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Showing 25 to 36 of 214 entries
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Supporting the Next Generation of Scientists to Lead Cancer Immunology Research.

Cancer immunology research

Alspach E, Chow RD, Demehri S, Guerriero JL, Gujar S, Hartmann FJ, Helmink BA, Hudson WH, Ho WJ, Ma L, Maier BB, Maltez VI, Miller BC, Moran AE, Parry EM, Pillai PS, Rafiq S, Reina-Campos M, Rosato PC, Rudqvist NP, Ruhland MK, Sagiv-Barfi I, Sahu AD, Samstein RM, Schürch CM, Sen DR, Thommen DS, Wolf Y, Zappasodi R.
PMID: 34544686
Cancer Immunol Res. 2021 Nov;9(11):1245-1251. doi: 10.1158/2326-6066.CIR-21-0519. Epub 2021 Sep 20.

Recent success in the use of immunotherapy for a broad range of cancers has propelled the field of cancer immunology to the forefront of cancer research. As more and more young investigators join the community of cancer immunologists, the...

Increased Levels of Genomic Instability and Mutations in Homologous Recombination Genes in Locally Advanced Rectal Carcinomas.

Frontiers in oncology

do Canto LM, Larsen SJ, Catin Kupper BE, Begnami MDFS, Scapulatempo-Neto C, Petersen AH, Aagaard MM, Baumbach J, Aguiar S, Rogatto SR.
PMID: 31192117
Front Oncol. 2019 May 14;9:395. doi: 10.3389/fonc.2019.00395. eCollection 2019.

Pre-operative 5-fluoracil-based chemoradiotherapy (nCRT) is the standard treatment for patients with locally advanced rectal cancer (LARC). Patients with pathological complete response (pCR-0% of tumor cells in the surgical specimen after nCRT) have better overall survival and lower risk of...

Ensemble Switching Unveils a Kinetic Rheostat Mechanism of the Eukaryotic Thiamine Pyrophosphate Riboswitch.

RNA (New York, N.Y.)

Ma J, Saikia N, Godar S, Hamilton GL, Ding F, Alper J, Sanabria H.
PMID: 33863818
RNA. 2021 Apr 16; doi: 10.1261/rna.075937.120. Epub 2021 Apr 16.

Thiamine pyrophosphate (TPP) riboswitches regulate thiamine metabolism by inhibiting the translation of enzymes essential to thiamine synthesis pathways upon binding to thiamine pyrophosphate in cells across all domains of life. Recent work on the Arabidopsis thaliana TPP riboswitch suggests...

Automated eloquent cortex localization in brain tumor patients using multi-task graph neural networks.

Medical image analysis

Nandakumar N, Manzoor K, Agarwal S, Pillai JJ, Gujar SK, Sair HI, Venkataraman A.
PMID: 34474216
Med Image Anal. 2021 Dec;74:102203. doi: 10.1016/j.media.2021.102203. Epub 2021 Aug 21.

Localizing the eloquent cortex is a crucial part of presurgical planning. While invasive mapping is the gold standard, there is increasing interest in using noninvasive fMRI to shorten and improve the process. However, many surgical patients cannot adequately perform...

Novel compound heterozygous STN1 variants are associated with Coats Plus syndrome.

Molecular genetics & genomic medicine

Acharya T, Firth HV, Dugar S, Grammatikopoulos T, Seabra L, Walters A, Crow YJ, Parker APJ.
PMID: 34110109
Mol Genet Genomic Med. 2021 Dec;9(12):e1708. doi: 10.1002/mgg3.1708. Epub 2021 Jun 10.

AIM: Coats plus syndrome (CP) is a rare autosomal recessive disorder, characterised by retinal telangiectasia exudates (Coats disease), leukodystrophy, distinctive intracranial calcification and cysts, as well as extra-neurological features including abnormal vasculature of the gastrointestinal tract, portal hypertension and...

Simultaneous removal of arsenic and toxic metals from contaminated soil: Laboratory development and pilot scale demonstration.

Environmental pollution (Barking, Essex : 1987)

Morales Arteaga JF, Gluhar S, Kaurin A, Lestan D.
PMID: 34890746
Environ Pollut. 2021 Dec 07;294:118656. doi: 10.1016/j.envpol.2021.118656. Epub 2021 Dec 07.

