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Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Fisher-Wellman KH, Hagen JT, Kassai M, Kao LP, Nelson MAM, McLaughlin KL, Coalson HS, Fox TE, Tan SF, Feith DJ, Kester M, Loughran TP, Claxton DF, Cabot MC.
PMID: 34888943
FASEB J. 2022 Jan;36(1):e22094. doi: 10.1096/fj.202101194RRR.

Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. In the present work, we utilized acute myeloid leukemia (AML) cell lines, selected to be refractory to various...

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Fisher-Wellman KH, Hagen JT, Kassai M, et al. Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia. FASEB J. 2022;36(1):e22094doi: 10.1096/fj.202101194RRR.
Fisher-Wellman, K. H., Hagen, J. T., Kassai, M., Kao, L. P., Nelson, M. A. M., McLaughlin, K. L., Coalson, H. S., Fox, T. E., Tan, S. F., Feith, D. J., Kester, M., Loughran, T. P., Claxton, D. F., & Cabot, M. C. (2022). Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36(1), e22094. https://doi.org/10.1096/fj.202101194RRR
Fisher-Wellman, Kelsey H, et al. "Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia." FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 36,1 (2022): e22094. doi: https://doi.org/10.1096/fj.202101194RRR
Fisher-Wellman KH, Hagen JT, Kassai M, Kao LP, Nelson MAM, McLaughlin KL, Coalson HS, Fox TE, Tan SF, Feith DJ, Kester M, Loughran TP, Claxton DF, Cabot MC. Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia. FASEB J. 2022 Jan;36(1):e22094. doi: 10.1096/fj.202101194RRR. PMID: 34888943.
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Assessing quality of life using WHOQOL-BREF: A cross-sectional insight among patients on warfarin in Malaysia.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Iqbal MS, Kassab YW, Al-Saikhan FI, Almalki ZS, Haseeb A, Iqbal MZ, Ali M.
PMID: 32792838
Saudi Pharm J. 2020 Aug;28(8):936-942. doi: 10.1016/j.jsps.2020.06.014. Epub 2020 Jun 25.

BACKGROUND AND AIM: The effect of anticoagulation control on overall Health-Related Quality of Life (HRQoL) in patients taking warfarin in Malaysia has not been explored yet. Therefore, this study aimed to evaluate HRQoL among patients on warfarin in Malaysia.METHODS:...

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Iqbal MS, Kassab YW, Al-Saikhan FI, et al. Assessing quality of life using WHOQOL-BREF: A cross-sectional insight among patients on warfarin in Malaysia. Saudi Pharm J. 2020;28(8):936-942doi: 10.1016/j.jsps.2020.06.014.
Iqbal, M. S., Kassab, Y. W., Al-Saikhan, F. I., Almalki, Z. S., Haseeb, A., Iqbal, M. Z., & Ali, M. (2020). Assessing quality of life using WHOQOL-BREF: A cross-sectional insight among patients on warfarin in Malaysia. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 28(8), 936-942. https://doi.org/10.1016/j.jsps.2020.06.014
Iqbal, Muhammad Shahid, et al. "Assessing quality of life using WHOQOL-BREF: A cross-sectional insight among patients on warfarin in Malaysia." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 28,8 (2020): 936-942. doi: https://doi.org/10.1016/j.jsps.2020.06.014
Iqbal MS, Kassab YW, Al-Saikhan FI, Almalki ZS, Haseeb A, Iqbal MZ, Ali M. Assessing quality of life using WHOQOL-BREF: A cross-sectional insight among patients on warfarin in Malaysia. Saudi Pharm J. 2020 Aug;28(8):936-942. doi: 10.1016/j.jsps.2020.06.014. Epub 2020 Jun 25. PMID: 32792838; PMCID: PMC7414056.
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Dental Rehabilitation of a Child with Ectodermal Dysplasia: A Case Report.

International journal of clinical pediatric dentistry

Gholman RR, Kassar WM, El Meligy OA.
PMID: 31866726
Int J Clin Pediatr Dent. 2019 Jul-Aug;12(4):362-365. doi: 10.5005/jp-journals-10005-1651.

A nine-year-old girl was presented to the dental clinic at King Abdulaziz Medical City in Jeddah with carious posterior primary teeth and discolored teeth. She was referred to a pediatric geneticist to rule out any medical conditions. She was...

