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iScience

Syed S, Nissilä E, Ruhanen H, Fudo S, Gaytán MO, Sihvo SP, Lorey MB, Metso J, Öörni K, King SJ, Oommen OP, Jauhiainen M, Meri S, Käkelä R, Haapasalo K.
PMID: 34124613
iScience. 2021 May 12;24(6):102535. doi: 10.1016/j.isci.2021.102535. eCollection 2021 Jun 25.

High-density lipoproteins (HDLs) are a group of different subpopulations of sialylated particles that have an essential role in the reverse cholesterol transport (RCT) pathway. Importantly, changes in the protein and lipid composition of HDLs may lead to the formation...

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Syed S, Nissilä E, Ruhanen H, et al. . iScience. 2021;24(6):102535doi: 10.1016/j.isci.2021.102535.
Syed, S., Nissilä, E., Ruhanen, H., Fudo, S., Gaytán, M. O., Sihvo, S. P., Lorey, M. B., Metso, J., Öörni, K., King, S. J., Oommen, O. P., Jauhiainen, M., Meri, S., Käkelä, R., & Haapasalo, K. (2021). . iScience, 24(6), 102535. https://doi.org/10.1016/j.isci.2021.102535
Syed, Shahan, et al. "." iScience vol. 24,6 (2021): 102535. doi: https://doi.org/10.1016/j.isci.2021.102535
Syed S, Nissilä E, Ruhanen H, Fudo S, Gaytán MO, Sihvo SP, Lorey MB, Metso J, Öörni K, King SJ, Oommen OP, Jauhiainen M, Meri S, Käkelä R, Haapasalo K. . iScience. 2021 May 12;24(6):102535. doi: 10.1016/j.isci.2021.102535. eCollection 2021 Jun 25. PMID: 34124613; PMCID: PMC8175417.
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CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity.

JCI insight

Filppu P, Tanjore Ramanathan J, Granberg KJ, Gucciardo E, Haapasalo H, Lehti K, Nykter M, Le Joncour V, Laakkonen P.
PMID: 33986188
JCI Insight. 2021 May 10;6(9). doi: 10.1172/jci.insight.141486.

Glioma stem cells (GSCs) drive propagation and therapeutic resistance of glioblastomas, the most aggressive diffuse brain tumors. However, the molecular mechanisms that maintain the stemness and promote therapy resistance remain poorly understood. Here we report CD109/STAT3 axis as crucial...

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Filppu P, Tanjore Ramanathan J, Granberg KJ, et al. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021;6(9)doi: 10.1172/jci.insight.141486.
Filppu, P., Tanjore Ramanathan, J., Granberg, K. J., Gucciardo, E., Haapasalo, H., Lehti, K., Nykter, M., Le Joncour, V., & Laakkonen, P. (2021). CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI insight, 6(9), . https://doi.org/10.1172/jci.insight.141486
Filppu, Pauliina, et al. "CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity." JCI insight vol. 6,9 (2021). doi: https://doi.org/10.1172/jci.insight.141486
Filppu P, Tanjore Ramanathan J, Granberg KJ, Gucciardo E, Haapasalo H, Lehti K, Nykter M, Le Joncour V, Laakkonen P. CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity. JCI Insight. 2021 May 10;6(9). doi: 10.1172/jci.insight.141486. PMID: 33986188; PMCID: PMC8262342.
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S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5.

Neurobiology of disease

Ferreira CB, Marttinen M, Coelho JE, Paldanius KMA, Takalo M, Mäkinen P, Leppänen L, Miranda-Lourenço C, Fonseca-Gomes J, Tanqueiro SR, Vaz SH, Belo RF, Sebastião AM, Leinonen V, Soininen H, Pike I, Haapasalo A, Lopes LV, de Mendonça A, Diógenes MJ, Hiltunen M.
PMID: 34954322
Neurobiol Dis. 2021 Dec 24;163:105603. doi: 10.1016/j.nbd.2021.105603. Epub 2021 Dec 24.

Alzheimer's disease (AD) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Previous studies have suggested a role for septin (SEPTIN) protein...

