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Longitudinal assessment of COVID-19 vaccine acceptance and uptake among frontline medical workers in Los Angeles, California.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Halbrook M, Gadoth A, Martin-Blais R, Gray AN, Kashani S, Kazan C, Kane B, Tobin NH, Ferbas KG, Aldrovandi GM, Rimoin AW.
PMID: 34292319
Clin Infect Dis. 2021 Jul 22; doi: 10.1093/cid/ciab614. Epub 2021 Jul 22.

BACKGROUND: Sentiments of vaccine hesitancy and distrust in public health institutions have complicated the government-led COVID-19 vaccine control strategy in the United States. As the first to receive the vaccine, COVID-19 vaccine attitudes among front line workers are consequential...

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Halbrook M, Gadoth A, Martin-Blais R, et al. Longitudinal assessment of COVID-19 vaccine acceptance and uptake among frontline medical workers in Los Angeles, California. Clin Infect Dis. 2021;doi: 10.1093/cid/ciab614.
Halbrook, M., Gadoth, A., Martin-Blais, R., Gray, A. N., Kashani, S., Kazan, C., Kane, B., Tobin, N. H., Ferbas, K. G., Aldrovandi, G. M., & Rimoin, A. W. (2021). Longitudinal assessment of COVID-19 vaccine acceptance and uptake among frontline medical workers in Los Angeles, California. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, . https://doi.org/10.1093/cid/ciab614
Halbrook, Megan, et al. "Longitudinal assessment of COVID-19 vaccine acceptance and uptake among frontline medical workers in Los Angeles, California." Clinical infectious diseases : an official publication of the Infectious Diseases Society of America vol. (2021). doi: https://doi.org/10.1093/cid/ciab614
Halbrook M, Gadoth A, Martin-Blais R, Gray AN, Kashani S, Kazan C, Kane B, Tobin NH, Ferbas KG, Aldrovandi GM, Rimoin AW. Longitudinal assessment of COVID-19 vaccine acceptance and uptake among frontline medical workers in Los Angeles, California. Clin Infect Dis. 2021 Jul 22; doi: 10.1093/cid/ciab614. Epub 2021 Jul 22. PMID: 34292319.
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Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen.

Microbiological research

Ding Y, Gardiner DM, Kazan K.
PMID: 34972022
Microbiol Res. 2021 Dec 17;256:126951. doi: 10.1016/j.micres.2021.126951. Epub 2021 Dec 17.

The fungal pathogen Fusarium graminearum (Fg) infects both heads and roots of cereal crops causing several economically important diseases such as head blight, seedling blight, crown rot and root rot. Trichothecene mycotoxins such as deoxynivalenol (DON), a well-known virulence...

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Ding Y, Gardiner DM, Kazan K. Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen. Microbiol Res. 2021;256:126951doi: 10.1016/j.micres.2021.126951.
Ding, Y., Gardiner, D. M., & Kazan, K. (2021). Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen. Microbiological research, 256126951. https://doi.org/10.1016/j.micres.2021.126951
Ding, Yi, et al. "Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen." Microbiological research vol. 256 (2021): 126951. doi: https://doi.org/10.1016/j.micres.2021.126951
Ding Y, Gardiner DM, Kazan K. Transcriptome analysis reveals infection strategies employed by Fusarium graminearum as a root pathogen. Microbiol Res. 2021 Dec 17;256:126951. doi: 10.1016/j.micres.2021.126951. Epub 2021 Dec 17. PMID: 34972022.
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Application of bioorthogonal hetero-Diels-Alder cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid and vinyl thioether for imaging inside living cells.

Organic & biomolecular chemistry

Bazan B, Pałasz A, Skalniak Ł, Cież D, Buda S, Jędrzejowska K, Głomb S, Kamzol D, Czarnota K, Latos K, Kozieł K, Musielak B.
PMID: 34137394
Org Biomol Chem. 2021 Jul 21;19(27):6045-6058. doi: 10.1039/d1ob00697e. Epub 2021 Jun 17.

