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Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis.

Biomedicines

Eissa N, Elgazzar O, Hussein H, Hendy GN, Bernstein CN, Ghia JE.
PMID: 33535452
Biomedicines. 2021 Feb 01;9(2). doi: 10.3390/biomedicines9020134.

Ulcerative colitis (UC) is characterized by modifying alternatively activated macrophages (AAM) and epithelial homeostasis. Chromogranin-A (CHGA), released by enterochromaffin cells, is elevated in UC and is implicated in inflammation progression. CHGA can be cleaved into several derived peptides, including...

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Eissa N, Elgazzar O, Hussein H, et al. Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis. Biomedicines. 2021;9(2)doi: 10.3390/biomedicines9020134.
Eissa, N., Elgazzar, O., Hussein, H., Hendy, G. N., Bernstein, C. N., & Ghia, J. E. (2021). Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis. Biomedicines, 9(2), . https://doi.org/10.3390/biomedicines9020134
Eissa, Nour, et al. "Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis." Biomedicines vol. 9,2 (2021). doi: https://doi.org/10.3390/biomedicines9020134
Eissa N, Elgazzar O, Hussein H, Hendy GN, Bernstein CN, Ghia JE. Pancreastatin Reduces Alternatively Activated Macrophages, Disrupts the Epithelial Homeostasis and Aggravates Colonic Inflammation. A Descriptive Analysis. Biomedicines. 2021 Feb 01;9(2). doi: 10.3390/biomedicines9020134. PMID: 33535452; PMCID: PMC7912769.
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Screening and Counseling for Nicotine Use in Youth with Diabetes.

Pediatric diabetes

Chin A, Zonfrillo MR, Heinly A, Ford SR, Quintos JB, Topor LS.
PMID: 34766432
Pediatr Diabetes. 2021 Nov 11; doi: 10.1111/pedi.13287. Epub 2021 Nov 11.

INTRODUCTION: Electronic cigarettes are the most used tobacco product among adolescents and may be associated with increased risk of progression to combustible cigarette smoking, cardiovascular disease, and stroke. Diabetes mellitus is a known risk factor for cardiovascular disease, and...

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Chin A, Zonfrillo MR, Heinly A, et al. Screening and Counseling for Nicotine Use in Youth with Diabetes. Pediatr Diabetes. 2021;doi: 10.1111/pedi.13287.
Chin, A., Zonfrillo, M. R., Heinly, A., Ford, S. R., Quintos, J. B., & Topor, L. S. (2021). Screening and Counseling for Nicotine Use in Youth with Diabetes. Pediatric diabetes, . https://doi.org/10.1111/pedi.13287
Chin, Anna, et al. "Screening and Counseling for Nicotine Use in Youth with Diabetes." Pediatric diabetes vol. (2021). doi: https://doi.org/10.1111/pedi.13287
Chin A, Zonfrillo MR, Heinly A, Ford SR, Quintos JB, Topor LS. Screening and Counseling for Nicotine Use in Youth with Diabetes. Pediatr Diabetes. 2021 Nov 11; doi: 10.1111/pedi.13287. Epub 2021 Nov 11. PMID: 34766432.
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Eight new .

Fungal systematics and evolution

Castellano MA, Crabtree CD, Mitchell D, Healy RA.
PMID: 34124620
Fungal Syst Evol. 2021 Jun;7:113-131. doi: 10.3114/fuse.2021.07.06. Epub 2020 Dec 14.

The hypogeous, sequestrate ascomycete genus

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Castellano MA, Crabtree CD, Mitchell D, et al. Eight new . Fungal Syst Evol. 2020;7:113-131doi: 10.3114/fuse.2021.07.06.
Castellano, M. A., Crabtree, C. D., Mitchell, D., & Healy, R. A. (2021). Eight new . Fungal systematics and evolution, 7113-131. https://doi.org/10.3114/fuse.2021.07.06
Castellano, M A, et al. "Eight new ." Fungal systematics and evolution vol. 7 (2021): 113-131. doi: https://doi.org/10.3114/fuse.2021.07.06
Castellano MA, Crabtree CD, Mitchell D, Healy RA. Eight new . Fungal Syst Evol. 2021 Jun;7:113-131. doi: 10.3114/fuse.2021.07.06. Epub 2020 Dec 14. PMID: 34124620; PMCID: PMC8166207.
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Outcomes of male patients attending the symptomatic breast unit: adherence to local and national imaging guidelines and effectiveness of clinical examination and imaging in detecting male breast cancer.

