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Showing 25 to 36 of 161 entries
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Antipsychotic Use and Risk of Stroke Among Community-Dwelling People With Alzheimer's Disease.

Journal of the American Medical Directors Association

Koponen M, Rajamaki B, Lavikainen P, Bell JS, Taipale H, Tanskanen A, Hartikainen S, Tolppanen AM.
PMID: 34717887
J Am Med Dir Assoc. 2021 Oct 28; doi: 10.1016/j.jamda.2021.09.036. Epub 2021 Oct 28.

OBJECTIVES: Antipsychotic use for neuropsychiatric symptoms in Alzheimer's disease (AD) is common despite the increased risk of cardiovascular events and mortality. There is limited and inconsistent evidence on the possible risk of stroke. We assessed whether antipsychotic initiation increases...

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Koponen M, Rajamaki B, Lavikainen P, et al. Antipsychotic Use and Risk of Stroke Among Community-Dwelling People With Alzheimer's Disease. J Am Med Dir Assoc. 2021;doi: 10.1016/j.jamda.2021.09.036.
Koponen, M., Rajamaki, B., Lavikainen, P., Bell, J. S., Taipale, H., Tanskanen, A., Hartikainen, S., & Tolppanen, A. M. (2021). Antipsychotic Use and Risk of Stroke Among Community-Dwelling People With Alzheimer's Disease. Journal of the American Medical Directors Association, . https://doi.org/10.1016/j.jamda.2021.09.036
Koponen, Marjaana, et al. "Antipsychotic Use and Risk of Stroke Among Community-Dwelling People With Alzheimer's Disease." Journal of the American Medical Directors Association vol. (2021). doi: https://doi.org/10.1016/j.jamda.2021.09.036
Koponen M, Rajamaki B, Lavikainen P, Bell JS, Taipale H, Tanskanen A, Hartikainen S, Tolppanen AM. Antipsychotic Use and Risk of Stroke Among Community-Dwelling People With Alzheimer's Disease. J Am Med Dir Assoc. 2021 Oct 28; doi: 10.1016/j.jamda.2021.09.036. Epub 2021 Oct 28. PMID: 34717887.
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Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus.

Marine pollution bulletin

Lehtiniemi M, Hartikainen S, Turja R, Lehtonen KK, Vepsäläinen J, Peräniemi S, Leskinen J, Setälä O.
PMID: 34741928
Mar Pollut Bull. 2021 Dec;173:113103. doi: 10.1016/j.marpolbul.2021.113103. Epub 2021 Oct 30.

Effects of household post-consumer plastics and tyre rubber on a Baltic Sea copepod Limnocalanus macrurus were assessed. Fragments of commercial recycled low-density polyethylene vegetable bags and rubber originating from recycled car tyres were incubated in seawater, and the copepods...

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Lehtiniemi M, Hartikainen S, Turja R, et al. Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus. Mar Pollut Bull. 2021;173:113103doi: 10.1016/j.marpolbul.2021.113103.
Lehtiniemi, M., Hartikainen, S., Turja, R., Lehtonen, K. K., Vepsäläinen, J., Peräniemi, S., Leskinen, J., & Setälä, O. (2021). Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus. Marine pollution bulletin, 173113103. https://doi.org/10.1016/j.marpolbul.2021.113103
Lehtiniemi, Maiju, et al. "Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus." Marine pollution bulletin vol. 173 (2021): 113103. doi: https://doi.org/10.1016/j.marpolbul.2021.113103
Lehtiniemi M, Hartikainen S, Turja R, Lehtonen KK, Vepsäläinen J, Peräniemi S, Leskinen J, Setälä O. Exposure to leachates from post-consumer plastic and recycled rubber causes stress responses and mortality in a copepod Limnocalanus macrurus. Mar Pollut Bull. 2021 Dec;173:113103. doi: 10.1016/j.marpolbul.2021.113103. Epub 2021 Oct 30. PMID: 34741928.
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The debatable presence of PIWI-interacting RNAs in invasive breast cancer.

Cancer medicine

Kärkkäinen E, Heikkinen S, Tengström M, Kosma VM, Mannermaa A, Hartikainen JM.
PMID: 33960684
Cancer Med. 2021 Jun;10(11):3593-3603. doi: 10.1002/cam4.3915. Epub 2021 May 07.

Numerous factors influence breast cancer (BC) prognosis, thus complicating the prediction of outcome. By identifying biomarkers that would distinguish the cases with poorer response to therapy already at the time of diagnosis, the rate of survival could be improved....

