J. T., McDermott, K. D., Frechou, M. A., Shtrahman, M., & Gonçalves, J. T. (2021). Treadmill-based task for assessing spatial memory in head-fixed mice. STAR protocols, 2(3), 100770. https://doi.org/10.1016/j.xpro.2021.100770
Jordan, Jake T, et al. "Treadmill-based task for assessing spatial memory in head-fixed mice." STAR protocols vol. 2,3 (2021): 100770. doi: https://doi.org/10.1016/j.xpro.2021.100770
Jordan JT, McDermott KD, Frechou MA, Shtrahman M, Gonçalves JT. Treadmill-based task for assessing spatial memory in head-fixed mice. STAR Protoc. 2021 Aug 21;2(3):100770. doi: 10.1016/j.xpro.2021.100770. eCollection 2021 Sep 17. PMID: 34471907; PMCID: PMC8387801.
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Genomic characterisation of multiple myeloma: study of a Portuguese cohort.

Journal of clinical pathology

Couto Oliveira A, Ribeiro IP, Pires LM, Gonçalves AC, Paiva A, Geraldes C, Roque A, Sarmento-Ribeiro AB, Barbosa de Melo J, Carreira IM.
PMID: 33653728
J Clin Pathol. 2021 Mar 02; doi: 10.1136/jclinpath-2020-207204. Epub 2021 Mar 02.

Multiple myeloma (MM) genomic complexity reflects in the variable patients' clinical presentation. Genome-wide studies seem to be a reasonable alternative to identify critical genomic lesions. In the current study, we have performed the genomic characterisation of a Portuguese cohort...

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Couto Oliveira A, Ribeiro IP, Pires LM, et al. Genomic characterisation of multiple myeloma: study of a Portuguese cohort. J Clin Pathol. 2021;doi: 10.1136/jclinpath-2020-207204.
Couto Oliveira, A., Ribeiro, I. P., Pires, L. M., Gonçalves, A. C., Paiva, A., Geraldes, C., Roque, A., Sarmento-Ribeiro, A. B., Barbosa de Melo, J., & Carreira, I. M. (2021). Genomic characterisation of multiple myeloma: study of a Portuguese cohort. Journal of clinical pathology, . https://doi.org/10.1136/jclinpath-2020-207204
Couto Oliveira, Alexandra, et al. "Genomic characterisation of multiple myeloma: study of a Portuguese cohort." Journal of clinical pathology vol. (2021). doi: https://doi.org/10.1136/jclinpath-2020-207204
Couto Oliveira A, Ribeiro IP, Pires LM, Gonçalves AC, Paiva A, Geraldes C, Roque A, Sarmento-Ribeiro AB, Barbosa de Melo J, Carreira IM. Genomic characterisation of multiple myeloma: study of a Portuguese cohort. J Clin Pathol. 2021 Mar 02; doi: 10.1136/jclinpath-2020-207204. Epub 2021 Mar 02. PMID: 33653728.
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Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts.

Molecules (Basel, Switzerland)

Gonçalves AC, Costa AR, Flores-Félix JD, Falcão A, Alves G, Silva LR.
PMID: 35011501
Molecules. 2022 Jan 02;27(1). doi: 10.3390/molecules27010268.

Cherries have largely been investigated due to their high content in phenolics in order to fully explore their health-promoting properties. Therefore, this work aimed to assess, for the first time, the anti-inflammatory potential of phenolic-targeted fractions of the

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Gonçalves AC, Costa AR, Flores-Félix JD, et al. Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts. Molecules. 2022;27(1)doi: 10.3390/molecules27010268.
Gonçalves, A. C., Costa, A. R., Flores-Félix, J. D., Falcão, A., Alves, G., & Silva, L. R. (2022). Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts. Molecules (Basel, Switzerland), 27(1), . https://doi.org/10.3390/molecules27010268
Gonçalves, Ana C, et al. "Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts." Molecules (Basel, Switzerland) vol. 27,1 (2022). doi: https://doi.org/10.3390/molecules27010268
Gonçalves AC, Costa AR, Flores-Félix JD, Falcão A, Alves G, Silva LR. Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts. Molecules. 2022 Jan 02;27(1). doi: 10.3390/molecules27010268. PMID: 35011501; PMCID: PMC8747005.
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Prevalence and prognostic impact of apical sparing contractility pattern in patients with aortic stenosis referred for transcatheter aortic valve implantation.

