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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Cell

Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR.
PMID: 34653350
Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14.

While prime editing enables precise sequence changes in DNA, cellular determinants of prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that DNA mismatch repair (MMR) impedes prime editing and promotes undesired indel byproducts. We developed PE4...

Cite
Chen PJ, Hussmann JA, Yan J, et al. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021;184(22):5635-5652.e29doi: 10.1016/j.cell.2021.09.018.
Chen, P. J., Hussmann, J. A., Yan, J., Knipping, F., Ravisankar, P., Chen, P. F., Chen, C., Nelson, J. W., Newby, G. A., Sahin, M., Osborn, M. J., Weissman, J. S., Adamson, B., & Liu, D. R. (2021). Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell, 184(22), 5635-5652.e29. https://doi.org/10.1016/j.cell.2021.09.018
Chen, Peter J, et al. "Enhanced prime editing systems by manipulating cellular determinants of editing outcomes." Cell vol. 184,22 (2021): 5635-5652.e29. doi: https://doi.org/10.1016/j.cell.2021.09.018
Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14. PMID: 34653350; PMCID: PMC8584034.
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Environmental Screening of Electrode Materials for a Rechargeable Aluminum Battery with an AlCl₃/EMIMCl Electrolyte.

Materials (Basel, Switzerland)

Ellingsen LA, Holland A, Drillet JF, Peters W, Eckert M, Concepcion C, Ruiz O, Colin JF, Knipping E, Pan Q, Wills RGA, Majeau-Bettez G.
PMID: 29865218
Materials (Basel). 2018 Jun 01;11(6). doi: 10.3390/ma11060936.

Recently, rechargeable aluminum batteries have received much attention due to their low cost, easy operation, and high safety. As the research into rechargeable aluminum batteries with a room-temperature ionic liquid electrolyte is relatively new, research efforts have focused on...

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Ellingsen LA, Holland A, Drillet JF, et al. Environmental Screening of Electrode Materials for a Rechargeable Aluminum Battery with an AlCl₃/EMIMCl Electrolyte. Materials (Basel). 2018;11(6)doi: 10.3390/ma11060936.
Ellingsen, L. A., Holland, A., Drillet, J. F., Peters, W., Eckert, M., Concepcion, C., Ruiz, O., Colin, J. F., Knipping, E., Pan, Q., Wills, R. G. A., & Majeau-Bettez, G. (2018). Environmental Screening of Electrode Materials for a Rechargeable Aluminum Battery with an AlCl₃/EMIMCl Electrolyte. Materials (Basel, Switzerland), 11(6), . https://doi.org/10.3390/ma11060936
Ellingsen, Linda Ager-Wick, et al. "Environmental Screening of Electrode Materials for a Rechargeable Aluminum Battery with an AlCl₃/EMIMCl Electrolyte." Materials (Basel, Switzerland) vol. 11,6 (2018). doi: https://doi.org/10.3390/ma11060936
Ellingsen LA, Holland A, Drillet JF, Peters W, Eckert M, Concepcion C, Ruiz O, Colin JF, Knipping E, Pan Q, Wills RGA, Majeau-Bettez G. Environmental Screening of Electrode Materials for a Rechargeable Aluminum Battery with an AlCl₃/EMIMCl Electrolyte. Materials (Basel). 2018 Jun 01;11(6). doi: 10.3390/ma11060936. PMID: 29865218; PMCID: PMC6025533.
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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Cell

Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR.
PMID: 34653350
Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14.

While prime editing enables precise sequence changes in DNA, cellular determinants of prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that DNA mismatch repair (MMR) impedes prime editing and promotes undesired indel byproducts. We developed PE4...