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Kärkkäinen E, Heikkinen S, Tengström M, et al. The debatable presence of PIWI-interacting RNAs in invasive breast cancer. Cancer Med. 2021;10(11):3593-3603doi: 10.1002/cam4.3915.
Kärkkäinen, E., Heikkinen, S., Tengström, M., Kosma, V. M., Mannermaa, A., & Hartikainen, J. M. (2021). The debatable presence of PIWI-interacting RNAs in invasive breast cancer. Cancer medicine, 10(11), 3593-3603. https://doi.org/10.1002/cam4.3915
Kärkkäinen, Emmi, et al. "The debatable presence of PIWI-interacting RNAs in invasive breast cancer." Cancer medicine vol. 10,11 (2021): 3593-3603. doi: https://doi.org/10.1002/cam4.3915
Kärkkäinen E, Heikkinen S, Tengström M, Kosma VM, Mannermaa A, Hartikainen JM. The debatable presence of PIWI-interacting RNAs in invasive breast cancer. Cancer Med. 2021 Jun;10(11):3593-3603. doi: 10.1002/cam4.3915. Epub 2021 May 07. PMID: 33960684; PMCID: PMC8178507.
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Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D.

Gene therapy

Leikas AJ, Hassinen I, Hedman A, Kivelä A, Ylä-Herttuala S, Hartikainen JEK.
PMID: 34593990
Gene Ther. 2021 Oct 01; doi: 10.1038/s41434-021-00295-1. Epub 2021 Oct 01.

In phase I KAT301 trial, intramyocardial adenovirus-mediated vascular endothelial growth factor -D

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Leikas AJ, Hassinen I, Hedman A, et al. Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D. Gene Ther. 2021;doi: 10.1038/s41434-021-00295-1.
Leikas, A. J., Hassinen, I., Hedman, A., Kivelä, A., Ylä-Herttuala, S., & Hartikainen, J. E. K. (2021). Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D. Gene therapy, . https://doi.org/10.1038/s41434-021-00295-1
Leikas, Aleksi J, et al. "Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D." Gene therapy vol. (2021). doi: https://doi.org/10.1038/s41434-021-00295-1
Leikas AJ, Hassinen I, Hedman A, Kivelä A, Ylä-Herttuala S, Hartikainen JEK. Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D. Gene Ther. 2021 Oct 01; doi: 10.1038/s41434-021-00295-1. Epub 2021 Oct 01. PMID: 34593990.
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Graphene Wrapping of Electrospun Nanofibers for Enhanced Electrochemical Sensing.

ACS omega

Tsiamis A, Diaz Sanchez F, Hartikainen N, Chung M, Mitra S, Lim YC, Tan HL, Radacsi N.
PMID: 34056211
ACS Omega. 2021 Apr 13;6(16):10568-10577. doi: 10.1021/acsomega.0c05823. eCollection 2021 Apr 27.

This paper presents a scalable method of developing ultrasensitive electrochemical biosensors. This is achieved by maximizing sensor conductivity through graphene wrapping of carbonized electrospun nanofibers. The effectiveness of the graphene wrap was determined visually by scanning electron microscopy and...

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Tsiamis A, Diaz Sanchez F, Hartikainen N, et al. Graphene Wrapping of Electrospun Nanofibers for Enhanced Electrochemical Sensing. ACS Omega. 2021;6(16):10568-10577doi: 10.1021/acsomega.0c05823.
Tsiamis, A., Diaz Sanchez, F., Hartikainen, N., Chung, M., Mitra, S., Lim, Y. C., Tan, H. L., & Radacsi, N. (2021). Graphene Wrapping of Electrospun Nanofibers for Enhanced Electrochemical Sensing. ACS omega, 6(16), 10568-10577. https://doi.org/10.1021/acsomega.0c05823
Tsiamis, Andreas, et al. "Graphene Wrapping of Electrospun Nanofibers for Enhanced Electrochemical Sensing." ACS omega vol. 6,16 (2021): 10568-10577. doi: https://doi.org/10.1021/acsomega.0c05823
Tsiamis A, Diaz Sanchez F, Hartikainen N, Chung M, Mitra S, Lim YC, Tan HL, Radacsi N. Graphene Wrapping of Electrospun Nanofibers for Enhanced Electrochemical Sensing. ACS Omega. 2021 Apr 13;6(16):10568-10577. doi: 10.1021/acsomega.0c05823. eCollection 2021 Apr 27. PMID: 34056211; PMCID: PMC8153741.
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IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma.

