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Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies.

Neuro-oncology advances

Traunwieser T, Kandels D, Pauls F, Pietsch T, Warmuth-Metz M, Bison B, Krauss J, Kortmann RD, Timmermann B, Thomale UW, Luettich P, Neumann-Holbeck A, Tischler T, Hernáiz Driever P, Witt O, Gnekow AK.
PMID: 32968720
Neurooncol Adv. 2020 Aug 08;2(1):vdaa094. doi: 10.1093/noajnl/vdaa094. eCollection 2020.

BACKGROUND: Disease and treatment contribute to cognitive late effects following pediatric low-grade glioma (LGG). We analyzed prospectively collected neuropsychological data of German pediatric LGG survivors and focused on the impact of hydrocephalus at diagnosis, neurofibromatosis type 1 (NF1) status,...

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Traunwieser T, Kandels D, Pauls F, et al. Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies. Neurooncol Adv. 2020;2(1):vdaa094doi: 10.1093/noajnl/vdaa094.
Traunwieser, T., Kandels, D., Pauls, F., Pietsch, T., Warmuth-Metz, M., Bison, B., Krauss, J., Kortmann, R. D., Timmermann, B., Thomale, U. W., Luettich, P., Neumann-Holbeck, A., Tischler, T., Hernáiz Driever, P., Witt, O., & Gnekow, A. K. (2020). Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies. Neuro-oncology advances, 2(1), vdaa094. https://doi.org/10.1093/noajnl/vdaa094
Traunwieser, Thomas, et al. "Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies." Neuro-oncology advances vol. 2,1 (2020): vdaa094. doi: https://doi.org/10.1093/noajnl/vdaa094
Traunwieser T, Kandels D, Pauls F, Pietsch T, Warmuth-Metz M, Bison B, Krauss J, Kortmann RD, Timmermann B, Thomale UW, Luettich P, Neumann-Holbeck A, Tischler T, Hernáiz Driever P, Witt O, Gnekow AK. Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies. Neurooncol Adv. 2020 Aug 08;2(1):vdaa094. doi: 10.1093/noajnl/vdaa094. eCollection 2020. PMID: 32968720; PMCID: PMC7497816.
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Adjuvant Therapy with Budesonide Post-Kasai Reduces the Need for Liver Transplantation in Biliary Atresia.

Journal of clinical medicine

Kuebler JF, Madadi-Sanjani O, Pfister ED, Baumann U, Fortmann D, Leonhardt J, Ure BM, Manns MP, Taubert R, Petersen C.
PMID: 34945055
J Clin Med. 2021 Dec 09;10(24). doi: 10.3390/jcm10245758.

Based on the hypothesis that autoimmunological factors coregulate the pathomechanism in biliary atresia (BA), adjuvant therapy with steroids has become routine, although its efficacy has never been proven. In 2010, a study on the advantages of budesonide compared to...

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Kuebler JF, Madadi-Sanjani O, Pfister ED, et al. Adjuvant Therapy with Budesonide Post-Kasai Reduces the Need for Liver Transplantation in Biliary Atresia. J Clin Med. 2021;10(24)doi: 10.3390/jcm10245758.
Kuebler, J. F., Madadi-Sanjani, O., Pfister, E. D., Baumann, U., Fortmann, D., Leonhardt, J., Ure, B. M., Manns, M. P., Taubert, R., & Petersen, C. (2021). Adjuvant Therapy with Budesonide Post-Kasai Reduces the Need for Liver Transplantation in Biliary Atresia. Journal of clinical medicine, 10(24), . https://doi.org/10.3390/jcm10245758
Kuebler, Joachim F, et al. "Adjuvant Therapy with Budesonide Post-Kasai Reduces the Need for Liver Transplantation in Biliary Atresia." Journal of clinical medicine vol. 10,24 (2021). doi: https://doi.org/10.3390/jcm10245758
Kuebler JF, Madadi-Sanjani O, Pfister ED, Baumann U, Fortmann D, Leonhardt J, Ure BM, Manns MP, Taubert R, Petersen C. Adjuvant Therapy with Budesonide Post-Kasai Reduces the Need for Liver Transplantation in Biliary Atresia. J Clin Med. 2021 Dec 09;10(24). doi: 10.3390/jcm10245758. PMID: 34945055.
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Is There an Indication for First Line Radiotherapy in Primary CNS Lymphoma?.

