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Showing 325 to 333 of 333 entries
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Factors associated with attendance at screening for breast cancer: a systematic review and meta-analysis.

BMJ open

Mottram R, Knerr WL, Gallacher D, Fraser H, Al-Khudairy L, Ayorinde A, Williamson S, Nduka C, Uthman OA, Johnson S, Tsertsvadze A, Stinton C, Taylor-Phillips S, Clarke A.
PMID: 34848507
BMJ Open. 2021 Nov 30;11(11):e046660. doi: 10.1136/bmjopen-2020-046660.

OBJECTIVE: Attendance at population-based breast cancer (mammographic) screening varies. This comprehensive systematic review and meta-analysis assesses all identified patient-level factors associated with routine population breast screening attendance.DESIGN: CINAHL, Cochrane Library, Embase, Medline, OVID, PsycINFO and Web of Science were...

Immune Checkpoint Blockade for Metastatic Uveal Melanoma: Patterns of Response and Survival According to the Presence of Hepatic and Extrahepatic Metastasis.

Cancers

Koch EAT, Petzold A, Wessely A, Dippel E, Gesierich A, Gutzmer R, Hassel JC, Haferkamp S, Hohberger B, Kähler KC, Knorr H, Kreuzberg N, Leiter U, Loquai C, Meier F, Meissner M, Mohr P, Pföhler C, Rahimi F, Schadendorf D, Schell B, Schlaak M, Terheyden P, Thoms KM, Schuler-Thurner B, Ugurel S, Ulrich J, Utikal J, Weichenthal M, Ziller F, Berking C, Heppt MV, On Behalf Of The German Dermatologic Cooperative Oncology Group DeCOG Committee Ocular Melanoma.
PMID: 34283061
Cancers (Basel). 2021 Jul 04;13(13). doi: 10.3390/cancers13133359.

BACKGROUND: Since there is no standardized and effective treatment for advanced uveal melanoma (UM), the prognosis is dismal once metastases develop. Due to the availability of immune checkpoint blockade (ICB) in the real-world setting, the prognosis of metastatic UM...

Influence of Interfacial Bonding on the Mechanical and Impact Properties Ring-Opening Metathesis Polymer (ROMP) Silica Composites.

ACS applied materials & interfaces

Tran NT, Patterson BA, Harris DE, Napadensky E, Lenhart JL, Knorr DB, Bain ED.
PMID: 33190488
ACS Appl Mater Interfaces. 2020 Nov 25;12(47):53342-53355. doi: 10.1021/acsami.0c16280. Epub 2020 Nov 15.

Polymers formed by ring-opening metathesis polymerization (ROMP) such as poly(dicyclopentadiene) (pDCPD) exhibit a technologically desirable combination of high toughness, high glass transition temperature, and outstanding low-temperature performance. However, because of their nonpolar molecular structure, they tend to suffer from...

Pyroptosis in Steatohepatitis and Liver Diseases.

Journal of molecular biology

Knorr J, Wree A, Feldstein AE.
PMID: 34592216
J Mol Biol. 2021 Sep 27;167271. doi: 10.1016/j.jmb.2021.167271. Epub 2021 Sep 27.

Pyroptosis is an inflammatory form of regulated cell death, which functions in the clearance of intracellularly replicating pathogens by cell lysis in order to induce further immune response. Since the discovery of the gasdermin (GSDM) family, pyroptosis has attracted...

Activity and Adverse Events of Actinium-225-PSMA-617 in Advanced Metastatic Castration-resistant Prostate Cancer After Failure of Lutetium-177-PSMA.

European urology

Feuerecker B, Tauber R, Knorr K, Heck M, Beheshti A, Seidl C, Bruchertseifer F, Pickhard A, Gafita A, Kratochwil C, Retz M, Gschwend JE, Weber WA, D'Alessandria C, Morgenstern A, Eiber M.
PMID: 33293081
Eur Urol. 2021 Mar;79(3):343-350. doi: 10.1016/j.eururo.2020.11.013. Epub 2020 Dec 05.

BACKGROUND: Beta-emitting Lu-177-labeled prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) is a new option for metastatic castration-resistant prostate cancer (mCRPC), but its antitumor effect can decrease over time.OBJECTIVE: To report the safety and activity of alpha-emitting Ac-225-PSMA-617 RLT in...

Antarctic icebergs reorganize ocean circulation during Pleistocene glacials.

Nature

Starr A, Hall IR, Barker S, Rackow T, Zhang X, Hemming SR, van der Lubbe HJL, Knorr G, Berke MA, Bigg GR, Cartagena-Sierra A, Jiménez-Espejo FJ, Gong X, Gruetzner J, Lathika N, LeVay LJ, Robinson RS, Ziegler M.
PMID: 33442043
Nature. 2021 Jan;589(7841):236-241. doi: 10.1038/s41586-020-03094-7. Epub 2021 Jan 13.

The dominant feature of large-scale mass transfer in the modern ocean is the Atlantic meridional overturning circulation (AMOC). The geometry and vigour of this circulation influences global climate on various timescales. Palaeoceanographic evidence suggests that during glacial periods of...

Impact of Removing the Race Coefficient in Renal Function Estimate Equations on Drug Dosage Recommendations.

The Annals of pharmacotherapy

Miller J, Knorr JP.
PMID: 33866823
Ann Pharmacother. 2022 Jan;56(1):44-51. doi: 10.1177/10600280211010228. Epub 2021 Apr 17.

BACKGROUND: The appropriateness of including the race coefficient in glomerular filtration rate (GFR) equations in Black patients is debated, and the impact on drug dosing is unknown.OBJECTIVE: This study explored the impact of removing the race coefficient on drug...

Alzheimer's Disease: Efficacy of Mono- and Combination Therapy. A Systematic Review.

Journal of geriatric psychiatry and neurology

Knorz AL, Quante A.
PMID: 34476990
J Geriatr Psychiatry Neurol. 2021 Sep 03;8919887211044746. doi: 10.1177/08919887211044746. Epub 2021 Sep 03.

IMPORTANCE: Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most prevalent cause of dementia. In spite of the urgent need for more effective AD drug therapy strategies, evidence of the efficacy of combination therapy with existing drugs...

Efficacy and safety of fevipiprant in patients with uncontrolled asthma: Two replicate, phase 3, randomised, double-blind, placebo-controlled trials (ZEAL-1 and ZEAL-2).

EClinicalMedicine

Castro M, Kerwin E, Miller D, Pedinoff A, Sher L, Cardenas P, Knorr B, Lawrence D, Ossa D, Wang W, Maspero JF.
PMID: 33997741
EClinicalMedicine. 2021 Apr 25;35:100847. doi: 10.1016/j.eclinm.2021.100847. eCollection 2021 May.

BACKGROUND: These studies assessed the efficacy and safety of fevipiprant, an oral antagonist of the prostaglandin DMETHODS: ZEAL-1 (NCT03215758) and ZEAL-2 (NCT03226392) are two replicate, phase 3, multicentre, randomised, double-blind, placebo-controlled, parallel-group studies in which fevipiprant 150 mg once...

Showing 325 to 333 of 333 entries