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Showing 25 to 36 of 163 entries
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Identification of neutralising pembrolizumab anti-drug antibodies in patients with melanoma.

Scientific reports

Sasson SC, Wilkins LE, Watson RA, Jolly C, Brain O, Klenerman P, Olsson-Brown A, Fairfax BP.
PMID: 34584157
Sci Rep. 2021 Sep 28;11(1):19253. doi: 10.1038/s41598-021-98700-7.

Development of anti-drug antibodies (ADAs) can interfere with therapeutic monoclonal antibodies and may lead to drug neutralisation and clinical disease progression. Measurement of circulating drug levels and development of ADAs in the setting of anti-programmed cell death-1 agent pembrolizumab...

Defining T Cell Subsets in Human Tonsils Using ChipCytometry.

Journal of immunology (Baltimore, Md. : 1950)

Hagel JP, Bennett K, Buffa F, Klenerman P, Willberg CB, Powell K.
PMID: 34099545
J Immunol. 2021 Jun 15;206(12):3073-3082. doi: 10.4049/jimmunol.2100063. Epub 2021 Jun 07.

ChipCytometry is a multiplex imaging method that can be used to analyze either cell suspensions or tissue sections. Images are acquired by iterative cycles of immunostaining with fluorescently labeled Abs, followed by photobleaching, which allows the accumulation of multiple...

Risk of Reactivation of Hepatitis B Virus (HBV) and Tuberculosis (TB) and Complications of Hepatitis C Virus (HCV) Following Tocilizumab Therapy: A Systematic Review to Inform Risk Assessment in the COVID-19 Era.

Frontiers in medicine

Campbell C, Andersson MI, Ansari MA, Moswela O, Misbah SA, Klenerman P, Matthews PC.
PMID: 34490299
Front Med (Lausanne). 2021 Aug 20;8:706482. doi: 10.3389/fmed.2021.706482. eCollection 2021.

No abstract available.

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.

Brain communications

Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, Selkoe DJ, Bartels T.
PMID: 32280944
Brain Commun. 2020;2(1):fcaa010. doi: 10.1093/braincomms/fcaa010. Epub 2020 Feb 11.

Since researchers identified α-synuclein as the principal component of Lewy bodies and Lewy neurites, studies have suggested that it plays a causative role in the pathogenesis of dementia with Lewy bodies and other 'synucleinopathies'. While α-synuclein dyshomeostasis likely contributes...

Distribution of the heavy metals Co, Cu, and Pb in sediments and Typha spp. And Phragmites mauritianus in three Zambian wetlands.

Journal of environmental management

Nabuyanda MM, Kelderman P, van Bruggen J, Irvine K.
PMID: 34864515
J Environ Manage. 2021 Dec 02;304:114133. doi: 10.1016/j.jenvman.2021.114133. Epub 2021 Dec 02.

Zambia has been mining cobalt (Co), copper (Cu), and lead (Pb) for over a century, with discharges entering wetlands without investigations on the level of sediment pollution and how to solve it. This present study investigated: 1) the extent...

Adenovirus vectors activate Vδ2.

European journal of immunology

Provine NM, Amini A, Garner LC, FitzPatrick MEB, Dold C, Reyes LS, Chinnakannan S, Oguti B, Raymond M, Troise F, Capone S, Folgori A, Barnes E, Rollier CS, Pollard AJ, Klenerman P.
PMID: 34958459
Eur J Immunol. 2021 Dec 27; doi: 10.1002/eji.202149367. Epub 2021 Dec 27.

No abstract available.

Defining T Cell Subsets in Human Tonsils Using ChipCytometry.

Journal of immunology (Baltimore, Md. : 1950)

Hagel JP, Bennett K, Buffa F, Klenerman P, Willberg CB, Powell K.
PMID: 34099545
J Immunol. 2021 Jun 15;206(12):3073-3082. doi: 10.4049/jimmunol.2100063. Epub 2021 Jun 07.

