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Showing 25 to 36 of 144 entries
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The Process of Modeling Information System Architectures with IHE.

Studies in health technology and informatics

Merzweiler A, Stäubert S, Strübing A, Tonmbiak A, Kaulke K, Drepper J, Bergh B, Winter A.
PMID: 34042890
Stud Health Technol Inform. 2021 May 24;278:163-170. doi: 10.3233/SHTI210065.

IHE has defined more than 200 integration profiles in order to improve the interoperability of application systems in healthcare. These profiles describe how standards should be used in particular use cases. These profiles are very helpful but their correct...

Activated CD4.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Duizendstra AA, de Knegt RJ, Mancham S, Klepper M, Roelen DL, Brand-Schaaf SH, Boor PP, Doukas M, de Man RA, Sprengers D, Peppelenbosch MP, Betjes MGH, Kwekkeboom J, Litjens NHR.
PMID: 34081828
Liver Transpl. 2022 Jan;28(1):98-112. doi: 10.1002/lt.26188. Epub 2021 Jul 21.

Spontaneous operational tolerance to the allograft develops in a proportion of liver transplantation (LT) recipients weaned off immunosuppressive (IS) drugs. Several studies have investigated whether peripheral blood circulating T cells could play a role in the development or identify...

Mode-Selective Vibrational Energy Transfer Dynamics in 1,3,5-Trinitroperhydro-1,3,5-triazine (RDX) Thin Films.

The journal of physical chemistry. A

Cole-Filipiak NC, Knepper R, Wood M, Ramasesha K, Panigrahi R, Srivastava PR.
PMID: 34464533
J Phys Chem A. 2021 Sep 16;125(36):7788-7802. doi: 10.1021/acs.jpca.1c04800. Epub 2021 Aug 31.

The coupling of inter- and intramolecular vibrations plays a critical role in initiating chemistry during the shock-to-detonation transition in energetic materials. Herein, we report on the subpicosecond to subnanosecond vibrational energy transfer (VET) dynamics of the solid energetic material...

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Cell metabolism

Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B.
PMID: 34800366
Cell Metab. 2021 Dec 07;33(12):2464-2483.e18. doi: 10.1016/j.cmet.2021.11.001. Epub 2021 Nov 19.

Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality control and have been linked to various diseases. Different views exist on the composition of the human mitochondrial proteome. We classified >8,000 proteins in mitochondrial preparations of human...

Tactics of care for young infants by forest-living ruffed lemurs (Varecia variegata variegata): Ground nests, parking, and biparental guarding.

American journal of primatology

Pereira ME, Klepper A, Simons EL.
PMID: 31973474
Am J Primatol. 1987;13(2):129-144. doi: 10.1002/ajp.1350130204.

Over a 4 month period, systematic and ad libitum observations were conducted on two adult female black-and-white ruffed lemurs (Varecia variegata variegata) and their infants in a 3.5 ha forest enclosure. The females were mother and daughter, members of...

Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women.

Cell reports. Medicine

Srinivasan S, Treacy R, Herrero T, Olsen R, Leonardo TR, Zhang X, DeHoff P, To C, Poling LG, Fernando A, Leon-Garcia S, Knepper K, Tran V, Meads M, Tasarz J, Vuppala A, Park S, Laurent CD, Bui T, Cheah PS, Overcash RT, Ramos GA, Roeder H, Ghiran I, Parast M, Breakefield XO, Lueth AJ, Rust SR, Dufford MT, Fox AC, Hickok DE, Burchard J, Boniface JJ, Laurent LC.
PMID: 32864636
Cell Rep Med. 2020 May 19;1(2). doi: 10.1016/j.xcrm.2020.100013.

Development of effective prevention and treatment strategies for pre-eclampsia is limited by the lack of accurate methods for identification of at-risk pregnancies. We performed small RNA sequencing (RNA-seq) of maternal serum extracellular RNAs (exRNAs) to discover and verify microRNAs...