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Gholman RR, Kassar WM, El Meligy OA. Dental Rehabilitation of a Child with Ectodermal Dysplasia: A Case Report. Int J Clin Pediatr Dent. 2019;12(4):362-365doi: 10.5005/jp-journals-10005-1651.
Gholman, R. R., Kassar, W. M., & El Meligy, O. A. (2019). Dental Rehabilitation of a Child with Ectodermal Dysplasia: A Case Report. International journal of clinical pediatric dentistry, 12(4), 362-365. https://doi.org/10.5005/jp-journals-10005-1651
Gholman, Raed R, et al. "Dental Rehabilitation of a Child with Ectodermal Dysplasia: A Case Report." International journal of clinical pediatric dentistry vol. 12,4 (2019): 362-365. doi: https://doi.org/10.5005/jp-journals-10005-1651
Gholman RR, Kassar WM, El Meligy OA. Dental Rehabilitation of a Child with Ectodermal Dysplasia: A Case Report. Int J Clin Pediatr Dent. 2019 Jul-Aug;12(4):362-365. doi: 10.5005/jp-journals-10005-1651. PMID: 31866726; PMCID: PMC6898874.
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LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway.

Oncogenesis

Wang X, Wang X, Liu Y, Dong Y, Wang Y, Kassab MA, Fan W, Yu X, Wu C.
PMID: 30089773
Oncogenesis. 2018 Aug 09;7(8):57. doi: 10.1038/s41389-018-0071-5.

LGR5 plays a critical role in tissue development and the maintenance of adult stem cells in gastrointestinal tract. However, the oncogenic role of LGR5 in the development of gastric adenocarcinoma remains elusive. Here, we show that LGR5 promotes gastric...

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Wang X, Wang X, Liu Y, et al. LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway. Oncogenesis. 2018;7(8):57doi: 10.1038/s41389-018-0071-5.
Wang, X., Wang, X., Liu, Y., Dong, Y., Wang, Y., Kassab, M. A., Fan, W., Yu, X., & Wu, C. (2018). LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway. Oncogenesis, 7(8), 57. https://doi.org/10.1038/s41389-018-0071-5
Wang, Xiangfei, et al. "LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway." Oncogenesis vol. 7,8 (2018): 57. doi: https://doi.org/10.1038/s41389-018-0071-5
Wang X, Wang X, Liu Y, Dong Y, Wang Y, Kassab MA, Fan W, Yu X, Wu C. LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway. Oncogenesis. 2018 Aug 09;7(8):57. doi: 10.1038/s41389-018-0071-5. PMID: 30089773; PMCID: PMC6082861.
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Pharmacovigilance and adverse drug reaction reporting: a perspective of community pharmacists and pharmacy technicians in Sana'a, Yemen.

Therapeutics and clinical risk management

Al-Worafi YM, Kassab YW, Alseragi WM, Almutairi MS, Ahmed A, Ming LC, Alkhoshaiban AS, Hadi MA.
PMID: 28924350
Ther Clin Risk Manag. 2017 Sep 07;13:1175-1181. doi: 10.2147/TCRM.S140674. eCollection 2017.

OBJECTIVE: The aim of this study was to compare the knowledge, attitude and barriers of pharmacy technicians and pharmacists toward pharmacovigilance, adverse drug reactions (ADRs) and ADR reporting in community pharmacies in Yemen.METHODS: This cross-sectional survey was conducted among...

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Al-Worafi YM, Kassab YW, Alseragi WM, et al. Pharmacovigilance and adverse drug reaction reporting: a perspective of community pharmacists and pharmacy technicians in Sana'a, Yemen. Ther Clin Risk Manag. 2017;13:1175-1181doi: 10.2147/TCRM.S140674.
Al-Worafi, Y. M., Kassab, Y. W., Alseragi, W. M., Almutairi, M. S., Ahmed, A., Ming, L. C., Alkhoshaiban, A. S., & Hadi, M. A. (2017). Pharmacovigilance and adverse drug reaction reporting: a perspective of community pharmacists and pharmacy technicians in Sana'a, Yemen. Therapeutics and clinical risk management, 131175-1181. https://doi.org/10.2147/TCRM.S140674
Al-Worafi, Yaser Mohammed, et al. "Pharmacovigilance and adverse drug reaction reporting: a perspective of community pharmacists and pharmacy technicians in Sana'a, Yemen." Therapeutics and clinical risk management vol. 13 (2017): 1175-1181. doi: https://doi.org/10.2147/TCRM.S140674
Al-Worafi YM, Kassab YW, Alseragi WM, Almutairi MS, Ahmed A, Ming LC, Alkhoshaiban AS, Hadi MA. Pharmacovigilance and adverse drug reaction reporting: a perspective of community pharmacists and pharmacy technicians in Sana'a, Yemen. Ther Clin Risk Manag. 2017 Sep 07;13:1175-1181. doi: 10.2147/TCRM.S140674. eCollection 2017. PMID: 28924350; PMCID: PMC5595359.
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ABCD2 Score and Large-Artery Atherosclerosis.