Soil chemistry of toxic metalloids and metals differs, making their simultaneous removal difficult. Soil contaminated with As, Pb, Zn and Cd was washed with oxalic acid, Na-dithionite and EDTA solution. Toxic elements were removed from the washing solution by...

A Pharmacogenetic Study of VDR fok1 and TYMS Polymorphisms and Their Association With Glucocorticoid-Induced Osteonecrosis in Egyptian Children With Acute Lymphoblastic Leukemia.

Frontiers in oncology

ElHarouni D, Yassin D, Ali N, Gohar S, Zaky I, Adwan H, Sidhom I.
PMID: 30533396
Front Oncol. 2018 Nov 23;8:541. doi: 10.3389/fonc.2018.00541. eCollection 2018.

No abstract available.

Trial Watch: Oncolytic viro-immunotherapy of hematologic and solid tumors.

Oncoimmunology

Pol JG, Lévesque S, Workenhe ST, Gujar S, Le Boeuf F, Clements DR, Fahrner JE, Fend L, Bell JC, Mossman KL, Fucikova J, Spisek R, Zitvogel L, Kroemer G, Galluzzi L.
PMID: 30524901
Oncoimmunology. 2018 Aug 27;7(12):e1503032. doi: 10.1080/2162402X.2018.1503032. eCollection 2018.

Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncolytic herpes simplex virus T-VEC for...

Long-segment thoracoabdominal aortic coarctation in a child with Down syndrome.

Journal of vascular surgery cases

Vasconcelos VT, Cal RGR, Gomes AL, Aguiar S, Camargo MFC, Baptista-Silva JCC.
PMID: 31724602
J Vasc Surg Cases. 2015 Jun 19;1(2):171-173. doi: 10.1016/j.jvsc.2015.04.011. eCollection 2015 Jun.

Midaortic syndrome is a rare vascular anomaly characterized by coarctation of the descending thoracic and abdominal aorta. Down syndrome is associated with multiple congenital cardiac malformations but is rarely associated with developmental vascular anomalies. Midaortic syndrome may result in...

Substrate mediated nitridation of niobium into superconducting Nb.

Scientific reports

Gajar B, Yadav S, Sawle D, Maurya KK, Gupta A, Aloysius RP, Sahoo S.
PMID: 31217545
Sci Rep. 2019 Jun 19;9(1):8811. doi: 10.1038/s41598-019-45338-1.

Here we report a novel nitridation technique for transforming niobium into hexagonal Nb

OCT-Angiography as a reliable prognostic tool in laser-treated proliferative diabetic retinopathy: The RENOCTA Study.

European journal of ophthalmology

Lupidi M, Gujar R, Cerquaglia A, Chablani J, Fruttini D, Muzi A, Corbucci R, Fiore T, Coscas F, Coscas G, Parravano M, Cagini C.
PMID: 33135494
Eur J Ophthalmol. 2021 Sep;31(5):2511-2519. doi: 10.1177/1120672120963451. Epub 2020 Nov 02.

PURPOSE: To quantitatively assess retinal neovascularizations (RNVs) in proliferative diabetic retinopathy (PDR) before and after photocoagulative laser treatment (PLT) using Optical Coherence Tomography Angiography (OCT-A).METHODS: Consecutive patients with PDR were examined with fluorescein angiography (FA) and OCT-A before and...

Comprehensive Analysis of DNA Methylation and Prediction of Response to NeoadjuvantTherapy in Locally Advanced Rectal Cancer.

Cancers

do Canto LM, Barros-Filho MC, Rainho CA, Marinho D, Kupper BEC, Begnami MDFS, Scapulatempo-Neto C, Havelund BM, Lindebjerg J, Marchi FA, Baumbach J, Aguiar S, Rogatto SR.
PMID: 33105711
Cancers (Basel). 2020 Oct 22;12(11). doi: 10.3390/cancers12113079.

The treatment for locally advanced rectal carcinomas (LARC) is based on neoadjuvant chemoradiotherapy (nCRT) and surgery, which results in pathological complete response (pCR) in up to 30% of patients. Since epigenetic changes may influence response to therapy, we aimed...

Showing 25 to 36 of 214 entries