Clinical radiology

Healy NA, Parag Y, Wallis MG, Tanner J, Kilburn-Toppin F.
PMID: 34716007
Clin Radiol. 2021 Oct 27; doi: 10.1016/j.crad.2021.09.018. Epub 2021 Oct 27.

AIM: To review outcomes of male patients attending the breast unit, evaluate effectiveness of imaging and examination in detecting breast cancer and review adherence to guidelines for male breast imaging.MATERIALS AND METHODS: A retrospective review was undertaken of male...

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Healy NA, Parag Y, Wallis MG, et al. Outcomes of male patients attending the symptomatic breast unit: adherence to local and national imaging guidelines and effectiveness of clinical examination and imaging in detecting male breast cancer. Clin Radiol. 2021;doi: 10.1016/j.crad.2021.09.018.
Healy, N. A., Parag, Y., Wallis, M. G., Tanner, J., & Kilburn-Toppin, F. (2021). Outcomes of male patients attending the symptomatic breast unit: adherence to local and national imaging guidelines and effectiveness of clinical examination and imaging in detecting male breast cancer. Clinical radiology, . https://doi.org/10.1016/j.crad.2021.09.018
Healy, N A, et al. "Outcomes of male patients attending the symptomatic breast unit: adherence to local and national imaging guidelines and effectiveness of clinical examination and imaging in detecting male breast cancer." Clinical radiology vol. (2021). doi: https://doi.org/10.1016/j.crad.2021.09.018
Healy NA, Parag Y, Wallis MG, Tanner J, Kilburn-Toppin F. Outcomes of male patients attending the symptomatic breast unit: adherence to local and national imaging guidelines and effectiveness of clinical examination and imaging in detecting male breast cancer. Clin Radiol. 2021 Oct 27; doi: 10.1016/j.crad.2021.09.018. Epub 2021 Oct 27. PMID: 34716007.
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First-in-human phase 1 study of the anti-TIGIT antibody vibostolimab as monotherapy or with pembrolizumab for advanced solid tumors, including non-small-cell lung cancer.

Annals of oncology : official journal of the European Society for Medical Oncology

Niu J, Maurice-Dror C, Lee DH, Kim DW, Nagrial A, Voskoboynik M, Chung HC, Mileham K, Vaishampayan U, Rasco D, Golan T, Bauer TM, Jimeno A, Chung V, Chartash E, Lala M, Chen Q, Healy JA, Ahn MJ.
PMID: 34800678
Ann Oncol. 2021 Nov 18; doi: 10.1016/j.annonc.2021.11.002. Epub 2021 Nov 18.

BACKGROUND: In this first-in-human phase 1 study (NCT02964013; MK-7684-001), we investigated the safety and efficacy of the anti-TIGIT (T cell immunoglobulin and ITIM domain) antibody vibostolimab as monotherapy or in combination with pembrolizumab.PATIENTS AND METHODS: Part A enrolled patients...

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Niu J, Maurice-Dror C, Lee DH, et al. First-in-human phase 1 study of the anti-TIGIT antibody vibostolimab as monotherapy or with pembrolizumab for advanced solid tumors, including non-small-cell lung cancer. Ann Oncol. 2021;doi: 10.1016/j.annonc.2021.11.002.
Niu, J., Maurice-Dror, C., Lee, D. H., Kim, D. W., Nagrial, A., Voskoboynik, M., Chung, H. C., Mileham, K., Vaishampayan, U., Rasco, D., Golan, T., Bauer, T. M., Jimeno, A., Chung, V., Chartash, E., Lala, M., Chen, Q., Healy, J. A., & Ahn, M. J. (2021). First-in-human phase 1 study of the anti-TIGIT antibody vibostolimab as monotherapy or with pembrolizumab for advanced solid tumors, including non-small-cell lung cancer. Annals of oncology : official journal of the European Society for Medical Oncology, . https://doi.org/10.1016/j.annonc.2021.11.002
Niu, J, et al. "First-in-human phase 1 study of the anti-TIGIT antibody vibostolimab as monotherapy or with pembrolizumab for advanced solid tumors, including non-small-cell lung cancer." Annals of oncology : official journal of the European Society for Medical Oncology vol. (2021). doi: https://doi.org/10.1016/j.annonc.2021.11.002
Niu J, Maurice-Dror C, Lee DH, Kim DW, Nagrial A, Voskoboynik M, Chung HC, Mileham K, Vaishampayan U, Rasco D, Golan T, Bauer TM, Jimeno A, Chung V, Chartash E, Lala M, Chen Q, Healy JA, Ahn MJ. First-in-human phase 1 study of the anti-TIGIT antibody vibostolimab as monotherapy or with pembrolizumab for advanced solid tumors, including non-small-cell lung cancer. Ann Oncol. 2021 Nov 18; doi: 10.1016/j.annonc.2021.11.002. Epub 2021 Nov 18. PMID: 34800678.
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Indwelling ureteric stents: Patterns of use and nomenclature.

