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Showing 13 to 24 of 297 entries
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ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.

Oncoimmunology

Steinbach A, Winter J, Reuschenbach M, Blatnik R, Klevenz A, Bertrand M, Hoppe S, von Knebel Doeberitz M, Grabowska AK, Riemer AB.
PMID: 28811980
Oncoimmunology. 2017 Jun 20;6(7):e1336594. doi: 10.1080/2162402X.2017.1336594. eCollection 2017.

Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and...

Stable DHLA-PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging.

Journal of materials chemistry. B

Zamberlan F, Turyanska L, Patanè A, Liu Z, Williams HEL, Fay MW, Clarke PA, Imamura Y, Jin T, Bradshaw TD, Thomas NR, Grabowska AM.
PMID: 32254483
J Mater Chem B. 2018 Jan 28;6(4):550-555. doi: 10.1039/c7tb02912h. Epub 2018 Jan 12.

The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid-polyethylene glycol (DHLA-PEG) ligands terminated with functional groups...

Validation of the Asante HIV-1 Rapid Recency Assay for Detection of Recent HIV-1 Infections in Uganda.

AIDS research and human retroviruses

Galiwango RM, Ssuuna C, Kaleebu P, Kigozi G, Kagaayi J, Nakigozi G, Reynolds SJ, Lutalo T, Kankaka EN, Wasswa JB, Kalibbala SN, Kigozi AN, Watera C, Ejang J, Ndyanabo A, Anok AJ, Ssemwanga D, Kibengo FM, Quinn TC, Grabowski M, Chang LW, Wawer M, Gray R, Laeyendecker O, Serwadda D.
PMID: 33499732
AIDS Res Hum Retroviruses. 2021 Feb 25; doi: 10.1089/AID.2020.0279. Epub 2021 Feb 25.

Point of care rapid recency testing for HIV-1 may be a cost-effective tool to identify recently infected individuals for incidence estimation, and focused HIV prevention through intensified contact tracing. We validated the Asante™ HIV-1 rapid recency

Effects of Simultaneous Exposure to a Western Diet and Wheel-Running Training on Brain Energy Metabolism in Female Rats.

Nutrients

Nowacka-Chmielewska MM, Liśkiewicz D, Grabowska K, Liśkiewicz A, Marczak Ł, Wojakowska A, Pondel N, Grabowski M, Barski JJ, Małecki A.
PMID: 34959794
Nutrients. 2021 Nov 26;13(12). doi: 10.3390/nu13124242.

BACKGROUND: In the pathogenesis of central nervous system disorders (e.g., neurodegenerative), an important role is attributed to an unhealthy lifestyle affecting brain energy metabolism. Physical activity in the prevention and treatment of lifestyle-related diseases is getting increasing attention.METHODS: We...

Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity.

Journal of molecular and cellular cardiology

Grabowska ME, Chun B, Moya R, Saucerman JJ.
PMID: 33667419
J Mol Cell Cardiol. 2021 Jun;155:66-77. doi: 10.1016/j.yjmcc.2021.02.014. Epub 2021 Mar 03.

Despite clinical observations of cardiotoxicity among cancer patients treated with tyrosine kinase inhibitors (TKIs), the molecular mechanisms by which these drugs affect the heart remain largely unknown. Mechanistic understanding of TKI-induced cardiotoxicity has been limited in part due to...

Numerical Simulation of a Scanning Illumination System for Deep Tissue Fluorescence Imaging.

Journal of imaging

Zhang Q, Grabowska AM, Clarke PA, Morgan SP.
PMID: 34460506
J Imaging. 2019 Oct 24;5(11). doi: 10.3390/jimaging5110083.

The spatial resolution and light detected in fluorescence imaging for small animals are limited by light scattering, absorption and autofluorescence. To address this, novel near-infrared fluorescent contrast agents and imaging configurations have been investigated. In this paper, the influence...

ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.

Neuro-oncology advances

Nasir A, Cardall A, Othman RT, Nicolaou N, Lourdusamy A, Linke F, Onion D, Ryzhova M, Cameron H, Valente C, Ritchie A, Korshunov A, Pfister SM, Grabowska AM, Kerr ID, Coyle B.
PMID: 33948561
Neurooncol Adv. 2021 Apr 28;3(1):vdab030. doi: 10.1093/noajnl/vdab030. eCollection 2021.

