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Showing 13 to 24 of 155 entries
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Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD.

Clinical epigenetics

Johnson ND, Wu X, Still CD, Chu X, Petrick AT, Gerhard GS, Conneely KN, DiStefano JK.
PMID: 34353365
Clin Epigenetics. 2021 Aug 05;13(1):152. doi: 10.1186/s13148-021-01129-y.

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA methylation (DNAm) is a plausible mechanism underlying these shifts,...

Telmisartan induces a specific gut microbiota signature which may mediate its antiobesity effect.

Pharmacological research

Beckmann L, Künstner A, Freschi ML, Huber G, Stölting I, Ibrahim SM, Hirose M, Freitag M, Langan EA, Matschl U, Galuska CE, Fuchs B, Knobloch JK, Busch H, Raasch W.
PMID: 34116209
Pharmacol Res. 2021 Aug;170:105724. doi: 10.1016/j.phrs.2021.105724. Epub 2021 Jun 09.

Telmisartan prevents diet-induced obesity (DIO) in rodents. Given that the precise underlying mechanism is not known, we examined whether a gut-related mechanism might be involved. Sprague-Dawley rats received cafeteria diet (CD) for 3 months to develop DIO and were...

Influence of Menstrual Cycle or Hormonal Contraceptive Phase on Physiological Variables Monitored During Treadmill Testing.

Frontiers in physiology

Taipale-Mikkonen RS, Raitanen A, Hackney AC, Solli GS, Valtonen M, Peltonen H, McGawley K, Kyröläinen H, Ihalainen JK.
PMID: 34975520
Front Physiol. 2021 Dec 16;12:761760. doi: 10.3389/fphys.2021.761760. eCollection 2021.

No abstract available.

Stepwise effective molarities in porphyrin oligomer complexes: preorganization results in exceptionally strong chelate cooperativity.

Journal of the American Chemical Society

Hogben HJ, Sprafke JK, Hoffmann M, Pawlicki M, Anderson HL.
PMID: 22091586
J Am Chem Soc. 2011 Dec 28;133(51):20962-9. doi: 10.1021/ja209254r. Epub 2011 Dec 06.

Complexes of zinc porphyrin oligomers with multivalent ligands can be denatured by adding a large excess of a monodentate ligand, such as quinuclidine. We have used denaturation titrations to determine the stabilities of the complexes of a cyclic zinc-porphyrin...

Photophysical and Electro-Optical Properties of Copolymers Bearing Blue and Red Chromophores for Single-Layer White OLEDs.

Nanomaterials (Basel, Switzerland)

Tselekidou D, Papadopoulos K, Kyriazopoulos V, Andrikopoulos KC, Andreopoulou AK, Kallitsis JK, Laskarakis A, Logothetidis S, Gioti M.
PMID: 34685063
Nanomaterials (Basel). 2021 Oct 06;11(10). doi: 10.3390/nano11102629.

In this study, novel copolymers consisting of blue and red chromophores are presented to induce emission tuning, enabling the definition of white light emission in a single polymeric layer. These aromatic polyether sulfones exhibit high molecular weights, excellent solubility...

Eye Movements during Dynamic Scene Viewing are Affected by Visual Attention Skills and Events of the Scene: Evidence from First-Person Shooter Gameplay Videos.

Journal of eye movement research

Holm SK, Häikiö T, Olli K, Kaakinen JK.
PMID: 34745442
J Eye Mov Res. 2021 Oct 21;14(2). doi: 10.16910/jemr.14.2.3. eCollection 2021.

The role of individual differences during dynamic scene viewing was explored. Participants (N=38) watched a gameplay video of a first-person shooter (FPS) videogame while their eye movements were recorded. In addition, the participants' skills in three visual attention tasks...

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis.

