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Showing 25 to 36 of 210 entries
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Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity.

Molecular psychiatry

Wang XL, Kooijman S, Gao Y, Tzeplaeff L, Cosquer B, Milanova I, Wolff SEC, Korpel N, Champy MF, Petit-Demoulière B, Goncalves Da Cruz I, Sorg-Guss T, Rensen PCN, Cassel JC, Kalsbeek A, Boutillier AL, Yi CX.
PMID: 34050326
Mol Psychiatry. 2021 Nov;26(11):6336-6349. doi: 10.1038/s41380-021-01169-z. Epub 2021 May 28.

Microglia play a critical role in maintaining neural function. While microglial activity follows a circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially in stimulated conditions such as in the control of systemic...

Meta-Analysis Comparing Gender-Based Cardiovascular Outcomes of Transradial Versus Transfemoral Access of Percutaneous Coronary Intervention.

The American journal of cardiology

Sattar Y, Song D, Kompella R, Arshad J, Zghouzi M, Mir T, Ullah W, Elgendy IY, Alraies MC.
PMID: 34903346
Am J Cardiol. 2022 Jan 01;162:49-57. doi: 10.1016/j.amjcard.2021.08.059.

Transradial (TR) access for percutaneous coronary intervention (PCI) improves outcomes and reduces the risk of major bleeding compared with transfemoral (TF) access. However, data on gender-stratified outcomes based on vascular access are limited. Databases were queried to find relevant...

Design and Performance of the ICON EUV Spectrograph.

Space science reviews

Sirk MM, Korpela EJ, Ishikawa Y, Edelstein J, Wishnow EH, Smith C, McCauley J, McPhate JB, Curtis J, Curtis T, Gibson SR, Jelinsky S, Lynn JA, Marckwordt M, Miller N, Raffanti M, Van Shourt W, Stephan AW, Immel TJ.
PMID: 33688106
Space Sci Rev. 2017 Oct;212:631-643. doi: 10.1007/s11214-017-0384-2. Epub 2017 Jul 20.

We present the design, implementation, and on-ground performance measurements of the Ionospheric Connection Explorer EUV spectrometer,

Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux.

Frontiers in oncology

Saha J, Kim JH, Amaya CN, Witcher C, Khammanivong A, Korpela DM, Brown DR, Taylor J, Bryan BA, Dickerson EB.
PMID: 33598432
Front Oncol. 2021 Feb 01;10:614288. doi: 10.3389/fonc.2020.614288. eCollection 2020.

Angiosarcoma is a rare cancer of blood vessel-forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance. We previously identified...

Proof of Concept of Novel Visuo-Spatial-Motor Fall Prevention Training for Old People.

Geriatrics (Basel, Switzerland)

Koppelaar H, Kordestani-Moghadam P, Kouhkani S, Irandoust F, Segers G, de Haas L, Bantje T, van Warmerdam M.
PMID: 34210015
Geriatrics (Basel). 2021 Jun 29;6(3). doi: 10.3390/geriatrics6030066.

Falls in the geriatric population are one of the most important causes of disabilities in this age group. Its consequences impose a great deal of economic burden on health and insurance systems. This study was conducted by a multidisciplinary...

Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity.

Molecular psychiatry

Wang XL, Kooijman S, Gao Y, Tzeplaeff L, Cosquer B, Milanova I, Wolff SEC, Korpel N, Champy MF, Petit-Demoulière B, Goncalves Da Cruz I, Sorg-Guss T, Rensen PCN, Cassel JC, Kalsbeek A, Boutillier AL, Yi CX.
PMID: 34050326
Mol Psychiatry. 2021 May 28; doi: 10.1038/s41380-021-01169-z. Epub 2021 May 28.

Microglia play a critical role in maintaining neural function. While microglial activity follows a circadian rhythm, it is not clear how this intrinsic clock relates to their function, especially in stimulated conditions such as in the control of systemic...

