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Showing 25 to 36 of 37 entries
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Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.

Cellular and molecular gastroenterology and hepatology

Mareninova OA, Dillon DL, Wightman CJM, Yakubov I, Takahashi T, Gaisano HY, Munson K, Ohmuraya M, Dawson D, Gukovsky I, Gukovskaya AS.
PMID: 34610499
Cell Mol Gastroenterol Hepatol. 2021 Oct 02;13(2):599-622. doi: 10.1016/j.jcmgh.2021.09.017. Epub 2021 Oct 02.

BACKGROUND: Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonical autophagy is essential for exocrine pancreas...

Letter on Convergence of In-Parameter-Linear Nonlinear Neural Architectures With Gradient Learnings.

IEEE transactions on neural networks and learning systems

Bukovsky I, Dohnal G, Benes PM, Ichiji K, Homma N.
PMID: 34780334
IEEE Trans Neural Netw Learn Syst. 2021 Nov 17; doi: 10.1109/TNNLS.2021.3123533. Epub 2021 Nov 17.

This letter summarizes and proves the concept of bounded-input bounded-state (BIBS) stability for weight convergence of a broad family of in-parameter-linear nonlinear neural architectures (IPLNAs) as it generally applies to a broad family of incremental gradient learning algorithms. A...

A metabolic modeling platform for the computation of microbial ecosystems in time and space (COMETS).

Nature protocols

Dukovski I, Bajić D, Chacón JM, Quintin M, Vila JCC, Sulheim S, Pacheco AR, Bernstein DB, Riehl WJ, Korolev KS, Sanchez A, Harcombe WR, Segrè D.
PMID: 34635859
Nat Protoc. 2021 Nov;16(11):5030-5082. doi: 10.1038/s41596-021-00593-3. Epub 2021 Oct 11.

Genome-scale stoichiometric modeling of metabolism has become a standard systems biology tool for modeling cellular physiology and growth. Extensions of this approach are emerging as a valuable avenue for predicting, understanding and designing microbial communities. Computation of microbial ecosystems...

Abnormal expression of p27kip1 protein in levator ani muscle of aging women with pelvic floor disorders - a relationship to the cellular differentiation and degeneration.

BMC clinical pathology

Bukovsky A, Copas P, Caudle MR, Cekanova M, Dassanayake T, Asbury B, Van Meter SE, Elder RF, Brown JB, Cross SB.
PMID: 11696252
BMC Clin Pathol. 2001;1(1):4. doi: 10.1186/1472-6890-1-4.

BACKGROUND: Pelvic floor disorders affect almost 50% of aging women. An important role in the pelvic floor support belongs to the levator ani muscle. The p27/kip1 (p27) protein, multifunctional cyclin-dependent kinase inhibitor, shows changing expression in differentiating skeletal muscle...

Invaded cluster simulations of the XY model in two and three dimensions.

Physical review. E, Statistical, nonlinear, and soft matter physics

Dukovski I, Machta J, Chayes LV.
PMID: 11863689
Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Feb;65(2):026702. doi: 10.1103/PhysRevE.65.026702. Epub 2002 Jan 03.

The invaded cluster algorithm is used to study the XY model in two and three dimensions up to sizes 2000(2) and 120(3), respectively. A soft spin O(2) model, in the same universality class as the three-dimensional XY model, is...

Delayed fluorescence of porphyrins in different media.

Journal of fluorescence

Lukomsky I, Gottfried V, Kimel S.
PMID: 24233293
J Fluoresc. 1994 Mar;4(1):49-51. doi: 10.1007/BF01876653.

Lifetimes of TPPS4 (meso-tetraphenylporphine tetrasulfonate) triplet states were measured for liquid solutions of different acidity and viscosity and as a function of acceptor concentration for different acceptors (bovine serum albumin, tryptophan and furfuryl alcohol). Triplet lifetimes were estimated by...

New insights into the pathways initiating and driving pancreatitis.

Current opinion in gastroenterology

Gukovskaya AS, Pandol SJ, Gukovsky I.
PMID: 27428704
Curr Opin Gastroenterol. 2016 Sep;32(5):429-435. doi: 10.1097/MOG.0000000000000301.

PURPOSE OF REVIEW: In this article, we discuss recent studies that advance our understanding of molecular and cellular factors initiating and driving pancreatitis, with the emphasis on the role of acinar cell organelle disorders.RECENT FINDINGS: The central physiologic function...

Morphological control and photoluminescence of zinc oxide nanocrystals.

The journal of physical chemistry. B

Andelman T, Gong Y, Polking M, Yin M, Kuskovsky I, Neumark G, O'Brien S.
PMID: 16852799
J Phys Chem B. 2005 Aug 04;109(30):14314-8. doi: 10.1021/jp050540o.

Nanocrystals of the wide band gap semiconductor zinc oxide of controllable morphologies were synthesized by a simple thermal decomposition method. The predominating factor in determining the morphology (spheres, triangular prisms, and rods) was the solvent, selected on the basis...

Protein kinase d regulates cell death pathways in experimental pancreatitis.

Frontiers in physiology

Yuan J, Liu Y, Tan T, Guha S, Gukovsky I, Gukovskaya A, Pandol SJ.
PMID: 22470346
Front Physiol. 2012 Mar 27;3:60. doi: 10.3389/fphys.2012.00060. eCollection 2012.

Inflammation and acinar cell necrosis are two major pathological responses of acute pancreatitis, a serious disorder with no current therapies directed to its molecular pathogenesis. Serine/threonine protein kinase D family, which includes PKD/PKD1, PKD2, and PKD3, has been increasingly...

The Effects of Vegetarian and Vegan Diets on Gut Microbiota.

Frontiers in nutrition

Tomova A, Bukovsky I, Rembert E, Yonas W, Alwarith J, Barnard ND, Kahleova H.
PMID: 31058160
Front Nutr. 2019 Apr 17;6:47. doi: 10.3389/fnut.2019.00047. eCollection 2019.

The difference in gut microbiota composition between individuals following vegan or vegetarian diets and those following omnivorous diets is well documented. A plant-based diet appears to be beneficial for human health by promoting the development of more diverse and...

Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.

Cellular and molecular gastroenterology and hepatology

Mareninova OA, Dillon DL, Wightman CJM, Yakubov I, Takahashi T, Gaisano HY, Munson K, Ohmuraya M, Dawson D, Gukovsky I, Gukovskaya AS.
PMID: 34610499
Cell Mol Gastroenterol Hepatol. 2021 Oct 02;13(2):599-622. doi: 10.1016/j.jcmgh.2021.09.017. Epub 2021 Oct 02.

BACKGROUND: Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonical autophagy is essential for exocrine pancreas...

Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.

Cellular and molecular gastroenterology and hepatology

Mareninova OA, Dillon DL, Wightman CJM, Yakubov I, Takahashi T, Gaisano HY, Munson K, Ohmuraya M, Dawson D, Gukovsky I, Gukovskaya AS.
PMID: 34610499
Cell Mol Gastroenterol Hepatol. 2021 Oct 02;13(2):599-622. doi: 10.1016/j.jcmgh.2021.09.017. Epub 2021 Oct 02.

BACKGROUND: Autophagosome, the central organelle in autophagy process, can assemble via canonical pathway mediated by LC3-II, the lipidated form of autophagy-related protein LC3/ATG8, or noncanonical pathway mediated by the small GTPase Rab9. Canonical autophagy is essential for exocrine pancreas...

Showing 25 to 36 of 37 entries