The Neurohospitalist

Bhatt A, Farooq MU, Safdar A, Hejabian S, Razak A, Hussain SI, Kassab MY, Majid A.
PMID: 23983858
Neurohospitalist. 2012 Jan;2(1):12-7. doi: 10.1177/1941874411418239.

BACKGROUND AND PURPOSE: Extracranial stenosis (ECS) or intracranial stenosis (ICS) are independent risk factors for stroke after transient ischemic attack (TIA). We examined the association of the age, blood pressure, clinical features, duration of symptoms and diabetes (ABCD2) score,...

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Bhatt A, Farooq MU, Safdar A, et al. ABCD2 Score and Large-Artery Atherosclerosis. Neurohospitalist. 2012;2(1):12-7doi: 10.1177/1941874411418239.
Bhatt, A., Farooq, M. U., Safdar, A., Hejabian, S., Razak, A., Hussain, S. I., Kassab, M. Y., & Majid, A. (2012). ABCD2 Score and Large-Artery Atherosclerosis. The Neurohospitalist, 2(1), 12-7. https://doi.org/10.1177/1941874411418239
Bhatt, Archit, et al. "ABCD2 Score and Large-Artery Atherosclerosis." The Neurohospitalist vol. 2,1 (2012): 12-7. doi: https://doi.org/10.1177/1941874411418239
Bhatt A, Farooq MU, Safdar A, Hejabian S, Razak A, Hussain SI, Kassab MY, Majid A. ABCD2 Score and Large-Artery Atherosclerosis. Neurohospitalist. 2012 Jan;2(1):12-7. doi: 10.1177/1941874411418239. PMID: 23983858; PMCID: PMC3726095.
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In-flight calibration of mesospheric rocket plasma probes.

The Review of scientific instruments

Havnes O, Hartquist TW, Kassa M, Morfill GE.
PMID: 21806207
Rev Sci Instrum. 2011 Jul;82(7):074503. doi: 10.1063/1.3611007.

Many effects and factors can influence the efficiency of a rocket plasma probe. These include payload charging, solar illumination, rocket payload orientation and rotation, and dust impact induced secondary charge production. As a consequence, considerable uncertainties can arise in...

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Havnes O, Hartquist TW, Kassa M, et al. In-flight calibration of mesospheric rocket plasma probes. Rev Sci Instrum. 2011;82(7):074503doi: 10.1063/1.3611007.
Havnes, O., Hartquist, T. W., Kassa, M., & Morfill, G. E. (2011). In-flight calibration of mesospheric rocket plasma probes. The Review of scientific instruments, 82(7), 074503. https://doi.org/10.1063/1.3611007
Havnes, Ove, et al. "In-flight calibration of mesospheric rocket plasma probes." The Review of scientific instruments vol. 82,7 (2011): 074503. doi: https://doi.org/10.1063/1.3611007
Havnes O, Hartquist TW, Kassa M, Morfill GE. In-flight calibration of mesospheric rocket plasma probes. Rev Sci Instrum. 2011 Jul;82(7):074503. doi: 10.1063/1.3611007. PMID: 21806207.
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Predictors of occult paroxysmal atrial fibrillation in cryptogenic strokes detected by long-term noninvasive cardiac monitoring.

Stroke research and treatment

Bhatt A, Majid A, Razak A, Kassab M, Hussain S, Safdar A.
PMID: 21423555
Stroke Res Treat. 2011 Feb 22;2011:172074. doi: 10.4061/2011/172074.

