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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.

PLoS biology

Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR.
PMID: 34914695
PLoS Biol. 2021 Dec 16;19(12):e3001480. doi: 10.1371/journal.pbio.3001480. eCollection 2021 Dec.

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro and in vivo. The small GTPase...

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Mamais A, Kluss JH, Bonet-Ponce L, et al. Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. PLoS Biol. 2021;19(12):e3001480doi: 10.1371/journal.pbio.3001480.
Mamais, A., Kluss, J. H., Bonet-Ponce, L., Landeck, N., Langston, R. G., Smith, N., Beilina, A., Kaganovich, A., Ghosh, M. C., Pellegrini, L., Kumaran, R., Papazoglou, I., Heaton, G. R., Bandopadhyay, R., Maio, N., Kim, C., LaVoie, M. J., Gershlick, D. C., & Cookson, M. R. (2021). Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. PLoS biology, 19(12), e3001480. https://doi.org/10.1371/journal.pbio.3001480
Mamais, Adamantios, et al. "Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia." PLoS biology vol. 19,12 (2021): e3001480. doi: https://doi.org/10.1371/journal.pbio.3001480
Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR. Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. PLoS Biol. 2021 Dec 16;19(12):e3001480. doi: 10.1371/journal.pbio.3001480. eCollection 2021 Dec. PMID: 34914695; PMCID: PMC8675653.
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Erratum: Self-Organization, Structures, and Anomalous Transport in Turbulent Partially Magnetized Plasmas with Crossed Electric and Magnetic Fields [Phys. Rev. Lett. 122, 185001 (2019)].

Physical review letters

Koshkarov O, Smolyakov A, Raitses Y, Kaganovich I.
PMID: 31868442
Phys Rev Lett. 2019 Dec 06;123(23):239903. doi: 10.1103/PhysRevLett.123.239903.

This corrects the article DOI: 10.1103/PhysRevLett.122.185001.

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Koshkarov O, Smolyakov A, Raitses Y, et al. Erratum: Self-Organization, Structures, and Anomalous Transport in Turbulent Partially Magnetized Plasmas with Crossed Electric and Magnetic Fields [Phys. Rev. Lett. 122, 185001 (2019)]. Phys Rev Lett. 2019;123(23):239903doi: 10.1103/PhysRevLett.123.239903.
Koshkarov, O., Smolyakov, A., Raitses, Y., & Kaganovich, I. (2019). Erratum: Self-Organization, Structures, and Anomalous Transport in Turbulent Partially Magnetized Plasmas with Crossed Electric and Magnetic Fields [Phys. Rev. Lett. 122, 185001 (2019)]. Physical review letters, 123(23), 239903. https://doi.org/10.1103/PhysRevLett.123.239903
Koshkarov, Oleksandr, et al. "Erratum: Self-Organization, Structures, and Anomalous Transport in Turbulent Partially Magnetized Plasmas with Crossed Electric and Magnetic Fields [Phys. Rev. Lett. 122, 185001 (2019)]." Physical review letters vol. 123,23 (2019): 239903. doi: https://doi.org/10.1103/PhysRevLett.123.239903
Koshkarov O, Smolyakov A, Raitses Y, Kaganovich I. Erratum: Self-Organization, Structures, and Anomalous Transport in Turbulent Partially Magnetized Plasmas with Crossed Electric and Magnetic Fields [Phys. Rev. Lett. 122, 185001 (2019)]. Phys Rev Lett. 2019 Dec 06;123(23):239903. doi: 10.1103/PhysRevLett.123.239903. PMID: 31868442.
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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.

PLoS biology

Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR.
PMID: 34914695
PLoS Biol. 2021 Dec 16;19(12):e3001480. doi: 10.1371/journal.pbio.3001480. eCollection 2021 Dec.

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro and in vivo. The small GTPase...