Arab journal of urology

Leong JY, Steward JE, Healy KA, Hubosky SG, Bagley DH.
PMID: 33312735
Arab J Urol. 2020 May 19;18(4):241-246. doi: 10.1080/2090598X.2020.1761675.

No abstract available.

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Leong JY, Steward JE, Healy KA, et al. Indwelling ureteric stents: Patterns of use and nomenclature. Arab J Urol. 2020;18(4):241-246doi: 10.1080/2090598X.2020.1761675.
Leong, J. Y., Steward, J. E., Healy, K. A., Hubosky, S. G., & Bagley, D. H. (2020). Indwelling ureteric stents: Patterns of use and nomenclature. Arab journal of urology, 18(4), 241-246. https://doi.org/10.1080/2090598X.2020.1761675
Leong, Joon Yau, et al. "Indwelling ureteric stents: Patterns of use and nomenclature." Arab journal of urology vol. 18,4 (2020): 241-246. doi: https://doi.org/10.1080/2090598X.2020.1761675
Leong JY, Steward JE, Healy KA, Hubosky SG, Bagley DH. Indwelling ureteric stents: Patterns of use and nomenclature. Arab J Urol. 2020 May 19;18(4):241-246. doi: 10.1080/2090598X.2020.1761675. PMID: 33312735; PMCID: PMC7717614.
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Control of Virulent .

Infection and drug resistance

El-Zamkan MA, Hendy BA, Diab HM, Marraiki N, Batiha GE, Saber H, Younis W, Thangamani S, Alzahrani KJ, Ahmed AS.
PMID: 34290510
Infect Drug Resist. 2021 Jul 15;14:2721-2739. doi: 10.2147/IDR.S300593. eCollection 2021.

No abstract available.

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El-Zamkan MA, Hendy BA, Diab HM, et al. Control of Virulent . Infect Drug Resist. 2021;14:2721-2739doi: 10.2147/IDR.S300593.
El-Zamkan, M. A., Hendy, B. A., Diab, H. M., Marraiki, N., Batiha, G. E., Saber, H., Younis, W., Thangamani, S., Alzahrani, K. J., & Ahmed, A. S. (2021). Control of Virulent . Infection and drug resistance, 142721-2739. https://doi.org/10.2147/IDR.S300593
El-Zamkan, Mona A, et al. "Control of Virulent ." Infection and drug resistance vol. 14 (2021): 2721-2739. doi: https://doi.org/10.2147/IDR.S300593
El-Zamkan MA, Hendy BA, Diab HM, Marraiki N, Batiha GE, Saber H, Younis W, Thangamani S, Alzahrani KJ, Ahmed AS. Control of Virulent . Infect Drug Resist. 2021 Jul 15;14:2721-2739. doi: 10.2147/IDR.S300593. eCollection 2021. PMID: 34290510; PMCID: PMC8289371.
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Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older Adults.

Medicine and science in sports and exercise

Blankenship JM, Winkler EAH, Healy GN, Dempsey PC, Bellettiere J, Owen N, Dunstan DW.
PMID: 34310494
Med Sci Sports Exerc. 2021 Dec 01;53(12):2503-2511. doi: 10.1249/MSS.0000000000002750.

PURPOSE: To describe the frequency and characteristics (i.e., duration, stepping time, and estimated intensity) of all interruptions and physically active interruptions to adults' free-living sitting time (i.e., transitions from sitting to upright posture) across segments of the population.METHODS: Australian...

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Blankenship JM, Winkler EAH, Healy GN, et al. Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older Adults. Med Sci Sports Exerc. 2021;53(12):2503-2511doi: 10.1249/MSS.0000000000002750.
Blankenship, J. M., Winkler, E. A. H., Healy, G. N., Dempsey, P. C., Bellettiere, J., Owen, N., & Dunstan, D. W. (2021). Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older Adults. Medicine and science in sports and exercise, 53(12), 2503-2511. https://doi.org/10.1249/MSS.0000000000002750
Blankenship, Jennifer M, et al. "Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older Adults." Medicine and science in sports and exercise vol. 53,12 (2021): 2503-2511. doi: https://doi.org/10.1249/MSS.0000000000002750
Blankenship JM, Winkler EAH, Healy GN, Dempsey PC, Bellettiere J, Owen N, Dunstan DW. Descriptive Epidemiology of Interruptions to Free-Living Sitting Time in Middle-Age and Older Adults. Med Sci Sports Exerc. 2021 Dec 01;53(12):2503-2511. doi: 10.1249/MSS.0000000000002750. PMID: 34310494; PMCID: PMC8595533.
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Pre-operative radiomics model for prognostication in resectable pancreatic adenocarcinoma with external validation.