Cite
Chen PJ, Hussmann JA, Yan J, et al. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021;184(22):5635-5652.e29doi: 10.1016/j.cell.2021.09.018.
Chen, P. J., Hussmann, J. A., Yan, J., Knipping, F., Ravisankar, P., Chen, P. F., Chen, C., Nelson, J. W., Newby, G. A., Sahin, M., Osborn, M. J., Weissman, J. S., Adamson, B., & Liu, D. R. (2021). Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell, 184(22), 5635-5652.e29. https://doi.org/10.1016/j.cell.2021.09.018
Chen, Peter J, et al. "Enhanced prime editing systems by manipulating cellular determinants of editing outcomes." Cell vol. 184,22 (2021): 5635-5652.e29. doi: https://doi.org/10.1016/j.cell.2021.09.018
Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14. PMID: 34653350; PMCID: PMC8584034.
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Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Cell

Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR.
PMID: 34653350
Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14.

While prime editing enables precise sequence changes in DNA, cellular determinants of prime editing remain poorly understood. Using pooled CRISPRi screens, we discovered that DNA mismatch repair (MMR) impedes prime editing and promotes undesired indel byproducts. We developed PE4...

Cite
Chen PJ, Hussmann JA, Yan J, et al. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021;184(22):5635-5652.e29doi: 10.1016/j.cell.2021.09.018.
Chen, P. J., Hussmann, J. A., Yan, J., Knipping, F., Ravisankar, P., Chen, P. F., Chen, C., Nelson, J. W., Newby, G. A., Sahin, M., Osborn, M. J., Weissman, J. S., Adamson, B., & Liu, D. R. (2021). Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell, 184(22), 5635-5652.e29. https://doi.org/10.1016/j.cell.2021.09.018
Chen, Peter J, et al. "Enhanced prime editing systems by manipulating cellular determinants of editing outcomes." Cell vol. 184,22 (2021): 5635-5652.e29. doi: https://doi.org/10.1016/j.cell.2021.09.018
Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14. PMID: 34653350; PMCID: PMC8584034.
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Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing.

Molecular therapy : the journal of the American Society of Gene Therapy

Knipping F, Newby GA, Eide CR, McElroy AN, Nielsen SC, Smith K, Fang Y, Cornu TI, Costa C, Gutierrez-Guerrero A, Bingea SP, Feser CJ, Steinbeck B, Hippen KL, Blazar BR, McCaffrey A, Mussolino C, Verhoeyen E, Tolar J, Liu DR, Osborn MJ.
PMID: 34737067
Mol Ther. 2022 Jan 05;30(1):130-144. doi: 10.1016/j.ymthe.2021.10.026. Epub 2021 Nov 02.

Disruption of CCR5 or CXCR4, the main human immunodeficiency virus type 1 (HIV-1) co-receptors, has been shown to protect primary human CD4

Cite
Knipping F, Newby GA, Eide CR, et al. Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing. Mol Ther. 2021;30(1):130-144doi: 10.1016/j.ymthe.2021.10.026.
Knipping, F., Newby, G. A., Eide, C. R., McElroy, A. N., Nielsen, S. C., Smith, K., Fang, Y., Cornu, T. I., Costa, C., Gutierrez-Guerrero, A., Bingea, S. P., Feser, C. J., Steinbeck, B., Hippen, K. L., Blazar, B. R., McCaffrey, A., Mussolino, C., Verhoeyen, E., Tolar, J., Liu, D. R., & Osborn, M. J. (2022). Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing. Molecular therapy : the journal of the American Society of Gene Therapy, 30(1), 130-144. https://doi.org/10.1016/j.ymthe.2021.10.026
Knipping, Friederike, et al. "Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing." Molecular therapy : the journal of the American Society of Gene Therapy vol. 30,1 (2022): 130-144. doi: https://doi.org/10.1016/j.ymthe.2021.10.026
Knipping F, Newby GA, Eide CR, McElroy AN, Nielsen SC, Smith K, Fang Y, Cornu TI, Costa C, Gutierrez-Guerrero A, Bingea SP, Feser CJ, Steinbeck B, Hippen KL, Blazar BR, McCaffrey A, Mussolino C, Verhoeyen E, Tolar J, Liu DR, Osborn MJ. Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing. Mol Ther. 2022 Jan 05;30(1):130-144. doi: 10.1016/j.ymthe.2021.10.026. Epub 2021 Nov 02. PMID: 34737067.
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Disruption of HIV-1 co-receptors CCR5 and CXCR4in primary human T cells and hematopoietic stemand progenitor cells using base editing.