American journal of cardiovascular disease

Ferreira VV, Rosa SA, Pereira-da-Silva T, Rodrigues I, Gonçalves AV, Mendonça T, Castelo A, Branco LM, Galrinho A, Fiarresga A, Ramos R, Patrício L, Cacela D, Ferreira RC.
PMID: 34322299
Am J Cardiovasc Dis. 2021 Jun 15;11(3):283-294. eCollection 2021.

INTRODUCTION: Prolonged afterload increase in aortic stenosis (AS) may alter left ventricular (LV) contractility, irrespective of LV ejection fraction (LVEF). The prevalence and morbimortality associated with the apical sparing strain pattern (ASP), a typical finding of cardiac amyloidosis (CA),...

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Ferreira VV, Rosa SA, Pereira-da-Silva T, et al. Prevalence and prognostic impact of apical sparing contractility pattern in patients with aortic stenosis referred for transcatheter aortic valve implantation. Am J Cardiovasc Dis. 2021;11(3):283-294
Ferreira, V. V., Rosa, S. A., Pereira-da-Silva, T., Rodrigues, I., Gonçalves, A. V., Mendonça, T., Castelo, A., Branco, L. M., Galrinho, A., Fiarresga, A., Ramos, R., Patrício, L., Cacela, D., & Ferreira, R. C. (2021). Prevalence and prognostic impact of apical sparing contractility pattern in patients with aortic stenosis referred for transcatheter aortic valve implantation. American journal of cardiovascular disease, 11(3), 283-294.
Ferreira, Vera V, et al. "Prevalence and prognostic impact of apical sparing contractility pattern in patients with aortic stenosis referred for transcatheter aortic valve implantation." American journal of cardiovascular disease vol. 11,3 (2021): 283-294.
Ferreira VV, Rosa SA, Pereira-da-Silva T, Rodrigues I, Gonçalves AV, Mendonça T, Castelo A, Branco LM, Galrinho A, Fiarresga A, Ramos R, Patrício L, Cacela D, Ferreira RC. Prevalence and prognostic impact of apical sparing contractility pattern in patients with aortic stenosis referred for transcatheter aortic valve implantation. Am J Cardiovasc Dis. 2021 Jun 15;11(3):283-294. eCollection 2021. PMID: 34322299; PMCID: PMC8303034.
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Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development.

Journal of pregnancy

Brandão AH, Pereira LM, Gonçalves AC, Reis ZS, Leite HV, Cabral AC.
PMID: 22888435
J Pregnancy. 2012;2012:909315. doi: 10.1155/2012/909315. Epub 2012 Jul 19.

Background. Poor placentation and systemic endothelial dysfunction have been identified as main events in Preeclampsia (PE). The relationship and chronology of these phenomena are important if we are to understand the pathophysiological mechanisms underlying this major clinical problem. Objectives....

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Brandão AH, Pereira LM, Gonçalves AC, et al. Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development. J Pregnancy. 2012;2012:909315doi: 10.1155/2012/909315.
Brandão, A. H., Pereira, L. M., Gonçalves, A. C., Reis, Z. S., Leite, H. V., & Cabral, A. C. (2012). Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development. Journal of pregnancy, 2012909315. https://doi.org/10.1155/2012/909315
Brandão, Augusto Henriques Fulgêncio, et al. "Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development." Journal of pregnancy vol. 2012 (2012): 909315. doi: https://doi.org/10.1155/2012/909315
Brandão AH, Pereira LM, Gonçalves AC, Reis ZS, Leite HV, Cabral AC. Comparative Study of Endothelial Function and Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development. J Pregnancy. 2012;2012:909315. doi: 10.1155/2012/909315. Epub 2012 Jul 19. PMID: 22888435; PMCID: PMC3409611.
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