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Showing 661 to 665 of 665 entries
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Clonal relationship and directionality of progression of synchronous endometrial and ovarian carcinomas in patients with DNA mismatch repair-deficiency associated syndromes.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Moukarzel LA, Da Cruz Paula A, Ferrando L, Hoang T, Sebastiao APM, Pareja F, Park KJ, Jungbluth AA, Capella G, Pineda M, Levin JD, Abu-Rustum NR, Ellenson LH, Bel AV, Reis-Filho JS, Matias-Guiu X, Cadoo K, Stadler ZK, Weigelt B.
PMID: 33328602
Mod Pathol. 2021 May;34(5):994-1007. doi: 10.1038/s41379-020-00721-6. Epub 2020 Dec 16.

Sporadic synchronous endometrial (ECs) and ovarian cancers (OCs), although clinically considered to be independent primaries, have been shown to be clonally related and likely constitute metastases from each other. We sought to define whether synchronous ECs/OCs in patients with...

The Role of Real-World Evidence in FDA-Approved New Drug and Biologics License Applications.

Clinical pharmacology and therapeutics

Purpura CA, Garry EM, Honig N, Case A, Rassen JA.
PMID: 34726771
Clin Pharmacol Ther. 2022 Jan;111(1):135-144. doi: 10.1002/cpt.2474. Epub 2021 Nov 22.

The US Food and Drug Administration (FDA) is open to accepting real-world evidence (RWE) to support its assessment of medical products. However, RWE stakeholders lack a shared understanding of FDA's evidentiary expectations for the use of RWE in applications...

A single motor neuron determines the rhythm of early motor behavior in .

Science advances

Akahoshi T, Utsumi MK, Oonuma K, Murakami M, Horie T, Kusakabe TG, Oka K, Hotta K.
PMID: 34890229
Sci Adv. 2021 Dec 10;7(50):eabl6053. doi: 10.1126/sciadv.abl6053. Epub 2021 Dec 10.

[Figure: see text].

Spontaneous Splenic Artery Rupture as the First Symptom of Systemic Amyloidosis.

Case reports in critical care

Bruserud Ø, Tvedt THA, Ahmed AB, Vintermyr OK, Hervig T, Guttormsen AB, Reikvam H.
PMID: 33763260
Case Rep Crit Care. 2021 Mar 08;2021:6676407. doi: 10.1155/2021/6676407. eCollection 2021.

Spontaneous splenic rupture is a life-threatening condition leading to a rapidly progressing hypovolemic shock due to intra-abdominal blood loss, with a mortality rate of about 10%. Spontaneous splenic rupture can be caused by widely different disorders including acute and...

Functions and structure of roots and their contributions to salinity tolerance in plants.

Breeding science

Karahara I, Horie T.
PMID: 33762879
Breed Sci. 2021 Feb;71(1):89-108. doi: 10.1270/jsbbs.20123. Epub 2021 Feb 05.

Soil salinity is an increasing threat to the productivity of glycophytic crops worldwide. The root plays vital roles under various stress conditions, including salinity, as well as has diverse functions in non-stress soil environments. In this review, we focus...

Showing 661 to 665 of 665 entries