Molecular therapy oncolytics

Martikainen M, Ramachandran M, Lugano R, Ma J, Martikainen MM, Dimberg A, Yu D, Merits A, Essand M.
PMID: 33869741
Mol Ther Oncolytics. 2021 Mar 17;21:37-46. doi: 10.1016/j.omto.2021.03.008. eCollection 2021 Jun 25.

Oncolytic virotherapy holds promise of effective immunotherapy against otherwise nonresponsive cancers such as glioblastoma. Our previous findings have shown that although oncolytic Semliki Forest virus (SFV) is effective against various mouse glioblastoma models, its therapeutic potency is hampered by...

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Martikainen M, Ramachandran M, Lugano R, et al. IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma. Mol Ther Oncolytics. 2021;21:37-46doi: 10.1016/j.omto.2021.03.008.
Martikainen, M., Ramachandran, M., Lugano, R., Ma, J., Martikainen, M. M., Dimberg, A., Yu, D., Merits, A., & Essand, M. (2021). IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma. Molecular therapy oncolytics, 2137-46. https://doi.org/10.1016/j.omto.2021.03.008
Martikainen, Miika, et al. "IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma." Molecular therapy oncolytics vol. 21 (2021): 37-46. doi: https://doi.org/10.1016/j.omto.2021.03.008
Martikainen M, Ramachandran M, Lugano R, Ma J, Martikainen MM, Dimberg A, Yu D, Merits A, Essand M. IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma. Mol Ther Oncolytics. 2021 Mar 17;21:37-46. doi: 10.1016/j.omto.2021.03.008. eCollection 2021 Jun 25. PMID: 33869741; PMCID: PMC8042242.
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GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance.

Journal of neurology, neurosurgery, and psychiatry

Katisko K, Cajanus A, Huber N, Jääskeläinen O, Kokkola T, Kärkkäinen V, Rostalski H, Hartikainen P, Koivisto AM, Hannonen S, Lehtola JM, Korhonen VE, Helisalmi S, Koivumaa-Honkanen H, Herukka SK, Remes AM, Solje E, Haapasalo A.
PMID: 34187866
J Neurol Neurosurg Psychiatry. 2021 Dec;92(12):1305-1312. doi: 10.1136/jnnp-2021-326487. Epub 2021 Jun 29.

BACKGROUND: Frontotemporal lobar degeneration (FTLD) and primary psychiatric disorders (PPD) are characterised by overlapping clinical features but different aetiologies. Here, we assessed for the first time the potential of blood glial fibrillar acidic protein (GFAP), marker of astrogliosis, as...

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Katisko K, Cajanus A, Huber N, et al. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance. J Neurol Neurosurg Psychiatry. 2021;92(12):1305-1312doi: 10.1136/jnnp-2021-326487.
Katisko, K., Cajanus, A., Huber, N., Jääskeläinen, O., Kokkola, T., Kärkkäinen, V., Rostalski, H., Hartikainen, P., Koivisto, A. M., Hannonen, S., Lehtola, J. M., Korhonen, V. E., Helisalmi, S., Koivumaa-Honkanen, H., Herukka, S. K., Remes, A. M., Solje, E., & Haapasalo, A. (2021). GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance. Journal of neurology, neurosurgery, and psychiatry, 92(12), 1305-1312. https://doi.org/10.1136/jnnp-2021-326487
Katisko, Kasper, et al. "GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance." Journal of neurology, neurosurgery, and psychiatry vol. 92,12 (2021): 1305-1312. doi: https://doi.org/10.1136/jnnp-2021-326487
Katisko K, Cajanus A, Huber N, Jääskeläinen O, Kokkola T, Kärkkäinen V, Rostalski H, Hartikainen P, Koivisto AM, Hannonen S, Lehtola JM, Korhonen VE, Helisalmi S, Koivumaa-Honkanen H, Herukka SK, Remes AM, Solje E, Haapasalo A. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance. J Neurol Neurosurg Psychiatry. 2021 Dec;92(12):1305-1312. doi: 10.1136/jnnp-2021-326487. Epub 2021 Jun 29. PMID: 34187866.
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Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease.

Clinical epidemiology

Pisa F, Reinold J, Lavikainen P, Koponen M, Taipale H, Tanskanen A, Tiihonen J, Hartikainen S, Tolppanen AM.
PMID: 33911901
Clin Epidemiol. 2021 Apr 22;13:295-307. doi: 10.2147/CLEP.S278306. eCollection 2021.

