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Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors.

Bioorganic & medicinal chemistry

Bessho Y, Akaki T, Hara Y, Yamakawa M, Obika S, Mori G, Ubukata M, Yasue K, Nakane Y, Terasako Y, Orita T, Doi S, Iwanaga T, Fujishima A, Adachi T, Ueno H, Motomura T.
PMID: 34808405
Bioorg Med Chem. 2021 Dec 15;52:116514. doi: 10.1016/j.bmc.2021.116514. Epub 2021 Nov 10.

Pyruvate dehydrogenase kinases (PDHKs) are fascinating drug targets for numerous diseases, including diabetes and cancers. In this report, we describe the result of our structure-based drug design from tricyclic lead compounds that led to the discovery of highly potent...

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Bessho Y, Akaki T, Hara Y, et al. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem. 2021;52:116514doi: 10.1016/j.bmc.2021.116514.
Bessho, Y., Akaki, T., Hara, Y., Yamakawa, M., Obika, S., Mori, G., Ubukata, M., Yasue, K., Nakane, Y., Terasako, Y., Orita, T., Doi, S., Iwanaga, T., Fujishima, A., Adachi, T., Ueno, H., & Motomura, T. (2021). Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorganic & medicinal chemistry, 52116514. https://doi.org/10.1016/j.bmc.2021.116514
Bessho, Yuki, et al. "Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors." Bioorganic & medicinal chemistry vol. 52 (2021): 116514. doi: https://doi.org/10.1016/j.bmc.2021.116514
Bessho Y, Akaki T, Hara Y, Yamakawa M, Obika S, Mori G, Ubukata M, Yasue K, Nakane Y, Terasako Y, Orita T, Doi S, Iwanaga T, Fujishima A, Adachi T, Ueno H, Motomura T. Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors. Bioorg Med Chem. 2021 Dec 15;52:116514. doi: 10.1016/j.bmc.2021.116514. Epub 2021 Nov 10. PMID: 34808405.
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Prognostic significance of neutrophil-to-lymphocyte ratio for long-term outcomes in patients with poorly differentiated thyroid cancer.

Endocrine journal

Oba T, Maeno K, Amitani M, Shimizu T, Ohno K, Ono M, Ito T, Kanai T, Uehara T, Ito KI.
PMID: 34219074
Endocr J. 2021 Nov 29;68(11):1329-1336. doi: 10.1507/endocrj.EJ21-0237. Epub 2021 Jul 02.

Poorly differentiated thyroid cancer (PDTC) is a distinct but rare type of thyroid cancer with intermediate biological behavior between differentiated and anaplastic thyroid cancers. PDTC was first defined in 2005 in Japan, but the diagnostic criteria changed in 2015,...

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Oba T, Maeno K, Amitani M, et al. Prognostic significance of neutrophil-to-lymphocyte ratio for long-term outcomes in patients with poorly differentiated thyroid cancer. Endocr J. 2021;68(11):1329-1336doi: 10.1507/endocrj.EJ21-0237.
Oba, T., Maeno, K., Amitani, M., Shimizu, T., Ohno, K., Ono, M., Ito, T., Kanai, T., Uehara, T., & Ito, K. I. (2021). Prognostic significance of neutrophil-to-lymphocyte ratio for long-term outcomes in patients with poorly differentiated thyroid cancer. Endocrine journal, 68(11), 1329-1336. https://doi.org/10.1507/endocrj.EJ21-0237
Oba, Takaaki, et al. "Prognostic significance of neutrophil-to-lymphocyte ratio for long-term outcomes in patients with poorly differentiated thyroid cancer." Endocrine journal vol. 68,11 (2021): 1329-1336. doi: https://doi.org/10.1507/endocrj.EJ21-0237
Oba T, Maeno K, Amitani M, Shimizu T, Ohno K, Ono M, Ito T, Kanai T, Uehara T, Ito KI. Prognostic significance of neutrophil-to-lymphocyte ratio for long-term outcomes in patients with poorly differentiated thyroid cancer. Endocr J. 2021 Nov 29;68(11):1329-1336. doi: 10.1507/endocrj.EJ21-0237. Epub 2021 Jul 02. PMID: 34219074.
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The skin biopsy punch: a novel technique for half pin site incisions in circular frame application.