Implementation of cryogenic tender X-ray HR-XANES spectroscopy at the ACT station of the CAT-ACT beamline at the KIT Light Source.

Journal of synchrotron radiation

Schacherl B, Prüssmann T, Dardenne K, Hardock K, Krepper V, Rothe J, Vitova T, Geckeis H.
PMID: 34985425
J Synchrotron Radiat. 2022 Jan 01;29:80-88. doi: 10.1107/S1600577521012650. Epub 2022 Jan 01.

The ACT experimental station of the CAT-ACT wiggler beamline at the Karlsruhe Institute of Technology (KIT) Light Source is dedicated to the investigation of radionuclide materials with radioactivities up to 1000000 times the exemption limit by various speciation techniques...

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

Cell metabolism

Morgenstern M, Peikert CD, Lübbert P, Suppanz I, Klemm C, Alka O, Steiert C, Naumenko N, Schendzielorz A, Melchionda L, Mühlhäuser WWD, Knapp B, Busch JD, Stiller SB, Dannenmaier S, Lindau C, Licheva M, Eickhorst C, Galbusera R, Zerbes RM, Ryan MT, Kraft C, Kozjak-Pavlovic V, Drepper F, Dennerlein S, Oeljeklaus S, Pfanner N, Wiedemann N, Warscheid B.
PMID: 34800366
Cell Metab. 2021 Dec 07;33(12):2464-2483.e18. doi: 10.1016/j.cmet.2021.11.001. Epub 2021 Nov 19.

Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality control and have been linked to various diseases. Different views exist on the composition of the human mitochondrial proteome. We classified >8,000 proteins in mitochondrial preparations of human...

Tocilizumab-Induced Acute Liver Injury in Adult Onset Still's Disease.

Case reports in hepatology

Drepper M, Rubbia-Brandt L, Spahr L.
PMID: 25374723
Case Reports Hepatol. 2013;2013:964828. doi: 10.1155/2013/964828. Epub 2013 Jul 15.

Background. Tocilizumab, a monoclonal humanized anti-IL-6 receptor antibody, is used in treatment of refractory adult onset Still's disease (AOSD). Mild to moderate liver enzyme elevation is a well-known side effect, but severe liver injury has only been reported in...

Bartoli indole synthesis on solid supports.

Organic letters

Knepper K, Bräse S.
PMID: 12889885
Org Lett. 2003 Aug 07;5(16):2829-32. doi: 10.1021/ol034851y.

[reaction: see text] Bartoli indole synthesis has been performed for the first time on solid supports. Starting from Merrifield resin, immobilization of five nitro benzoic acids was performed. Addition of four different alkenyl Grignard reagents and basic cleavage leads...

Detecting Data Quality Issues in Clinical Trials: Current Practices and Recommendations.

Therapeutic innovation & regulatory science

Knepper D, Fenske C, Nadolny P, Bedding A, Gribkova E, Polzer J, Neumann J, Wilson B, Benedict J, Lawton A.
PMID: 30236017
Ther Innov Regul Sci. 2016 Jan;50(1):15-21. doi: 10.1177/2168479015620248.

BACKGROUND: Data quality issues in clinical trials can be caused by a variety of behaviors including fraud, misconduct, intentional or unintentional noncompliance, and significant carelessness. Regardless of how these behaviors are defined, they may compromise the validity of the...

Fractal dimension of antibody-PEG precipitate: Light microscopy for the reconstruction of 3D precipitate structures.

Engineering in life sciences

Satzer P, Burgstaller D, Krepper W, Jungbauer A.
PMID: 32874171
Eng Life Sci. 2019 Nov 11;20(3):67-78. doi: 10.1002/elsc.201900110. eCollection 2020 Mar.

Protein and in particular antibody precipitation by PEG is a cost-effective alternative for the first capture step. The 3D structure of precipitates has a large impact on the process parameters for the recovery and dissolution, but current technologies for...

Showing 25 to 36 of 144 entries