New bioorthogonal cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid as 1-oxa-1,3-butadienes and vinyl thioether as a dienophile has been applied to imaging inside living cells. The reaction is high yielding, selective, and fast in aqueous media. The proposed 1-oxa-1,3-butadiene...

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Bazan B, Pałasz A, Skalniak Ł, et al. Application of bioorthogonal hetero-Diels-Alder cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid and vinyl thioether for imaging inside living cells. Org Biomol Chem. 2021;19(27):6045-6058doi: 10.1039/d1ob00697e.
Bazan, B., Pałasz, A., Skalniak, �. �., Cież, D., Buda, S., Jędrzejowska, K., Głomb, S., Kamzol, D., Czarnota, K., Latos, K., Kozieł, K., & Musielak, B. (2021). Application of bioorthogonal hetero-Diels-Alder cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid and vinyl thioether for imaging inside living cells. Organic & biomolecular chemistry, 19(27), 6045-6058. https://doi.org/10.1039/d1ob00697e
Bazan, Bartłomiej, et al. "Application of bioorthogonal hetero-Diels-Alder cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid and vinyl thioether for imaging inside living cells." Organic & biomolecular chemistry vol. 19,27 (2021): 6045-6058. doi: https://doi.org/10.1039/d1ob00697e
Bazan B, Pałasz A, Skalniak Ł, Cież D, Buda S, Jędrzejowska K, Głomb S, Kamzol D, Czarnota K, Latos K, Kozieł K, Musielak B. Application of bioorthogonal hetero-Diels-Alder cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid and vinyl thioether for imaging inside living cells. Org Biomol Chem. 2021 Jul 21;19(27):6045-6058. doi: 10.1039/d1ob00697e. Epub 2021 Jun 17. PMID: 34137394.
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Determination of Selected Texture Features on a Single-Layer Grinding Wheel Active Surface for Tracking Their Changes as a Result of Wear.

Materials (Basel, Switzerland)

Bazan A, Kawalec A, Rydzak T, Kubik P, Olko A.
PMID: 33375090
Materials (Basel). 2020 Dec 22;14(1). doi: 10.3390/ma14010006.

Measurements of the active surface microgeometry of the grinding wheel by contact and optical methods are commonly used to obtain a cloud of points representing the surface of the examined tool. Parameters that can be determined on the basis...

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Bazan A, Kawalec A, Rydzak T, et al. Determination of Selected Texture Features on a Single-Layer Grinding Wheel Active Surface for Tracking Their Changes as a Result of Wear. Materials (Basel). 2020;14(1)doi: 10.3390/ma14010006.
Bazan, A., Kawalec, A., Rydzak, T., Kubik, P., & Olko, A. (2020). Determination of Selected Texture Features on a Single-Layer Grinding Wheel Active Surface for Tracking Their Changes as a Result of Wear. Materials (Basel, Switzerland), 14(1), . https://doi.org/10.3390/ma14010006
Bazan, Anna, et al. "Determination of Selected Texture Features on a Single-Layer Grinding Wheel Active Surface for Tracking Their Changes as a Result of Wear." Materials (Basel, Switzerland) vol. 14,1 (2020). doi: https://doi.org/10.3390/ma14010006
Bazan A, Kawalec A, Rydzak T, Kubik P, Olko A. Determination of Selected Texture Features on a Single-Layer Grinding Wheel Active Surface for Tracking Their Changes as a Result of Wear. Materials (Basel). 2020 Dec 22;14(1). doi: 10.3390/ma14010006. PMID: 33375090; PMCID: PMC7792803.
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Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism.

Translational psychiatry

Gerlach AR, Karim HT, Kazan J, Aizenstein HJ, Krafty RT, Andreescu C.
PMID: 34711810
Transl Psychiatry. 2021 Oct 28;11(1):550. doi: 10.1038/s41398-021-01648-5.