European radiology

Healy GM, Salinas-Miranda E, Jain R, Dong X, Deniffel D, Borgida A, Hosni A, Ryan DT, Njeze N, McGuire A, Conlon KC, Dodd JD, Ryan ER, Grant RC, Gallinger S, Haider MA.
PMID: 34757450
Eur Radiol. 2021 Nov 10; doi: 10.1007/s00330-021-08314-w. Epub 2021 Nov 10.

OBJECTIVES: In resectable pancreatic ductal adenocarcinoma (PDAC), few pre-operative prognostic biomarkers are available. Radiomics has demonstrated potential but lacks external validation. We aimed to develop and externally validate a pre-operative clinical-radiomic prognostic model.METHODS: Retrospective international, multi-center study in resectable...

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Healy GM, Salinas-Miranda E, Jain R, et al. Pre-operative radiomics model for prognostication in resectable pancreatic adenocarcinoma with external validation. Eur Radiol. 2021;doi: 10.1007/s00330-021-08314-w.
Healy, G. M., Salinas-Miranda, E., Jain, R., Dong, X., Deniffel, D., Borgida, A., Hosni, A., Ryan, D. T., Njeze, N., McGuire, A., Conlon, K. C., Dodd, J. D., Ryan, E. R., Grant, R. C., Gallinger, S., & Haider, M. A. (2021). Pre-operative radiomics model for prognostication in resectable pancreatic adenocarcinoma with external validation. European radiology, . https://doi.org/10.1007/s00330-021-08314-w
Healy, Gerard M, et al. "Pre-operative radiomics model for prognostication in resectable pancreatic adenocarcinoma with external validation." European radiology vol. (2021). doi: https://doi.org/10.1007/s00330-021-08314-w
Healy GM, Salinas-Miranda E, Jain R, Dong X, Deniffel D, Borgida A, Hosni A, Ryan DT, Njeze N, McGuire A, Conlon KC, Dodd JD, Ryan ER, Grant RC, Gallinger S, Haider MA. Pre-operative radiomics model for prognostication in resectable pancreatic adenocarcinoma with external validation. Eur Radiol. 2021 Nov 10; doi: 10.1007/s00330-021-08314-w. Epub 2021 Nov 10. PMID: 34757450.
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Contrasting compositions of sitting, standing, stepping, and sleeping time: associations with glycaemic outcome by diabetes risk.

The international journal of behavioral nutrition and physical activity

Brakenridge CJ, Healy GN, Sethi P, Carver A, Bellettiere J, Salim A, Chastin SFM, Owen N, Dunstan DW.
PMID: 34863205
Int J Behav Nutr Phys Act. 2021 Dec 04;18(1):155. doi: 10.1186/s12966-021-01209-5.

BACKGROUND: Recent evidence suggests that prolonged sitting and its adverse impact on glycaemic indicators appear to be proportional to the degree of insulin resistance. To investigate this finding in a free-living context, we aimed to examine associations of device-measured...

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Brakenridge CJ, Healy GN, Sethi P, et al. Contrasting compositions of sitting, standing, stepping, and sleeping time: associations with glycaemic outcome by diabetes risk. Int J Behav Nutr Phys Act. 2021;18(1):155doi: 10.1186/s12966-021-01209-5.
Brakenridge, C. J., Healy, G. N., Sethi, P., Carver, A., Bellettiere, J., Salim, A., Chastin, S. F. M., Owen, N., & Dunstan, D. W. (2021). Contrasting compositions of sitting, standing, stepping, and sleeping time: associations with glycaemic outcome by diabetes risk. The international journal of behavioral nutrition and physical activity, 18(1), 155. https://doi.org/10.1186/s12966-021-01209-5
Brakenridge, Christian J, et al. "Contrasting compositions of sitting, standing, stepping, and sleeping time: associations with glycaemic outcome by diabetes risk." The international journal of behavioral nutrition and physical activity vol. 18,1 (2021): 155. doi: https://doi.org/10.1186/s12966-021-01209-5
Brakenridge CJ, Healy GN, Sethi P, Carver A, Bellettiere J, Salim A, Chastin SFM, Owen N, Dunstan DW. Contrasting compositions of sitting, standing, stepping, and sleeping time: associations with glycaemic outcome by diabetes risk. Int J Behav Nutr Phys Act. 2021 Dec 04;18(1):155. doi: 10.1186/s12966-021-01209-5. PMID: 34863205; PMCID: PMC8642848.
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Implementation and evaluation of a curriculum on the assessment and treatment of disruptive behaviour disorders.