Molecular therapy : the journal of the American Society of Gene Therapy

Knipping F, Newby GA, Eide CR, McElroy AN, Nielsen SC, Smith K, Fang Y, Cornu TI, Costa C, Gutierrez-Guerrero A, Bingea SP, Feser CJ, Steinbeck B, Hippen KL, Blazar BR, McCaffrey A, Mussolino C, Verhoeyen E, Tolar J, Liu DR, Osborn MJ.
PMID: 34737067
Mol Ther. 2021 Nov 02; doi: 10.1016/j.ymthe.2021.10.026. Epub 2021 Nov 02.

Disruption of CCR5 or CXCR4, the main human immunodeficiency virus type 1 (HIV-1) co-receptors, has been shown to protect primary human CD4

Cite
Knipping F, Newby GA, Eide CR, et al. Disruption of HIV-1 co-receptors CCR5 and CXCR4in primary human T cells and hematopoietic stemand progenitor cells using base editing. Mol Ther. 2021;doi: 10.1016/j.ymthe.2021.10.026.
Knipping, F., Newby, G. A., Eide, C. R., McElroy, A. N., Nielsen, S. C., Smith, K., Fang, Y., Cornu, T. I., Costa, C., Gutierrez-Guerrero, A., Bingea, S. P., Feser, C. J., Steinbeck, B., Hippen, K. L., Blazar, B. R., McCaffrey, A., Mussolino, C., Verhoeyen, E., Tolar, J., Liu, D. R., & Osborn, M. J. (2021). Disruption of HIV-1 co-receptors CCR5 and CXCR4in primary human T cells and hematopoietic stemand progenitor cells using base editing. Molecular therapy : the journal of the American Society of Gene Therapy, . https://doi.org/10.1016/j.ymthe.2021.10.026
Knipping, Friederike, et al. "Disruption of HIV-1 co-receptors CCR5 and CXCR4in primary human T cells and hematopoietic stemand progenitor cells using base editing." Molecular therapy : the journal of the American Society of Gene Therapy vol. (2021). doi: https://doi.org/10.1016/j.ymthe.2021.10.026
Knipping F, Newby GA, Eide CR, McElroy AN, Nielsen SC, Smith K, Fang Y, Cornu TI, Costa C, Gutierrez-Guerrero A, Bingea SP, Feser CJ, Steinbeck B, Hippen KL, Blazar BR, McCaffrey A, Mussolino C, Verhoeyen E, Tolar J, Liu DR, Osborn MJ. Disruption of HIV-1 co-receptors CCR5 and CXCR4in primary human T cells and hematopoietic stemand progenitor cells using base editing. Mol Ther. 2021 Nov 02; doi: 10.1016/j.ymthe.2021.10.026. Epub 2021 Nov 02. PMID: 34737067.
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Experiments and simulations of ion-enhanced interfacial chemistry on aqueous NaCl aerosols.

Science (New York, N.Y.)

Knipping EM, Lakin MJ, Foster KL, Jungwirth P, Tobias DJ, Gerber RB, Dabdub D, Finlayson-Pitts BJ.
PMID: 10764637
Science. 2000 Apr 14;288(5464):301-6. doi: 10.1126/science.288.5464.301.

A combination of experimental, molecular dynamics, and kinetics modeling studies is applied to a system of concentrated aqueous sodium chloride particles suspended in air at room temperature with ozone, irradiated at 254 nanometers to generate hydroxyl radicals. Measurements of...