Cancers

Seidel C, Viehweger C, Kortmann RD.
PMID: 34070309
Cancers (Basel). 2021 May 25;13(11). doi: 10.3390/cancers13112580.

No abstract available.

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Seidel C, Viehweger C, Kortmann RD. Is There an Indication for First Line Radiotherapy in Primary CNS Lymphoma?. Cancers (Basel). 2021;13(11)doi: 10.3390/cancers13112580.
Seidel, C., Viehweger, C., & Kortmann, R. D. (2021). Is There an Indication for First Line Radiotherapy in Primary CNS Lymphoma?. Cancers, 13(11), . https://doi.org/10.3390/cancers13112580
Seidel, Clemens, et al. "Is There an Indication for First Line Radiotherapy in Primary CNS Lymphoma?." Cancers vol. 13,11 (2021). doi: https://doi.org/10.3390/cancers13112580
Seidel C, Viehweger C, Kortmann RD. Is There an Indication for First Line Radiotherapy in Primary CNS Lymphoma?. Cancers (Basel). 2021 May 25;13(11). doi: 10.3390/cancers13112580. PMID: 34070309; PMCID: PMC8197540.
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Long-Term Use of Oral Hygiene Products Containing Stannous and Fluoride Ions: Effect on Viable Salivary Bacteria.

Antibiotics (Basel, Switzerland)

Kruse AB, Schlueter N, Kortmann VK, Frese C, Anderson A, Wittmer A, Hellwig E, Vach K, Al-Ahmad A.
PMID: 33921981
Antibiotics (Basel). 2021 Apr 22;10(5). doi: 10.3390/antibiotics10050481.

The aim of this randomized, controlled clinical trial was to isolate and identify viable microorganisms in the saliva of study participants that continuously used a stannous and fluoride ion (F/Sn)-containing toothpaste and mouth rinse over a period of three...

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Kruse AB, Schlueter N, Kortmann VK, et al. Long-Term Use of Oral Hygiene Products Containing Stannous and Fluoride Ions: Effect on Viable Salivary Bacteria. Antibiotics (Basel). 2021;10(5)doi: 10.3390/antibiotics10050481.
Kruse, A. B., Schlueter, N., Kortmann, V. K., Frese, C., Anderson, A., Wittmer, A., Hellwig, E., Vach, K., & Al-Ahmad, A. (2021). Long-Term Use of Oral Hygiene Products Containing Stannous and Fluoride Ions: Effect on Viable Salivary Bacteria. Antibiotics (Basel, Switzerland), 10(5), . https://doi.org/10.3390/antibiotics10050481
Kruse, Anne Brigitte, et al. "Long-Term Use of Oral Hygiene Products Containing Stannous and Fluoride Ions: Effect on Viable Salivary Bacteria." Antibiotics (Basel, Switzerland) vol. 10,5 (2021). doi: https://doi.org/10.3390/antibiotics10050481
Kruse AB, Schlueter N, Kortmann VK, Frese C, Anderson A, Wittmer A, Hellwig E, Vach K, Al-Ahmad A. Long-Term Use of Oral Hygiene Products Containing Stannous and Fluoride Ions: Effect on Viable Salivary Bacteria. Antibiotics (Basel). 2021 Apr 22;10(5). doi: 10.3390/antibiotics10050481. PMID: 33921981; PMCID: PMC8143473.
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[The global Corona Pandemic in the mirror of personal postings-Platform-related modes of communication in social media].

OZS, Osterreichische Zeitschrift fur Soziologie

Eisewicht P, Steinmann N, Kortmann P.
PMID: 34866859
OZS Osterr Z Soziol. 2021 Nov 30;1-32. doi: 10.1007/s11614-021-00465-w. Epub 2021 Nov 30.

The article typifies individual experiences as well as collective negotiations of the crisis and the handling of it in the course of the COVID-19 pandemic on the basis of the platform Imgur.com. For this, we draw on a sample...

