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Showing 13 to 24 of 194 entries
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Thermophilic .

ACS omega

Iwasa H, Hiratsuka A, Yokoyama K, Uzawa H, Orihara K, Muguruma H.
PMID: 30023641
ACS Omega. 2017 Apr 30;2(4):1660-1665. doi: 10.1021/acsomega.7b00277. Epub 2017 Apr 26.

Flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenase (GDH) was identified and cloned from thermophilic filamentous fungi

Effect of S-1 on blood levels of phenobarbital and phenytoin: A case report.

Clinical case reports

Shiraiwa K, Ono H, Tanaka R, Fujinaga A, Hiratsuka T, Tatsuta R, Inomata M, Itoh H.
PMID: 33768879
Clin Case Rep. 2021 Feb 04;9(3):1514-1517. doi: 10.1002/ccr3.3813. eCollection 2021 Mar.

Drug-drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S-1 (tegafur/gimeracil/oteracil) and radiation therapy...

Oncologic impact of lateral lymph node metastasis at the distal lateral compartment in locally advanced low rectal cancer after neoadjuvant (chemo)radiotherapy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Akiyoshi T, Yamaguchi T, Hiratsuka M, Mukai T, Hiyoshi Y, Nagasaki T, Ueno M, Fukunaga Y, Konishi T.
PMID: 34284904
Eur J Surg Oncol. 2021 Jul 16; doi: 10.1016/j.ejso.2021.07.011. Epub 2021 Jul 16.

INTRODUCTION: The frequency and oncologic outcomes of lateral lymph node (LLN) metastasis at the most distal lateral compartment (DLC) among clinical stage II-III low rectal cancer patients treated with neoadjuvant (chemo)radiotherapy (nCRT) are poorly understood. The aim was to...

Efficacy of Proportional Sedation and Deep Sedation Defined by Sedation Protocols: A Multicenter, Prospective, Observational Comparative Study.

Journal of pain and symptom management

Imai K, Morita T, Yokomichi N, Kawaguchi T, Kohara H, Yamaguchi T, Kikuchi A, Odagiri T, Watanabe YS, Kamura R, Maeda I, Kawashima N, Ito S, Baba M, Matsuda Y, Oya K, Kaneishi K, Hiratsuka Y, Naito AS, Mori M.
PMID: 34118372
J Pain Symptom Manage. 2021 Dec;62(6):1165-1174. doi: 10.1016/j.jpainsymman.2021.06.005. Epub 2021 Jun 10.

PURPOSE: To investigate the efficacy of two types of palliative sedation: proportional and deep sedation, defined by sedation protocols.METHODS: From a multicenter prospective observational study, we analyzed the data of those patients who received the continuous infusion of midazolam...

Corneal Eccentricity in a Rural Japanese Population: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS).

Ophthalmic epidemiology

Yoshida Y, Ono K, Tano T, Hiratsuka Y, Otani K, Sekiguchi M, Konno S, Kikuchi S, Yamada M, Fukuhara S, Murakami A.
PMID: 34427161
Ophthalmic Epidemiol. 2021 Aug 24;1-6. doi: 10.1080/09286586.2021.1968004. Epub 2021 Aug 24.

PURPOSE: To determine normal corneal eccentricity in a rural Japanese population and to examine factors associated with eccentricity value.METHODS: This used data from the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) project between 2009 and 2012....

Real-world effectiveness of screening programs for age-related macular degeneration: amended Japanese specific health checkups and augmented screening programs with OCT or AI.

Japanese journal of ophthalmology

Tamura H, Akune Y, Hiratsuka Y, Kawasaki R, Kido A, Miyake M, Goto R, Yamada M.
PMID: 34993676
Jpn J Ophthalmol. 2022 Jan;66(1):19-32. doi: 10.1007/s10384-021-00890-0. Epub 2022 Jan 07.

PURPOSE: To investigate the effectiveness of screening and subsequent intervention for age-related macular degeneration (AMD) in Japan.STUDY DESIGN: Best-case-scenario analysis using a Markov model.METHODS: The clinical effectiveness and cost-effectiveness of screening for AMD were assessed by calculating the reduction...

Usefulness of the patient-specific contrast enhancement optimizer simulation software during the whole-body computed tomography angiography.