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Knipping EM, Lakin MJ, Foster KL, et al. Experiments and simulations of ion-enhanced interfacial chemistry on aqueous NaCl aerosols. Science. 2000;288(5464):301-6doi: 10.1126/science.288.5464.301.
Knipping, E. M., Lakin, M. J., Foster, K. L., Jungwirth, P., Tobias, D. J., Gerber, R. B., Dabdub, D., & Finlayson-Pitts, B. J. (2000). Experiments and simulations of ion-enhanced interfacial chemistry on aqueous NaCl aerosols. Science (New York, N.Y.), 288(5464), 301-6. https://doi.org/10.1126/science.288.5464.301
Knipping, et al. "Experiments and simulations of ion-enhanced interfacial chemistry on aqueous NaCl aerosols." Science (New York, N.Y.) vol. 288,5464 (2000): 301-6. doi: https://doi.org/10.1126/science.288.5464.301
Knipping EM, Lakin MJ, Foster KL, Jungwirth P, Tobias DJ, Gerber RB, Dabdub D, Finlayson-Pitts BJ. Experiments and simulations of ion-enhanced interfacial chemistry on aqueous NaCl aerosols. Science. 2000 Apr 14;288(5464):301-6. doi: 10.1126/science.288.5464.301. PMID: 10764637.
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[Robert KOCH's importance in medicine].

Zeitschrift fur Tuberkulose und Erkrankungen der Thoraxorgane

KNIPPING HW, BOLT W.
PMID: 13757131
Z Tuberk Erkr Thoraxorg. 1960 Jun;115:15-7.

No abstract available.

Cite
KNIPPING HW, BOLT W. [Robert KOCH's importance in medicine]. Z Tuberk Erkr Thoraxorg. 1960;115:15-7
KNIPPING, H. W., & BOLT, W. (1960). [Robert KOCH's importance in medicine]. Zeitschrift fur Tuberkulose und Erkrankungen der Thoraxorgane, 11515-7.
KNIPPING, H W, and BOLT, W. "[Robert KOCH's importance in medicine]." Zeitschrift fur Tuberkulose und Erkrankungen der Thoraxorgane vol. 115 (1960): 15-7.
KNIPPING HW, BOLT W. [Robert KOCH's importance in medicine]. Z Tuberk Erkr Thoraxorg. 1960 Jun;115:15-7. German. PMID: 13757131.
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Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification.

Molecular therapy. Methods & clinical development

Knipping F, Osborn MJ, Petri K, Tolar J, Glimm H, von Kalle C, Schmidt M, Gabriel R.
PMID: 28345006
Mol Ther Methods Clin Dev. 2017 Feb 12;4:213-224. doi: 10.1016/j.omtm.2017.01.005. eCollection 2017 Mar 17.

In T cells with transgenic high-avidity T cell receptors (TCRs), endogenous and transferred TCR chains compete for surface expression and may pair inappropriately, potentially causing autoimmunity. To knock out endogenous TCR expression, we assembled 12 transcription activator-like effector nucleases...

Cite
Knipping F, Osborn MJ, Petri K, et al. Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification. Mol Ther Methods Clin Dev. 2017;4:213-224doi: 10.1016/j.omtm.2017.01.005.
Knipping, F., Osborn, M. J., Petri, K., Tolar, J., Glimm, H., von Kalle, C., Schmidt, M., & Gabriel, R. (2017). Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification. Molecular therapy. Methods & clinical development, 4213-224. https://doi.org/10.1016/j.omtm.2017.01.005
Knipping, Friederike, et al. "Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification." Molecular therapy. Methods & clinical development vol. 4 (2017): 213-224. doi: https://doi.org/10.1016/j.omtm.2017.01.005
Knipping F, Osborn MJ, Petri K, Tolar J, Glimm H, von Kalle C, Schmidt M, Gabriel R. Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification. Mol Ther Methods Clin Dev. 2017 Feb 12;4:213-224. doi: 10.1016/j.omtm.2017.01.005. eCollection 2017 Mar 17. PMID: 28345006; PMCID: PMC5363317.
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Atomically resolved scanning tunneling microscopy images of dislocations.

Physical review. B, Condensed matter

Burt DM, Knipping U, Krinsley DH, Tsong IS, Wilson IH, Zheng NJ.
PMID: 9946247
Phys Rev B Condens Matter. 1988 Dec 15;38(17):12780-12782. doi: 10.1103/physrevb.38.12780.

No abstract available.