Cite
Mamais A, Kluss JH, Bonet-Ponce L, et al. Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. PLoS Biol. 2021;19(12):e3001480doi: 10.1371/journal.pbio.3001480.
Mamais, A., Kluss, J. H., Bonet-Ponce, L., Landeck, N., Langston, R. G., Smith, N., Beilina, A., Kaganovich, A., Ghosh, M. C., Pellegrini, L., Kumaran, R., Papazoglou, I., Heaton, G. R., Bandopadhyay, R., Maio, N., Kim, C., LaVoie, M. J., Gershlick, D. C., & Cookson, M. R. (2021). Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. PLoS biology, 19(12), e3001480. https://doi.org/10.1371/journal.pbio.3001480
Mamais, Adamantios, et al. "Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia." PLoS biology vol. 19,12 (2021): e3001480. doi: https://doi.org/10.1371/journal.pbio.3001480
Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR. Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia. PLoS Biol. 2021 Dec 16;19(12):e3001480. doi: 10.1371/journal.pbio.3001480. eCollection 2021 Dec. PMID: 34914695; PMCID: PMC8675653.
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Benchmarking background oriented schlieren against interferometric measurement using open source tools.

Applied optics

Kaganovich D, Johnson LA, Mamonau AA, Hafizi B.
PMID: 33104676
Appl Opt. 2020 Oct 20;59(30):9553-9557. doi: 10.1364/AO.406301.

Gas flow from an under-expanding jet nozzle is measured using synchronized background oriented schlieren and interferometry diagnostics. The gas density distribution is obtained from a shift vector field of the background oriented schlieren and compared to the interferometric data....

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Kaganovich D, Johnson LA, Mamonau AA, et al. Benchmarking background oriented schlieren against interferometric measurement using open source tools. Appl Opt. 2020;59(30):9553-9557doi: 10.1364/AO.406301.
Kaganovich, D., Johnson, L. A., Mamonau, A. A., & Hafizi, B. (2020). Benchmarking background oriented schlieren against interferometric measurement using open source tools. Applied optics, 59(30), 9553-9557. https://doi.org/10.1364/AO.406301
Kaganovich, D, et al. "Benchmarking background oriented schlieren against interferometric measurement using open source tools." Applied optics vol. 59,30 (2020): 9553-9557. doi: https://doi.org/10.1364/AO.406301
Kaganovich D, Johnson LA, Mamonau AA, Hafizi B. Benchmarking background oriented schlieren against interferometric measurement using open source tools. Appl Opt. 2020 Oct 20;59(30):9553-9557. doi: 10.1364/AO.406301. PMID: 33104676.
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Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics.

Molecular biology of the cell

Amen T, Guihur A, Zelent C, Ursache R, Wilting J, Kaganovich D.
PMID: 34432484
Mol Biol Cell. 2021 Nov 01;32(21):ar18. doi: 10.1091/mbc.E21-02-0066. Epub 2021 Aug 25.

Stress granules (SGs) are ribonucleoprotein functional condensates that form under stress conditions in all eukaryotic cells. Although their stress-survival function is far from clear, SGs have been implicated in the regulation of many vital cellular pathways. Consequently, SG dysfunction...

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Amen T, Guihur A, Zelent C, et al. Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics. Mol Biol Cell. 2021;32(21):ar18doi: 10.1091/mbc.E21-02-0066.
Amen, T., Guihur, A., Zelent, C., Ursache, R., Wilting, J., & Kaganovich, D. (2021). Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics. Molecular biology of the cell, 32(21), ar18. https://doi.org/10.1091/mbc.E21-02-0066
Amen, Triana, et al. "Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics." Molecular biology of the cell vol. 32,21 (2021): ar18. doi: https://doi.org/10.1091/mbc.E21-02-0066
Amen T, Guihur A, Zelent C, Ursache R, Wilting J, Kaganovich D. Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics. Mol Biol Cell. 2021 Nov 01;32(21):ar18. doi: 10.1091/mbc.E21-02-0066. Epub 2021 Aug 25. PMID: 34432484.
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Spatiotemporal dynamics of charged species in the afterglow of plasmas containing negative ions.