Severe worry is a complex transdiagnostic phenotype independently associated with increased morbidity, including cognitive impairment and cardiovascular diseases. We investigated the neurobiological basis of worry in older adults by analyzing resting state fMRI using a large-scale network-based approach. We...

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Gerlach AR, Karim HT, Kazan J, et al. Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism. Transl Psychiatry. 2021;11(1):550doi: 10.1038/s41398-021-01648-5.
Gerlach, A. R., Karim, H. T., Kazan, J., Aizenstein, H. J., Krafty, R. T., & Andreescu, C. (2021). Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism. Translational psychiatry, 11(1), 550. https://doi.org/10.1038/s41398-021-01648-5
Gerlach, Andrew R, et al. "Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism." Translational psychiatry vol. 11,1 (2021): 550. doi: https://doi.org/10.1038/s41398-021-01648-5
Gerlach AR, Karim HT, Kazan J, Aizenstein HJ, Krafty RT, Andreescu C. Networks of worry-towards a connectivity-based signature of late-life worry using higher criticism. Transl Psychiatry. 2021 Oct 28;11(1):550. doi: 10.1038/s41398-021-01648-5. PMID: 34711810; PMCID: PMC8553743.
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Intensive Care in India in 2018-2019: The Second Indian Intensive Care Case Mix and Practice Patterns Study.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Divatia JV, Mehta Y, Govil D, Zirpe K, Amin PR, Ramakrishnan N, Kapadia FN, Sircar M, Sahu S, Bhattacharya PK, Myatra SN, Samavedam S, Dixit S, Pande RK, Mehta SN, Venkataraman R, Bajan K, Kumar V, Harne R, Thakur L, Rathod D, Sathe P, Gurav S, D'Silva C, Pasha SA, Todi SK.
PMID: 34916740
Indian J Crit Care Med. 2021 Oct;25(10):1093-1107. doi: 10.5005/jp-journals-10071-23965.

BACKGROUND: We aimed to study organizational aspects, case mix, and practices in Indian intensive care units (ICUs) from 2018 to 2019, following the Indian Intensive Care Case Mix and Practice Patterns Study (INDICAPS) of 2010-2011.METHODS: An observational, 4-day point...

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Divatia JV, Mehta Y, Govil D, et al. Intensive Care in India in 2018-2019: The Second Indian Intensive Care Case Mix and Practice Patterns Study. Indian J Crit Care Med. 2021;25(10):1093-1107doi: 10.5005/jp-journals-10071-23965.
Divatia, J. V., Mehta, Y., Govil, D., Zirpe, K., Amin, P. R., Ramakrishnan, N., Kapadia, F. N., Sircar, M., Sahu, S., Bhattacharya, P. K., Myatra, S. N., Samavedam, S., Dixit, S., Pande, R. K., Mehta, S. N., Venkataraman, R., Bajan, K., Kumar, V., Harne, R., Thakur, L., Rathod, D., Sathe, P., Gurav, S., D'Silva, C., Pasha, S. A., & Todi, S. K. (2021). Intensive Care in India in 2018-2019: The Second Indian Intensive Care Case Mix and Practice Patterns Study. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 25(10), 1093-1107. https://doi.org/10.5005/jp-journals-10071-23965
Divatia, Jigeeshu V, et al. "Intensive Care in India in 2018-2019: The Second Indian Intensive Care Case Mix and Practice Patterns Study." Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine vol. 25,10 (2021): 1093-1107. doi: https://doi.org/10.5005/jp-journals-10071-23965
Divatia JV, Mehta Y, Govil D, Zirpe K, Amin PR, Ramakrishnan N, Kapadia FN, Sircar M, Sahu S, Bhattacharya PK, Myatra SN, Samavedam S, Dixit S, Pande RK, Mehta SN, Venkataraman R, Bajan K, Kumar V, Harne R, Thakur L, Rathod D, Sathe P, Gurav S, D'Silva C, Pasha SA, Todi SK. Intensive Care in India in 2018-2019: The Second Indian Intensive Care Case Mix and Practice Patterns Study. Indian J Crit Care Med. 2021 Oct;25(10):1093-1107. doi: 10.5005/jp-journals-10071-23965. PMID: 34916740; PMCID: PMC8645819.
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Rapunzel Syndrome in Congenital Mental Retardation Patient Requiring Emergency Laparotomy. Case report.

