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Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma.

JAMA oncology

Hirsch L, Martinez Chanza N, Farah S, Xie W, Flippot R, Braun DA, Rathi N, Thouvenin J, Collier KA, Seront E, de Velasco G, Dzimitrowicz H, Beuselinck B, Xu W, Bowman IA, Lam ET, Abuqayas B, Bilen MA, Varkaris A, Zakharia Y, Harrison MR, Mortazavi A, Barthélémy P, Agarwal N, McKay RR, Brastianos PK, Krajewski KM, Albigès L, Harshman LC, Choueiri TK.
PMID: 34673916
JAMA Oncol. 2021 Dec 01;7(12):1815-1823. doi: 10.1001/jamaoncol.2021.4544.

IMPORTANCE: Patients with brain metastases from renal cell carcinoma (RCC) have been underrepresented in clinical trials, and effective systemic therapy is lacking. Cabozantinib shows robust clinical activity in metastatic RCC, but its effect on brain metastases remains unclear.OBJECTIVE: To...

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Hirsch L, Martinez Chanza N, Farah S, et al. Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma. JAMA Oncol. 2021;7(12):1815-1823doi: 10.1001/jamaoncol.2021.4544.
Hirsch, L., Martinez Chanza, N., Farah, S., Xie, W., Flippot, R., Braun, D. A., Rathi, N., Thouvenin, J., Collier, K. A., Seront, E., de Velasco, G., Dzimitrowicz, H., Beuselinck, B., Xu, W., Bowman, I. A., Lam, E. T., Abuqayas, B., Bilen, M. A., Varkaris, A., Zakharia, Y., Harrison, M. R., Mortazavi, A., Barthélémy, P., Agarwal, N., McKay, R. R., Brastianos, P. K., Krajewski, K. M., Albigès, L., Harshman, L. C., & Choueiri, T. K. (2021). Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma. JAMA oncology, 7(12), 1815-1823. https://doi.org/10.1001/jamaoncol.2021.4544
Hirsch, Laure, et al. "Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma." JAMA oncology vol. 7,12 (2021): 1815-1823. doi: https://doi.org/10.1001/jamaoncol.2021.4544
Hirsch L, Martinez Chanza N, Farah S, Xie W, Flippot R, Braun DA, Rathi N, Thouvenin J, Collier KA, Seront E, de Velasco G, Dzimitrowicz H, Beuselinck B, Xu W, Bowman IA, Lam ET, Abuqayas B, Bilen MA, Varkaris A, Zakharia Y, Harrison MR, Mortazavi A, Barthélémy P, Agarwal N, McKay RR, Brastianos PK, Krajewski KM, Albigès L, Harshman LC, Choueiri TK. Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma. JAMA Oncol. 2021 Dec 01;7(12):1815-1823. doi: 10.1001/jamaoncol.2021.4544. PMID: 34673916; PMCID: PMC8532040.
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Impact of Interobserver Variability in Manual Segmentation of Non-Small Cell Lung Cancer (NSCLC) Applying Low-Rank Radiomic Representation on Computed Tomography.

Cancers

Hershman M, Yousefi B, Serletti L, Galperin-Aizenberg M, Roshkovan L, Luna JM, Thompson JC, Aggarwal C, Carpenter EL, Kontos D, Katz SI.
PMID: 34885094
Cancers (Basel). 2021 Nov 28;13(23). doi: 10.3390/cancers13235985.

This study tackles interobserver variability with respect to specialty training in manual segmentation of non-small cell lung cancer (NSCLC). Four readers included for segmentation are: a data scientist (BY), a medical student (LS), a radiology trainee (MH), and a...

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Hershman M, Yousefi B, Serletti L, et al. Impact of Interobserver Variability in Manual Segmentation of Non-Small Cell Lung Cancer (NSCLC) Applying Low-Rank Radiomic Representation on Computed Tomography. Cancers (Basel). 2021;13(23)doi: 10.3390/cancers13235985.
Hershman, M., Yousefi, B., Serletti, L., Galperin-Aizenberg, M., Roshkovan, L., Luna, J. M., Thompson, J. C., Aggarwal, C., Carpenter, E. L., Kontos, D., & Katz, S. I. (2021). Impact of Interobserver Variability in Manual Segmentation of Non-Small Cell Lung Cancer (NSCLC) Applying Low-Rank Radiomic Representation on Computed Tomography. Cancers, 13(23), . https://doi.org/10.3390/cancers13235985
Hershman, Michelle, et al. "Impact of Interobserver Variability in Manual Segmentation of Non-Small Cell Lung Cancer (NSCLC) Applying Low-Rank Radiomic Representation on Computed Tomography." Cancers vol. 13,23 (2021). doi: https://doi.org/10.3390/cancers13235985
Hershman M, Yousefi B, Serletti L, Galperin-Aizenberg M, Roshkovan L, Luna JM, Thompson JC, Aggarwal C, Carpenter EL, Kontos D, Katz SI. Impact of Interobserver Variability in Manual Segmentation of Non-Small Cell Lung Cancer (NSCLC) Applying Low-Rank Radiomic Representation on Computed Tomography. Cancers (Basel). 2021 Nov 28;13(23). doi: 10.3390/cancers13235985. PMID: 34885094; PMCID: PMC8657389.
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Adolescent and young adult enrollment to a National Cancer Institute-sponsored National Clinical Trials Network Research Group over 25 years.

Cancer

Unger JM, Beauchemin M, Hershman DL.
PMID: 34351619
Cancer. 2021 Dec 15;127(24):4574-4584. doi: 10.1002/cncr.33855. Epub 2021 Aug 05.

BACKGROUND: Adolescent and young adult (AYA) patients with cancer have not seen the same improvements in survival as younger (pediatric) patients and older patients (adults 40 years old or older). This may be related to their lower participation in...

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Unger JM, Beauchemin M, Hershman DL. Adolescent and young adult enrollment to a National Cancer Institute-sponsored National Clinical Trials Network Research Group over 25 years. Cancer. 2021;127(24):4574-4584doi: 10.1002/cncr.33855.
Unger, J. M., Beauchemin, M., & Hershman, D. L. (2021). Adolescent and young adult enrollment to a National Cancer Institute-sponsored National Clinical Trials Network Research Group over 25 years. Cancer, 127(24), 4574-4584. https://doi.org/10.1002/cncr.33855
Unger, Joseph M, et al. "Adolescent and young adult enrollment to a National Cancer Institute-sponsored National Clinical Trials Network Research Group over 25 years." Cancer vol. 127,24 (2021): 4574-4584. doi: https://doi.org/10.1002/cncr.33855
Unger JM, Beauchemin M, Hershman DL. Adolescent and young adult enrollment to a National Cancer Institute-sponsored National Clinical Trials Network Research Group over 25 years. Cancer. 2021 Dec 15;127(24):4574-4584. doi: 10.1002/cncr.33855. Epub 2021 Aug 05. PMID: 34351619; PMCID: PMC8665001.
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Showing 289 to 291 of 291 entries