Physical review. E, Statistical, nonlinear, and soft matter physics

Kaganovich ID, Ramamurthi BN, Economou DJ.
PMID: 11580449
Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Sep;64(3):036402. doi: 10.1103/PhysRevE.64.036402. Epub 2001 Aug 27.

The spatiotemporal evolution of charged species densities and wall fluxes during the afterglow of an electronegative discharge has been investigated. The decay of a plasma with negative ions consists of two stages. During the first stage of the afterglow,...

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Kaganovich ID, Ramamurthi BN, Economou DJ. Spatiotemporal dynamics of charged species in the afterglow of plasmas containing negative ions. Phys Rev E Stat Nonlin Soft Matter Phys. 2001;64(3):036402doi: 10.1103/PhysRevE.64.036402.
Kaganovich, I. D., Ramamurthi, B. N., & Economou, D. J. (2001). Spatiotemporal dynamics of charged species in the afterglow of plasmas containing negative ions. Physical review. E, Statistical, nonlinear, and soft matter physics, 64(3), 036402. https://doi.org/10.1103/PhysRevE.64.036402
Kaganovich, I D, et al. "Spatiotemporal dynamics of charged species in the afterglow of plasmas containing negative ions." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 64,3 (2001): 036402. doi: https://doi.org/10.1103/PhysRevE.64.036402
Kaganovich ID, Ramamurthi BN, Economou DJ. Spatiotemporal dynamics of charged species in the afterglow of plasmas containing negative ions. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Sep;64(3):036402. doi: 10.1103/PhysRevE.64.036402. Epub 2001 Aug 27. PMID: 11580449.
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Wakefield generation and GeV acceleration in tapered plasma channels.

Physical review. E, Statistical, nonlinear, and soft matter physics

Sprangle P, Hafizi B, Peñano JR, Hubbard RF, Ting A, Moore CI, Gordon DF, Zigler A, Kaganovich D, Antonsen TM.
PMID: 11415017
Phys Rev E Stat Nonlin Soft Matter Phys. 2001 May;63(5):056405. doi: 10.1103/PhysRevE.63.056405. Epub 2001 Apr 18.

To achieve multi-GeV electron energies in the laser wakefield accelerator (LWFA), it is necessary to propagate an intense laser pulse long distances in a plasma without disruption. One of the purposes of this paper is to evaluate the stability...

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Sprangle P, Hafizi B, Peñano JR, et al. Wakefield generation and GeV acceleration in tapered plasma channels. Phys Rev E Stat Nonlin Soft Matter Phys. 2001;63(5):056405doi: 10.1103/PhysRevE.63.056405.
Sprangle, P., Hafizi, B., Peñano, J. R., Hubbard, R. F., Ting, A., Moore, C. I., Gordon, D. F., Zigler, A., Kaganovich, D., & Antonsen, T. M. (2001). Wakefield generation and GeV acceleration in tapered plasma channels. Physical review. E, Statistical, nonlinear, and soft matter physics, 63(5), 056405. https://doi.org/10.1103/PhysRevE.63.056405
Sprangle, P, et al. "Wakefield generation and GeV acceleration in tapered plasma channels." Physical review. E, Statistical, nonlinear, and soft matter physics vol. 63,5 (2001): 056405. doi: https://doi.org/10.1103/PhysRevE.63.056405
Sprangle P, Hafizi B, Peñano JR, Hubbard RF, Ting A, Moore CI, Gordon DF, Zigler A, Kaganovich D, Antonsen TM. Wakefield generation and GeV acceleration in tapered plasma channels. Phys Rev E Stat Nonlin Soft Matter Phys. 2001 May;63(5):056405. doi: 10.1103/PhysRevE.63.056405. Epub 2001 Apr 18. PMID: 11415017.
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Convenient analytical formula for cluster mean diameter and diameter dispersion after nucleation burst.

Physical review. E

Tacu M, Khrabry A, Kaganovich ID.
PMID: 32942497
Phys Rev E. 2020 Aug;102(2):022116. doi: 10.1103/PhysRevE.102.022116.