Annals of the Royal College of Surgeons of England

Walker MJ, Banks T, Thomas P.
PMID: 34719951
Ann R Coll Surg Engl. 2021 Nov;103(10):776-777. doi: 10.1308/rcsann.2021.0140.

No abstract available.

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Walker MJ, Banks T, Thomas P. The skin biopsy punch: a novel technique for half pin site incisions in circular frame application. Ann R Coll Surg Engl. 2021;103(10):776-777doi: 10.1308/rcsann.2021.0140.
Walker, M. J., Banks, T., & Thomas, P. (2021). The skin biopsy punch: a novel technique for half pin site incisions in circular frame application. Annals of the Royal College of Surgeons of England, 103(10), 776-777. https://doi.org/10.1308/rcsann.2021.0140
Walker, M J, et al. "The skin biopsy punch: a novel technique for half pin site incisions in circular frame application." Annals of the Royal College of Surgeons of England vol. 103,10 (2021): 776-777. doi: https://doi.org/10.1308/rcsann.2021.0140
Walker MJ, Banks T, Thomas P. The skin biopsy punch: a novel technique for half pin site incisions in circular frame application. Ann R Coll Surg Engl. 2021 Nov;103(10):776-777. doi: 10.1308/rcsann.2021.0140. PMID: 34719951.
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Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.

Bioorganic & medicinal chemistry

Akaki T, Bessho Y, Ito T, Fujioka S, Ubukata M, Mori G, Yamanaka K, Orita T, Doi S, Iwanaga T, Ikegashira K, Hantani Y, Nakanishi I, Adachi T.
PMID: 34274549
Bioorg Med Chem. 2021 Aug 15;44:116283. doi: 10.1016/j.bmc.2021.116283. Epub 2021 Jul 08.

A fragment-based lead discovery approach was applied to Pyruvate Dehydrogenase Kinases (PDHKs) to discover inhibitors against the ATP binding site with novel chemotypes. X-ray fragment screening toward PDHK4 provided a fragment hit 1 with a characteristic interaction in a...

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Akaki T, Bessho Y, Ito T, et al. Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg Med Chem. 2021;44:116283doi: 10.1016/j.bmc.2021.116283.
Akaki, T., Bessho, Y., Ito, T., Fujioka, S., Ubukata, M., Mori, G., Yamanaka, K., Orita, T., Doi, S., Iwanaga, T., Ikegashira, K., Hantani, Y., Nakanishi, I., & Adachi, T. (2021). Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorganic & medicinal chemistry, 44116283. https://doi.org/10.1016/j.bmc.2021.116283
Akaki, Tatsuo, et al. "Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases." Bioorganic & medicinal chemistry vol. 44 (2021): 116283. doi: https://doi.org/10.1016/j.bmc.2021.116283
Akaki T, Bessho Y, Ito T, Fujioka S, Ubukata M, Mori G, Yamanaka K, Orita T, Doi S, Iwanaga T, Ikegashira K, Hantani Y, Nakanishi I, Adachi T. Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg Med Chem. 2021 Aug 15;44:116283. doi: 10.1016/j.bmc.2021.116283. Epub 2021 Jul 08. PMID: 34274549.
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Impact of Enteral Nutrition Within 24 Hours Versus Between 24 and 48 Hours in Patients With Severe Acute Pancreatitis: A Multicenter Retrospective Study.

Pancreas

Nakashima I, Horibe M, Sanui M, Sasaki M, Sawano H, Goto T, Ikeura T, Takeda T, Oda T, Yasuda H, Ogura Y, Miyazaki D, Kitamura K, Chiba N, Ozaki T, Yamashita T, Koinuma T, Oshima T, Yamamoto T, Hirota M, Moriya T, Shirai K, Izai J, Takeda K, Sekino M, Iwasaki E, Kanai T, Mayumi T.
PMID: 33835968
Pancreas. 2021 Mar 01;50(3):371-377. doi: 10.1097/MPA.0000000000001768.

OBJECTIVES: In patients with severe acute pancreatitis (SAP), early enteral nutrition (EN) is recommended by major clinical practice guidelines, but the exact timing for the initiation of EN is unknown.METHODS: We conducted a post hoc analysis of the database...