Annals of medicine and surgery (2012)

Alibraheem A, Danial A, Kazan A, Masri E, Obari MY, Basha SR.
PMID: 32963774
Ann Med Surg (Lond). 2020 Sep 01;58:99-101. doi: 10.1016/j.amsu.2020.08.026. eCollection 2020 Oct.

INTRODUCTION: When hair accumulates inside the stomach, it causes what is called a Trichobezoar, which leads to a stomach blockage. When the accumulated hair extends into the small intestine, it causes a rare disturbance called Rapunzel syndrome (RS).DISCUSSION: Affected...

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Alibraheem A, Danial A, Kazan A, et al. Rapunzel Syndrome in Congenital Mental Retardation Patient Requiring Emergency Laparotomy. Case report. Ann Med Surg (Lond). 2020;58:99-101doi: 10.1016/j.amsu.2020.08.026.
Alibraheem, A., Danial, A., Kazan, A., Masri, E., Obari, M. Y., & Basha, S. R. (2020). Rapunzel Syndrome in Congenital Mental Retardation Patient Requiring Emergency Laparotomy. Case report. Annals of medicine and surgery (2012), 5899-101. https://doi.org/10.1016/j.amsu.2020.08.026
Alibraheem, Abdelaziz, et al. "Rapunzel Syndrome in Congenital Mental Retardation Patient Requiring Emergency Laparotomy. Case report." Annals of medicine and surgery (2012) vol. 58 (2020): 99-101. doi: https://doi.org/10.1016/j.amsu.2020.08.026
Alibraheem A, Danial A, Kazan A, Masri E, Obari MY, Basha SR. Rapunzel Syndrome in Congenital Mental Retardation Patient Requiring Emergency Laparotomy. Case report. Ann Med Surg (Lond). 2020 Sep 01;58:99-101. doi: 10.1016/j.amsu.2020.08.026. eCollection 2020 Oct. PMID: 32963774; PMCID: PMC7490442.
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Tuning electrical and thermal conductivities of the two-dimensional electron gas in AlN/GaN heterostructures by piezoelectricity.

Nanotechnology

Abou-Hamdan L, Hamyeh S, Iskandar A, Tauk R, Brault J, Tabbal M, Adam PM, Kazan M.
PMID: 33246321
Nanotechnology. 2021 Mar 12;32(11):115703. doi: 10.1088/1361-6528/abce79.

We investigate the electrical and thermal conductivities of the two-dimensional electron gas (2DEG) confined in the quantum well formed at the heterojunction between a thin GaN layer and an AlN layer strained by an Al

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Abou-Hamdan L, Hamyeh S, Iskandar A, et al. Tuning electrical and thermal conductivities of the two-dimensional electron gas in AlN/GaN heterostructures by piezoelectricity. Nanotechnology. 2021;32(11):115703doi: 10.1088/1361-6528/abce79.
Abou-Hamdan, L., Hamyeh, S., Iskandar, A., Tauk, R., Brault, J., Tabbal, M., Adam, P. M., & Kazan, M. (2021). Tuning electrical and thermal conductivities of the two-dimensional electron gas in AlN/GaN heterostructures by piezoelectricity. Nanotechnology, 32(11), 115703. https://doi.org/10.1088/1361-6528/abce79
Abou-Hamdan, L, et al. "Tuning electrical and thermal conductivities of the two-dimensional electron gas in AlN/GaN heterostructures by piezoelectricity." Nanotechnology vol. 32,11 (2021): 115703. doi: https://doi.org/10.1088/1361-6528/abce79
Abou-Hamdan L, Hamyeh S, Iskandar A, Tauk R, Brault J, Tabbal M, Adam PM, Kazan M. Tuning electrical and thermal conductivities of the two-dimensional electron gas in AlN/GaN heterostructures by piezoelectricity. Nanotechnology. 2021 Mar 12;32(11):115703. doi: 10.1088/1361-6528/abce79. PMID: 33246321.
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Materials challenges and opportunities for quantum computing hardware.

