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Showing 481 to 489 of 489 entries
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Plasma Metabolomic Signatures of Healthy Dietary Patterns in the Chronic Renal Insufficiency Cohort (CRIC) Study.

The Journal of nutrition

Kim H, Anderson CA, Hu EA, Zheng Z, Appel LJ, He J, Feldman HI, Anderson AH, Ricardo AC, Bhat Z, Kelly TN, Chen J, Vasan RS, Kimmel PL, Grams ME, Coresh J, Clish CB, Rhee EP, Rebholz CM.
PMID: 34195833
J Nutr. 2021 Oct 01;151(10):2894-2907. doi: 10.1093/jn/nxab203.

BACKGROUND: In individuals with chronic kidney disease (CKD), healthy dietary patterns are inversely associated with CKD progression. Metabolomics, an approach that measures many small molecules in biofluids, can identify biomarkers of healthy dietary patterns.OBJECTIVES: We aimed to identify known...

Glial Nrf2 signaling mediates the neuroprotection exerted by .

eLife

Lin YE, Lin CH, Ho EP, Ke YC, Petridi S, Elliott CJ, Sheen LY, Chien CT.
PMID: 34779396
Elife. 2021 Nov 15;10. doi: 10.7554/eLife.73753.

The most frequent missense mutations in familial Parkinson's disease (PD) occur in the highly conserved

Percutaneous Mechanical Thrombectomy of Submassive Pulmonary Embolism and Extensive Deep Venous Thrombosis for Early Thrombus Removal.

Vascular specialist international

Jo EA, Choi KW, Han A, Ahn S, Min S, Jae H, Lee M, Min SK.
PMID: 35008066
Vasc Specialist Int. 2021 Dec 31;37:47. doi: 10.5758/vsi.210061.

Traditional treatment with anticoagulation in nonfatal submassive pulmonary embolism can result in serious sequelae of chronic thromboembolic pulmonary hypertension or poor exercise tolerance, and functional impairment. To prevent long-term complications in previously healthy young patients, other treatment options to...

Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease.

Clinical journal of the American Society of Nephrology : CJASN

He WJ, Chen J, Razavi AC, Hu EA, Grams ME, Yu B, Parikh CR, Boerwinkle E, Bazzano L, Qi L, Kelly TN, Coresh J, Rebholz CM.
PMID: 34737201
Clin J Am Soc Nephrol. 2021 Nov;16(11):1620-1629. doi: 10.2215/CJN.05520421. Epub 2021 Nov 04.

BACKGROUND AND OBJECTIVES: Moderate coffee consumption has been associated with lower risk of CKD; however, the exact biologic mechanisms underlying this association are unknown. Metabolomic profiling may identify metabolic pathways that explain the association between coffee and CKD. The...

Hematologic and systemic metabolic alterations due to Mediterranean class II G6PD deficiency in mice.

JCI insight

D'Alessandro A, Howie HL, Hay AM, Dziewulska KH, Brown BC, Wither MJ, Karafin M, Stone EF, Spitalnik SL, Hod EA, Francis RO, Fu X, Thomas T, Zimring JC.
PMID: 34138756
JCI Insight. 2021 Jul 22;6(14). doi: 10.1172/jci.insight.147056.

Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is the single most common enzymopathy, present in approximately 400 million humans (approximately 5%). Its prevalence is hypothesized to be due to conferring resistance to malaria. However, G6PD deficiency also results in hemolytic sequelae...

Donor genetic and nongenetic factors affecting red blood cell transfusion effectiveness.

JCI insight

Roubinian NH, Reese SE, Qiao H, Plimier C, Fang F, Page GP, Cable RG, Custer B, Gladwin MT, Goel R, Harris B, Hendrickson JE, Kanias T, Kleinman S, Mast AE, Sloan SR, Spencer BR, Spitalnik SL, Busch MP, Hod EA.
PMID: 34793330
JCI Insight. 2022 Jan 11;7(1). doi: 10.1172/jci.insight.152598.

BACKGROUNDRBC transfusion effectiveness varies due to donor, component, and recipient factors. Prior studies identified characteristics associated with variation in hemoglobin increments following transfusion. We extended these observations, examining donor genetic and nongenetic factors affecting transfusion effectiveness.METHODSThis is a multicenter...

Therapeutic Efficacy of Autologous Platelet Concentrate Injection on Macular Holes with High Myopia, Large Macular Holes, or Recurrent Macular Holes: A Multicenter Randomized Controlled Trial.

Journal of clinical medicine

Kim M, Won JY, Choi SY, Kim M, Ra H, Jee D, Kwon JW, Kang KD, Roh YJ, Park YG, Kang S, Shin JA, Yim HW, Park YH.
PMID: 34205522
J Clin Med. 2021 Jun 21;10(12). doi: 10.3390/jcm10122727.

We aimed to evaluate the anatomical and functional outcomes of pars-plana vitrectomy (PPV) with or without autologous platelet concentrate (APC) injection in patients with recurrent macular holes (MHs), large MHs, or MHs with high myopia. This multicenter, prospective, interventional...

Current therapeutic approaches in the management of hemophilia-a consensus view by the Romanian Society of Hematology.

Annals of translational medicine

Hotea I, Brinza M, Blag C, Zimta AA, Dirzu N, Burzo C, Rus I, Apostu D, Benea H, Marian M, Mester A, Pasca S, Iluta S, Teodorescu P, Jitaru C, Zdrenghea M, Bojan A, Torok-Vistai T, Niculescu R, Tarniceriu C, Dima D, Truica C, Serban M, Tomuleasa C, Coriu D.
PMID: 34423003
Ann Transl Med. 2021 Jul;9(13):1091. doi: 10.21037/atm-21-747.

Hemophilia A (HA) and hemophilia B (HB) are rare disorders, being caused by the total lack or under-expression of two factors from the coagulation cascade coded by genes of the X chromosome. Thus, in hemophilic patients, the blood does...

Oral Antibiotics in Patients with Short Bowel Syndrome: Hurdles and Caveats.

European journal of drug metabolism and pharmacokinetics

Law LS, Hong WB, Yeoh SF, Tan WK, Ong DE, Lo EA.
PMID: 34609730
Eur J Drug Metab Pharmacokinet. 2021 Nov;46(6):825-826. doi: 10.1007/s13318-021-00717-w. Epub 2021 Oct 05.

No abstract available.

Showing 481 to 489 of 489 entries