Heart and vessels

Masuda T, Higaki T, Nakaura T, Funama Y, Matsumoto Y, Sato T, Okimoto T, Gotanda R, Arao K, Imaizumi H, Arao S, Hiratsuka J, Awai K.
PMID: 35028684
Heart Vessels. 2022 Jan 13; doi: 10.1007/s00380-022-02024-z. Epub 2022 Jan 13.

To evaluate whether the patient-specific contrast enhancement optimizer simulation software (p-COP) is useful for predicting contrast enhancement during whole-body computed tomography angiography (WBCTA). We randomly divided the patients into two groups using a random number table. We used the...

Smoking patterns among urban Alaska Native and American Indian adults: The Alaska EARTH 10-year follow-up study.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Patten CA, Hiratsuka VY, Nash SH, Day G, Redwood DG, Beans JA, Howard BV, Umans JG, Koller KR.
PMID: 34850172
Nicotine Tob Res. 2021 Nov 25; doi: 10.1093/ntr/ntab245. Epub 2021 Nov 25.

INTRODUCTION: Data on cigarette smoking prevalence among Alaska Native and American Indian (ANAI) people are limited to cross-sectional studies or specific subpopulations. Using data from the Alaska Education and Research toward Health (EARTH) Study 10-year follow-up, this study assessed...

Identification of management units in threatened populations of Arnica mallotopus Makino (Asteraceae) using novel EST-SSR markers.

Genes & genetic systems

Masuda K, Setoguchi H, Nagasawa K, Fukumoto S, Ishihara MI, Miura RI, Mizusawa L, Hiratsuka KI, Sakaguchi S.
PMID: 34148896
Genes Genet Syst. 2021 Oct 09;96(3):159-164. doi: 10.1266/ggs.21-00021. Epub 2021 Jun 18.

Arnica mallotopus is a perennial herb endemic to the snowy regions of Japan. At the southern edge of its distribution, in Kyoto Prefecture, overgrazing by sika deer and decreased snowfall have resulted in the rapid decline of A. mallotopus...

Clinical patterns of rhegmatogenous retinal detachment during the first state of emergency for the COVID-19 pandemic in a Tokyo center.

PloS one

Hirakata T, Huang T, Hiratsuka Y, Yamamoto S, Inoue A, Murakami A.
PMID: 34972153
PLoS One. 2021 Dec 31;16(12):e0261779. doi: 10.1371/journal.pone.0261779. eCollection 2021.

The coronavirus disease 2019 (COVID-19) pandemic is disturbing and overwhelming a regular medical care in the world. We evaluated the clinical characteristics of patients with primary rhegmatogenous retinal detachment (RRD) during the state of emergency for COVID-19 pandemic in...

Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1'-Hydroxylation and Testosterone 6.

Drug metabolism and disposition: the biological fate of chemicals

Kumondai M, Gutiérrez Rico EM, Hishinuma E, Ueda A, Saito S, Saigusa D, Tadaka S, Kinoshita K, Nakayoshi T, Oda A, Abe A, Maekawa M, Mano N, Hirasawa N, Hiratsuka M.
PMID: 33384383
Drug Metab Dispos. 2021 Mar;49(3):212-220. doi: 10.1124/dmd.120.000261. Epub 2020 Dec 31.

CYP3A4 is among the most abundant liver and intestinal drug-metabolizing cytochrome P450 enzymes, contributing to the metabolism of more than 30% of clinically used drugs. Therefore, interindividual variability in CYP3A4 activity is a frequent cause of reduced drug efficacy...

Relationship between osteoid formation and iron deposition induced by chronic cadmium exposure in ovariectomized rats.

Journal of applied toxicology : JAT

Wako Y, Hiratsuka H, Kurotaki T, Tsuchitani M, Umemura T.
PMID: 33283302
J Appl Toxicol. 2021 Aug;41(8):1304-1315. doi: 10.1002/jat.4118. Epub 2020 Dec 06.

Itai-itai (Japanese, "It hurts! It hurts!") disease (IID), a form of osteomalacia, can be induced in ovariectomized rats by long-term administration of cadmium (Cd). This IID rat model shows severe anemia, severe nephropathy, and osteomalacia accompanied by iron (Fe)...

Showing 13 to 24 of 194 entries