ChipCytometry is a multiplex imaging method that can be used to analyze either cell suspensions or tissue sections. Images are acquired by iterative cycles of immunostaining with fluorescently labeled Abs, followed by photobleaching, which allows the accumulation of multiple...

Distribution of the heavy metals Co, Cu, and Pb in sediments and Typha spp. And Phragmites mauritianus in three Zambian wetlands.

Journal of environmental management

Nabuyanda MM, Kelderman P, van Bruggen J, Irvine K.
PMID: 34864515
J Environ Manage. 2021 Dec 02;304:114133. doi: 10.1016/j.jenvman.2021.114133. Epub 2021 Dec 02.

Zambia has been mining cobalt (Co), copper (Cu), and lead (Pb) for over a century, with discharges entering wetlands without investigations on the level of sediment pollution and how to solve it. This present study investigated: 1) the extent...

T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study.

The Lancet. Microbe

Angyal A, Longet S, Moore SC, Payne RP, Harding A, Tipton T, Rongkard P, Ali M, Hering LM, Meardon N, Austin J, Brown R, Skelly D, Gillson N, Dobson SL, Cross A, Sandhar G, Kilby JA, Tyerman JK, Nicols AR, Spegarova JS, Mehta H, Hornsby H, Whitham R, Conlon CP, Jeffery K, Goulder P, Frater J, Dold C, Pace M, Ogbe A, Brown H, Ansari MA, Adland E, Brown A, Chand M, Shields A, Matthews PC, Hopkins S, Hall V, James W, Rowland-Jones SL, Klenerman P, Dunachie S, Richter A, Duncan CJA, Barnes E, Carroll M, Turtle L, de Silva TI.
PMID: 34778853
Lancet Microbe. 2022 Jan;3(1):e21-e31. doi: 10.1016/S2666-5247(21)00275-5. Epub 2021 Nov 09.

BACKGROUND: Previous infection with SARS-CoV-2 affects the immune response to the first dose of the SARS-CoV-2 vaccine. We aimed to compare SARS-CoV-2-specific T-cell and antibody responses in health-care workers with and without previous SARS-CoV-2 infection following a single dose...

Human MAIT cells respond to and suppress HIV-1.

eLife

Phetsouphanh C, Phalora P, Hackstein CP, Thornhill J, Munier CML, Meyerowitz J, Murray L, VanVuuren C, Goedhals D, Drexhage L, Moore R, Sattentau QJ, Mak JY, Fairlie DP, Fidler S, Kelleher AD, Frater J, Klenerman P.
PMID: 34951583
Elife. 2021 Dec 24;10. doi: 10.7554/eLife.50324.

Human MAIT cells sit at the interface between innate and adaptive immunity, are polyfunctional and are capable of killing pathogen infected cells via recognition of the Class IB molecule MR1. MAIT cells have recently been shown to possess an...

Mucosal-associated invariant T-cells: new players in anti-bacterial immunity.

Frontiers in immunology

Ussher JE, Klenerman P, Willberg CB.
PMID: 25339949
Front Immunol. 2014 Oct 08;5:450. doi: 10.3389/fimmu.2014.00450. eCollection 2014.

Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population involved in anti-bacterial immunity. In human beings, MAIT cells are abundant, comprising ~10% of the CD8(+) T-cell compartment in blood. They are enriched at mucosal sites and are particularly...

The adaptation of the foot to heavy loads: plantar foot pressures study.

Clinical biomechanics (Bristol, Avon)

Nyska M, Linge K, McCabe C, Klenerman L.
PMID: 11415706
Clin Biomech (Bristol, Avon). 1997 Apr;12(3):S8. doi: 10.1016/s0268-0033(97)88317-9.

INTRODUCTION:: The foot serves as the main shock absorber during various activities as walking running and jumping. There are static and dynamic mechanisms which play a role in the adaptation of the foot to weight bearing walking with weights....

Showing 25 to 36 of 163 entries