Cite
Burt DM, Knipping U, Krinsley DH, et al. Atomically resolved scanning tunneling microscopy images of dislocations. Phys Rev B Condens Matter. 1988;38(17):12780-12782doi: 10.1103/physrevb.38.12780.
Burt, D. M., Knipping, U., Krinsley, D. H., Tsong, I. S., Wilson, I. H., & Zheng, N. J. (1988). Atomically resolved scanning tunneling microscopy images of dislocations. Physical review. B, Condensed matter, 38(17), 12780-12782. https://doi.org/10.1103/physrevb.38.12780
Burt, et al. "Atomically resolved scanning tunneling microscopy images of dislocations." Physical review. B, Condensed matter vol. 38,17 (1988): 12780-12782. doi: https://doi.org/10.1103/physrevb.38.12780
Burt DM, Knipping U, Krinsley DH, Tsong IS, Wilson IH, Zheng NJ. Atomically resolved scanning tunneling microscopy images of dislocations. Phys Rev B Condens Matter. 1988 Dec 15;38(17):12780-12782. doi: 10.1103/physrevb.38.12780. PMID: 9946247.
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Accumulation of magnetite by flotation on bubbles during decompression of silicate magma.

Scientific reports

Knipping JL, Webster JD, Simon AC, Holtz F.
PMID: 30846740
Sci Rep. 2019 Mar 07;9(1):3852. doi: 10.1038/s41598-019-40376-1.

Magnetite (Fe

Cite
Knipping JL, Webster JD, Simon AC, et al. Accumulation of magnetite by flotation on bubbles during decompression of silicate magma. Sci Rep. 2019;9(1):3852doi: 10.1038/s41598-019-40376-1.
Knipping, J. L., Webster, J. D., Simon, A. C., & Holtz, F. (2019). Accumulation of magnetite by flotation on bubbles during decompression of silicate magma. Scientific reports, 9(1), 3852. https://doi.org/10.1038/s41598-019-40376-1
Knipping, Jaayke L, et al. "Accumulation of magnetite by flotation on bubbles during decompression of silicate magma." Scientific reports vol. 9,1 (2019): 3852. doi: https://doi.org/10.1038/s41598-019-40376-1
Knipping JL, Webster JD, Simon AC, Holtz F. Accumulation of magnetite by flotation on bubbles during decompression of silicate magma. Sci Rep. 2019 Mar 07;9(1):3852. doi: 10.1038/s41598-019-40376-1. PMID: 30846740; PMCID: PMC6405838.
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Effects of isolated atomic collision cascades on SiO2/Si interfaces studied by scanning tunneling microscopy.

Physical review. B, Condensed matter

Knipping U, Tsong IS, Wilson IH, Zheng NJ.
PMID: 9945604
Phys Rev B Condens Matter. 1988 Oct 15;38(12):8444-8450. doi: 10.1103/physrevb.38.8444.

No abstract available.

Cite
Knipping U, Tsong IS, Wilson IH, et al. Effects of isolated atomic collision cascades on SiO2/Si interfaces studied by scanning tunneling microscopy. Phys Rev B Condens Matter. 1988;38(12):8444-8450doi: 10.1103/physrevb.38.8444.
Knipping, U., Tsong, I. S., Wilson, I. H., & Zheng, N. J. (1988). Effects of isolated atomic collision cascades on SiO2/Si interfaces studied by scanning tunneling microscopy. Physical review. B, Condensed matter, 38(12), 8444-8450. https://doi.org/10.1103/physrevb.38.8444
Knipping, et al. "Effects of isolated atomic collision cascades on SiO2/Si interfaces studied by scanning tunneling microscopy." Physical review. B, Condensed matter vol. 38,12 (1988): 8444-8450. doi: https://doi.org/10.1103/physrevb.38.8444
Knipping U, Tsong IS, Wilson IH, Zheng NJ. Effects of isolated atomic collision cascades on SiO2/Si interfaces studied by scanning tunneling microscopy. Phys Rev B Condens Matter. 1988 Oct 15;38(12):8444-8450. doi: 10.1103/physrevb.38.8444. PMID: 9945604.
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Showing 13 to 24 of 36 entries