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Ferreira CB, Marttinen M, Coelho JE, et al. S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5. Neurobiol Dis. 2021;163:105603doi: 10.1016/j.nbd.2021.105603.
Ferreira, C. B., Marttinen, M., Coelho, J. E., Paldanius, K. M. A., Takalo, M., Mäkinen, P., Leppänen, L., Miranda-Lourenço, C., Fonseca-Gomes, J., Tanqueiro, S. R., Vaz, S. H., Belo, R. F., Sebastião, A. M., Leinonen, V., Soininen, H., Pike, I., Haapasalo, A., Lopes, L. V., de Mendonça, A., Diógenes, M. J., & Hiltunen, M. (2021). S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5. Neurobiology of disease, 163105603. https://doi.org/10.1016/j.nbd.2021.105603
Ferreira, Catarina B, et al. "S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5." Neurobiology of disease vol. 163 (2021): 105603. doi: https://doi.org/10.1016/j.nbd.2021.105603
Ferreira CB, Marttinen M, Coelho JE, Paldanius KMA, Takalo M, Mäkinen P, Leppänen L, Miranda-Lourenço C, Fonseca-Gomes J, Tanqueiro SR, Vaz SH, Belo RF, Sebastião AM, Leinonen V, Soininen H, Pike I, Haapasalo A, Lopes LV, de Mendonça A, Diógenes MJ, Hiltunen M. S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5. Neurobiol Dis. 2021 Dec 24;163:105603. doi: 10.1016/j.nbd.2021.105603. Epub 2021 Dec 24. PMID: 34954322.
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State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm.

Diagnostics (Basel, Switzerland)

Solje E, Benussi A, Buratti E, Remes AM, Haapasalo A, Borroni B.
PMID: 33925655
Diagnostics (Basel). 2021 Apr 27;11(5). doi: 10.3390/diagnostics11050788.

The most common neurodegenerative dementias include Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). The correct etiology-based diagnosis is pivotal for clinical management of these diseases as well as for the suitable timing and choosing...

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Solje E, Benussi A, Buratti E, et al. State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm. Diagnostics (Basel). 2021;11(5)doi: 10.3390/diagnostics11050788.
Solje, E., Benussi, A., Buratti, E., Remes, A. M., Haapasalo, A., & Borroni, B. (2021). State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm. Diagnostics (Basel, Switzerland), 11(5), . https://doi.org/10.3390/diagnostics11050788
Solje, Eino, et al. "State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm." Diagnostics (Basel, Switzerland) vol. 11,5 (2021). doi: https://doi.org/10.3390/diagnostics11050788
Solje E, Benussi A, Buratti E, Remes AM, Haapasalo A, Borroni B. State-of-the-Art Methods and Emerging Fluid Biomarkers in the Diagnostics of Dementia-A Short Review and Diagnostic Algorithm. Diagnostics (Basel). 2021 Apr 27;11(5). doi: 10.3390/diagnostics11050788. PMID: 33925655; PMCID: PMC8145467.
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C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction.

Neurobiology of disease

Huber N, Hoffmann D, Giniatullina R, Rostalski H, Leskelä S, Takalo M, Natunen T, Solje E, Remes AM, Giniatullin R, Hiltunen M, Haapasalo A.
PMID: 34915153
Neurobiol Dis. 2021 Dec 13;105584. doi: 10.1016/j.nbd.2021.105584. Epub 2021 Dec 13.

Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of progressive neurodegenerative syndromes. To date, no validated biomarkers or effective disease-modifying therapies exist for the different clinical or genetic subtypes of FTLD. The most common genetic cause underlying FTLD and...

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Huber N, Hoffmann D, Giniatullina R, et al. C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction. Neurobiol Dis. 2021;105584doi: 10.1016/j.nbd.2021.105584.
Huber, N., Hoffmann, D., Giniatullina, R., Rostalski, H., Leskelä, S., Takalo, M., Natunen, T., Solje, E., Remes, A. M., Giniatullin, R., Hiltunen, M., & Haapasalo, A. (2021). C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction. Neurobiology of disease, 105584. https://doi.org/10.1016/j.nbd.2021.105584
Huber, Nadine, et al. "C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction." Neurobiology of disease vol. (2021): 105584. doi: https://doi.org/10.1016/j.nbd.2021.105584
Huber N, Hoffmann D, Giniatullina R, Rostalski H, Leskelä S, Takalo M, Natunen T, Solje E, Remes AM, Giniatullin R, Hiltunen M, Haapasalo A. C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction. Neurobiol Dis. 2021 Dec 13;105584. doi: 10.1016/j.nbd.2021.105584. Epub 2021 Dec 13. PMID: 34915153.
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The ability of different irrigation methods to remove mixtures of calcium hydroxide and barium sulphate from isthmuses in 3D printed transparent root canal models.

