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Showing 13 to 24 of 91 entries
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Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication.

Journal of atherosclerosis and thrombosis

Furuhashi M, Kataoka Y, Nishikawa R, Koyama M, Sakai A, Higashiura Y, Tanaka M, Saitoh S, Shimamoto K, Ohnishi H.
PMID: 34565765
J Atheroscler Thromb. 2021 Sep 25; doi: 10.5551/jat.63159. Epub 2021 Sep 25.

AIM: Dyslipidemia and altered iron metabolism are typical features of non-alcoholic fatty liver disease (NAFLD). Proprotein convertase subtilisin/kexin type 7 (PCSK7), a transmembrane-anchored endonuclease, is associated with triglycerides level and processing of transferrin receptor 1. However, the significance of...

SF3B14 is involved in the centrosome regulation trough splicing of TUBGCP6 pre-mRNA.

Biochemical and biophysical research communications

Kato K, Udagawa R, Hayashi Y, Maki M, Yanagida M, Higashiura S, Yagishita R, Shimamoto H, Kimura K.
PMID: 34954520
Biochem Biophys Res Commun. 2021 Dec 18;588:133-139. doi: 10.1016/j.bbrc.2021.12.059. Epub 2021 Dec 18.

Splicing precursor messenger RNA (pre-mRNA) is a critical step to produce physiologically functional protein. Splicing failure not only gives rise to dysfunctional proteins but also generates abnormal protein function, which causes several diseases. Several pre-mRNA splicing factors are reported...

U-shaped relationship between serum uric acid level and decline in renal function during a 10-year period in female subjects: BOREAS-CKD2.

Hypertension research : official journal of the Japanese Society of Hypertension

Mori K, Furuhashi M, Tanaka M, Numata K, Hisasue T, Hanawa N, Koyama M, Osanami A, Higashiura Y, Inyaku M, Matsumoto M, Moniwa N, Ohnishi H, Miura T.
PMID: 32792577
Hypertens Res. 2021 Jan;44(1):107-116. doi: 10.1038/s41440-020-0532-z. Epub 2020 Aug 13.

While hyperuricemia is recognized as a risk factor for chronic kidney disease (CKD), the risk of CKD in subjects with a low level of serum uric acid (UA) remains controversial. Here, we examined whether the association of CKD risk...

Bone turnover markers in the early stage of rapidly progressive osteoarthritis of the hip.

European journal of rheumatology

Yasuda T, Matsunaga K, Hashimura T, Tsukamoto Y, Sueyoshi T, Ota S, Fujita S, Onishi E.
PMID: 32910766
Eur J Rheumatol. 2020 Sep 03; doi: 10.5152/eurjrheum.2020.20046. Epub 2020 Sep 03.

OBJECTIVE: Previous reports have demonstrated that patients with end-stage rapidly progressive osteoarthritis of the hip (RPOH) show significantly higher serum levels of bone turnover markers than those with osteoarthritis (OA). However, the characteristics of bone turnover markers in the...

Intraosseous infusion of liposome-encapsulated hemoglobin (HbV) acutely prevents hemorrhagic anemia-induced lethal arrhythmias and its efficacy persists with preventing proarrhythmic side effects in subacute phase of severe hemodilution model.

Artificial organs

Takase B, Higashimura Y, Asahina H, Masaki N, Kinoshita M, Sakai H.
PMID: 35006625
Artif Organs. 2022 Jan 10; doi: 10.1111/aor.14170. Epub 2022 Jan 10.

BACKGROUND: Artificial oxygen carriers (HbV) can treat hemorrhagic shock with lethal arrhythmias (VT/VF). No reports exist on subacute HbV's effects.METHODS: Acute and subacute resuscitation effects with anti-arrhythmogenesis of HbV were studied in 85% blood exchange rat model (85%-Model). Lethal...

A design strategy for high mobility stretchable polymer semiconductors.

Nature communications

Mun J, Ochiai Y, Wang W, Zheng Y, Zheng YQ, Wu HC, Matsuhisa N, Higashihara T, Tok JB, Yun Y, Bao Z.
PMID: 34117254
Nat Commun. 2021 Jun 11;12(1):3572. doi: 10.1038/s41467-021-23798-2.