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Eisewicht P, Steinmann N, Kortmann P. Die globale Corona-Pandemie im Spiegel persönlicher Postings – Plattformbezogene Kommunikationsmodi in Sozialen Medien. [The global Corona Pandemic in the mirror of personal postings-Platform-related modes of communication in social media]. OZS Osterr Z Soziol. 2021;1-32doi: 10.1007/s11614-021-00465-w.
Eisewicht, P., Steinmann, N., & Kortmann, P. (2021). Die globale Corona-Pandemie im Spiegel persönlicher Postings – Plattformbezogene Kommunikationsmodi in Sozialen Medien. [The global Corona Pandemic in the mirror of personal postings-Platform-related modes of communication in social media]. OZS, Osterreichische Zeitschrift fur Soziologie, 1-32. https://doi.org/10.1007/s11614-021-00465-w
Eisewicht, Paul, et al. "Die globale Corona-Pandemie im Spiegel persönlicher Postings – Plattformbezogene Kommunikationsmodi in Sozialen Medien." [The global Corona Pandemic in the mirror of personal postings-Platform-related modes of communication in social media]. OZS, Osterreichische Zeitschrift fur Soziologie vol. (2021): 1-32. doi: https://doi.org/10.1007/s11614-021-00465-w
Eisewicht P, Steinmann N, Kortmann P. Die globale Corona-Pandemie im Spiegel persönlicher Postings – Plattformbezogene Kommunikationsmodi in Sozialen Medien. [The global Corona Pandemic in the mirror of personal postings-Platform-related modes of communication in social media]. OZS Osterr Z Soziol. 2021 Nov 30;1-32. doi: 10.1007/s11614-021-00465-w. Epub 2021 Nov 30. German. PMID: 34866859; PMCID: PMC8630298.
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miR-338-3p Blocks TGFβ-Induced Myofibroblast Differentiation through the Induction of PTEN.

American journal of physiology. Lung cellular and molecular physiology

Rackow AR, Judge JL, Woller CF, Sime PJ, Kottmann RM.
PMID: 34986654
Am J Physiol Lung Cell Mol Physiol. 2022 Jan 05; doi: 10.1152/ajplung.00251.2021. Epub 2022 Jan 05.

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease. The pathogenesis of IPF is not completely understood. However, numerous genes are associated with the development and progression of pulmonary fibrosis, indicating there is a significant genetic component to...

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Rackow AR, Judge JL, Woller CF, et al. miR-338-3p Blocks TGFβ-Induced Myofibroblast Differentiation through the Induction of PTEN. Am J Physiol Lung Cell Mol Physiol. 2022;doi: 10.1152/ajplung.00251.2021.
Rackow, A. R., Judge, J. L., Woller, C. F., Sime, P. J., & Kottmann, R. M. (2022). miR-338-3p Blocks TGFβ-Induced Myofibroblast Differentiation through the Induction of PTEN. American journal of physiology. Lung cellular and molecular physiology, . https://doi.org/10.1152/ajplung.00251.2021
Rackow, Ashley Rose, et al. "miR-338-3p Blocks TGFβ-Induced Myofibroblast Differentiation through the Induction of PTEN." American journal of physiology. Lung cellular and molecular physiology vol. (2022). doi: https://doi.org/10.1152/ajplung.00251.2021
Rackow AR, Judge JL, Woller CF, Sime PJ, Kottmann RM. miR-338-3p Blocks TGFβ-Induced Myofibroblast Differentiation through the Induction of PTEN. Am J Physiol Lung Cell Mol Physiol. 2022 Jan 05; doi: 10.1152/ajplung.00251.2021. Epub 2022 Jan 05. PMID: 34986654.
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Clinical and echocardiographic characteristics of patients with pathology proven right-sided papillary fibroelastomas.

International journal of cardiology

Ahmad A, El-Am EA, Kurmann RD, Sorour AA, Bois MC, Maleszewski JJ, Klarich KW.
PMID: 34871621
Int J Cardiol. 2022 Feb 15;349:123-126. doi: 10.1016/j.ijcard.2021.11.083. Epub 2021 Dec 04.

BACKGROUND: Papillary fibroelastoma (PFE) are one of the most common primary cardiac neoplasms. They are most commonly found on cardiac valves especially on the left side of the heart and have been associated with an increased risk of embolization....