Background and Purpose. Paroxysmal Atrial fibrillation/Flutter (PAF) detection rates in cryptogenic strokes have been variable. We sought to determine the percentage of patients with cryptogenic stroke who had PAF on prolonged non-invasive cardiac monitoring. Methods and Results. Sixty-two consecutive...

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Bhatt A, Majid A, Razak A, et al. Predictors of occult paroxysmal atrial fibrillation in cryptogenic strokes detected by long-term noninvasive cardiac monitoring. Stroke Res Treat. 2011;2011:172074doi: 10.4061/2011/172074.
Bhatt, A., Majid, A., Razak, A., Kassab, M., Hussain, S., & Safdar, A. (2011). Predictors of occult paroxysmal atrial fibrillation in cryptogenic strokes detected by long-term noninvasive cardiac monitoring. Stroke research and treatment, 2011172074. https://doi.org/10.4061/2011/172074
Bhatt, Archit, et al. "Predictors of occult paroxysmal atrial fibrillation in cryptogenic strokes detected by long-term noninvasive cardiac monitoring." Stroke research and treatment vol. 2011 (2011): 172074. doi: https://doi.org/10.4061/2011/172074
Bhatt A, Majid A, Razak A, Kassab M, Hussain S, Safdar A. Predictors of occult paroxysmal atrial fibrillation in cryptogenic strokes detected by long-term noninvasive cardiac monitoring. Stroke Res Treat. 2011 Feb 22;2011:172074. doi: 10.4061/2011/172074. PMID: 21423555; PMCID: PMC3056431.
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Assessment of Control Measures and Trends of Malaria in Burie-Zuria District, West Gojjam Zone, Amhara Region, North West Ethiopia.

Malaria research and treatment

Kassa AW, Tamiru MA, Yeshanew AG.
PMID: 26171274
Malar Res Treat. 2015;2015:302194. doi: 10.1155/2015/302194. Epub 2015 Jun 11.

Introduction. Malaria is caused by the protozoan parasite Plasmodium and transmitted by the bite of Anopheles mosquitoes. The aim of this study was to assess control measures and trends of malaria and guide intervention measures at Burie-Zuria district, Amhara...

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Kassa AW, Tamiru MA, Yeshanew AG. Assessment of Control Measures and Trends of Malaria in Burie-Zuria District, West Gojjam Zone, Amhara Region, North West Ethiopia. Malar Res Treat. 2015;2015:302194doi: 10.1155/2015/302194.
Kassa, A. W., Tamiru, M. A., & Yeshanew, A. G. (2015). Assessment of Control Measures and Trends of Malaria in Burie-Zuria District, West Gojjam Zone, Amhara Region, North West Ethiopia. Malaria research and treatment, 2015302194. https://doi.org/10.1155/2015/302194
Kassa, Addisu Workineh, et al. "Assessment of Control Measures and Trends of Malaria in Burie-Zuria District, West Gojjam Zone, Amhara Region, North West Ethiopia." Malaria research and treatment vol. 2015 (2015): 302194. doi: https://doi.org/10.1155/2015/302194
Kassa AW, Tamiru MA, Yeshanew AG. Assessment of Control Measures and Trends of Malaria in Burie-Zuria District, West Gojjam Zone, Amhara Region, North West Ethiopia. Malar Res Treat. 2015;2015:302194. doi: 10.1155/2015/302194. Epub 2015 Jun 11. PMID: 26171274; PMCID: PMC4478407.
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Performance evaluation of malaria microscopists working at rechecking laboratories in Ethiopia.

MalariaWorld journal

Abebe A, Belayneh M, Asrat H, Kassa W, Gashu A, Desale A, Hailu G, Mekonnen T, Girmachew F, Mulugeta A, Abose E, Yenealem D, Tsadik AG, Kebede A, Ayana G, Desta K.
PMID: 34532230
Malariaworld J. 2017 Jun 01;8:6. eCollection 2017.

BACKGROUND: Microscopic diagnosis of Giemsa-stained thick and thin blood films has remained the standard laboratory method for diagnosing malaria. High quality performance of microscopists that examine blood slides in health facilities remains critically important.MATERIALS AND METHODS: A cross-sectional study...

