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Showing 313 to 321 of 321 entries
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Blocking the orexin system following therapeutic exposure promoted between session habituation, but not PTSD symptom reduction.

Journal of psychiatric research

Kobayashi I, Mellman TA, Cannon A, Brown I, Boadi L, Howell MK, Lavela P, Sandhu I.
PMID: 34933185
J Psychiatr Res. 2021 Dec 14;145:222-229. doi: 10.1016/j.jpsychires.2021.12.027. Epub 2021 Dec 14.

There is a need to identify strategies to increase the effectiveness of treatments for posttraumatic stress disorder (PTSD). Sleep is often disturbed in PTSD and has been implicated in learning processes that underlie recovery from PTSD, including extinction of...

Utilization of epidural volume extension technique for external cephalic version.

Proceedings (Baylor University. Medical Center)

Hussey H, Damron J, Powell MF, Tubinis M.
PMID: 33953486
Proc (Bayl Univ Med Cent). 2021 Feb 02;34(3):422-423. doi: 10.1080/08998280.2021.1878870.

External cephalic version (ECV) has been successfully utilized to reduce breech presentations at term and offers an alternative to elective cesarean delivery. Unfortunately, there is not a consensus on which type of regional anesthesia conveys the highest chances for...

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths.

Molecular imaging

Li M, Nyayapathi N, Kilian HI, Xia J, Lovell JF, Yao J.
PMID: 33336621
Mol Imaging. 2020 Jan-Dec;19:1536012120981518. doi: 10.1177/1536012120981518.

Photoacoustic tomography (PAT) has become increasingly popular for molecular imaging due to its unique optical absorption contrast, high spatial resolution, deep imaging depth, and high imaging speed. Yet, the strong optical attenuation of biological tissues has traditionally prevented PAT...

Traceless antibiotic-crosslinked micelles for rapid clearance of intracellular bacteria.

Journal of controlled release : official journal of the Controlled Release Society

Yang X, Qiu Q, Liu G, Ren H, Wang X, Lovell JF, Zhang Y.
PMID: 34843813
J Control Release. 2021 Nov 26;341:329-340. doi: 10.1016/j.jconrel.2021.11.037. Epub 2021 Nov 26.

Effective delivery of antimicrobial agents to intracellular pathogens represents a major bottleneck for a wide variety of infectious diseases. To address this, we developed SIR-micelles(+), as a new delivery vehicle comprising antibiotic-loaded micelles with rapid self-immolation within cells for...

Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

He X, Zhou S, Quinn B, Huang WC, Jahagirdar D, Vega M, Ortega J, Long MD, Ito F, Abrams SI, Lovell JF.
PMID: 34716694
Adv Sci (Weinh). 2021 Dec;8(24):e2103023. doi: 10.1002/advs.202103023. Epub 2021 Oct 30.

Short peptides reflecting major histocompatibility complex (MHC) class I (MHC-I) epitopes frequently lack sufficient immunogenicity to induce robust antigen (Ag)-specific CD8

REM Sleep Without Atonia and Gait Impairment in People with Mild-to-Moderate Parkinson's Disease.

Journal of Parkinson's disease

Amundsen-Huffmaster SL, Petrucci MN, Linn-Evans ME, Chung JW, Howell MJ, Videnovic A, Tuite PJ, Cooper SE, MacKinnon CD.
PMID: 33523016
J Parkinsons Dis. 2021;11(2):767-778. doi: 10.3233/JPD-202098.

BACKGROUND: Subtle gait deficits can be seen in people with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD), a prodromal stage of Parkinson's disease (PD) and related alpha-synucleinopathies. It is unknown if the presence and level of REM...

Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs.

Frontiers in immunology

Howell MC, Green R, McGill AR, Kahlil RM, Dutta R, Mohapatra SS, Mohapatra S.
PMID: 34899680
Front Immunol. 2021 Nov 24;12:700705. doi: 10.3389/fimmu.2021.700705. eCollection 2021.

A novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), arose late in 2019, with disease pathology ranging from asymptomatic to severe respiratory distress with multi-organ failure requiring mechanical ventilator support. It has been found that SARS-CoV-2 infection drives...

Traceless antibiotic-crosslinked micelles for rapid clearance of intracellular bacteria.

Journal of controlled release : official journal of the Controlled Release Society

Yang X, Qiu Q, Liu G, Ren H, Wang X, Lovell JF, Zhang Y.
PMID: 34843813
J Control Release. 2021 Nov 26;341:329-340. doi: 10.1016/j.jconrel.2021.11.037. Epub 2021 Nov 26.

Effective delivery of antimicrobial agents to intracellular pathogens represents a major bottleneck for a wide variety of infectious diseases. To address this, we developed SIR-micelles(+), as a new delivery vehicle comprising antibiotic-loaded micelles with rapid self-immolation within cells for...

An In Vivo Screen to Identify Short Peptide Mimotopes with Enhanced Antitumor Immunogenicity.

Cancer immunology research

He X, Zhou S, Quinn B, Jahagirdar D, Ortega J, Long MD, Abrams SI, Lovell JF.
PMID: 34992135
Cancer Immunol Res. 2022 Jan 06; doi: 10.1158/2326-6066.CIR-21-0332. Epub 2022 Jan 06.

Tumor-associated self-antigens are potential cancer vaccine targets but suffer from limited immunogenicity. There are examples of mutated, short self-peptides inducing epitope-specific CD8⁺ T cells more efficiently than the wild-type epitope, but current approaches cannot yet reliably identify such epitopes,...

Showing 313 to 321 of 321 entries