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Ahmad A, El-Am EA, Kurmann RD, et al. Clinical and echocardiographic characteristics of patients with pathology proven right-sided papillary fibroelastomas. Int J Cardiol. 2021;349:123-126doi: 10.1016/j.ijcard.2021.11.083.
Ahmad, A., El-Am, E. A., Kurmann, R. D., Sorour, A. A., Bois, M. C., Maleszewski, J. J., & Klarich, K. W. (2022). Clinical and echocardiographic characteristics of patients with pathology proven right-sided papillary fibroelastomas. International journal of cardiology, 349123-126. https://doi.org/10.1016/j.ijcard.2021.11.083
Ahmad, Ali, et al. "Clinical and echocardiographic characteristics of patients with pathology proven right-sided papillary fibroelastomas." International journal of cardiology vol. 349 (2022): 123-126. doi: https://doi.org/10.1016/j.ijcard.2021.11.083
Ahmad A, El-Am EA, Kurmann RD, Sorour AA, Bois MC, Maleszewski JJ, Klarich KW. Clinical and echocardiographic characteristics of patients with pathology proven right-sided papillary fibroelastomas. Int J Cardiol. 2022 Feb 15;349:123-126. doi: 10.1016/j.ijcard.2021.11.083. Epub 2021 Dec 04. PMID: 34871621.
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Resolving complex atomic-scale spin structures by spin-polarized scanning tunneling microscopy.

Physical review letters

Wortmann D, Heinze S, Kurz P, Bihlmayer G, Blügel S.
PMID: 11328113
Phys Rev Lett. 2001 Apr 30;86(18):4132-5. doi: 10.1103/PhysRevLett.86.4132.

The spin-polarized scanning tunneling microscope (SP-STM) operated in the constant current mode is proposed as a powerful tool to investigate complex atomic-scale magnetic structures of otherwise chemically equivalent atoms. The potential of this approach is demonstrated by successfully resolving...

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Wortmann D, Heinze S, Kurz P, et al. Resolving complex atomic-scale spin structures by spin-polarized scanning tunneling microscopy. Phys Rev Lett. 2001;86(18):4132-5doi: 10.1103/PhysRevLett.86.4132.
Wortmann, D., Heinze, S., Kurz, P., Bihlmayer, G., & Blügel, S. (2001). Resolving complex atomic-scale spin structures by spin-polarized scanning tunneling microscopy. Physical review letters, 86(18), 4132-5. https://doi.org/10.1103/PhysRevLett.86.4132
Wortmann, D, et al. "Resolving complex atomic-scale spin structures by spin-polarized scanning tunneling microscopy." Physical review letters vol. 86,18 (2001): 4132-5. doi: https://doi.org/10.1103/PhysRevLett.86.4132
Wortmann D, Heinze S, Kurz P, Bihlmayer G, Blügel S. Resolving complex atomic-scale spin structures by spin-polarized scanning tunneling microscopy. Phys Rev Lett. 2001 Apr 30;86(18):4132-5. doi: 10.1103/PhysRevLett.86.4132. PMID: 11328113.
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Chromophore design for photorefractive organic materials.

Chemphyschem : a European journal of chemical physics and physical chemistry

Würthner F, Wortmann R, Meerholz K.
PMID: 12465473
Chemphyschem. 2002 Jan 18;3(1):17-31. doi: 10.1002/1439-7641(20020118)3:1<17::AID-CPHC17>3.0.CO;2-N.

During the last years, significant progress has been achieved in understanding the mechanism of the photorefractive effect in amorphous organic materials. New chromophores could be devised which provided a substantial increase in the electrooptical response and lead to photorefractive...

