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Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen.

bioRxiv : the preprint server for biology

Saul S, Karim M, Huang PT, Ghita L, Chiu W, Kumar S, Bhalla N, Leyssen P, Cohen CA, Huie K, Tindle C, Sibai M, Pinsky BA, Das S, Ghosh P, Dye JM, Solow-Cordero DE, Jin J, Jochmans D, Neyts J, Narayanan A, De Jonghe S, Einav S.
PMID: 34159337
bioRxiv. 2021 Jun 15; doi: 10.1101/2021.05.15.444128.

Effective therapies are needed to combat emerging viruses. Seventeen candidates that rescue cells from SARS-CoV-2-induced lethality and target diverse functions emerged in a screen of 4,413 compounds. Among the hits was lapatinib, an approved inhibitor of the ErbB family...

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Saul S, Karim M, Huang PT, et al. Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen. bioRxiv. 2021;doi: 10.1101/2021.05.15.444128.
Saul, S., Karim, M., Huang, P. T., Ghita, L., Chiu, W., Kumar, S., Bhalla, N., Leyssen, P., Cohen, C. A., Huie, K., Tindle, C., Sibai, M., Pinsky, B. A., Das, S., Ghosh, P., Dye, J. M., Solow-Cordero, D. E., Jin, J., Jochmans, D., Neyts, J., Narayanan, A., De Jonghe, S., & Einav, S. (2021). Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen. bioRxiv : the preprint server for biology, . https://doi.org/10.1101/2021.05.15.444128
Saul, Sirle, et al. "Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen." bioRxiv : the preprint server for biology vol. (2021). doi: https://doi.org/10.1101/2021.05.15.444128
Saul S, Karim M, Huang PT, Ghita L, Chiu W, Kumar S, Bhalla N, Leyssen P, Cohen CA, Huie K, Tindle C, Sibai M, Pinsky BA, Das S, Ghosh P, Dye JM, Solow-Cordero DE, Jin J, Jochmans D, Neyts J, Narayanan A, De Jonghe S, Einav S. Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen. bioRxiv. 2021 Jun 15; doi: 10.1101/2021.05.15.444128. PMID: 34159337; PMCID: PMC8219101.
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Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens".

EBioMedicine

Liesenborghs L, Spriet I, Jochmans D, Belmans A, Gyselinck I, Teuwen LA, Ter Horst S, Dreesen E, Geukens T, Engelen MM, Landeloos E, Geldhof V, Ceunen H, Debaveye B, Vandenberk B, Van der Linden L, Jacobs S, Langendries L, Boudewijns R, Dan Do TN, Chiu W, Wang X, Zhang X, Weynand B, Vanassche T, Devos T, Meyfroidt G, Janssens W, Vos R, Vermeersch P, Wauters J, Verbeke G, De Munter P, Kaptein SJF, Rocha-Pereira J, Delang L, Van Wijngaerden E, Neyts J, Verhamme P.
PMID: 34186486
EBioMedicine. 2021 Jul;69:103454. doi: 10.1016/j.ebiom.2021.103454. Epub 2021 Jun 26.

No abstract available.

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Liesenborghs L, Spriet I, Jochmans D, et al. Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens". EBioMedicine. 2021;69:103454doi: 10.1016/j.ebiom.2021.103454.
Liesenborghs, L., Spriet, I., Jochmans, D., Belmans, A., Gyselinck, I., Teuwen, L. A., Ter Horst, S., Dreesen, E., Geukens, T., Engelen, M. M., Landeloos, E., Geldhof, V., Ceunen, H., Debaveye, B., Vandenberk, B., Van der Linden, L., Jacobs, S., Langendries, L., Boudewijns, R., Dan Do, T. N., Chiu, W., Wang, X., Zhang, X., Weynand, B., Vanassche, T., Devos, T., Meyfroidt, G., Janssens, W., Vos, R., Vermeersch, P., Wauters, J., Verbeke, G., De Munter, P., Kaptein, S. J. F., Rocha-Pereira, J., Delang, L., Van Wijngaerden, E., Neyts, J., & Verhamme, P. (2021). Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens". EBioMedicine, 69103454. https://doi.org/10.1016/j.ebiom.2021.103454
Liesenborghs, Laurens, et al. "Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens"." EBioMedicine vol. 69 (2021): 103454. doi: https://doi.org/10.1016/j.ebiom.2021.103454
Liesenborghs L, Spriet I, Jochmans D, Belmans A, Gyselinck I, Teuwen LA, Ter Horst S, Dreesen E, Geukens T, Engelen MM, Landeloos E, Geldhof V, Ceunen H, Debaveye B, Vandenberk B, Van der Linden L, Jacobs S, Langendries L, Boudewijns R, Dan Do TN, Chiu W, Wang X, Zhang X, Weynand B, Vanassche T, Devos T, Meyfroidt G, Janssens W, Vos R, Vermeersch P, Wauters J, Verbeke G, De Munter P, Kaptein SJF, Rocha-Pereira J, Delang L, Van Wijngaerden E, Neyts J, Verhamme P. Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens". EBioMedicine. 2021 Jul;69:103454. doi: 10.1016/j.ebiom.2021.103454. Epub 2021 Jun 26. PMID: 34186486; PMCID: PMC8233477.
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Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry.