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Abebe A, Belayneh M, Asrat H, et al. Performance evaluation of malaria microscopists working at rechecking laboratories in Ethiopia. Malariaworld J. 2017;8:6
Abebe, A., Belayneh, M., Asrat, H., Kassa, W., Gashu, A., Desale, A., Hailu, G., Mekonnen, T., Girmachew, F., Mulugeta, A., Abose, E., Yenealem, D., Tsadik, A. G., Kebede, A., Ayana, G., & Desta, K. (2017). Performance evaluation of malaria microscopists working at rechecking laboratories in Ethiopia. MalariaWorld journal, 86.
Abebe, Abnet, et al. "Performance evaluation of malaria microscopists working at rechecking laboratories in Ethiopia." MalariaWorld journal vol. 8 (2017): 6.
Abebe A, Belayneh M, Asrat H, Kassa W, Gashu A, Desale A, Hailu G, Mekonnen T, Girmachew F, Mulugeta A, Abose E, Yenealem D, Tsadik AG, Kebede A, Ayana G, Desta K. Performance evaluation of malaria microscopists working at rechecking laboratories in Ethiopia. Malariaworld J. 2017 Jun 01;8:6. eCollection 2017. PMID: 34532230; PMCID: PMC8415073.
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Targeting dePARylation for cancer therapy.

Cell & bioscience

Kassab MA, Yu LL, Yu X.
PMID: 32010441
Cell Biosci. 2020 Jan 29;10:7. doi: 10.1186/s13578-020-0375-y. eCollection 2020.

Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects. Thus, PARP inhibitors have...

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Kassab MA, Yu LL, Yu X. Targeting dePARylation for cancer therapy. Cell Biosci. 2020;10:7doi: 10.1186/s13578-020-0375-y.
Kassab, M. A., Yu, L. L., & Yu, X. (2020). Targeting dePARylation for cancer therapy. Cell & bioscience, 107. https://doi.org/10.1186/s13578-020-0375-y
Kassab, Muzaffer Ahmad, et al. "Targeting dePARylation for cancer therapy." Cell & bioscience vol. 10 (2020): 7. doi: https://doi.org/10.1186/s13578-020-0375-y
Kassab MA, Yu LL, Yu X. Targeting dePARylation for cancer therapy. Cell Biosci. 2020 Jan 29;10:7. doi: 10.1186/s13578-020-0375-y. eCollection 2020. PMID: 32010441; PMCID: PMC6988220.
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The Magnitude of Psychological Problem and Associated Factor in Response to COVID-19 Pandemic Among Communities Living in Addis Ababa, Ethiopia, March 2020: A Cross-Sectional Study Design.

Psychology research and behavior management

Kassaw C.
PMID: 32848481
Psychol Res Behav Manag. 2020 Aug 10;13:631-640. doi: 10.2147/PRBM.S256551. eCollection 2020.

PURPOSE: COVID-19 pandemic is a World Health Organization day-to-day work and has a significant crisis on the physical and mental health of humans. However, little is known about the mental health crisis of the pandemic in Sub-Saharan countries. Therefore,...

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Kassaw C. The Magnitude of Psychological Problem and Associated Factor in Response to COVID-19 Pandemic Among Communities Living in Addis Ababa, Ethiopia, March 2020: A Cross-Sectional Study Design. Psychol Res Behav Manag. 2020;13:631-640doi: 10.2147/PRBM.S256551.
Kassaw, C. (2020). The Magnitude of Psychological Problem and Associated Factor in Response to COVID-19 Pandemic Among Communities Living in Addis Ababa, Ethiopia, March 2020: A Cross-Sectional Study Design. Psychology research and behavior management, 13631-640. https://doi.org/10.2147/PRBM.S256551
Kassaw, Chalachew. "The Magnitude of Psychological Problem and Associated Factor in Response to COVID-19 Pandemic Among Communities Living in Addis Ababa, Ethiopia, March 2020: A Cross-Sectional Study Design." Psychology research and behavior management vol. 13 (2020): 631-640. doi: https://doi.org/10.2147/PRBM.S256551
Kassaw C. The Magnitude of Psychological Problem and Associated Factor in Response to COVID-19 Pandemic Among Communities Living in Addis Ababa, Ethiopia, March 2020: A Cross-Sectional Study Design. Psychol Res Behav Manag. 2020 Aug 10;13:631-640. doi: 10.2147/PRBM.S256551. eCollection 2020. PMID: 32848481; PMCID: PMC7428405.
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Showing 25 to 36 of 140 entries