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Würthner F, Wortmann R, Meerholz K. Chromophore design for photorefractive organic materials. Chemphyschem. 2002;3(1):17-31doi: 10.1002/1439-7641(20020118)3:1<17::AID-CPHC17>3.0.CO;2-N.
Würthner, F., Wortmann, R., & Meerholz, K. (2002). Chromophore design for photorefractive organic materials. Chemphyschem : a European journal of chemical physics and physical chemistry, 3(1), 17-31. https://doi.org/10.1002/1439-7641(20020118)3:1<17::AID-CPHC17>3.0.CO;2-N
Würthner, Frank, et al. "Chromophore design for photorefractive organic materials." Chemphyschem : a European journal of chemical physics and physical chemistry vol. 3,1 (2002): 17-31. doi: https://doi.org/10.1002/1439-7641(20020118)3:1<17::AID-CPHC17>3.0.CO;2-N
Würthner F, Wortmann R, Meerholz K. Chromophore design for photorefractive organic materials. Chemphyschem. 2002 Jan 18;3(1):17-31. doi: 10.1002/1439-7641(20020118)3:1<17::AID-CPHC17>3.0.CO;2-N. PMID: 12465473.
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Transfer of apiose from UDP-apiose to 7-O-(beta-D-glucosyl)-apigenin and 7-O-(beta-D-glucosyl)-chrysoeriol with an enzyme preparation from parsley.

FEBS letters

Ortmann R, Sandermann H, Grisebach H.
PMID: 11947458
FEBS Lett. 1970 Apr 02;7(2):164-166. doi: 10.1016/0014-5793(70)80146-6.

An enzyme preparation from parsley (Petroselinum hortense Hoffm.) catalyses the formation of apiin (7-O-[beta-D-apio-furanosyl(1-->2)beta-D-glycosyl]-5,7,4'-trihydroxyflavone) from 7-O-(beta-D-glycosyl)-apigenin and UDP-apiose and of the corresponding chrysoeriol-7-apiosyl-glucoside from 7-O(beta-D-glucosyl)-chrysoeriol and UDP-apiose. Neither free apiose nor cyclic apiose-1,2-phosphate can function as a substrate for...

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Ortmann R, Sandermann H, Grisebach H. Transfer of apiose from UDP-apiose to 7-O-(beta-D-glucosyl)-apigenin and 7-O-(beta-D-glucosyl)-chrysoeriol with an enzyme preparation from parsley. FEBS Lett. 1970;7(2):164-166doi: 10.1016/0014-5793(70)80146-6.
Ortmann, R., Sandermann, H., & Grisebach, H. (1970). Transfer of apiose from UDP-apiose to 7-O-(beta-D-glucosyl)-apigenin and 7-O-(beta-D-glucosyl)-chrysoeriol with an enzyme preparation from parsley. FEBS letters, 7(2), 164-166. https://doi.org/10.1016/0014-5793(70)80146-6
Ortmann, R, et al. "Transfer of apiose from UDP-apiose to 7-O-(beta-D-glucosyl)-apigenin and 7-O-(beta-D-glucosyl)-chrysoeriol with an enzyme preparation from parsley." FEBS letters vol. 7,2 (1970): 164-166. doi: https://doi.org/10.1016/0014-5793(70)80146-6
Ortmann R, Sandermann H, Grisebach H. Transfer of apiose from UDP-apiose to 7-O-(beta-D-glucosyl)-apigenin and 7-O-(beta-D-glucosyl)-chrysoeriol with an enzyme preparation from parsley. FEBS Lett. 1970 Apr 02;7(2):164-166. doi: 10.1016/0014-5793(70)80146-6. PMID: 11947458.
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Southeast Atmosphere Studies: learning from model-observation syntheses.

Atmospheric chemistry and physics

Mao J, Carlton A, Cohen RC, Brune WH, Brown SS, Wolfe GM, Jimenez JL, Pye HOT, Ng NL, Xu L, McNeill VF, Tsigaridis K, McDonald BC, Warneke C, Guenther A, Alvarado MJ, de Gouw J, Mickley LJ, Leibensperger EM, Mathur R, Nolte CG, Portmann RW, Unger N, Tosca M, Horowitz LW.
PMID: 29963079
Atmos Chem Phys. 2018;18(4):2615-2651. doi: 10.5194/acp-18-2615-2018. Epub 2018 Feb 22.

Concentrations of atmospheric trace species in the United States have changed dramatically over the past several decades in response to pollution control strategies, shifts in domestic energy policy and economics, and economic development (and resulting emission changes) elsewhere in...