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Nakashima I, Horibe M, Sanui M, et al. Impact of Enteral Nutrition Within 24 Hours Versus Between 24 and 48 Hours in Patients With Severe Acute Pancreatitis: A Multicenter Retrospective Study. Pancreas. 2021;50(3):371-377doi: 10.1097/MPA.0000000000001768.
Nakashima, I., Horibe, M., Sanui, M., Sasaki, M., Sawano, H., Goto, T., Ikeura, T., Takeda, T., Oda, T., Yasuda, H., Ogura, Y., Miyazaki, D., Kitamura, K., Chiba, N., Ozaki, T., Yamashita, T., Koinuma, T., Oshima, T., Yamamoto, T., Hirota, M., Moriya, T., Shirai, K., Izai, J., Takeda, K., Sekino, M., Iwasaki, E., Kanai, T., & Mayumi, T. (2021). Impact of Enteral Nutrition Within 24 Hours Versus Between 24 and 48 Hours in Patients With Severe Acute Pancreatitis: A Multicenter Retrospective Study. Pancreas, 50(3), 371-377. https://doi.org/10.1097/MPA.0000000000001768
Nakashima, Ikue, et al. "Impact of Enteral Nutrition Within 24 Hours Versus Between 24 and 48 Hours in Patients With Severe Acute Pancreatitis: A Multicenter Retrospective Study." Pancreas vol. 50,3 (2021): 371-377. doi: https://doi.org/10.1097/MPA.0000000000001768
Nakashima I, Horibe M, Sanui M, Sasaki M, Sawano H, Goto T, Ikeura T, Takeda T, Oda T, Yasuda H, Ogura Y, Miyazaki D, Kitamura K, Chiba N, Ozaki T, Yamashita T, Koinuma T, Oshima T, Yamamoto T, Hirota M, Moriya T, Shirai K, Izai J, Takeda K, Sekino M, Iwasaki E, Kanai T, Mayumi T. Impact of Enteral Nutrition Within 24 Hours Versus Between 24 and 48 Hours in Patients With Severe Acute Pancreatitis: A Multicenter Retrospective Study. Pancreas. 2021 Mar 01;50(3):371-377. doi: 10.1097/MPA.0000000000001768. PMID: 33835968.
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True Mechanism of Spontaneous Order from Turbulence in Two-Dimensional Superfluid Manifolds.

Physical review letters

Kanai T, Guo W.
PMID: 34506186
Phys Rev Lett. 2021 Aug 27;127(9):095301. doi: 10.1103/PhysRevLett.127.095301.

In a 2D turbulent fluid containing pointlike vortices, Lars Onsager predicted that adding energy to the fluid can lead to the formation of persistent clusters of like-signed vortices, i.e., Onsager vortex (OV) clusters. In the evolution of 2D superfluid...

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Kanai T, Guo W. True Mechanism of Spontaneous Order from Turbulence in Two-Dimensional Superfluid Manifolds. Phys Rev Lett. 2021;127(9):095301doi: 10.1103/PhysRevLett.127.095301.
Kanai, T., & Guo, W. (2021). True Mechanism of Spontaneous Order from Turbulence in Two-Dimensional Superfluid Manifolds. Physical review letters, 127(9), 095301. https://doi.org/10.1103/PhysRevLett.127.095301
Kanai, Toshiaki, and Guo, Wei. "True Mechanism of Spontaneous Order from Turbulence in Two-Dimensional Superfluid Manifolds." Physical review letters vol. 127,9 (2021): 095301. doi: https://doi.org/10.1103/PhysRevLett.127.095301
Kanai T, Guo W. True Mechanism of Spontaneous Order from Turbulence in Two-Dimensional Superfluid Manifolds. Phys Rev Lett. 2021 Aug 27;127(9):095301. doi: 10.1103/PhysRevLett.127.095301. PMID: 34506186.
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Superiority of urgent vs early endoscopic hemostasis in patients with upper gastrointestinal bleeding with high-risk stigmata.

