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Showing 289 to 293 of 293 entries
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JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study.

Rheumatology (Oxford, England)

Le Voyer T, Gitiaux C, Authier FJ, Bodemer C, Melki I, Quartier P, Aeschlimann F, Isapof A, Herbeuval JP, Bondet V, Charuel JL, Frémond ML, Duffy D, Rodero MP, Bader-Meunier B.
PMID: 33576769
Rheumatology (Oxford). 2021 Dec 01;60(12):5801-5808. doi: 10.1093/rheumatology/keab116.

OBJECTIVE: To evaluate the efficacy and safety of Janus kinase inhibitors (JAKis) in JDM.METHODS: We conducted a single-centre retrospective study of patients with JDM treated by JAKi with a follow-up of at least 6 months. Proportion of clinically inactive...

A Comparison of Clinicopathologic Outcomes Across Neoadjuvant and Adjuvant Treatment Modalities in Resectable Gastric Cancer.

JAMA network open

Anderson E, LeVee A, Kim S, Atkins K, Guan M, Placencio-Hickok V, Moshayedi N, Hendifar A, Osipov A, Gangi A, Burch M, Waters K, Cho M, Klempner S, Chao J, Kamrava M, Gong J.
PMID: 34889947
JAMA Netw Open. 2021 Dec 01;4(12):e2138432. doi: 10.1001/jamanetworkopen.2021.38432.

IMPORTANCE: Treatment of resectable gastric cancer (RGC) uses a multimodal approach, including surgical treatment and chemotherapy with or without radiation therapy, and the optimal treatment strategy and timing of each of these modalities is unknown.OBJECTIVE: To investigate the association...

Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice.

Communications biology

Malkov A, Popova I, Ivanov A, Jang SS, Yoon SY, Osypov A, Huang Y, Zilberter Y, Zilberter M.
PMID: 34504272
Commun Biol. 2021 Sep 09;4(1):1054. doi: 10.1038/s42003-021-02551-x.

A predominant trigger and driver of sporadic Alzheimer's disease (AD) is the synergy of brain oxidative stress and glucose hypometabolism starting at early preclinical stages. Oxidative stress damages macromolecules, while glucose hypometabolism impairs cellular energy supply and antioxidant defense....

Associations between tumor and edema volumes with tumor infiltrating lymphocytes in brain metastasis - A preliminary study.

Clinical neurology and neurosurgery

Meyer HJ, Höhn AK, Prasse G, Hoffmann KT, Surov A.
PMID: 34915356
Clin Neurol Neurosurg. 2021 Dec 08;212:107088. doi: 10.1016/j.clineuro.2021.107088. Epub 2021 Dec 08.

OBJECTIVE: Perifocal edema of brain tumors is associated with survival and neurological symptoms. The present study sought to elucidate the association between edema volume and tumor infiltrating lymphocytes (TIL) in brain metastasis.METHODS: 25 patients with brain metastasis were included...

Mining and Tailings Dam Detection in Satellite Imagery Using Deep Learning.

Sensors (Basel, Switzerland)

Balaniuk R, Isupova O, Reece S.
PMID: 33291634
Sensors (Basel). 2020 Dec 04;20(23). doi: 10.3390/s20236936.

This work explores the combination of free cloud computing, free open-source software, and deep learning methods to analyze a real, large-scale problem: the automatic country-wide identification and classification of surface mines and mining tailings dams in Brazil. Locations of...

Showing 289 to 293 of 293 entries