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Showing 169 to 173 of 173 entries
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Treatment with ribociclib shows favourable immunomodulatory effects in patients with hormone receptor-positive breast cancer-findings from the RIBECCA trial.

European journal of cancer (Oxford, England : 1990)

Peuker CA, Yaghobramzi S, Grunert C, Keilholz L, Gjerga E, Hennig S, Schaper S, Na IK, Keller U, Brucker S, Decker T, Fasching P, Fehm T, Janni W, Kümmel S, Schneeweiss A, Schuler M, Lüftner D, Busse A.
PMID: 34953442
Eur J Cancer. 2021 Dec 22;162:45-55. doi: 10.1016/j.ejca.2021.11.025. Epub 2021 Dec 22.

BACKGROUND: Inhibitors of the cyclin-dependent kinases 4 and 6 (CDK4/6i) have significantly improved clinical outcomes in patients with advanced hormone receptor-positive (HR+) breast cancer and have demonstrated favourable antitumour immune responses in preclinical studies.METHODS: Here, we investigated peripheral immune...

High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies.

Journal for immunotherapy of cancer

Çınar Ö, Brzezicha B, Grunert C, Kloetzel PM, Beier C, Peuker CA, Keller U, Pezzutto A, Busse A.
PMID: 34330762
J Immunother Cancer. 2021 Jul;9(7). doi: 10.1136/jitc-2021-002410.

BACKGROUND: Adoptive transfer of engineered T cells has shown remarkable success in B-cell malignancies. However, the most common strategy of targeting lineage-specific antigens can lead to undesirable side effects. Also, a substantial fraction of patients have refractory disease. Novel...

Diagnostic Performance of Kwak, EU, ACR, and Korean TIRADS as Well as ATA Guidelines for the Ultrasound Risk Stratification of Non-Autonomously Functioning Thyroid Nodules in a Region with Long History of Iodine Deficiency: A German Multicenter Trial.

Cancers

Seifert P, Schenke S, Zimny M, Stahl A, Grunert M, Klemenz B, Freesmeyer M, Kreissl MC, Herrmann K, Görges R.
PMID: 34503277
Cancers (Basel). 2021 Sep 04;13(17). doi: 10.3390/cancers13174467.

Germany has a long history of insufficient iodine supply and thyroid nodules occur in over 30% of the adult population, the vast majority of which are benign. Non-invasive diagnostics remain challenging, and ultrasound-based risk stratification systems are essential for...

In-Depth Observation on the Microbial and Fungal Community Structure of Four Contrasting Tomato Cultivation Systems in Soil Based and Soilless Culture Systems.

Frontiers in plant science

Grunert O, Hernandez-Sanabria E, Buysens S, De Neve S, Van Labeke MC, Reheul D, Boon N.
PMID: 33224155
Front Plant Sci. 2020 Nov 05;11:520834. doi: 10.3389/fpls.2020.520834. eCollection 2020.

As soil and soilless culture systems are highly dynamic environments, the structure of rhizosphere microbial communities is consistently adapting. There is a knowledge gap between the microbial community structure of soil based and soilless culture systems and thus we...

Sailing the 7C's: Starfield Revisited as a Foundation of Family Medicine Residency Redesign.

Family medicine

Bazemore A, Grunert T.
PMID: 33970469
Fam Med. 2021 Jul 07;53(7):506-515. doi: 10.22454/FamMed.2021.383659. Epub 2021 May 06.

Amidst a pandemic that has acutely highlighted longstanding failings of the US health care system and the graduate medical education (GME) enterprise that serves it, educators prepare to embark on another revision of the program requirements for family medicine...

Showing 169 to 173 of 173 entries