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Showing 685 to 696 of 696 entries
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Quantitative mobility measures complement the MDS-UPDRS for characterization of Parkinson's disease heterogeneity.

Parkinsonism & related disorders

Hill EJ, Mangleburg CG, Alfradique-Dunham I, Ripperger B, Stillwell A, Saade H, Rao S, Fagbongbe O, von Coelln R, Tarakad A, Hunter C, Dawe RJ, Jankovic J, Shulman LM, Buchman AS, Shulman JM.
PMID: 33607526
Parkinsonism Relat Disord. 2021 Mar;84:105-111. doi: 10.1016/j.parkreldis.2021.02.006. Epub 2021 Feb 10.

INTRODUCTION: Emerging technologies show promise for enhanced characterization of Parkinson's Disease (PD) motor manifestations. We evaluated quantitative mobility measures from a wearable device compared to the conventional motor assessment, the Movement Disorders Society-Unified PD Rating Scale part III (motor...

Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common C.

mAbs

Cao M, Jiao Y, Parthemore C, Korman S, Ma J, Hunter A, Kilby G, Chen X.
PMID: 34719342
MAbs. 2021 Jan-Dec;13(1):1981806. doi: 10.1080/19420862.2021.1981806.

Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis-sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in C

Improving the detection and treatment of depression in Australians with multiple sclerosis: A qualitative analysis.

Multiple sclerosis and related disorders

Hunter A, Marck CH, Butler E, Allan M, Edward KL, Giles A, Kulkarni J, Rajendran D, Shaw S, Grech LB.
PMID: 34614457
Mult Scler Relat Disord. 2021 Nov;56:103290. doi: 10.1016/j.msard.2021.103290. Epub 2021 Sep 28.

BACKGROUND: Depression is common in people with multiple sclerosis (MS), yet often goes undetected, untreated or undertreated.OBJECTIVE: This qualitative research explored current practices, barriers and facilitators for detection and treatment of depression in Australians with MS.METHODS: Participants were 26...

Reporting guidelines for human microbiome research: the STORMS checklist.

Nature medicine

Mirzayi C, Renson A, Zohra F, Elsafoury S, Geistlinger L, Kasselman LJ, Eckenrode K, van de Wijgert J, Loughman A, Marques FZ, MacIntyre DA, Arumugam M, Azhar R, Beghini F, Bergstrom K, Bhatt A, Bisanz JE, Braun J, Bravo HC, Buck GA, Bushman F, Casero D, Clarke G, Collado MC, Cotter PD, Cryan JF, Demmer RT, Devkota S, Elinav E, Escobar JS, Fettweis J, Finn RD, Fodor AA, Forslund S, Franke A, Furlanello C, Gilbert J, Grice E, Haibe-Kains B, Handley S, Herd P, Holmes S, Jacobs JP, Karstens L, Knight R, Knights D, Koren O, Kwon DS, Langille M, Lindsay B, McGovern D, McHardy AC, McWeeney S, Mueller NT, Nezi L, Olm M, Palm N, Pasolli E, Raes J, Redinbo MR, Rühlemann M, Balfour Sartor R, Schloss PD, Schriml L, Segal E, Shardell M, Sharpton T, Smirnova E, Sokol H, Sonnenburg JL, Srinivasan S, Thingholm LB, Turnbaugh PJ, Upadhyay V, Walls RL, Wilmes P, Yamada T, Zeller G, Zhang M, Zhao N, Zhao L, Bao W, Culhane A, Devanarayan V, Dopazo J, Fan X, Fischer M, Jones W, Kusko R, Mason CE, Mercer TR, Sansone SA, Scherer A, Shi L, Thakkar S, Tong W, Wolfinger R, Hunter C, Segata N, Huttenhower C, Dowd JB, Jones HE, Waldron L.
PMID: 34789871
Nat Med. 2021 Nov;27(11):1885-1892. doi: 10.1038/s41591-021-01552-x. Epub 2021 Nov 17.

The particularly interdisciplinary nature of human microbiome research makes the organization and reporting of results spanning epidemiology, biology, bioinformatics, translational medicine and statistics a challenge. Commonly used reporting guidelines for observational or genetic epidemiology studies lack key features specific...

Islet transplantation into brown adipose tissue can delay immune rejection.

JCI insight

Kepple JD, Barra JM, Young ME, Hunter CS, Tse HM.
PMID: 35015736
JCI Insight. 2022 Jan 11; doi: 10.1172/jci.insight.152800. Epub 2022 Jan 11.

Type 1 diabetes is an autoimmune disease characterized by insulin-producing beta-cell destruction. While islet transplantation restores euglycemia and improves patient outcomes, an ideal transplant site remains elusive. Brown adipose tissue (BAT) is a highly vascularized and anti-inflammatory microenvironment. As...