OBJECTIVE: To determine the risk of hip fracture in persons with Alzheimer´s disease (AD) who initiated antiepileptic drugs (AEDs).METHODS: In the Medication use and AD (MEDALZ) cohort of 70,719 Finnish community dwellers with clinically verified incident AD diagnosis in...

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Pisa F, Reinold J, Lavikainen P, et al. Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease. Clin Epidemiol. 2021;13:295-307doi: 10.2147/CLEP.S278306.
Pisa, F., Reinold, J., Lavikainen, P., Koponen, M., Taipale, H., Tanskanen, A., Tiihonen, J., Hartikainen, S., & Tolppanen, A. M. (2021). Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease. Clinical epidemiology, 13295-307. https://doi.org/10.2147/CLEP.S278306
Pisa, Federica, et al. "Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease." Clinical epidemiology vol. 13 (2021): 295-307. doi: https://doi.org/10.2147/CLEP.S278306
Pisa F, Reinold J, Lavikainen P, Koponen M, Taipale H, Tanskanen A, Tiihonen J, Hartikainen S, Tolppanen AM. Hip Fracture Risk in Antiepileptic Drug Initiators and Non-Initiators with Alzheimer's Disease. Clin Epidemiol. 2021 Apr 22;13:295-307. doi: 10.2147/CLEP.S278306. eCollection 2021. PMID: 33911901; PMCID: PMC8075175.
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Executive Functions and Emotion-Attention Interaction in Assessment of Brain Health: Reliability of Repeated Testing With Executive RT Test and Correlation With BRIEF-A Questionnaire.

Frontiers in psychology

Erkkilä M, Peräkylä J, Hartikainen KM.
PMID: 30618977
Front Psychol. 2018 Dec 11;9:2556. doi: 10.3389/fpsyg.2018.02556. eCollection 2018.

Executive functions (EF) rely on intact fronto-subcortical networks. An insult, disorder or treatment compromising brain health may impair the functioning of these widespread networks and consequently disrupt EF. Changes in brain health due to treatment or disorder can be...

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Erkkilä M, Peräkylä J, Hartikainen KM. Executive Functions and Emotion-Attention Interaction in Assessment of Brain Health: Reliability of Repeated Testing With Executive RT Test and Correlation With BRIEF-A Questionnaire. Front Psychol. 2018;9:2556doi: 10.3389/fpsyg.2018.02556.
Erkkilä, M., Peräkylä, J., & Hartikainen, K. M. (2018). Executive Functions and Emotion-Attention Interaction in Assessment of Brain Health: Reliability of Repeated Testing With Executive RT Test and Correlation With BRIEF-A Questionnaire. Frontiers in psychology, 92556. https://doi.org/10.3389/fpsyg.2018.02556
Erkkilä, Mikko, et al. "Executive Functions and Emotion-Attention Interaction in Assessment of Brain Health: Reliability of Repeated Testing With Executive RT Test and Correlation With BRIEF-A Questionnaire." Frontiers in psychology vol. 9 (2018): 2556. doi: https://doi.org/10.3389/fpsyg.2018.02556
Erkkilä M, Peräkylä J, Hartikainen KM. Executive Functions and Emotion-Attention Interaction in Assessment of Brain Health: Reliability of Repeated Testing With Executive RT Test and Correlation With BRIEF-A Questionnaire. Front Psychol. 2018 Dec 11;9:2556. doi: 10.3389/fpsyg.2018.02556. eCollection 2018. PMID: 30618977; PMCID: PMC6297677.
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Changes in the use of diabetes drugs among community-dwelling people with Alzheimer's disease.

BMC geriatrics

López-Rubio C, Koponen M, Lampela P, Taipale H, Tanskanen A, Bell JS, Tolppanen AM, Hartikainen S.
PMID: 34911481
BMC Geriatr. 2021 Dec 15;21(1):701. doi: 10.1186/s12877-021-02694-w.

BACKGROUND: Type 2 diabetes is common in persons with Alzheimer's disease (AD). Management of diabetes in persons with AD is challenging due to changing goals of care and susceptibility to adverse drug events including hypoglycemia. The aim of this...

