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Showing 1333 to 1344 of 1344 entries
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Relationship between Dasatinib-induced Pulmonary Hypertension and Drug Dose.

Internal medicine (Tokyo, Japan)

Kubota K, Imai Y, Oh I, Ueno S, Kanda Y, Kario K.
PMID: 35022343
Intern Med. 2022 Jan 13; doi: 10.2169/internalmedicine.8392-21. Epub 2022 Jan 13.

Objective Dasatinib, a second-generation tyrosine kinase inhibitor, is used for chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It reportedly causes pulmonary arterial hypertension (PAH) and the dose-dependent induction of apoptosis in pulmonary endothelial cells....

A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders.

Stem cell reports

Autar K, Guo X, Rumsey JW, Long CJ, Akanda N, Jackson M, Narasimhan NS, Caneus J, Morgan D, Hickman JJ.
PMID: 34942087
Stem Cell Reports. 2022 Jan 11;17(1):96-109. doi: 10.1016/j.stemcr.2021.11.009. Epub 2021 Dec 22.

The maturation and functional characteristics of human induced pluripotent stem cell (hiPSC)-cortical neurons has not been fully documented. This study developed a phenotypic model of hiPSC-derived cortical neurons, characterized their maturation process, and investigated its application for disease modeling...

Assessment of the Diagnostic Efficiency of a Liquid Biopsy Assay for Early Detection of Gastric Cancer.

JAMA network open

Izumi D, Zhu Z, Chen Y, Toden S, Huo X, Kanda M, Ishimoto T, Gu D, Tan M, Kodera Y, Baba H, Li W, Chen J, Wang X, Goel A.
PMID: 34427680
JAMA Netw Open. 2021 Aug 02;4(8):e2121129. doi: 10.1001/jamanetworkopen.2021.21129.

IMPORTANCE: Noninvasive detection of early-stage disease is a key strategy for reducing gastric cancer (GC)-associated patient mortality.OBJECTIVE: To establish a novel, noninvasive, microRNA (miRNA)-based signature for the early detection of GC using a comprehensive biomarker discovery approach with retrospective...

The Risk of Postoperative Complications After Major Elective Surgery in Active or Resolved COVID-19 in the United States.

Annals of surgery

Deng JZ, Chan JS, Potter AL, Chen YW, Sandhu HS, Panda N, Chang DC, Yang CJ.
PMID: 34793348
Ann Surg. 2022 Feb 01;275(2):242-246. doi: 10.1097/SLA.0000000000005308.

OBJECTIVE: To assess the association between the timing of surgery relative to the development of Covid-19 and the risks of postoperative complications.SUMMARY BACKGROUND DATA: It is unknown whether patients who recovered from Covid-19 and then underwent a major elective...

An infant with X-linked anhidrotic ectodermal dysplasia with immunodeficiency presenting with .

Clinical case reports

Toyohara M, Kajiho Y, Toyofuku E, Takahashi C, Owada K, Kanda S, Harita Y, Ohnishi H, Wada T, Imai K, Kanegane H, Morio T, Oka A.
PMID: 34815879
Clin Case Rep. 2021 Nov 16;9(11):e05093. doi: 10.1002/ccr3.5093. eCollection 2021 Nov.

No abstract available.

Evaluation of Barrier Functions in Human iPSC-Derived Intestinal Epithelium.

Methods in molecular biology (Clifton, N.J.)

Yamada S, Kanda Y.
PMID: 33661485
Methods Mol Biol. 2021;2367:27-35. doi: 10.1007/7651_2021_346.

The small intestine plays roles in the absorption and metabolism of orally administered drugs and chemicals. Tight junctions between intestinal epithelial cells, which form a tight barrier preventing the invasion of pathogens and toxins, are essential components of the...

Successful detection of covert paroxysmal atrial fibrillation due to insertable cardiac monitor in embolic stroke of undetermined source in a patient with situs inversus totalis.

Clinical case reports

Kasai Y, Shakya S, Miyaji K, Kanda J.
PMID: 33768885
Clin Case Rep. 2021 Jan 19;9(3):1544-1547. doi: 10.1002/ccr3.3826. eCollection 2021 Mar.

Insertable cardiac monitors in patients with situs inversus totalis can detect atrial arrhythmia as a cause of embolic stroke. It is important to premap the position of ICM in order to clearly visualize the P wave.

Chronic cardiotoxicity assessment of BMS-986094, a guanosine nucleotide analogue, using human iPS cell-derived cardiomyocytes.

The Journal of toxicological sciences

Yanagida S, Satsuka A, Hayashi S, Ono A, Kanda Y.
PMID: 34334557
J Toxicol Sci. 2021;46(8):359-369. doi: 10.2131/jts.46.359.

Predicting drug-induced side effects in the cardiovascular system is very important because it can lead to the discontinuation of new drugs/candidates or the withdrawal of marketed drugs. Although chronic assessment of cardiac contractility is an important issue in safety...

Frameworks for selecting appropriate rural sanitation technology options in low- and middle-income countries: a critical review.

International journal of environmental health research

Kanda A, Ncube EJ, Voyi K.
PMID: 34420432
Int J Environ Health Res. 2021 Aug 22;1-13. doi: 10.1080/09603123.2021.1963685. Epub 2021 Aug 22.

Several rural technology options exist on the sanitation market with different characteristics, yet project failures in some developing countries were attributable to inappropriate technology choices. Frameworks that are used to select sanitation technology options (hard copy, computer programmes) were...

Production of granulomas in .

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

Suwanruengsri M, Uemura R, Kanda T, Fuke N, Nueangphuet P, Pornthummawat A, Yasuda M, Hirai T, Yamaguchi R.
PMID: 34802307
J Vet Diagn Invest. 2022 Jan;34(1):68-76. doi: 10.1177/10406387211053254. Epub 2021 Nov 22.

No abstract available.

The Outcome and CT Findings of Low-Dose Intensity Modulated Radiation Therapy with SQAP in a Cat with Thymoma.

Veterinary sciences

Kutara K, Mochizuki Y, Ohnishi A, Mitsui I, Kanda T, Sugiyama A, Maeta N, Kobayashi K, Shimizu Y, Okamura Y, Asanuma T.
PMID: 33327647
Vet Sci. 2020 Dec 14;7(4). doi: 10.3390/vetsci7040203.

A 9-year-old male intact domestic cat weighing 4.6 kg was referred for tachypnea. A large mass was visible in computed tomography (CT) scans of the thoracic cavity. A histopathological evaluation of the mass was consistent with thymoma. The cat...

A Comparative Study of Profile of Patients Receiving Electroconvulsive Therapy During the COVID-19 Pandemic and a Year Before.

The journal of ECT

Grover S, Rani S, Chakrabarti S, Mehra A, Sahoo S, Panda N.
PMID: 34387287
J ECT. 2021 Dec 01;37(4):e41-e42. doi: 10.1097/YCT.0000000000000798.

No abstract available.

Showing 1333 to 1344 of 1344 entries