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Showing 97 to 103 of 103 entries
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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.

PLoS biology

Mamais A, Kluss JH, Bonet-Ponce L, Landeck N, Langston RG, Smith N, Beilina A, Kaganovich A, Ghosh MC, Pellegrini L, Kumaran R, Papazoglou I, Heaton GR, Bandopadhyay R, Maio N, Kim C, LaVoie MJ, Gershlick DC, Cookson MR.
PMID: 34914695
PLoS Biol. 2021 Dec 16;19(12):e3001480. doi: 10.1371/journal.pbio.3001480. eCollection 2021 Dec.

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant Parkinson disease (PD), while polymorphic LRRK2 variants are associated with sporadic PD. PD-linked mutations increase LRRK2 kinase activity and induce neurotoxicity in vitro and in vivo. The small GTPase...

Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability.

Cell reports

Amen T, Kaganovich D.
PMID: 34133922
Cell Rep. 2021 Jun 15;35(11):109237. doi: 10.1016/j.celrep.2021.109237.

The formation of stress granules (SGs) is an essential aspect of the cellular response to many kinds of stress, but its adaptive role is far from clear. SG dysfunction is implicated in aging-onset neurodegenerative diseases, prompting interest in their...

Mechanochemical Nucleophilic Substitution of Alcohols via Isouronium Intermediates.

ChemSusChem

Aav R, Dalidovich T, Nallaparaju JV, Shalima T, Kananovich DG.
PMID: 34932893
ChemSusChem. 2021 Dec 21; doi: 10.1002/cssc.202102286. Epub 2021 Dec 21.

An expansion of the solvent-free synthetic toolbox is essential for advances in the sustainable chemical industry. Mechanochemical reactions offer a superior safety profile and reduced amount of waste compared to conventional solvent-based synthesis. Herein we report a new mechanochemical...

Boron nitride nanotube precursor formation during high-temperature synthesis: kinetic and thermodynamic modelling.

Nanotechnology

Barsukov Y, Dwivedi O, Kaganovich I, Jubin S, Khrabry A, Ethier S.
PMID: 34375961
Nanotechnology. 2021 Aug 31;32(47). doi: 10.1088/1361-6528/ac1c20.

We performed integrated modelling of the chemical pathways of formation for boron nitride nanotube (BNNT) precursors during high-temperature synthesis in a B/N

Small Molecule Screen Reveals Joint Regulation of Stress Granule Formation and Lipid Droplet Biogenesis.

Frontiers in cell and developmental biology

Amen T, Kaganovich D.
PMID: 33972926
Front Cell Dev Biol. 2021 Apr 16;8:606111. doi: 10.3389/fcell.2020.606111. eCollection 2020.

Metabolic regulation is a necessary component of all stress response pathways, because all different mechanisms of stress-adaptation place high-energy demands on the cell. Mechanisms that integrate diverse stress response pathways with their metabolic components are therefore of great interest,...

Immunohistochemical Analysis of 4-HNE, NGAL, and HO-1 Tissue Expression after Apocynin Treatment and HBO Preconditioning in Postischemic Acute Kidney Injury Induced in Spontaneously Hypertensive Rats.

Antioxidants (Basel, Switzerland)

Kovacevic S, Ivanov M, Zivotic M, Brkic P, Miloradovic Z, Jeremic R, Mihailovic-Stanojevic N, Vajic UJ, Karanovic D, Jovovic D, Nesovic Ostojic J.
PMID: 34439411
Antioxidants (Basel). 2021 Jul 22;10(8). doi: 10.3390/antiox10081163.

Oxidative stress has been considered as a central aggravating factor in the development of postischemic acute kidney injury (AKI). The aim of this study was to perform the immunohistochemical analysis of 4-hydroxynonenal (4-HNE), neutrophil gelatinase-associated lipocalin (NGAL), and heme...

A computational model of familiarity detection for natural pictures, abstract images, and random patterns: Combination of deep learning and anti-Hebbian training.

Neural networks : the official journal of the International Neural Network Society

Kazanovich Y, Borisyuk R.
PMID: 34343776
Neural Netw. 2021 Nov;143:628-637. doi: 10.1016/j.neunet.2021.07.022. Epub 2021 Jul 22.

We present a neural network model for familiarity recognition of different types of images in the perirhinal cortex (the FaRe model). The model is designed as a two-stage system. At the first stage, the parameters of an image are...

Showing 97 to 103 of 103 entries