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Showing 13 to 24 of 201 entries
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Highly enantioselective metallation-substitution alpha to a chiral nitrile.

Chemical science

Sadhukhan A, Hobbs MC, Meijer AJHM, Coldham I.
PMID: 28616143
Chem Sci. 2017 Feb 01;8(2):1436-1441. doi: 10.1039/c6sc03712g. Epub 2016 Oct 25.

We report the deprotonation of a chiral nitrile and reaction of the resulting chiral organometallic species with a variety of electrophiles to give highly enantiomerically enriched 2-substituted nitrile products. The nitrile was treated with TMPMgCl and the resulting anion,...

Pragmatic treatment options for depression and anxiety disorders are needed.

World psychiatry : official journal of the World Psychiatric Association (WPA)

Andrews G, Hobbs MJ.
PMID: 27717253
World Psychiatry. 2016 Oct;15(3):241-242. doi: 10.1002/wps.20364.

No abstract available.

Complement fragments suppress lymphocyte immune responses.

Immunology today

Weiler JM, Ballas ZK, Needleman BW, Hobbs MV, Feldbush TL.
PMID: 25290053
Immunol Today. 1982 Sep;3(9):238-43. doi: 10.1016/0167-5699(82)90009-3.

There has been controversy as to whether complement augments immune responses or inhibits them. In this article John Weiler and his colleagues discuss recent evidence that complement fragments can inhibit immune responses that depend upon cellular proliferation.

Distinctive Pathophysiology Underlying Constipation in Parkinson's Disease: Implications for Cognitive Inefficiency.

Journal of clinical medicine

Tucker RM, Ryan S, Hayee BH, Bjarnason I, Augustin AD, Umamahesan C, Taylor D, Weller C, Dobbs SM, Dobbs RJ, Charlett A.
PMID: 32575365
J Clin Med. 2020 Jun 19;9(6). doi: 10.3390/jcm9061916.

Depression is associated with constipation within and outside Parkinson's disease (PD). Since inefficient cognitive-processing (bradyphrenia) features in PD and an enterokinetic agent improved cognitive performance in healthy individuals, bradyphrenia may be associated with constipation. We aim to define the...

The genetics of isolated and syndromic clubfoot.

Journal of children's orthopaedics

Sadler B, Gurnett CA, Dobbs MB.
PMID: 31312262
J Child Orthop. 2019 Jun 01;13(3):238-244. doi: 10.1302/1863-2548.13.190063.

PURPOSE: Congenital clubfoot is a serious birth defect that affects nearly 0.1% of all births. Though there is strong evidence for a genetic basis of isolated clubfoot, aside from a handful of associations, much of the heritability remains unexplained.METHODS:...

Evidence Supporting Selective Dorsal Rhizotomy for Treatment of Spastic Cerebral Palsy.

Cureus

Park TS, Dobbs MB, Cho J.
PMID: 30585282
Cureus. 2018 Oct 19;10(10):e3466. doi: 10.7759/cureus.3466.

The objective of this review is to analyze the evidence supporting selective dorsal rhizotomy (SDR) for the treatment of spastic cerebral palsy (CP). We reviewed 85 outcome studies from 12 countries between 1990 and 2017. The published results are...

Functional Outcome of Adulthood Selective Dorsal Rhizotomy for Spastic Diplegia.

Cureus

Park TS, Uhm SY, Walter DM, Meyer NL, Dobbs MB.
PMID: 31565593
Cureus. 2019 Jul 21;11(7):e5184. doi: 10.7759/cureus.5184.

Objective The medical evidence supporting the efficacy of selective dorsal rhizotomy (SDR) on children with spastic diplegia is strong. However, the outcome of SDR on adults with spastic diplegia remains undetermined. The aim is to study the effectiveness and...

Frontiers in medicine

Augustin AD, Savio A, Nevel A, Ellis RJ, Weller C, Taylor D, Tucker RM, Ibrahim MAA, Bjarnason I, Dobbs SM, Dobbs RJ, Charlett A.
PMID: 31555648
Front Med (Lausanne). 2019 Aug 28;6:188. doi: 10.3389/fmed.2019.00188. eCollection 2019.

No abstract available.

Blast and accelerated phase CML: room for improvement.

Hematology. American Society of Hematology. Education Program

How J, Venkataraman V, Hobbs GS.
PMID: 34889372
Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):122-128. doi: 10.1182/hematology.2021000240.

Tyrosine kinase inhibitors (TKIs) revolutionized the treatment of chronic myeloid leukemia (CML). With TKI therapy, the percentage of patients who progress to accelerated phase (AP) or blast phase (BP) CML has decreased from more than 20% to 1% to...

Validation of a Home Food Environment Instrument Assessing Household Food Patterning and Quality.

Nutrients

Barrett KJ, Hibbs-Shipp SK, Hobbs S, Boles RE, Johnson SL, Bellows LL.
PMID: 34836185
Nutrients. 2021 Nov 03;13(11). doi: 10.3390/nu13113930.

The home food environment (HFE) is associated with dietary intake; yet measuring HFE quality often requires burdensome collection of detailed inventories. This project evaluated the capacity of the Home Inventory to Describe Eating and Activity, version 2 (Home-IDEA2) to...

Characteristics and risk factors for thrombosis in POEMS syndrome: A retrospective evaluation of 230 patients.

American journal of hematology

Mellors PW, Kourelis T, Go RS, Muchtar E, Gertz MA, Kumar SK, Buadi FK, Kapoor P, Lacy MQ, Dingli D, Hwa Y, Fonder A, Hobbs M, Hayman S, Warsame R, Leung NR, Lin Y, Gonsalves W, Siddiqui M, Kyle RA, Rajkumar SV, Dispenzieri A.
PMID: 34822175
Am J Hematol. 2022 Feb 01;97(2):209-215. doi: 10.1002/ajh.26422. Epub 2021 Nov 30.

Thromboses are prevalent in POEMS syndrome, but few risk factors for POEMS-associated thrombosis have been identified. The objective of this study is to identify novel risk factors for POEMS-associated thrombosis. In this retrospective cohort of 230 POEMS patients, 27%...

Waldenström Macroglobulinemia: Clinical Presentation, Diagnosis, and Management.

Journal of the advanced practitioner in oncology

Hobbs M, Fonder A, Hwa YL.
PMID: 33604098
J Adv Pract Oncol. 2020 May-Jun;11(4):381-389. doi: 10.6004/jadpro.2020.11.4.5. Epub 2020 May 01.

Waldenström macroglobulinemia is a rare hematologic malignancy characterized by an IgM-associated lymphoplasmacytic lymphoma. Often, it is associated with an indolent disease course, and many patients are candidates for careful monitoring. As many patients present with advanced age and nonspecific...

Showing 13 to 24 of 201 entries