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Showing 13 to 24 of 134 entries
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Absence of single critical dose for the amorphization of quartz under ion irradiation.

Journal of physics. Condensed matter : an Institute of Physics journal

Zhang S, Pakarinen OH, Backholm M, Djurabekova F, Nordlund K, Keinonen J, Wang TS.
PMID: 29105649
J Phys Condens Matter. 2018 Jan 10;30(1):015403. doi: 10.1088/1361-648X/aa9868.

In this work, we first simulated the amorphization of crystalline quartz under 50 keV [Formula: see text]Na ion irradiation with classical molecular dynamics (MD). We then used binary collision approximation algorithms to simulate the Rutherford backscattering spectrometry in channeling...

Pretargeted PET Imaging of .

ACS omega

Keinänen O, Mäkilä EM, Lindgren R, Virtanen H, Liljenbäck H, Oikonen V, Sarparanta M, Molthoff C, Windhorst AD, Roivainen A, Salonen JJ, Airaksinen AJ.
PMID: 28649670
ACS Omega. 2017 Jan 31;2(1):62-69. doi: 10.1021/acsomega.6b00269. Epub 2017 Jan 06.

Pretargeted positron emission tomography (PET) imaging based on bioorthogonal chemical reactions has proven its potential in immunoimaging. It may also have great potential in nanotheranostic applications. Here, we report the first successful pretargeted PET imaging of

Pretargeting of internalizing trastuzumab and cetuximab with a .

EJNMMI research

Keinänen O, Fung K, Pourat J, Jallinoja V, Vivier D, Pillarsetty NK, Airaksinen AJ, Lewis JS, Zeglis BM, Sarparanta M.
PMID: 29198065
EJNMMI Res. 2017 Dec 02;7(1):95. doi: 10.1186/s13550-017-0344-6.

BACKGROUND: Pretargeting-based approaches are being investigated for radioimmunoimaging and therapy applications to reduce the effective radiation burden to the patient. To date, only a few studies have used short-lived radioisotopes for pretargeting of antibodies, and such examples with internalizing...

Is It Possible to Predict the Future in First-Episode Psychosis?.

Frontiers in psychiatry

Suvisaari J, Mantere O, Keinänen J, Mäntylä T, Rikandi E, Lindgren M, Kieseppä T, Raij TT.
PMID: 30483163
Front Psychiatry. 2018 Nov 13;9:580. doi: 10.3389/fpsyt.2018.00580. eCollection 2018.

The outcome of first-episode psychosis (FEP) is highly variable, ranging from early sustained recovery to antipsychotic treatment resistance from the onset of illness. For clinicians, a possibility to predict patient outcomes would be highly valuable for the selection of...

Analysis of magnetic dipole transitions between sd-shell states.

Physical review. C, Nuclear physics

Brown BA, Etchegoyen MC, Etchegoyen A, Keinonen J, Wildenthal BH.
PMID: 9954941
Phys Rev C Nucl Phys. 1988 Sep;38(3):1382-1391. doi: 10.1103/physrevc.38.1382.

No abstract available.

Cost of providing cell-free DNA screening for Down syndrome in Finland using different strategies.

Journal of perinatal medicine

Cuckle H, Heinonen S, Anttonen AK, Stefanovic V.
PMID: 34860478
J Perinat Med. 2021 Dec 03; doi: 10.1515/jpm-2021-0467. Epub 2021 Dec 03.

INTRODUCTION: A financial analysis is carried out to assess costs and benefits of providing cell-free DNA screening in Finland, using different strategies.MATERIALS AND METHODS: Three cell-free DNA screening strategies are considered: Primary, all women; Secondary, those with positive Combined...

How to Validate Data Quality in a Trauma Registry? The Helsinki Trauma Registry Internal Audit.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

Heinänen M, Brinck T, Lefering R, Handolin L, Söderlund T.
PMID: 31694457
Scand J Surg. 2021 Jun;110(2):199-207. doi: 10.1177/1457496919883961. Epub 2019 Nov 06.

BACKGROUND AND AIMS: Trauma registry data are used for analyzing and improving patient care, comparison of different units, and for research and administrative purposes. Data should therefore be reliable. The aim of this study was to audit the quality...

The incidence of iatrogenic deaths in the Finnish cause-of-death statistics; a retrospective study.

Journal of forensic and legal medicine

Kuvaja P, Keinänen N, Pakanen L.
PMID: 34999300
J Forensic Leg Med. 2022 Jan 04;86:102302. doi: 10.1016/j.jflm.2021.102302. Epub 2022 Jan 04.

PURPOSE: An adverse event in health care leading to death is a significant event when assessing patient safety. This study was designed in order to assess, how many iatrogenic deaths are registered in Finland annually, and what type of...

Maternal and neonatal outcomes in the following delivery after previous preterm caesarean breech birth: a national cohort study.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

Toijonen A, Hinnenberg P, Gissler M, Heinonen S, Macharey G.
PMID: 33938353
J Obstet Gynaecol. 2022 Jan;42(1):49-54. doi: 10.1080/01443615.2021.1871888. Epub 2021 May 02.

The objective of this retrospective, nationwide Finnish population-based cohort study was to determine whether there is an association between preterm caesarean breech delivery in the first pregnancy and maternal and neonatal morbidity in the subsequent pregnancy and delivery. We...

The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites.

Nature metabolism

Bean C, Audano M, Varanita T, Favaretto F, Medaglia M, Gerdol M, Pernas L, Stasi F, Giacomello M, Herkenne S, Muniandy M, Heinonen S, Cazaly E, Ollikainen M, Milan G, Pallavicini A, Pietiläinen KH, Vettor R, Mitro N, Scorrano L.
PMID: 34873337
Nat Metab. 2021 Dec 06; doi: 10.1038/s42255-021-00497-2. Epub 2021 Dec 06.

White to brown/beige adipocytes conversion is a possible therapeutic strategy to tackle the current obesity epidemics. While mitochondria are key for energy dissipation in brown fat, it is unknown if they can drive adipocyte browning. Here, we show that...

Need for maternal critical care in obstetrics: a population-based analysis.

International journal of obstetric anesthesia

Heinonen S, Tyrväinen E, Saarikoski S, Ruokonen E.
PMID: 15321532
Int J Obstet Anesth. 2002 Oct;11(4):260-4. doi: 10.1054/ijoa.2002.0985.

The purpose of this study was to note potential obstetric risk factors leading to maternal intensive care and to estimate the frequency, costs and outcomes of management. In a cross-sectional study of intensive care admissions in Kuopio from March...

Birch PR-10c is induced by factors causing oxidative stress but appears not to confer tolerance to these agents.

The New phytologist

Koistinen KM, Hassinen VH, Gynther PAM, Lehesranta SJ, Keinänen SI, Kokko HI, Oksanen EJ, Tervahauta AI, Auriola S, Kärenlampi SO.
PMID: 33873308
New Phytol. 2002 Sep;155(3):381-391. doi: 10.1046/j.1469-8137.2002.00481.x.

•  Expression of all known and newly found pathogenesis-related PR-10 proteins (PR-10a, b, c, d, e) was analysed from Cu-sensitive and -tolerant birch clones to find out whether they follow the same expression pattern. The relationship of PR-10 proteins,...

Showing 13 to 24 of 134 entries