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Showing 25 to 36 of 194 entries
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Oncologic impact of lateral lymph node metastasis at the distal lateral compartment in locally advanced low rectal cancer after neoadjuvant (chemo)radiotherapy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Akiyoshi T, Yamaguchi T, Hiratsuka M, Mukai T, Hiyoshi Y, Nagasaki T, Ueno M, Fukunaga Y, Konishi T.
PMID: 34284904
Eur J Surg Oncol. 2021 Dec;47(12):3157-3165. doi: 10.1016/j.ejso.2021.07.011. Epub 2021 Jul 16.

INTRODUCTION: The frequency and oncologic outcomes of lateral lymph node (LLN) metastasis at the most distal lateral compartment (DLC) among clinical stage II-III low rectal cancer patients treated with neoadjuvant (chemo)radiotherapy (nCRT) are poorly understood. The aim was to...

Long-term outcomes of neoadjuvant-synchronous S-1 plus radiotherapy for locally advanced rectal cancer: a multi-institutional prospective phase II study.

Journal of the anus, rectum and colon

Hiratsuka T, Etoh T, Hara T, Akagi T, Tahara K, Matsumoto T, Ogawa T, Fujii K, Shiromizu A, Shiroshita H, Inomata M.
PMID: 31559360
J Anus Rectum Colon. 2018 Oct 29;2(4):168-175. doi: 10.23922/jarc.2018-011. eCollection 2018.

OBJECTIVES: This study aimed to evaluate the long-term outcomes of neoadjuvant chemoradiotherapy with S-1 in patients with locally advanced rectal cancer.METHODS: A multi-institutional, prospective, phase II trial was conducted between April 2009 and August 2011. The study enrolled 37...

Precision medicine research with American Indian and Alaska Native communities: Results of a deliberative engagement with tribal leaders.

Genetics in medicine : official journal of the American College of Medical Genetics

Trinidad SB, Blacksher E, Woodbury RB, Hopkins SE, Burke W, Woodahl EL, Boyer BB, Hiratsuka VY.
PMID: 34906504
Genet Med. 2021 Nov 30; doi: 10.1016/j.gim.2021.11.003. Epub 2021 Nov 30.

PURPOSE: Amid calls for greater diversity in precision medicine research, the perspectives of Indigenous people have been underexplored. Our goals were to understand tribal leaders' views regarding the potential benefits and risks of such research, explore its priority for...

Micrometer-sized molecular robot changes its shape in response to signal molecules.

Science robotics

Sato Y, Hiratsuka Y, Kawamata I, Murata S, Nomura SM.
PMID: 33157867
Sci Robot. 2017 Mar 01;2(4). doi: 10.1126/scirobotics.aal3735. Epub 2017 Mar 01.

Rapid progress in nanoscale bioengineering has allowed for the design of biomolecular devices that act as sensors, actuators, and even logic circuits. Realization of micrometer-sized robots assembled from these components is one of the ultimate goals of bioinspired robotics....

Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning.

Evidence-based complementary and alternative medicine : eCAM

Yahiro T, Hara T, Matsumoto T, Ikebe E, Fife-Koshinomi N, Xu Z, Hiratsuka T, Iha H, Inomata M.
PMID: 31827547
Evid Based Complement Alternat Med. 2019 Nov 19;2019:2710587. doi: 10.1155/2019/2710587. eCollection 2019.

BACKGROUND: An alkalescent (pH 8.3) mineral water (AMW) of Hita basin, located in the northwestern part of Kyushu island in Japan, has been recognized for the unique quality of ingredients including highly concentrated silicic acid, sodium, potassium, and hydrogen...

Tumor-Associated Macrophages Induce Migration of Renal Cell Carcinoma Cells via Activation of the CCL20-CCR6 Axis.

Cancers

Kadomoto S, Izumi K, Hiratsuka K, Nakano T, Naito R, Makino T, Iwamoto H, Yaegashi H, Shigehara K, Kadono Y, Nakata H, Saito Y, Nakagawa-Goto K, Mizokami A.
PMID: 31905918
Cancers (Basel). 2019 Dec 30;12(1). doi: 10.3390/cancers12010089.