Science (New York, N.Y.)

de Leon NP, Itoh KM, Kim D, Mehta KK, Northup TE, Paik H, Palmer BS, Samarth N, Sangtawesin S, Steuerman DW.
PMID: 33859004
Science. 2021 Apr 16;372(6539). doi: 10.1126/science.abb2823.

Quantum computing hardware technologies have advanced during the past two decades, with the goal of building systems that can solve problems that are intractable on classical computers. The ability to realize large-scale systems depends on major advances in materials...

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de Leon NP, Itoh KM, Kim D, et al. Materials challenges and opportunities for quantum computing hardware. Science. 2021;372(6539)doi: 10.1126/science.abb2823.
de Leon, N. P., Itoh, K. M., Kim, D., Mehta, K. K., Northup, T. E., Paik, H., Palmer, B. S., Samarth, N., Sangtawesin, S., & Steuerman, D. W. (2021). Materials challenges and opportunities for quantum computing hardware. Science (New York, N.Y.), 372(6539), . https://doi.org/10.1126/science.abb2823
de Leon, Nathalie P, et al. "Materials challenges and opportunities for quantum computing hardware." Science (New York, N.Y.) vol. 372,6539 (2021). doi: https://doi.org/10.1126/science.abb2823
de Leon NP, Itoh KM, Kim D, Mehta KK, Northup TE, Paik H, Palmer BS, Samarth N, Sangtawesin S, Steuerman DW. Materials challenges and opportunities for quantum computing hardware. Science. 2021 Apr 16;372(6539). doi: 10.1126/science.abb2823. PMID: 33859004.
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Tracheal Bronchus: A Rare Etiology of Recurrent Pneumonia in Children.

Cureus

Alqahtani SA, Alghamdi AM, Babader RA, Aljehani DA, Alsultan RK, Mushari RY, Alyahya MY, Alajwad HI, Alibrahim AA, Altukruni EB, Alhasani RN, Mandurah AT, Halabi YA, Alghamdi BJ, Al-Hawaj F.
PMID: 35028237
Cureus. 2021 Dec 13;13(12):e20378. doi: 10.7759/cureus.20378. eCollection 2021 Dec.

Recurrent infections are a common cause for seeking medical care and they result in significant parental anxiety and concerns. Although immunodeficiency disorders are an important underlying cause of recurrent infections, the majority of children with recurrent infections do not...

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Alqahtani SA, Alghamdi AM, Babader RA, et al. Tracheal Bronchus: A Rare Etiology of Recurrent Pneumonia in Children. Cureus. 2021;13(12):e20378doi: 10.7759/cureus.20378.
Alqahtani, S. A., Alghamdi, A. M., Babader, R. A., Aljehani, D. A., Alsultan, R. K., Mushari, R. Y., Alyahya, M. Y., Alajwad, H. I., Alibrahim, A. A., Altukruni, E. B., Alhasani, R. N., Mandurah, A. T., Halabi, Y. A., Alghamdi, B. J., & Al-Hawaj, F. (2021). Tracheal Bronchus: A Rare Etiology of Recurrent Pneumonia in Children. Cureus, 13(12), e20378. https://doi.org/10.7759/cureus.20378
Alqahtani, Saif A, et al. "Tracheal Bronchus: A Rare Etiology of Recurrent Pneumonia in Children." Cureus vol. 13,12 (2021): e20378. doi: https://doi.org/10.7759/cureus.20378
Alqahtani SA, Alghamdi AM, Babader RA, Aljehani DA, Alsultan RK, Mushari RY, Alyahya MY, Alajwad HI, Alibrahim AA, Altukruni EB, Alhasani RN, Mandurah AT, Halabi YA, Alghamdi BJ, Al-Hawaj F. Tracheal Bronchus: A Rare Etiology of Recurrent Pneumonia in Children. Cureus. 2021 Dec 13;13(12):e20378. doi: 10.7759/cureus.20378. eCollection 2021 Dec. PMID: 35028237; PMCID: PMC8743048.
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Rates and Predictors of Deterioration in a Trial of Internet-Delivered Cognitive Behavioral Therapy for Reducing Suicidal Thoughts.