Paediatrics & child health

Doja A, Pringsheim T, Andrade BF, Cowley L, Healy SA, Baron T, Chan M, DiBartolo M, Gripp K, Manos S, Silverman JA, Writer H, Gorman DA.
PMID: 34987676
Paediatr Child Health. 2021 Apr 03;26(8):458-461. doi: 10.1093/pch/pxab008. eCollection 2021 Dec.

Disruptive behaviour disorders (DBDs)-which can include or be comorbid with disorders such as attention-deficit hyperactivity disorder, oppositional defiant disorder, conduct disorder and disruptive mood dysregulation disorder-are commonly seen in paediatric practice. Given increases in the prescribing of atypical antipsychotics...

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Doja A, Pringsheim T, Andrade BF, et al. Implementation and evaluation of a curriculum on the assessment and treatment of disruptive behaviour disorders. Paediatr Child Health. 2021;26(8):458-461doi: 10.1093/pch/pxab008.
Doja, A., Pringsheim, T., Andrade, B. F., Cowley, L., Healy, S. A., Baron, T., Chan, M., DiBartolo, M., Gripp, K., Manos, S., Silverman, J. A., Writer, H., & Gorman, D. A. (2021). Implementation and evaluation of a curriculum on the assessment and treatment of disruptive behaviour disorders. Paediatrics & child health, 26(8), 458-461. https://doi.org/10.1093/pch/pxab008
Doja, Asif, et al. "Implementation and evaluation of a curriculum on the assessment and treatment of disruptive behaviour disorders." Paediatrics & child health vol. 26,8 (2021): 458-461. doi: https://doi.org/10.1093/pch/pxab008
Doja A, Pringsheim T, Andrade BF, Cowley L, Healy SA, Baron T, Chan M, DiBartolo M, Gripp K, Manos S, Silverman JA, Writer H, Gorman DA. Implementation and evaluation of a curriculum on the assessment and treatment of disruptive behaviour disorders. Paediatr Child Health. 2021 Apr 03;26(8):458-461. doi: 10.1093/pch/pxab008. eCollection 2021 Dec. PMID: 34987676; PMCID: PMC8711686.
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Incidental Lymphoma Discovered During Surveillance for Low-Grade Upper Tract Urothelial Carcinoma Treated Ureteroscopically: A Case Report Series.

Journal of endourology case reports

Hubosky SG, Healy KA, Raval AJ, Lallas CD, Filicko-O'Hara J, Bagley DH.
PMID: 27579404
J Endourol Case Rep. 2016 Feb 01;2(1):14-7. doi: 10.1089/cren.2016.0008. eCollection 2016.

Two cases of incidentally found follicular lymphoma during surveillance for ureteroscopically treated upper tract urothelial carcinoma with cross-sectional imaging are described. Multiple independent primary malignancies should be considered in this population.

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Hubosky SG, Healy KA, Raval AJ, et al. Incidental Lymphoma Discovered During Surveillance for Low-Grade Upper Tract Urothelial Carcinoma Treated Ureteroscopically: A Case Report Series. J Endourol Case Rep. 2016;2(1):14-7doi: 10.1089/cren.2016.0008.
Hubosky, S. G., Healy, K. A., Raval, A. J., Lallas, C. D., Filicko-O'Hara, J., & Bagley, D. H. (2016). Incidental Lymphoma Discovered During Surveillance for Low-Grade Upper Tract Urothelial Carcinoma Treated Ureteroscopically: A Case Report Series. Journal of endourology case reports, 2(1), 14-7. https://doi.org/10.1089/cren.2016.0008
Hubosky, Scott G, et al. "Incidental Lymphoma Discovered During Surveillance for Low-Grade Upper Tract Urothelial Carcinoma Treated Ureteroscopically: A Case Report Series." Journal of endourology case reports vol. 2,1 (2016): 14-7. doi: https://doi.org/10.1089/cren.2016.0008
Hubosky SG, Healy KA, Raval AJ, Lallas CD, Filicko-O'Hara J, Bagley DH. Incidental Lymphoma Discovered During Surveillance for Low-Grade Upper Tract Urothelial Carcinoma Treated Ureteroscopically: A Case Report Series. J Endourol Case Rep. 2016 Feb 01;2(1):14-7. doi: 10.1089/cren.2016.0008. eCollection 2016. PMID: 27579404; PMCID: PMC4996584.
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