This study investigated tumor-associated macrophages activity in the microenvironment of renal cell carcinoma. Via a co-culture with macrophage-like cells differentiated from human monocyte cell line THP-1 and U937 cells, the migration ability of ACHN and Caki-1 cells, which are...

A single institute validation study comparing the international chronic ocular graft-versus-host disease consensus group diagnostic criteria with clinical parameters.

The ocular surface

Hiratsuka R, Shimizu E, Yamane M, Yazu H, Sato S, Fukui M, Mukai S, Uchino M, Kamoi M, Tatematsu Y, Saijo Y, Negishi K, Tsubota K, Ogawa Y.
PMID: 34933116
Ocul Surf. 2021 Dec 18;24:12-14. doi: 10.1016/j.jtos.2021.12.009. Epub 2021 Dec 18.

No abstract available.

A single institute validation study comparing the international chronic ocular graft-versus-host disease consensus group diagnostic criteria with clinical parameters.

The ocular surface

Hiratsuka R, Shimizu E, Yamane M, Yazu H, Sato S, Fukui M, Mukai S, Uchino M, Kamoi M, Tatematsu Y, Saijo Y, Negishi K, Tsubota K, Ogawa Y.
PMID: 34933116
Ocul Surf. 2021 Dec 18;24:12-14. doi: 10.1016/j.jtos.2021.12.009. Epub 2021 Dec 18.

No abstract available.

Detection of Glaucoma and Other Vision-Threatening Ocular Diseases in the Population Recruited at Specific Health Checkups in Japan.

Clinical epidemiology

Yamada M, Hiratsuka Y, Nakano T, Kita Y, Watanabe T, Tamura H, Kawasaki R, Yokoyama T, Takano S.
PMID: 33364847
Clin Epidemiol. 2020 Dec 17;12:1381-1388. doi: 10.2147/CLEP.S273016. eCollection 2020.

BACKGROUND: The efficacy of vision screening for adults has not been well established. The present study aimed to investigate the prevalence of vision-threatening ocular diseases, including glaucoma, among subjects who participated in specific health checkups in Japan.METHODS: This cross-sectional...

The risk of second malignancy after adjuvant chemotherapy for stomach cancer.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Takekuni K, Furukawa H, Tsukuma H, Hiratsuka M, Imaoka S, Ishikawa O, Kabuto T, Sasaki Y, Kameyama M, Ohigashi H, Yasuda T, Murata K, Yamada T, Kinoshita N.
PMID: 11957099
Gastric Cancer. 1999 Dec;2(4):206-209. doi: 10.1007/s101200050064.

BACKGROUND: Although many trials have been conducted to evaluate the feasibility and effectiveness of adjuvant chemotherapy (ACT) for patients with stomach cancer, the benefits of ACT remain unclear. Moreover, some authors have reported that ACT increased the incidence of...

Programmed cell death of Pinus nucellus in response to pollen tube penetration.

Journal of plant research

Hiratsuka R, Yamada Y, Terasaka O.
PMID: 12884137
J Plant Res. 2002 Apr;115(1118):141-8. doi: 10.1007/s102650200019.

In ovules of Pinus densiflora, pollen tubes elongate and branch into the nucellar tissue in the direction of the female gametophyte. After pollination, nucellar cells located around the pollen grain and tube die off. We showed here that the...

In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase.

Journal of clinical medicine

Hishinuma E, Gutiérrez Rico E, Hiratsuka M, Al-Turjman F, Abujubbeh M, Malekloo A.
PMID: 32707991
J Clin Med. 2020 Jul 22;9(8). doi: 10.3390/jcm9082342.

Fluoropyrimidine drugs (FPs), including 5-fluorouracil, tegafur, capecitabine, and doxifluridine, are among the most widely used anticancer agents in the treatment of solid tumors. However, severe toxicity occurs in approximately 30% of patients following FP administration, emphasizing the importance of...

Showing 25 to 36 of 194 entries