Gastroenterology report

Horibe M, Iwasaki E, Matsuzaki J, Bazerbachi F, Kaneko T, Minami K, Fukuhara S, Masaoka T, Hosoe N, Ogura Y, Namiki S, Hosoda Y, Ogata H, Kanai T.
PMID: 34925851
Gastroenterol Rep (Oxf). 2021 Nov 02;9(6):543-551. doi: 10.1093/gastro/goab042. eCollection 2021 Dec.

BACKGROUND: Guidelines recommend that all patients with upper gastrointestinal bleeding (UGIB) undergo endoscopy within 24 h. It is unclear whether a subgroup may benefit from an urgent intervention. We aimed to evaluate the influence of endoscopic hemostasis and urgent...

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Horibe M, Iwasaki E, Matsuzaki J, et al. Superiority of urgent vs early endoscopic hemostasis in patients with upper gastrointestinal bleeding with high-risk stigmata. Gastroenterol Rep (Oxf). 2021;9(6):543-551doi: 10.1093/gastro/goab042.
Horibe, M., Iwasaki, E., Matsuzaki, J., Bazerbachi, F., Kaneko, T., Minami, K., Fukuhara, S., Masaoka, T., Hosoe, N., Ogura, Y., Namiki, S., Hosoda, Y., Ogata, H., & Kanai, T. (2021). Superiority of urgent vs early endoscopic hemostasis in patients with upper gastrointestinal bleeding with high-risk stigmata. Gastroenterology report, 9(6), 543-551. https://doi.org/10.1093/gastro/goab042
Horibe, Masayasu, et al. "Superiority of urgent vs early endoscopic hemostasis in patients with upper gastrointestinal bleeding with high-risk stigmata." Gastroenterology report vol. 9,6 (2021): 543-551. doi: https://doi.org/10.1093/gastro/goab042
Horibe M, Iwasaki E, Matsuzaki J, Bazerbachi F, Kaneko T, Minami K, Fukuhara S, Masaoka T, Hosoe N, Ogura Y, Namiki S, Hosoda Y, Ogata H, Kanai T. Superiority of urgent vs early endoscopic hemostasis in patients with upper gastrointestinal bleeding with high-risk stigmata. Gastroenterol Rep (Oxf). 2021 Nov 02;9(6):543-551. doi: 10.1093/gastro/goab042. eCollection 2021 Dec. PMID: 34925851; PMCID: PMC8677506.
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Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Nishiguchi Y, Hata Y, Date R, Fujimoto D, Umemoto S, Kanki T, Yokoi H, Mori KP, Handa T, Watanabe-Takano H, Kanai Y, Yasoda A, Izumi Y, Kakizoe Y, Mochizuki N, Mukoyama M, Kuwabara T.
PMID: 34610136
Nephrol Dial Transplant. 2021 Oct 05; doi: 10.1093/ndt/gfab286. Epub 2021 Oct 05.

BACKGROUND: Osteocrin (OSTN), a bone-derived humoral factor, was reported to act on heart and bone by potentiating the natriuretic peptide (NP) system. Ostn gene polymorphisms have been associated with renal function decline, but its pathophysiological role in the kidney...

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Nishiguchi Y, Hata Y, Date R, et al. Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice. Nephrol Dial Transplant. 2021;doi: 10.1093/ndt/gfab286.
Nishiguchi, Y., Hata, Y., Date, R., Fujimoto, D., Umemoto, S., Kanki, T., Yokoi, H., Mori, K. P., Handa, T., Watanabe-Takano, H., Kanai, Y., Yasoda, A., Izumi, Y., Kakizoe, Y., Mochizuki, N., Mukoyama, M., & Kuwabara, T. (2021). Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, . https://doi.org/10.1093/ndt/gfab286
Nishiguchi, Yoshihiko, et al. "Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice." Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association vol. (2021). doi: https://doi.org/10.1093/ndt/gfab286
Nishiguchi Y, Hata Y, Date R, Fujimoto D, Umemoto S, Kanki T, Yokoi H, Mori KP, Handa T, Watanabe-Takano H, Kanai Y, Yasoda A, Izumi Y, Kakizoe Y, Mochizuki N, Mukoyama M, Kuwabara T. Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice. Nephrol Dial Transplant. 2021 Oct 05; doi: 10.1093/ndt/gfab286. Epub 2021 Oct 05. PMID: 34610136.
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