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Showing 241 to 251 of 251 entries
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Clinical Features of Familial Hypercholesterolemia in Children and Adults in EAS-FHSC Regional Center for Rare Diseases in Poland.

Journal of clinical medicine

Lewek J, Konopka A, Starostecka E, Penson PE, Maciejewski M, Banach M.
PMID: 34640319
J Clin Med. 2021 Sep 22;10(19). doi: 10.3390/jcm10194302.

BACKGROUND: Familial hypercholesterolemia (FH) is a genetic autosomal co-dominant metabolic disorder leading to elevated circulating concentrations of low-density lipoprotein cholesterol (LDL-C). Early development of atherosclerotic cardiovascular disease (ASCVD) is common in affected patients. We aimed to evaluate the characteristics...

Metabolomic Profile of Skeletal Muscle and Its Change Under a Mixed-Mode Exercise Intervention in Progressively Dysglycemic Subjects.

Frontiers in endocrinology

Szczerbinski L, Golonko A, Taylor M, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Gorska M, Zabielski P, Błachnio-Zabielska A, Larsen S, Kretowski A.
PMID: 34938272
Front Endocrinol (Lausanne). 2021 Dec 06;12:778442. doi: 10.3389/fendo.2021.778442. eCollection 2021.

Skeletal muscles play an essential role in whole-body glucose homeostasis. They are a key organ system engaged in the development of insulin resistance, and also a crucial tissue mediating the beneficial metabolic effects of physical activity. However, molecular mechanisms...

NIR-emitting styryl dyes with large Stokes' shifts for imaging application: From cellular plasma membrane, mitochondria to Zebrafish neuromast.

Dyes and pigments : an international journal

Dahal D, Ojha KR, Pokhrel S, Paruchuri S, Konopka M, Liu Q, Pang Y.
PMID: 34366501
Dyes Pigm. 2021 Oct;194. doi: 10.1016/j.dyepig.2021.109629. Epub 2021 Jul 06.

Near-infrared (NIR) emitting probes with very large Stokes' shifts play a crucial role in bioimaging applications, as the optical signals in this region exhibit high signal to background ratio and allow deeper tissue penetration. Herein we illustrate NIR-emitting probe

Eotaxins and Their Receptor as Biomarkers of Colorectal Cancer.

Journal of clinical medicine

Zajkowska M, Kulczyńska-Przybik A, Dulewicz M, Safiejko K, Juchimiuk M, Konopko M, Kozłowski L, Mroczko B.
PMID: 34204490
J Clin Med. 2021 Jun 17;10(12). doi: 10.3390/jcm10122675.

Colorectal cancer (CRC) is one of the most common malignancies. Despite the availability of diagnostic tests, an increasing number of new cases is observed. That is why it is very important to search new markers that would show high...

The Sur7 cytoplasmic C terminus regulates morphogenesis and stress responses in Candida albicans.

Molecular microbiology

Lanze CE, Zhou S, Konopka JB.
PMID: 34465004
Mol Microbiol. 2021 Oct;116(4):1201-1215. doi: 10.1111/mmi.14806. Epub 2021 Sep 15.

MCC/eisosome subdomains of the plasma membrane promote proper cell wall morphogenesis that is critical for the fungal pathogen Candida albicans to grow invasively and resist stressful environments in the host. Sur7 localizes to MCC/eisosomes and is needed for their...

The Use of Carbon Substrate Utilization Patterns in Environmental and Ecological Microbiology.

Microbial ecology

Konopka A, Oliver L, Turco RF.
PMID: 9541547
Microb Ecol. 1998 Mar;35(2):103-15. doi: 10.1007/s002489900065.

No abstract available.

Modeling Interaction and Dispersion Effects in the Analysis of Gene-by-Environment Interaction.

Behavior genetics

Domingue BW, Kanopka K, Mallard TT, Trejo S, Tucker-Drob EM.
PMID: 34855050
Behav Genet. 2021 Dec 02; doi: 10.1007/s10519-021-10090-8. Epub 2021 Dec 02.

Genotype-by-environment interaction (GxE) studies probe heterogeneity in response to risk factors or interventions. Popular methods for estimation of GxE examine multiplicative interactions between individual genetic and environmental measures. However, risk factors and interventions may modulate the total variance of...

Expanding structural diversity in a library of disulfide macrocycles through in-situ imide hydrolysis.

Scientific reports

Konopka M, Stefankiewicz AR.
PMID: 34997018
Sci Rep. 2022 Jan 07;12(1):38. doi: 10.1038/s41598-021-03944-y.

We describe here an unorthodox approach to dynamic covalent chemistry in which the initially-unexpected in-situ hydrolysis of a bis-imide is employed to control the composition of a library of structurally diverse macrocycles. A single building block is used to...

Expanding structural diversity in a library of disulfide macrocycles through in-situ imide hydrolysis.

Scientific reports

Konopka M, Stefankiewicz AR.
PMID: 34997018
Sci Rep. 2022 Jan 07;12(1):38. doi: 10.1038/s41598-021-03944-y.

We describe here an unorthodox approach to dynamic covalent chemistry in which the initially-unexpected in-situ hydrolysis of a bis-imide is employed to control the composition of a library of structurally diverse macrocycles. A single building block is used to...

A Comparison of Clinical Efficiency of Photodynamic Therapy and Topical Corticosteroid in Treatment of Oral Lichen Planus: A Split-Mouth Randomised Controlled Study.

Journal of clinical medicine

Zborowski J, Kida D, Szarwaryn A, Nartowski K, Rak P, Jurczyszyn K, Konopka T.
PMID: 34441967
J Clin Med. 2021 Aug 19;10(16). doi: 10.3390/jcm10163673.

BACKGROUND: The aim of the study was to compare the effectiveness of photodynamic therapy (PDT) to steroid therapy in the treatment of oral lichen planus (OLP). Due to the lack of commercially available drug carriers, innovative proprietary solutions were...

Clinical Correlates of the NR3C1 Gene Methylation at Various Stages of Psychosis.

The international journal of neuropsychopharmacology

Misiak B, Samochowiec J, Konopka A, Gawrońska-Szklarz B, Beszłej JA, Szmida E, Karpiński P.
PMID: 33284958
Int J Neuropsychopharmacol. 2021 Apr 21;24(4):322-332. doi: 10.1093/ijnp/pyaa094.

BACKGROUND: Dysregulation of epigenetic processes might account for alterations of the hypothalamic-pituitary-adrenal axis observed in patients with schizophrenia. Therefore, in this study, we aimed to investigate methylation of the glucocorticoid receptor (NR3C1) gene in patients with schizophrenia-spectrum disorders, individuals...

Showing 241 to 251 of 251 entries