As a key component in stretchable electronics, semiconducting polymers have been widely studied. However, it remains challenging to achieve stretchable semiconducting polymers with high mobility and mechanical reversibility against repeated mechanical stress. Here, we report a simple and universal...

A Versatile and Efficient Strategy to Discrete Conjugated Oligomers.

Journal of the American Chemical Society

Lawrence J, Goto E, Ren JM, McDearmon B, Kim DS, Ochiai Y, Clark PG, Laitar D, Higashihara T, Hawker CJ.
PMID: 28872865
J Am Chem Soc. 2017 Oct 04;139(39):13735-13739. doi: 10.1021/jacs.7b05299. Epub 2017 Sep 19.

An efficient and scalable strategy to prepare libraries of discrete conjugated oligomers (Đ = 1.0) using the combination of controlled polymerization and automated flash chromatography is reported. From this two-step process, a series of discrete conjugated materials from dimers...

Synthesis of dithienosilole-based highly photoluminescent donor-acceptor type compounds.

Dalton transactions (Cambridge, England : 2003)

Ohshita J, Tominaga Y, Tanaka D, Ooyama Y, Mizumo T, Kobayashi N, Higashimura H.
PMID: 23295388
Dalton Trans. 2013 Mar 14;42(10):3646-52. doi: 10.1039/c2dt32738d. Epub 2013 Jan 07.

Highly photoluminescent acceptor-donor-acceptor (A-D-A) and donor-acceptor (D-A) type compounds with a dithienosilole unit as the donor and perfluorotolyl or dimesitylboryl group(s) as the acceptor were prepared by the reaction of lithiated dithienosilole derivatives with perfluorotoluene or fluorodimesitylborane, respectively. The...

Efficacy of palmaz stent deployment for subclavian artery stenosis.

Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

Nakagawa H, Kichikawa K, Fukusumi A, Takayama K, Higashiura W, Kubota Y, Nakane M, Taoka T, Iwasaki S, Ohishi H, Uchida H, Sakaki T.
PMID: 20673472
Interv Neuroradiol. 1998 Nov 30;4:191-4. doi: 10.1177/15910199980040S139. Epub 2001 May 15.

SUMMARY: Percutaneous angioplasty is a useful method for improvement of posterior circulation of the brain in subclavian artery stenosis and occlusion. Recently, the Palmaz stent was introduced for peripheral vessels stenosis. We evaluated the efficacy and care point of...

Identification of multiple pathways involved in the malignant transformation of endometriosis (Review).

Oncology letters

Higashiura Y, Kajihara H, Shigetomi H, Kobayashi H.
PMID: 22807950
Oncol Lett. 2012 Jul;4(1):3-9. doi: 10.3892/ol.2012.690. Epub 2012 Apr 23.

The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant...

[Hormone refractory prostate carcinoma metastasizes to the penis: a case report.].

Hinyokika kiyo. Acta urologica Japonica

Kawahara T, Manabe Y, Asazuma A, Teruyoshi A, Hashimura T.
PMID: 19926949
Hinyokika Kiyo. 2009 Oct;55(10):627-629.

A 76-year-oldman presentedwith urinary retention andpenile discomfort. At 67 years old, he was diagnosedwith stage D2 prostate cancer andthen, was treatedwith hormone therapy. Several nodules were observedon the glans, andhistological examination of the penile tumor biopsy showedmetastatic adenocarcinoma of...

Donor-acceptor oligoimides for application in high-performance electrical memory devices.

Chemistry, an Asian journal

Lai YC, Kurosawa T, Higashihara T, Ueda M, Chen WC.
PMID: 23712951
Chem Asian J. 2013 Jul;8(7):1514-22. doi: 10.1002/asia.201300335. Epub 2013 May 27.

Two new oligoimides, OI(APAP-6FDA) and OI(APAN-6FDA), which consisted of electron-donating N-(4-aminophenyl)-N-phenyl-1-aminopyrene (APAP) or N-(4-aminophenyl)-N-phenyl-1-aminonaphthalene (APAN) moieties and electron-accepting 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) moieties, were designed and synthesized for application in electrical memory devices. Such devices, with the indium tin oxide...

Showing 13 to 24 of 91 entries