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Showing 433 to 443 of 443 entries
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Impact of COVID-19 pandemic on prevalence of Clostridioides difficile infection in a UK tertiary centre.

Anaerobe

Voona S, Abdic H, Montgomery R, Clarkson A, Twitchell H, Hills T, Briggs S, Crooks C, Monaghan TM.
PMID: 34801705
Anaerobe. 2021 Nov 18;73:102479. doi: 10.1016/j.anaerobe.2021.102479. Epub 2021 Nov 18.

Serious concerns have been raised about a possible increase in cases of Clostridioides difficile infection (CDI) during the COVID-19 pandemic. We conducted a retrospective observational single centre study which revealed that total combined community and hospital-based quarterly rates of...

Mice with an autism-associated R451C mutation in neuroligin-3 show a cautious but accurate response style in touchscreen attention tasks.

Genes, brain, and behavior

Burrows EL, May C, Hill T, Churliov L, Johnson KA, Hannan AJ.
PMID: 34085373
Genes Brain Behav. 2022 Jan;21(1):e12757. doi: 10.1111/gbb.12757. Epub 2021 Jul 02.

One of the earliest identifiable features of autism spectrum disorder (ASD) is altered attention. Mice expressing the ASD-associated R451C mutation in synaptic adhesion protein neuroligin-3 (NL3) exhibit impaired reciprocal social interactions and repetitive and restrictive behaviours. The role of...

Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes.

Structure (London, England : 1993)

Seraphim TV, Nano N, Cheung YWS, Aluksanasuwan S, Colleti C, Mao YQ, Bhandari V, Young G, Höll L, Phanse S, Gordiyenko Y, Southworth DR, Robinson CV, Thongboonkerd V, Gava LM, Borges JC, Babu M, Barbosa LRS, Ramos CHI, Kukura P, Houry WA.
PMID: 34492227
Structure. 2022 Jan 06;30(1):156-171.e12. doi: 10.1016/j.str.2021.08.002. Epub 2021 Sep 06.

R2TP is a highly conserved chaperone complex formed by two AAA+ ATPases, RUVBL1 and RUVBL2, that associate with PIH1D1 and RPAP3 proteins. R2TP acts in promoting macromolecular complex formation. Here, we establish the principles of R2TP assembly. Three distinct...

Performance of Spherical Quantum Well Down Converters in Solid State Lighting.

ACS applied materials & interfaces

Rreza I, Yang H, Hamachi L, Campos M, Hull T, Treadway J, Kurtin J, Chan EM, Owen JS.
PMID: 33682411
ACS Appl Mater Interfaces. 2021 Mar 17;13(10):12191-12197. doi: 10.1021/acsami.0c15161. Epub 2021 Mar 08.

We report the color conversion performance of amber and red emitting quantum dots (QDs) on InGaN solid-state lighting (SSL) light emitting diode (LED) packages. Spherical quantum well (SQW) architectures (CdS/CdSe

Frontiers in neuroscience

Kim HJJ, Zagzoog A, Smolyakova AM, Ezeaka UC, Benko MJ, Holt T, Laprairie RB.
PMID: 34992518
Front Neurosci. 2021 Dec 21;15:790546. doi: 10.3389/fnins.2021.790546. eCollection 2021.

The endocannabinoid and orexin neuromodulatory systems serve key roles in many of the same biological functions such as sleep, appetite, pain processing, and emotional behaviors related to reward. The type 1 cannabinoid receptor (CB1R) and both subtypes of the...

Dual trocar laparoscopy improves reduced-port surgery of the distal pancreas.

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

Mittermair C, Weiss M, Schirnhofer J, Brunner E, Obrist C, Biebl M, Hell T, Weiss H.
PMID: 33810777
Minim Invasive Ther Allied Technol. 2021 Apr 02;1-7. doi: 10.1080/13645706.2021.1904263. Epub 2021 Apr 02.

BACKGROUND: The technical feasibility of transumbilical single-incision surgery (SIL) for pancreatic resections has been demonstrated. However, this technique is hampered by the limited degrees of freedom for instrument handling. Dual-incision laparoscopy (DIL) with an additional trocar may simplify dissection...

First-Line Administration of Fibrinogen Concentrate in the Bleeding Trauma Patient: Searching for Effective Dosages and Optimal Post-Treatment Levels Limiting Massive Transfusion-Further Results of the RETIC Study.

Journal of clinical medicine

Innerhofer N, Treichl B, Rugg C, Fries D, Mittermayr M, Hell T, Oswald E, Innerhofer P, On Behalf Of The Retic Study Group.
PMID: 34501379
J Clin Med. 2021 Aug 31;10(17). doi: 10.3390/jcm10173930.

Fibrinogen supplementation is recommended for treatment of severe trauma hemorrhage. However, required dosages and aimed for post-treatment fibrinogen levels remain a matter of discussion. Within the published RETIC study, adult patients suffering trauma-induced coagulopathy were randomly assigned to receive...

A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke.

Frontiers in molecular biosciences

Eyford BA, Singh CSB, Abraham T, Munro L, Choi KB, Hill T, Hildebrandt R, Welch I, Vitalis TZ, Gabathuler R, Gordon JA, Adomat H, Guns EST, Lu CJ, Pfeifer CG, Tian MM, Jefferies WA.
PMID: 33869275
Front Mol Biosci. 2021 Mar 26;8:611367. doi: 10.3389/fmolb.2021.611367. eCollection 2021.

The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of neuroinflammation (NI) of the central nervous system. A twelve-amino acid peptide that transcytoses the BBB, termed MTfp, was chemically conjugated to siRNA to create a novel...

Right aortic arch forming a true vascular ring: a clinical review.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

Biermann D, Holst T, Hüners I, Rickers C, Kehl T, Rüffer A, Sachweh JS, Hazekamp MG.
PMID: 33970211
Eur J Cardiothorac Surg. 2021 Nov 02;60(5):1014-1021. doi: 10.1093/ejcts/ezab225.

OBJECTIVES: This review aims at presenting and summarizing the current state of literature on the presentation and surgical management of a right-sided aortic arch with a left-sided ligamentum forming a complete vascular ring around the oesophagus and trachea.METHODS: A...

Serial Clinical Scoring to Assess Transported Pediatric Patients.

Pediatric emergency care

Holt T, Parker K, Shaw A, Hansen G.
PMID: 32501885
Pediatr Emerg Care. 2021 Dec 01;37(12):e1600-e1602. doi: 10.1097/PEC.0000000000002132.

OBJECTIVES: The objective of this study was to evaluate serial Transport Risk Assessment in Pediatrics (TRAP) scoring during pediatric critical care transport as a potential measure for specialized pediatric transport teams (PTTs).METHODS: This was a retrospective study with a...

Motivation in Software Engineering: A systematic literature review.

Beecham S, Baddoo N, Hall T, Robinson H, Sharp H.
UIID-AD: 190
2008;50:860-878. doi: 10.1016/j.infsof.2007.09.004.

Objective: In this paper, we present a systematic literature review of motivation in Software Engineering. The objective of this review is to plot the landscape of current reported knowledge in terms of what motivates developers, what de-motivates them and...

Showing 433 to 443 of 443 entries