BACKGROUND: Therapeutic intervention in metastatic medulloblastoma is dependent on elucidating the underlying metastatic mechanism. We investigated whether an epithelial-mesenchymal transition (EMT)-like pathway could drive medulloblastoma metastasis.METHODS: A 3D Basement Membrane Extract (3D-BME) model was used to investigate medulloblastoma cell...

Markers of Cellular Proliferation, Apoptosis, Estrogen/Progesterone Receptor Expression and Fibrosis in Selective Progesterone Receptor Modulator (Ulipristal Acetate)-Treated Uterine Fibroids.

Journal of clinical medicine

Szydłowska I, Grabowska M, Nawrocka-Rutkowska J, Piasecka M, Starczewski A.
PMID: 33546154
J Clin Med. 2021 Feb 03;10(4). doi: 10.3390/jcm10040562.

There appear to be very few data on the exact mechanisms of a selective progesterone receptor modulator action in myomas. The aim of the study was to assess the effects of ulipristal acetate (UPA) on fibroids, especially on estrogen...

Antimicrobial Susceptibility of Lactic Acid Bacteria Strains of Potential Use as Feed Additives - The Basic Safety and Usefulness Criterion.

Frontiers in veterinary science

Stefańska I, Kwiecień E, Jóźwiak-Piasecka K, Garbowska M, Binek M, Rzewuska M.
PMID: 34277757
Front Vet Sci. 2021 Jul 01;8:687071. doi: 10.3389/fvets.2021.687071. eCollection 2021.

The spread of resistance to antibiotics is a major health concern worldwide due to the increasing rate of isolation of multidrug resistant pathogens hampering the treatment of infections. The food chain has been recognized as one of the key...

Structural and Magnetic Properties of BaFeO.

Inorganic chemistry

Wollstadt S, Ikeda Y, Sarkar A, Vasala S, Fasel C, Alff L, Kruk R, Grabowski B, Clemens O.
PMID: 34240868
Inorg Chem. 2021 Aug 02;60(15):10923-10933. doi: 10.1021/acs.inorgchem.1c00434. Epub 2021 Jul 09.

A vacancy-ordered perovskite-type compound Ba

Molecular landscape of IDH-mutant primary astrocytoma Grade IV/glioblastomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Wong QH, Li KK, Wang WW, Malta TM, Noushmehr H, Grabovska Y, Jones C, Chan AK, Kwan JS, Huang QJ, Wong GC, Li WC, Liu XZ, Chen H, Chan DT, Mao Y, Zhang ZY, Shi ZF, Ng HK.
PMID: 33692446
Mod Pathol. 2021 Jul;34(7):1245-1260. doi: 10.1038/s41379-021-00778-x. Epub 2021 Mar 10.

WHO 2016 classified glioblastomas into IDH-mutant and IDH-wildtype with the former having a better prognosis but there was no study on IDH-mutant primary glioblastomas only, as previous series included secondary glioblastomas. We recruited a series of 67 IDH-mutant primary...

Advances in the First Line Treatment of Pediatric Acute Myeloid Leukemia in the Polish Pediatric Leukemia and Lymphoma Study Group from 1983 to 2019.

Cancers

Czogała M, Balwierz W, Pawińska-Wąsikowska K, Książek T, Bukowska-Strakova K, Czogała W, Sikorska-Fic B, Matysiak M, Skalska-Sadowska J, Wachowiak J, Moj-Hackemer M, Kałwak K, Muszyńska-Rosłan K, Krawczuk-Rybak M, Grabowski D, Kowalczyk J, Maciejka-Kembłowska L, Irga-Jaworska N, Bobeff K, Młynarski W, Tomaszewska R, Szczepański T, Chodała-Grzywacz A, Karolczyk G, Mizia-Malarz A, Mycko K, Badowska W, Zielezińska K, Urasiński T, Urbańska-Rakus J, Ciebiera M, Chaber R, Bartoszewicz N, Wysocki M, Skoczeń S.
PMID: 34572762
Cancers (Basel). 2021 Sep 09;13(18). doi: 10.3390/cancers13184536.

BACKGROUND: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed the results of pediatric AML treatment in Poland from 1983 to 2019 (excluding promyelocytic,...

Showing 13 to 24 of 297 entries