Neuro-oncology

Erker C, Lane A, Chaney B, Leary S, Minturn JE, Bartels U, Packer RJ, Dorris K, Gottardo NG, Warren KE, Broniscer A, Mark WK, Zhu X, White P, Dexheimer P, Black K, Asher A, DeWire-Shottmiller M, Hansford JR, Gururangan S, Nazarian J, Ziegler DS, Sandler E, Wagner L, Koschmann C, Fuller C, Drissi R, Jones BV, Leach J, Fouladi M.
PMID: 34114629
Neuro Oncol. 2021 Jun 11; doi: 10.1093/neuonc/noab140. Epub 2021 Jun 11.

BACKGROUND: DIPG generally occurs in young school-age children, although can occur in adolescents and young adults. The purpose of this study was to describe clinical, radiological, pathologic, and molecular characteristics in patients ≥10 years of age with DIPG enrolled...

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Erker C, Lane A, Chaney B, et al. Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry. Neuro Oncol. 2021;doi: 10.1093/neuonc/noab140.
Erker, C., Lane, A., Chaney, B., Leary, S., Minturn, J. E., Bartels, U., Packer, R. J., Dorris, K., Gottardo, N. G., Warren, K. E., Broniscer, A., Mark, W. K., Zhu, X., White, P., Dexheimer, P., Black, K., Asher, A., DeWire-Shottmiller, M., Hansford, J. R., Gururangan, S., Nazarian, J., Ziegler, D. S., Sandler, E., Wagner, L., Koschmann, C., Fuller, C., Drissi, R., Jones, B. V., Leach, J., & Fouladi, M. (2021). Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry. Neuro-oncology, . https://doi.org/10.1093/neuonc/noab140
Erker, Craig, et al. "Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry." Neuro-oncology vol. (2021). doi: https://doi.org/10.1093/neuonc/noab140
Erker C, Lane A, Chaney B, Leary S, Minturn JE, Bartels U, Packer RJ, Dorris K, Gottardo NG, Warren KE, Broniscer A, Mark WK, Zhu X, White P, Dexheimer P, Black K, Asher A, DeWire-Shottmiller M, Hansford JR, Gururangan S, Nazarian J, Ziegler DS, Sandler E, Wagner L, Koschmann C, Fuller C, Drissi R, Jones BV, Leach J, Fouladi M. Characteristics of Patients ≥ 10 Years of Age with Diffuse Intrinsic Pontine Glioma: A Report from the International DIPG Registry. Neuro Oncol. 2021 Jun 11; doi: 10.1093/neuonc/noab140. Epub 2021 Jun 11. PMID: 34114629.
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Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2.

Journal of medicinal chemistry

Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H.
PMID: 33872498
J Med Chem. 2021 Apr 19; doi: 10.1021/acs.jmedchem.0c02258. Epub 2021 Apr 19.

A novel series of peptidomimetic aldehydes was designed and synthesized to target 3C protease (3C

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Dai W, Jochmans D, Xie H, et al. Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. J Med Chem. 2021;doi: 10.1021/acs.jmedchem.0c02258.
Dai, W., Jochmans, D., Xie, H., Yang, H., Li, J., Su, H., Chang, D., Wang, J., Peng, J., Zhu, L., Nian, Y., Hilgenfeld, R., Jiang, H., Chen, K., Zhang, L., Xu, Y., Neyts, J., & Liu, H. (2021). Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. Journal of medicinal chemistry, . https://doi.org/10.1021/acs.jmedchem.0c02258
Dai, Wenhao, et al. "Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2." Journal of medicinal chemistry vol. (2021). doi: https://doi.org/10.1021/acs.jmedchem.0c02258
Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, Peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H. Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. J Med Chem. 2021 Apr 19; doi: 10.1021/acs.jmedchem.0c02258. Epub 2021 Apr 19. PMID: 33872498; PMCID: PMC8084273.
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Performance of Abbott Alinity hq hematology analyzer for automated cell counting of body fluids.

International journal of laboratory hematology

Herroelen PH, Demeester S, Damiaens S, Evenepoel A, Jochmans K.
PMID: 34582122
Int J Lab Hematol. 2022 Feb;44(1):96-103. doi: 10.1111/ijlh.13704. Epub 2021 Sep 28.

INTRODUCTION: Body fluid cell counting and differentiation provide essential information for diagnosis and monitoring of diverse pathologies. We evaluated the performance of the newly launched Abbott Alinity hq hematology analyzer for automated cell counting in body fluids and compared...

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Herroelen PH, Demeester S, Damiaens S, et al. Performance of Abbott Alinity hq hematology analyzer for automated cell counting of body fluids. Int J Lab Hematol. 2021;44(1):96-103doi: 10.1111/ijlh.13704.
Herroelen, P. H., Demeester, S., Damiaens, S., Evenepoel, A., & Jochmans, K. (2022). Performance of Abbott Alinity hq hematology analyzer for automated cell counting of body fluids. International journal of laboratory hematology, 44(1), 96-103. https://doi.org/10.1111/ijlh.13704
Herroelen, Pauline H, et al. "Performance of Abbott Alinity hq hematology analyzer for automated cell counting of body fluids." International journal of laboratory hematology vol. 44,1 (2022): 96-103. doi: https://doi.org/10.1111/ijlh.13704
Herroelen PH, Demeester S, Damiaens S, Evenepoel A, Jochmans K. Performance of Abbott Alinity hq hematology analyzer for automated cell counting of body fluids. Int J Lab Hematol. 2022 Feb;44(1):96-103. doi: 10.1111/ijlh.13704. Epub 2021 Sep 28. PMID: 34582122.
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Showing 289 to 293 of 293 entries