β-eye: A benchtop system for in vivo molecular screening of labeled compounds.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Fysikopoulos E, Rouchota M, Georgiou M, Sfyris C, Cheimarios N, Sarpaki S, Kostopoulos S, Glotsos D, Larimer B, Hunter C, Lapi S, Houson H, Massicano AVF, Sorace A, Lamprou E, Loudos G.
PMID: 34894480
Appl Radiat Isot. 2021 Dec 01;180:110034. doi: 10.1016/j.apradiso.2021.110034. Epub 2021 Dec 01.

Preclinical nuclear molecular imaging speeds up the mean time from synthesis to market, in drug development process. Commercial imaging systems have in general high cost, require high-cost service contracts, special facilities and trained staff. In the current work, we...

Intervention Strategies and Lessons Learned From a Student-Led Initiative to Support Lactating Women in the University Setting.

Health promotion practice

Bell E, Hunter C, Benitez T, Uysal J, Walovich C, McConnell L, Vega C, Cisneros N, Hidalgo L, Reyes Walton J, Wang M.
PMID: 33884924
Health Promot Pract. 2021 Apr 22;15248399211004283. doi: 10.1177/15248399211004283. Epub 2021 Apr 22.

The benefits of breastfeeding for mother and baby are strongly supported by research. However, lactating parents who return to school or work soon after delivery face many barriers to continued breastfeeding. This article presents a student-led initiative to support...

Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1.

mAbs

Chen W, Pandey M, Sun H, Rolong A, Cao M, Liu D, Wang J, Zeng L, Hunter A, Lin S.
PMID: 33870864
MAbs. 2021 Jan-Dec;13(1):1914359. doi: 10.1080/19420862.2021.1914359.

T-cell-mediated immunotherapy has generated much excitement after the success of therapeutic biologics targeting immune checkpoint molecules. Bispecific antibodies (BsAbs) that recognize two antigen targets are a fast-growing class of biologics offering promising clinical benefits for cancer immunotherapy. Due to...

Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities.

JACC. Basic to translational science

Sharp TE, Scarborough AL, Li Z, Polhemus DJ, Hidalgo HA, Schumacher JD, Matsuura TR, Jenkins JS, Kelly DP, Goodchild TT, Lefer DJ.
PMID: 33665515
JACC Basic Transl Sci. 2021 Feb 03;6(2):154-170. doi: 10.1016/j.jacbts.2020.11.012. eCollection 2021 Feb.

A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed...

FRET measurement of cytochrome bc.

Biochimica et biophysica acta. Bioenergetics

Vasilev C, Swainsbury DJK, Cartron ML, Martin EC, Kumar S, Hobbs JK, Johnson MP, Hitchcock A, Hunter CN.
PMID: 34793767
Biochim Biophys Acta Bioenerg. 2021 Nov 15;1863(2):148508. doi: 10.1016/j.bbabio.2021.148508. Epub 2021 Nov 15.

In the model purple phototrophic bacterium Rhodobacter (Rba.) sphaeroides, solar energy is converted via coupled electron and proton transfer reactions within the intracytoplasmic membranes (ICMs), infoldings of the cytoplasmic membrane that form spherical 'chromatophore' vesicles. These bacterial 'organelles' are...

β-eye: A benchtop system for in vivo molecular screening of labeled compounds.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

Fysikopoulos E, Rouchota M, Georgiou M, Sfyris C, Cheimarios N, Sarpaki S, Kostopoulos S, Glotsos D, Larimer B, Hunter C, Lapi S, Houson H, Massicano AVF, Sorace A, Lamprou E, Loudos G.
PMID: 34894480
Appl Radiat Isot. 2021 Dec 01;180:110034. doi: 10.1016/j.apradiso.2021.110034. Epub 2021 Dec 01.

Preclinical nuclear molecular imaging speeds up the mean time from synthesis to market, in drug development process. Commercial imaging systems have in general high cost, require high-cost service contracts, special facilities and trained staff. In the current work, we...

Decision-making, attitudes, and understanding among patients and relatives invited to undergo genome sequencing in the 100,000 Genomes Project: A multisite survey study.

Genetics in medicine : official journal of the American College of Medical Genetics

Sanderson SC, Lewis C, Hill M, Peter M, McEntagart M, Gale D, Morris H, Moosajee M, Searle B, Hunter A, Patch C, Chitty LS.
PMID: 34906473
Genet Med. 2022 Jan;24(1):61-74. doi: 10.1016/j.gim.2021.08.010. Epub 2021 Nov 30.

PURPOSE: The purpose of this study was to assess decisions, attitudes, and understanding of participants (patients, parents, relatives) having genome sequencing for rare disease diagnosis.METHODS: This study involved a cross-sectional observational survey with participants in the 100,000 Genomes Project.RESULTS:...

Showing 685 to 696 of 696 entries