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Showing 25 to 36 of 244 entries
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Accelerated idioventricular rhythm observed under total intravenous anesthesia using remifentanil, propofol, and rocuronium.

JA clinical reports

Nakanishi M, Masumo K, Oota T, Kato T, Imanishi T.
PMID: 29497644
JA Clin Rep. 2015;1(1):12. doi: 10.1186/s40981-015-0016-3. Epub 2015 Sep 07.

Accelerated idioventricular rhythm (AIVR) during anesthesia has been described in several drug toxicity such as from cocaine, halothane, desflurane, and propofol. We present the case of a man who developed episodes of AIVR observed under total intravenous anesthesia (TIVA)...

Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors.

Neuron

Mishra-Gorur K, Çağlayan AO, Schaffer AE, Chabu C, Henegariu O, Vonhoff F, Akgümüş GT, Nishimura S, Han W, Tu S, Baran B, Gümüş H, Dilber C, Zaki MS, Hossni HAA, Rivière JB, Kayserili H, Spencer EG, Rosti RÖ, Schroth J, Per H, Çağlar C, Çağlar Ç, Dölen D, Baranoski JF, Kumandaş S, Minja FJ, Erson-Omay EZ, Mane SM, Lifton RP, Xu T, Keshishian H, Dobyns WB, Chi NC, Šestan N, Louvi A, Bilgüvar K, Yasuno K, Gleeson JG, Günel M.
PMID: 29654772
Neuron. 2015 Jan 07;85(1):228. doi: 10.1016/j.neuron.2014.12.046. Epub 2015 Jan 07.

No abstract available.

Association of .

Clinical cancer research : an official journal of the American Association for Cancer Research

Borowsky J, Haruki K, Lau MC, Dias Costa A, Väyrynen JP, Ugai T, Arima K, da Silva A, Felt KD, Zhao M, Gurjao C, Twombly TS, Fujiyoshi K, Väyrynen SA, Hamada T, Mima K, Bullman S, Harrison TA, Phipps AI, Peters U, Ng K, Meyerhardt JA, Song M, Giovannucci EL, Wu K, Zhang X, Freeman GJ, Huttenhower C, Garrett WS, Chan AT, Leggett BA, Whitehall VLJ, Walker N, Brown I, Bettington M, Nishihara R, Fuchs CS, Lennerz JK, Giannakis M, Nowak JA, Ogino S.
PMID: 33632927
Clin Cancer Res. 2021 May 15;27(10):2816-2826. doi: 10.1158/1078-0432.CCR-20-4009. Epub 2021 Feb 25.

PURPOSE: While evidence indicates that EXPERIMENTAL DESIGN: We measured RESULTS: The amount of CONCLUSIONS: The amount of tissue

A Modified Tumor-Node-Metastasis Classification for Primary Operable Colorectal Cancer.

JNCI cancer spectrum

Zhang C, Mei Z, Pei J, Abe M, Zeng X, Huang Q, Nishiyama K, Akimoto N, Haruki K, Nan H, Meyerhardt JA, Zhang R, Li X, Ogino S, Ugai T.
PMID: 33554032
JNCI Cancer Spectr. 2020 Oct 16;5(1):pkaa093. doi: 10.1093/jncics/pkaa093. eCollection 2021 Feb.

BACKGROUND: The American Joint Committee on Cancer (AJCC) 8th tumor-node-metastasis (TNM) classification for colorectal cancer (CRC) has limited ability to predict prognosis.METHODS: We included 45 379 eligible stage I-III CRC patients from the Surveillance, Epidemiology, and End Results Program....

Treatment outcomes of differentiated thyroid cancer with distant metastasis improve by tyrosine kinase inhibitors.

Oncology letters

Iwasaki H, Yamazaki H, Takasaki H, Suganuma N, Sakai R, Nakayama H, Hatori S, Toda S, Masudo K.
PMID: 31186746
Oncol Lett. 2019 Jun;17(6):5292-5300. doi: 10.3892/ol.2019.10180. Epub 2019 Mar 21.

In patients with distant metastasis, treatment for differentiated thyroid cancer (DTC) includes complete total thyroidectomy, followed by radioactive iodine (RAI) therapy for metastatic lesions. Tyrosine kinase inhibitor (TKI) treatment is the final treatment option for metastatic lesions, which is...

Pleural Effusion Caused by .

Frontiers in medicine

Niitsu T, Kuge T, Fukushima K, Matsumoto Y, Abe Y, Okamoto M, Haduki K, Saito H, Nitta T, Kawano A, Matsuki T, Motooka D, Tsujino K, Miki K, Nakamura S, Kida H, Kumanogoh A.
PMID: 34901097
Front Med (Lausanne). 2021 Nov 24;8:797171. doi: 10.3389/fmed.2021.797171. eCollection 2021.