Diabetes Remission After Bariatric Surgery in Patients on Glucocorticoids: A Pilot Study.

Surgical laparoscopy, endoscopy & percutaneous techniques

Vahibe A, Livia C, Portela R, Shah M, McKenzie T, Kellogg T, Ghanem OM.
PMID: 34966151
Surg Laparosc Endosc Percutan Tech. 2021 Dec 29; doi: 10.1097/SLE.0000000000001028. Epub 2021 Dec 29.

BACKGROUND: Diabetes mellitus type 2 (DM2) remission after bariatric surgery has long been reported in the medical literature. Glucocorticoid use is associated with weight gain and could theoretically affect diabetes remission post bariatric surgery.OBJECTIVES: The aim is to identify...

Transitions from One Electronic Health Record to Another: Challenges, Pitfalls, and Recommendations.

Applied clinical informatics

Huang C, Koppel R, McGreevey JD, Craven CK, Schreiber R.
PMID: 33176389
Appl Clin Inform. 2020 Oct;11(5):742-754. doi: 10.1055/s-0040-1718535. Epub 2020 Nov 11.

OBJECTIVE: We address the challenges of transitioning from one electronic health record (EHR) to another-a near ubiquitous phenomenon in health care. We offer mitigating strategies to reduce unintended consequences, maximize patient safety, and enhance health care delivery.METHODS: We searched...

PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion.

Scientific reports

Tamargo A, Molinero N, Reinosa JJ, Alcolea-Rodriguez V, Portela R, Bañares MA, Fernández JF, Moreno-Arribas MV.
PMID: 35017590
Sci Rep. 2022 Jan 11;12(1):528. doi: 10.1038/s41598-021-04489-w.

Microplastics (MPs) are a widely recognized global problem due to their prevalence in natural environments and the food chain. However, the impact of microplastics on human microbiota and their possible biotransformation in the gastrointestinal tract have not been well...

Early Mobilization in the ICU: A Collaborative, Integrated Approach.

Critical care explorations

Linke CA, Chapman LB, Berger LJ, Kelly TL, Korpela CA, Petty MG.
PMID: 32426732
Crit Care Explor. 2020 Apr 29;2(4):e0090. doi: 10.1097/CCE.0000000000000090. eCollection 2020 Apr.

To develop and implement a protocol to increase patient mobility in three adult ICUs using an interdisciplinary approach and existing resources.DESIGN: The Iowa Model of Evidence-Based Practice was used for synthesis of literature and intervention planning. A retrospective pre-...

Citrate-Saline-Formulated mRNA Delivery into the Heart Muscle with an Electromechanical Mapping and Injection Catheter Does Not Lead to Therapeutic Effects in a Porcine Chronic Myocardial Ischemia Model.

Human gene therapy

Järveläinen N, Halonen P, Nurro J, Hätinen OP, Korpela H, Mäkinen P, Gan LM, Fritsche-Danielson R, Ylä-Herttuala S.
PMID: 34494459
Hum Gene Ther. 2021 Oct;32(19):1295-1307. doi: 10.1089/hum.2021.149.

Based on recent success in using modified RNA in clinical applications, we tested the safety, feasibility, and efficacy of direct delivery of citrate-saline-formulated mRNA into an hibernating ischemic heart muscle using an electromechanical mapping and injection catheter system (NOGA/Myostar)...

Comparison of Electrolyte Composition and Crystallization Patterns in Bird and Reptile Tears.

Frontiers in veterinary science

Oriá AP, Lacerda AJ, Raposo ACS, Araújo NLLC, Portela R, Mendonça MA, Masmali AM.
PMID: 32903625
Front Vet Sci. 2020 Aug 13;7:574. doi: 10.3389/fvets.2020.00574. eCollection 2020.

To compare tear electrolytes and tear crystallization patterns in birds and reptiles, tears were sampled by Schirmer tear test from 10 animals each of

Showing 25 to 36 of 210 entries