We propose an alternative method of estimating the mean diameter and dispersion of clusters of particles, formed in a cooling gas, right after the nucleation stage. Using a moment model developed by Friedlander [S. K. Friedlander, Ann. N. Y....

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Tacu M, Khrabry A, Kaganovich ID. Convenient analytical formula for cluster mean diameter and diameter dispersion after nucleation burst. Phys Rev E. 2020;102(2):022116doi: 10.1103/PhysRevE.102.022116.
Tacu, M., Khrabry, A., & Kaganovich, I. D. (2020). Convenient analytical formula for cluster mean diameter and diameter dispersion after nucleation burst. Physical review. E, 102(2), 022116. https://doi.org/10.1103/PhysRevE.102.022116
Tacu, M, et al. "Convenient analytical formula for cluster mean diameter and diameter dispersion after nucleation burst." Physical review. E vol. 102,2 (2020): 022116. doi: https://doi.org/10.1103/PhysRevE.102.022116
Tacu M, Khrabry A, Kaganovich ID. Convenient analytical formula for cluster mean diameter and diameter dispersion after nucleation burst. Phys Rev E. 2020 Aug;102(2):022116. doi: 10.1103/PhysRevE.102.022116. PMID: 32942497.
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Pixel Prostate Software as a Reliable Tool in Depicting Spatial Distribution and Determination of the Prostate Cancer Volume.

Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH

Aganovic D, Kulovac B, Radović S, Bilalović N, Bajramović S, Kešmer A.
PMID: 31452565
Acta Inform Med. 2019 Jun;27(2):89-95. doi: 10.5455/aim.2019.27.89-95.

INTRODUCTION: Cancer of the prostate (PCa) is the second most common cancer-related cause of death among men and the most common non-cutaneous malignancy in Western countries. Numerous papers have been published on the topic of various aspects of this...

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Aganovic D, Kulovac B, Radović S, et al. Pixel Prostate Software as a Reliable Tool in Depicting Spatial Distribution and Determination of the Prostate Cancer Volume. Acta Inform Med. 2019;27(2):89-95doi: 10.5455/aim.2019.27.89-95.
Aganovic, D., Kulovac, B., Radović, S., Bilalović, N., Bajramović, S., & Kešmer, A. (2019). Pixel Prostate Software as a Reliable Tool in Depicting Spatial Distribution and Determination of the Prostate Cancer Volume. Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH, 27(2), 89-95. https://doi.org/10.5455/aim.2019.27.89-95
Aganovic, Damir, et al. "Pixel Prostate Software as a Reliable Tool in Depicting Spatial Distribution and Determination of the Prostate Cancer Volume." Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH vol. 27,2 (2019): 89-95. doi: https://doi.org/10.5455/aim.2019.27.89-95
Aganovic D, Kulovac B, Radović S, Bilalović N, Bajramović S, Kešmer A. Pixel Prostate Software as a Reliable Tool in Depicting Spatial Distribution and Determination of the Prostate Cancer Volume. Acta Inform Med. 2019 Jun;27(2):89-95. doi: 10.5455/aim.2019.27.89-95. PMID: 31452565; PMCID: PMC6688307.
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Patient relevant endpoints in oncology: current issues in the context of early benefit assessment in Germany.

Health economics review

Dabisch I, Dethling J, Dintsios CM, Drechsler M, Kalanovic D, Kaskel P, Langer F, Ruof J, Ruppert T, Wirth D.
PMID: 24460706
Health Econ Rev. 2014 Jan 24;4(1):2. doi: 10.1186/2191-1991-4-2.

UNLABELLED: The German AMNOG healthcare reform includes a mandatory early-benefit-assessment (EBA) at launch. As per German social code, EBA is based on registration trials and includes evaluation of the patient-relevant effect of the new medicines compared to an appropriate...