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Mao J, Carlton A, Cohen RC, et al. Southeast Atmosphere Studies: learning from model-observation syntheses. Atmos Chem Phys. 2018;18(4):2615-2651doi: 10.5194/acp-18-2615-2018.
Mao, J., Carlton, A., Cohen, R. C., Brune, W. H., Brown, S. S., Wolfe, G. M., Jimenez, J. L., Pye, H. O. T., Ng, N. L., Xu, L., McNeill, V. F., Tsigaridis, K., McDonald, B. C., Warneke, C., Guenther, A., Alvarado, M. J., de Gouw, J., Mickley, L. J., Leibensperger, E. M., Mathur, R., Nolte, C. G., Portmann, R. W., Unger, N., Tosca, M., & Horowitz, L. W. (2018). Southeast Atmosphere Studies: learning from model-observation syntheses. Atmospheric chemistry and physics, 18(4), 2615-2651. https://doi.org/10.5194/acp-18-2615-2018
Mao, Jingqiu, et al. "Southeast Atmosphere Studies: learning from model-observation syntheses." Atmospheric chemistry and physics vol. 18,4 (2018): 2615-2651. doi: https://doi.org/10.5194/acp-18-2615-2018
Mao J, Carlton A, Cohen RC, Brune WH, Brown SS, Wolfe GM, Jimenez JL, Pye HOT, Ng NL, Xu L, McNeill VF, Tsigaridis K, McDonald BC, Warneke C, Guenther A, Alvarado MJ, de Gouw J, Mickley LJ, Leibensperger EM, Mathur R, Nolte CG, Portmann RW, Unger N, Tosca M, Horowitz LW. Southeast Atmosphere Studies: learning from model-observation syntheses. Atmos Chem Phys. 2018;18(4):2615-2651. doi: 10.5194/acp-18-2615-2018. Epub 2018 Feb 22. PMID: 29963079; PMCID: PMC6020695.
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Management of primary thalamic low-grade glioma in pediatric patients: results of the multicenter treatment studies HIT-LGG 1996 and SIOP-LGG 2004.

Neuro-oncology practice

Boesten T, Gerber NU, Kandels D, Azizi AA, Schmidt R, Warmuth-Metz M, Pietsch T, Kortmann RD, Gnekow A, Grotzer MA.
PMID: 31385995
Neurooncol Pract. 2017 Mar;4(1):29-39. doi: 10.1093/nop/npw007. Epub 2016 Dec 09.

BACKGROUND: Thalamic low-grade glioma (LGG) poses a special therapeutic challenge, as complete resection is often not possible. To determine the survival outcomes of mono- and bithalamic LGG, we analyzed a large cohort of pediatric patients.METHODS: From 1996 until 2012,...

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Boesten T, Gerber NU, Kandels D, et al. Management of primary thalamic low-grade glioma in pediatric patients: results of the multicenter treatment studies HIT-LGG 1996 and SIOP-LGG 2004. Neurooncol Pract. 2016;4(1):29-39doi: 10.1093/nop/npw007.
Boesten, T., Gerber, N. U., Kandels, D., Azizi, A. A., Schmidt, R., Warmuth-Metz, M., Pietsch, T., Kortmann, R. D., Gnekow, A., & Grotzer, M. A. (2017). Management of primary thalamic low-grade glioma in pediatric patients: results of the multicenter treatment studies HIT-LGG 1996 and SIOP-LGG 2004. Neuro-oncology practice, 4(1), 29-39. https://doi.org/10.1093/nop/npw007
Boesten, Tineke, et al. "Management of primary thalamic low-grade glioma in pediatric patients: results of the multicenter treatment studies HIT-LGG 1996 and SIOP-LGG 2004." Neuro-oncology practice vol. 4,1 (2017): 29-39. doi: https://doi.org/10.1093/nop/npw007
Boesten T, Gerber NU, Kandels D, Azizi AA, Schmidt R, Warmuth-Metz M, Pietsch T, Kortmann RD, Gnekow A, Grotzer MA. Management of primary thalamic low-grade glioma in pediatric patients: results of the multicenter treatment studies HIT-LGG 1996 and SIOP-LGG 2004. Neurooncol Pract. 2017 Mar;4(1):29-39. doi: 10.1093/nop/npw007. Epub 2016 Dec 09. PMID: 31385995; PMCID: PMC6655541.
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