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Showing 157 to 165 of 165 entries
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Structure-based classification of EGFR mutations informs inhibitor selection for lung cancer therapy.

Cancer cell

Yenerall P, Kittler R, Minna J.
PMID: 34752753
Cancer Cell. 2021 Nov 08;39(11):1455-1457. doi: 10.1016/j.ccell.2021.10.012. Epub 2021 Nov 08.

EGFR oncogenic mutations predict sensitivity to EGFR inhibitors in NSCLC, but less is known about EGFR "variants of unknown significance." Using preclinical models, 3D structure analyses, and patient response data, Robichaux et al. show in Nature that mutations in...

Author Correction: A patient-centric dataset of images and metadata for identifying melanomas using clinical context.

Scientific data

Rotemberg V, Kurtansky N, Betz-Stablein B, Caffery L, Chousakos E, Codella N, Combalia M, Dusza S, Guitera P, Gutman D, Halpern A, Helba B, Kittler H, Kose K, Langer S, Lioprys K, Malvehy J, Musthaq S, Nanda J, Reiter O, Shih G, Stratigos A, Tschandl P, Weber J, Soyer HP.
PMID: 33674616
Sci Data. 2021 Mar 05;8(1):81. doi: 10.1038/s41597-021-00865-3.

No abstract available.

Characteristics of 637 melanomas documented by 27 general practitioners on the Skin Cancer Audit Research Database.

The Australasian journal of dermatology

Jimenez Balcells C, Hay J, Keir J, Rosendahl N, Coetzer-Botha M, Wilson T, Clark S, Baade A, Becker C, Bookallil L, Clifopoulos C, Dicker T, Denby MP, Duthie D, Elliott C, Fishburn P, Foley M, Franck M, Giam I, Gordillo P, Lilleyman A, Macauley R, Maher J, McPhee E, Reid M, Shirlaw B, Siggs G, Spark R, Stretch J, van den Heever K, van Rensburg T, Watson C, Kittler H, Rosendahl C.
PMID: 34423846
Australas J Dermatol. 2021 Nov;62(4):496-503. doi: 10.1111/ajd.13705. Epub 2021 Aug 23.

BACKGROUND AND OBJECTIVE: Most melanomas (including melanomas in situ), in Australasia, are treated by general practitioners (GPs). Previously undescribed, the characteristics of a series of melanomas treated by multiple GPs are examined.PATIENTS AND METHODS: Six hundred and thirty-seven melanomas...

Repetitive Fed-Batch: A Promising Process Mode for Biomanufacturing With .

Frontiers in bioengineering and biotechnology

Kopp J, Kittler S, Slouka C, Herwig C, Spadiut O, Wurm DJ.
PMID: 33240864
Front Bioeng Biotechnol. 2020 Nov 10;8:573607. doi: 10.3389/fbioe.2020.573607. eCollection 2020.

Recombinant protein production with

Relaxed Block-Diagonal Dictionary Pair Learning With Locality Constraint for Image Recognition.

IEEE transactions on neural networks and learning systems

Chen Z, Wu XJ, Kittler J.
PMID: 33764879
IEEE Trans Neural Netw Learn Syst. 2021 Mar 25; doi: 10.1109/TNNLS.2021.3053941. Epub 2021 Mar 25.

We propose a novel structured analysis-synthesis dictionary pair learning method for efficient representation and image classification, referred to as relaxed block-diagonal dictionary pair learning with a locality constraint (RBD-DPL). RBD-DPL aims to learn relaxed block-diagonal representations of the input...

Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER.

Clinical cancer research : an official journal of the American Association for Cancer Research

Servetto A, Kollipara R, Formisano L, Lin CC, Lee KM, Sudhan DR, Gonzalez-Ericsson PI, Chatterjee S, Guerrero-Zotano A, Mendiratta S, Akamatsu H, James N, Bianco R, Hanker AB, Kittler R, Arteaga CL.
PMID: 34011560
Clin Cancer Res. 2021 Aug 01;27(15):4379-4396. doi: 10.1158/1078-0432.CCR-20-3905. Epub 2021 May 19.

PURPOSE: FGFR1 overexpression has been associated with endocrine resistance in EREXPERIMENTAL DESIGN: Tumors from patients treated with letrozole were subjected to Ki67 and FGFR1 IHC. MCF7 cells were transduced with FGFR1(SP-)(NLS) to promote nuclear FGFR1 overexpression. FGFR1 genomic activity...

Publisher Correction: Author Correction: A patient-centric dataset of images and metadata for identifying melanomas using clinical context.

Scientific data

Rotemberg V, Kurtansky N, Betz-Stablein B, Caffery L, Chousakos E, Codella N, Combalia M, Dusza S, Guitera P, Gutman D, Halpern A, Helba B, Kittler H, Kose K, Langer S, Lioprys K, Malvehy J, Musthaq S, Nanda J, Reiter O, Shih G, Stratigos A, Tschandl P, Weber J, Soyer HP.
PMID: 33727560
Sci Data. 2021 Mar 16;8(1):88. doi: 10.1038/s41597-021-00879-x.

No abstract available.

Resveratrol Alleviates Acute .

Microorganisms

Heimesaat MM, Mousavi S, Escher U, Lobo de Sá FD, Peh E, Schulzke JD, Kittler S, Bücker R, Bereswill S.
PMID: 33255723
Microorganisms. 2020 Nov 25;8(12). doi: 10.3390/microorganisms8121858.

The polyphenolic compound resveratrol has been shown to exert health-beneficial properties. Given globally emerging

Lentiviral-Driven Discovery of Cancer Drug Resistance Mutations.

Cancer research

Yenerall P, Kollipara RK, Avila K, Peyton M, Eide CA, Bottomly D, McWeeney SK, Liu Y, Westover KD, Druker BJ, Minna JD, Kittler R.
PMID: 34301758
Cancer Res. 2021 Sep 15;81(18):4685-4695. doi: 10.1158/0008-5472.CAN-21-1153. Epub 2021 Jul 23.

Identifying resistance mutations in a drug target provides crucial information. Lentiviral transduction creates multiple types of mutations due to the error-prone nature of the HIV-1 reverse transcriptase (RT). Here we optimized and leveraged this property to identify drug resistance...

Showing 157 to 165 of 165 entries