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Dabisch I, Dethling J, Dintsios CM, et al. Patient relevant endpoints in oncology: current issues in the context of early benefit assessment in Germany. Health Econ Rev. 2014;4(1):2doi: 10.1186/2191-1991-4-2.
Dabisch, I., Dethling, J., Dintsios, C. M., Drechsler, M., Kalanovic, D., Kaskel, P., Langer, F., Ruof, J., Ruppert, T., & Wirth, D. (2014). Patient relevant endpoints in oncology: current issues in the context of early benefit assessment in Germany. Health economics review, 4(1), 2. https://doi.org/10.1186/2191-1991-4-2
Dabisch, Inna, et al. "Patient relevant endpoints in oncology: current issues in the context of early benefit assessment in Germany." Health economics review vol. 4,1 (2014): 2. doi: https://doi.org/10.1186/2191-1991-4-2
Dabisch I, Dethling J, Dintsios CM, Drechsler M, Kalanovic D, Kaskel P, Langer F, Ruof J, Ruppert T, Wirth D. Patient relevant endpoints in oncology: current issues in the context of early benefit assessment in Germany. Health Econ Rev. 2014 Jan 24;4(1):2. doi: 10.1186/2191-1991-4-2. PMID: 24460706; PMCID: PMC3901346.
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Kinetic theory of plasma sheaths surrounding electron-emitting surfaces.

Physical review letters

Sheehan JP, Hershkowitz N, Kaganovich ID, Wang H, Raitses Y, Barnat EV, Weatherford BR, Sydorenko D.
PMID: 23992073
Phys Rev Lett. 2013 Aug 16;111(7):075002. doi: 10.1103/PhysRevLett.111.075002. Epub 2013 Aug 16.

A one-dimensional kinetic theory of sheaths surrounding planar, electron-emitting surfaces is presented which accounts for plasma electrons lost to the surface and the temperature of the emitted electrons. It is shown that ratio of plasma electron temperature to emitted...

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Sheehan JP, Hershkowitz N, Kaganovich ID, et al. Kinetic theory of plasma sheaths surrounding electron-emitting surfaces. Phys Rev Lett. 2013;111(7):075002doi: 10.1103/PhysRevLett.111.075002.
Sheehan, J. P., Hershkowitz, N., Kaganovich, I. D., Wang, H., Raitses, Y., Barnat, E. V., Weatherford, B. R., & Sydorenko, D. (2013). Kinetic theory of plasma sheaths surrounding electron-emitting surfaces. Physical review letters, 111(7), 075002. https://doi.org/10.1103/PhysRevLett.111.075002
Sheehan, J P, et al. "Kinetic theory of plasma sheaths surrounding electron-emitting surfaces." Physical review letters vol. 111,7 (2013): 075002. doi: https://doi.org/10.1103/PhysRevLett.111.075002
Sheehan JP, Hershkowitz N, Kaganovich ID, Wang H, Raitses Y, Barnat EV, Weatherford BR, Sydorenko D. Kinetic theory of plasma sheaths surrounding electron-emitting surfaces. Phys Rev Lett. 2013 Aug 16;111(7):075002. doi: 10.1103/PhysRevLett.111.075002. Epub 2013 Aug 16. PMID: 23992073.
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[People's universities of health].

Sovetskoe zdravookhranenie

GROSSMAN IaL, KAGANOVICH RB.
PMID: 13709091
Sov Zdravookhr. 1961;20:51-5.

No abstract available.

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GROSSMAN IaL, KAGANOVICH RB. [People's universities of health]. Sov Zdravookhr. 1961;20:51-5
GROSSMAN, I. a. L., & KAGANOVICH, R. B. (1961). [People's universities of health]. Sovetskoe zdravookhranenie, 2051-5.
GROSSMAN, Ia L, and KAGANOVICH, R B. "[People's universities of health]." Sovetskoe zdravookhranenie vol. 20 (1961): 51-5.
GROSSMAN IaL, KAGANOVICH RB. [People's universities of health]. Sov Zdravookhr. 1961;20:51-5. Russian. PMID: 13709091.
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Showing 25 to 36 of 103 entries