Journal of hepatology

Teo K, Abeysekera KWM, Adams L, Aigner E, Anstee QM, Banales JM, Banerjee R, Basu P, Berg T, Bhatnagar P, Buch S, Canbay A, Caprio S, Chatterjee A, Ida Chen YD, Chowdhury A, Daly AK, Datz C, de Gracia Hahn D, DiStefano JK, Dong J, Duret A, Emdin C, Fairey M, Gerhard GS, Guo X, Hampe J, Hickman M, Heintz L, Hudert C, Hunter H, Kelly M, Kozlitina J, Krawczyk M, Lammert F, Langenberg C, Lavine J, Li L, Lim HK, Loomba R, Luukkonen PK, Melton PE, Mori TA, Palmer ND, Parisinos CA, Pillai SG, Qayyum F, Reichert MC, Romeo S, Rotter JI, Im YR, Santoro N, Schafmayer C, Speliotes EK, Stender S, Stickel F, Still CD, Strnad P, Taylor KD, Tybjærg-Hansen A, Umano GR, Utukuri M, Valenti L, Wagenknecht LE, Wareham NJ, Watanabe RM, Wattacheril J, Yaghootkar H, Yki-Järvinen H, Young KA, Mann JP.
PMID: 32882372
J Hepatol. 2021 Jan;74(1):20-30. doi: 10.1016/j.jhep.2020.08.027. Epub 2020 Aug 31.

BACKGROUND & AIMS: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in NAFLD; however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T...

Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort.

Arthritis & rheumatology (Hoboken, N.J.)

Bianchi M, Kozyrev SV, Notarnicola A, Hultin Rosenberg L, Karlsson Å, Pucholt P, Rothwell S, Alexsson A, Sandling JK, Andersson H, Cooper RG, Padyukov L, Tjärnlund A, Dastmalchi M, Meadows JRS, Pyndt Diederichsen L, Molberg Ø, Chinoy H, Lamb J, Rönnblom L, Lindblad-Toh K, Lundberg IE.
PMID: 34279065
Arthritis Rheumatol. 2021 Jul 19; doi: 10.1002/art.41929. Epub 2021 Jul 19.

OBJECTIVE: Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of complex autoimmune conditions characterized by inflammation in skeletal muscle and extramuscular compartments, and interferon (IFN) system activation. We undertook this study to examine the contribution of genetic variation to...

Evaluating differences in respiratory motion estimates during radiotherapy: a single planning 4DMRI versus daily 4DMRI.

Radiation oncology (London, England)

den Boer D, Veldman JK, van Tienhoven G, Bel A, van Kesteren Z.
PMID: 34565384
Radiat Oncol. 2021 Sep 26;16(1):188. doi: 10.1186/s13014-021-01915-1.

BACKGROUND: In radiotherapy, respiratory-induced tumor motion is typically measured using a single four-dimensional computed tomography acquisition (4DCT). Irregular breathing leads to inaccurate motion estimates, potentially resulting in undertreatment of the tumor and unnecessary dose to healthy tissue. The aim...

A "Rigid-Flexible" Approach for Processable Perylene Diimide-Based Polymers: Influence of the Specific Architecture on the Morphological, Dielectric, Optical, and Electronic Properties.

The journal of physical chemistry. B

Aivali S, Anastasopoulos C, Andreopoulou AK, Pipertzis A, Floudas G, Kallitsis JK.
PMID: 32459484
J Phys Chem B. 2020 Jun 18;124(24):5079-5090. doi: 10.1021/acs.jpcb.0c02940. Epub 2020 Jun 05.

Conjugation-break flexible spacers in-between π-conjugated segments were utilized herein toward processable perylene diimide (PDI)-based polymers. Aromatic-aliphatic PDI-based polymers were developed via the two-phase polyetherification of a phenol-difunctional PDI monomer and aliphatic dibromides. These polyethers showed excellent solubility and film-forming...

Quinoline Photobasicity: Investigation within Water-Soluble Light-Responsive Copolymers.

Chemistry (Weinheim an der Bergstrasse, Germany)

Sittig M, Tom JC, Elter JK, Schacher FH, Dietzek B.
PMID: 32986286
Chemistry. 2021 Jan 13;27(3):1072-1079. doi: 10.1002/chem.202003815. Epub 2020 Dec 04.

Quinoline photobases exhibit a distinctly higher pK

Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Amiodarone Toxicity.

International journal of molecular sciences

Bețiu AM, Chamkha I, Gustafsson E, Meijer E, Avram VF, Åsander Frostner E, Ehinger JK, Petrescu L, Muntean DM, Elmér E.
PMID: 34769217
Int J Mol Sci. 2021 Oct 29;22(21). doi: 10.3390/ijms222111786.

Amiodarone is a potent antiarrhythmic drug and displays substantial liver toxicity in humans. It has previously been demonstrated that amiodarone and its metabolite (desethylamiodarone, DEA) can inhibit mitochondrial function, particularly complexes I (CI) and II (CII) of the electron...

Showing 13 to 24 of 155 entries