Archives of suicide research : official journal of the International Academy for Suicide Research

Batterham PJ, Christensen H, Calear AL, Werner-Seidler A, Kazan D.
PMID: 33215554
Arch Suicide Res. 2020 Nov 20;1-11. doi: 10.1080/13811118.2020.1848671. Epub 2020 Nov 20.

OBJECTIVE: It is necessary for suicide prevention interventions to demonstrate safety. One important aspect of safety is evidence that deterioration rates are low. No studies have examined deterioration of suicidal ideation in the context of an internet-based cognitive behavioral...

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Batterham PJ, Christensen H, Calear AL, et al. Rates and Predictors of Deterioration in a Trial of Internet-Delivered Cognitive Behavioral Therapy for Reducing Suicidal Thoughts. Arch Suicide Res. 2020;1-11doi: 10.1080/13811118.2020.1848671.
Batterham, P. J., Christensen, H., Calear, A. L., Werner-Seidler, A., & Kazan, D. (2020). Rates and Predictors of Deterioration in a Trial of Internet-Delivered Cognitive Behavioral Therapy for Reducing Suicidal Thoughts. Archives of suicide research : official journal of the International Academy for Suicide Research, 1-11. https://doi.org/10.1080/13811118.2020.1848671
Batterham, Philip J, et al. "Rates and Predictors of Deterioration in a Trial of Internet-Delivered Cognitive Behavioral Therapy for Reducing Suicidal Thoughts." Archives of suicide research : official journal of the International Academy for Suicide Research vol. (2020): 1-11. doi: https://doi.org/10.1080/13811118.2020.1848671
Batterham PJ, Christensen H, Calear AL, Werner-Seidler A, Kazan D. Rates and Predictors of Deterioration in a Trial of Internet-Delivered Cognitive Behavioral Therapy for Reducing Suicidal Thoughts. Arch Suicide Res. 2020 Nov 20;1-11. doi: 10.1080/13811118.2020.1848671. Epub 2020 Nov 20. PMID: 33215554.
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Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling.

Journal of clinical immunology

Kaman K, Abrams M, Dobbs K, Notarangelo LD, Delmonte OM, Palterer B, Pai SY, Johnston A.
PMID: 33184721
J Clin Immunol. 2021 Feb;41(2):470-472. doi: 10.1007/s10875-020-00913-4. Epub 2020 Nov 13.

No abstract available.

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Kaman K, Abrams M, Dobbs K, et al. Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling. J Clin Immunol. 2020;41(2):470-472doi: 10.1007/s10875-020-00913-4.
Kaman, K., Abrams, M., Dobbs, K., Notarangelo, L. D., Delmonte, O. M., Palterer, B., Pai, S. Y., & Johnston, A. (2021). Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling. Journal of clinical immunology, 41(2), 470-472. https://doi.org/10.1007/s10875-020-00913-4
Kaman, Kelsey, et al. "Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling." Journal of clinical immunology vol. 41,2 (2021): 470-472. doi: https://doi.org/10.1007/s10875-020-00913-4
Kaman K, Abrams M, Dobbs K, Notarangelo LD, Delmonte OM, Palterer B, Pai SY, Johnston A. Novel Compound Heterozygous Mutations in ZAP70 Leading to a SCID Phenotype with Normal Downstream In vitro Signaling. J Clin Immunol. 2021 Feb;41(2):470-472. doi: 10.1007/s10875-020-00913-4. Epub 2020 Nov 13. PMID: 33184721; PMCID: PMC8319789.
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