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Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.

Cellular and molecular gastroenterology and hepatology

Mareninova OA, Dillon DL, Wightman CJM, Yakubov I, Takahashi T, Gaisano HY, Munson K, Ohmuraya M, Dawson D, Gukovsky I, Gukovskaya AS.
PMID: 34610499
Cell Mol Gastroenterol Hepatol. 2021 Oct 02;13(2):599-622. doi: 10.1016/j.jcmgh.2021.09.017. Epub 2021 Oct 02.

BACKGROUND: Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonical autophagy is essential for exocrine pancreas...

Showing 25 to 25 of 25 entries