No abstract available.

Prognostic impact of immune-related adverse events on patients with and without cardiovascular disease: a retrospective review.

Cardio-oncology (London, England)

Kazama S, Morimoto R, Kimura Y, Shibata N, Ozaki R, Araki T, Mizutani T, Oishi H, Arao Y, Kuwayama T, Hiraiwa H, Kondo T, Furusawa K, Shimokata T, Okumura T, Bando YK, Ando Y, Murohara T.
PMID: 34229760
Cardiooncology. 2021 Jul 06;7(1):26. doi: 10.1186/s40959-021-00112-z.

BACKGROUND: The emergence of immune checkpoint inhibitors (ICIs) has brought about a paradigm shift in cancer treatment as the use of these drugs has become more frequent and for a longer duration. As a result of T-cell-mediated inflammation at...

The Sulfur Microbial Diet and Risk of Colorectal Cancer by Molecular Subtypes and Intratumoral Microbial Species in Adult Men.

Clinical and translational gastroenterology

Sikavi DR, Nguyen LH, Haruki K, Ugai T, Ma W, Wang DD, Thompson KN, Yan Y, Branck T, Wilkinson JE, Akimoto N, Zhong R, Lau MC, Mima K, Kosumi K, Morikawa T, Rimm EB, Garrett WS, Izard J, Cao Y, Song M, Huttenhower C, Ogino S, Chan AT.
PMID: 34333506
Clin Transl Gastroenterol. 2021 Aug 01;12(8):e00338. doi: 10.14309/ctg.0000000000000338.

INTRODUCTION: We recently described the sulfur microbial diet, a pattern of intake associated with increased gut sulfur-metabolizing bacteria and incidence of distal colorectal cancer (CRC). We assessed whether this risk differed by CRC molecular subtypes or presence of intratumoral...

TAS-119, a novel selective Aurora A and TRK inhibitor, exhibits antitumor efficacy in preclinical models with deregulated activation of the Myc, β-Catenin, and TRK pathways.

Investigational new drugs

Miura A, Sootome H, Fujita N, Suzuki T, Fukushima H, Mizuarai S, Masuko N, Ito K, Hashimoto A, Uto Y, Sugimoto T, Takahashi H, Mitsuya M, Hirai H.
PMID: 33409897
Invest New Drugs. 2021 Jun;39(3):724-735. doi: 10.1007/s10637-020-01019-9. Epub 2021 Jan 06.

Aurora kinase A, a mitotic kinase that is overexpressed in various cancers, is a promising cancer drug target. Here, we performed preclinical characterization of TAS-119, a novel, orally active, and highly selective inhibitor of Aurora A. TAS-119 showed strong...

Feasible laparoscopic left trisectionectomy by Arantius' ligament approach (with video).

Surgical oncology

Haruki K, Onda S, Yasuda J, Ikegami T.
PMID: 34597864
Surg Oncol. 2021 Dec;39:101630. doi: 10.1016/j.suronc.2021.101630. Epub 2021 Jul 10.

BACKGROUND: Laparoscopic trisectionectomy is a technically challenging procedure with high rate of postoperative morbidity [1,2]. Arantius' ligament approach is useful to expose the root of middle hepatic vein, which is required in left trisectionectomy [3].METHODS: This video illustrates laparoscopic...

Urinary thioredoxin as a biomarker of renal redox dysregulation and a companion diagnostic to identify responders to redox-modulating therapeutics.

Antioxidants & redox signaling

Kasuno K, Yodoi J, Iwano M.
PMID: 34541903
Antioxid Redox Signal. 2021 Sep 20; doi: 10.1089/ars.2021.0194. Epub 2021 Sep 20.

SIGNIFICANCE: The development and progression of renal diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), are the result of heterogeneous pathophysiology that reflects a range of environmental factors and, in a lesser extent, genetic mutations. The...

Inflammatory biomarkers and dynamics of neutrophil-to-lymphocyte ratio in lenvatinib treatment for anaplastic thyroid carcinoma.

Gland surgery

Yamazaki H, Iwasaki H, Suganuma N, Toda S, Masudo K, Nakayama H, Rino Y, Masuda M.
PMID: 33842230
Gland Surg. 2021 Mar;10(3):852-860. doi: 10.21037/gs-20-871.

BACKGROUND: Inflammatory biomarkers have been reported to be associated with anticancer drug efficacy in various cancers. This study aimed to investigate the associations between baseline inflammatory biomarkers or dynamics of neutrophil-to-lymphocyte ratio (NLR) and treatment outcomes of lenvatinib in...

Showing 25 to 36 of 244 entries