Odontology

Liu H, Shen Y, Wang Z, Haapasalo M.
PMID: 34143348
Odontology. 2022 Jan;110(1):27-34. doi: 10.1007/s10266-021-00628-x. Epub 2021 Jun 18.

The purpose is to evaluate the efficacy of different irrigation techniques in the removal of various calcium hydroxide [Ca(OH)

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Liu H, Shen Y, Wang Z, et al. The ability of different irrigation methods to remove mixtures of calcium hydroxide and barium sulphate from isthmuses in 3D printed transparent root canal models. Odontology. 2021;110(1):27-34doi: 10.1007/s10266-021-00628-x.
Liu, H., Shen, Y., Wang, Z., & Haapasalo, M. (2022). The ability of different irrigation methods to remove mixtures of calcium hydroxide and barium sulphate from isthmuses in 3D printed transparent root canal models. Odontology, 110(1), 27-34. https://doi.org/10.1007/s10266-021-00628-x
Liu, He, et al. "The ability of different irrigation methods to remove mixtures of calcium hydroxide and barium sulphate from isthmuses in 3D printed transparent root canal models." Odontology vol. 110,1 (2022): 27-34. doi: https://doi.org/10.1007/s10266-021-00628-x
Liu H, Shen Y, Wang Z, Haapasalo M. The ability of different irrigation methods to remove mixtures of calcium hydroxide and barium sulphate from isthmuses in 3D printed transparent root canal models. Odontology. 2022 Jan;110(1):27-34. doi: 10.1007/s10266-021-00628-x. Epub 2021 Jun 18. PMID: 34143348.
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A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population.

Journal of Alzheimer's disease : JAD

Rostalski H, Korhonen V, Kuulasmaa T, Solje E, Krüger J, Gen F, Kaivola K, Eide PK, Lambert JC, Julkunen V, Tienari PJ, Remes AM, Leinonen V, Hiltunen M, Haapasalo A.
PMID: 34397416
J Alzheimers Dis. 2021;83(3):1325-1332. doi: 10.3233/JAD-210599.

BACKGROUND: C9orf72 repeat expansion (C9exp) is the most common genetic cause underlying frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). However, detection of the C9exp requires elaborative methods.OBJECTIVE: Identification of C9exp carriers from genotyped cohorts could be facilitated...

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Rostalski H, Korhonen V, Kuulasmaa T, et al. A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population. J Alzheimers Dis. 2021;83(3):1325-1332doi: 10.3233/JAD-210599.
Rostalski, H., Korhonen, V., Kuulasmaa, T., Solje, E., Krüger, J., Gen, F., Kaivola, K., Eide, P. K., Lambert, J. C., Julkunen, V., Tienari, P. J., Remes, A. M., Leinonen, V., Hiltunen, M., & Haapasalo, A. (2021). A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population. Journal of Alzheimer's disease : JAD, 83(3), 1325-1332. https://doi.org/10.3233/JAD-210599
Rostalski, Hannah, et al. "A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population." Journal of Alzheimer's disease : JAD vol. 83,3 (2021): 1325-1332. doi: https://doi.org/10.3233/JAD-210599
Rostalski H, Korhonen V, Kuulasmaa T, Solje E, Krüger J, Gen F, Kaivola K, Eide PK, Lambert JC, Julkunen V, Tienari PJ, Remes AM, Leinonen V, Hiltunen M, Haapasalo A. A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population. J Alzheimers Dis. 2021;83(3):1325-1332. doi: 10.3233/JAD-210599. PMID: 34397416.
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Showing 61 to 67 of 67 entries