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López-Rubio C, Koponen M, Lampela P, et al. Changes in the use of diabetes drugs among community-dwelling people with Alzheimer's disease. BMC Geriatr. 2021;21(1):701doi: 10.1186/s12877-021-02694-w.
López-Rubio, C., Koponen, M., Lampela, P., Taipale, H., Tanskanen, A., Bell, J. S., Tolppanen, A. M., & Hartikainen, S. (2021). Changes in the use of diabetes drugs among community-dwelling people with Alzheimer's disease. BMC geriatrics, 21(1), 701. https://doi.org/10.1186/s12877-021-02694-w
López-Rubio, Carlos, et al. "Changes in the use of diabetes drugs among community-dwelling people with Alzheimer's disease." BMC geriatrics vol. 21,1 (2021): 701. doi: https://doi.org/10.1186/s12877-021-02694-w
López-Rubio C, Koponen M, Lampela P, Taipale H, Tanskanen A, Bell JS, Tolppanen AM, Hartikainen S. Changes in the use of diabetes drugs among community-dwelling people with Alzheimer's disease. BMC Geriatr. 2021 Dec 15;21(1):701. doi: 10.1186/s12877-021-02694-w. PMID: 34911481; PMCID: PMC8672592.
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Emotion-Attention Interaction in the Right Hemisphere.

Brain sciences

Hartikainen KM.
PMID: 34439624
Brain Sci. 2021 Jul 29;11(8). doi: 10.3390/brainsci11081006.

Hemispheric asymmetries in affective and cognitive functions have been extensively studied. While both cerebral hemispheres contribute to most affective and cognitive processes, neuroscientific literature and neuropsychological evidence support an overall right hemispheric dominance for emotion, attention and arousal. Emotional...

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Hartikainen KM. Emotion-Attention Interaction in the Right Hemisphere. Brain Sci. 2021;11(8)doi: 10.3390/brainsci11081006.
Hartikainen, K. M. (2021). Emotion-Attention Interaction in the Right Hemisphere. Brain sciences, 11(8), . https://doi.org/10.3390/brainsci11081006
Hartikainen, Kaisa M. "Emotion-Attention Interaction in the Right Hemisphere." Brain sciences vol. 11,8 (2021). doi: https://doi.org/10.3390/brainsci11081006
Hartikainen KM. Emotion-Attention Interaction in the Right Hemisphere. Brain Sci. 2021 Jul 29;11(8). doi: 10.3390/brainsci11081006. PMID: 34439624; PMCID: PMC8394055.
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Association of non-shockable initial rhythm and psychotropic medication in sudden cardiac arrest.

International journal of cardiology. Heart & vasculature

Kauppila JP, Hantula A, Pakanen L, Perkiömäki JS, Martikainen M, Huikuri HV, Junttila MJ.
PMID: 32346603
Int J Cardiol Heart Vasc. 2020 Apr 22;28:100518. doi: 10.1016/j.ijcha.2020.100518. eCollection 2020 Jun.

BACKGROUND: Asystole (ASY) and pulseless electrical activity (PEA) have a poor outcome during sudden cardiac arrest (SCA). Psychotropic medication has been associated with a risk for sudden cardiac death (SCD). Our aim was to study the association of psychotropic...

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Kauppila JP, Hantula A, Pakanen L, et al. Association of non-shockable initial rhythm and psychotropic medication in sudden cardiac arrest. Int J Cardiol Heart Vasc. 2020;28:100518doi: 10.1016/j.ijcha.2020.100518.
Kauppila, J. P., Hantula, A., Pakanen, L., Perkiömäki, J. S., Martikainen, M., Huikuri, H. V., & Junttila, M. J. (2020). Association of non-shockable initial rhythm and psychotropic medication in sudden cardiac arrest. International journal of cardiology. Heart & vasculature, 28100518. https://doi.org/10.1016/j.ijcha.2020.100518
Kauppila, Janna P, et al. "Association of non-shockable initial rhythm and psychotropic medication in sudden cardiac arrest." International journal of cardiology. Heart & vasculature vol. 28 (2020): 100518. doi: https://doi.org/10.1016/j.ijcha.2020.100518
Kauppila JP, Hantula A, Pakanen L, Perkiömäki JS, Martikainen M, Huikuri HV, Junttila MJ. Association of non-shockable initial rhythm and psychotropic medication in sudden cardiac arrest. Int J Cardiol Heart Vasc. 2020 Apr 22;28:100518. doi: 10.1016/j.ijcha.2020.100518. eCollection 2020 Jun. PMID: 32346603; PMCID: PMC7182673.
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Showing 25 to 36 of 161 entries