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Showing 9985 to 9996 of 10691 entries
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Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia.

Genomics, proteomics & bioinformatics

Hong Y, Zhang D, Zhou X, Chen A, Abliz A, Bai J, Wang L, Hu Q, Gong K, Guan X, Liu M, Zheng X, Lai S, Qu H, Zhao F, Hao S, Wu Z, Cai H, Hu S, Ma Y, Zhang J, Ke Y, Wang QF, Chen W, Zeng C.
PMID: 34624550
Genomics Proteomics Bioinformatics. 2021 Oct 05; doi: 10.1016/j.gpb.2021.09.005. Epub 2021 Oct 05.

Postzygotic mutations are acquired in normal tissues throughout an individual's lifetime and hold clues for identifying mutagenic factors. We investigated postzygotic mutation spectra in healthy individuals using optimized ultra-deep exome sequencing of time-series samples from the same volunteer and...

Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Liu Q, Xie Z, Qiu M, Shim I, Yang Y, Xie S, Yang Q, Wang D, Chen S, Fan T, Ding B, Guo Z, Adah D, Yao X, Zhang Y, Wu H, Wu Z, Wei C, Wang H, Kim HS, Zou Q, Yan Q, Cai Z, Kim JS, Liu LP, Zhang H, Cao Y.
PMID: 33344115
Adv Sci (Weinh). 2020 Nov 05;7(24):2001191. doi: 10.1002/advs.202001191. eCollection 2020 Dec.

Conventional chemotherapy and photothermal therapy (PTT) face many major challenges, including systemic toxicity, low bioavailability, ineffective tissue penetration, chemotherapy/hyperthermia-induced inflammation, and tumor angiogenesis. A versatile nanomedicine offers an exciting opportunity to circumvent the abovementioned limitations for their successful translation...

Ultrasensitive, Specific, and Rapid Fluorescence Turn-On Nitrite Sensor Enabled by Precisely Modulated Fluorophore Binding.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Ma Z, Li J, Hu X, Cai Z, Dou X.
PMID: 33344140
Adv Sci (Weinh). 2020 Nov 13;7(24):2002991. doi: 10.1002/advs.202002991. eCollection 2020 Dec.

The precise regulation of fluorophore binding sites in an organic probe is of great significance toward the design of fluorescent sensing materials with specific functions. In this study, a probe with specific fluorescence properties and nitrite detection ability is...

Metformin .

Frontiers in physiology

Dong X, Hui T, Chen J, Yu Z, Ren D, Zou S, Wang S, Fei E, Jiao H, Lai X.
PMID: 34012406
Front Physiol. 2021 May 03;12:642908. doi: 10.3389/fphys.2021.642908. eCollection 2021.

Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disease characterized by progressive muscle weakness and wasting. Stimulation of AMP-activated protein kinase (AMPK) has been demonstrated to increase muscle function and protect muscle against damage in dystrophic mice. Metformin is...

High-resolution MD simulation studies to get mechanistic insights into the urea-induced denaturation of human Sphingosine kinase 1.

Current topics in medicinal chemistry

Khan FI, Ali S, Chen W, Anjum F, Shafie A, Hassan MI, Lai D.
PMID: 34749611
Curr Top Med Chem. 2021 Nov 04; doi: 10.2174/1568026621666211105095731. Epub 2021 Nov 04.

BACKGROUND: Sphingosine kinase 1 (SPhK1) is a crucial signaling enzyme involved in cell proliferation, cellular survival, stimulation of angiogenesis, and apoptosis prevention. Recently, we have reported the unfolding kinetics of SPhK1 using molecular dynamics (MD) simulation, circular dichroism and...

A Biocontrol Strain of .

Pathogens (Basel, Switzerland)

Wang X, Zhou X, Cai Z, Guo L, Chen X, Chen X, Liu J, Feng M, Qiu Y, Zhang Y, Wang A.
PMID: 33396336
Pathogens. 2020 Dec 31;10(1). doi: 10.3390/pathogens10010022.

Unsuspected mobility of Arctic hares revealed by longest journey ever recorded in a lagomorph.

Ecology

Lai S, Desjardins É, Caron-Carrier J, Couchoux C, Vézina F, Tam A, Koutroulides N, Berteaux D.
PMID: 34939184
Ecology. 2021 Dec 22; doi: 10.1002/ecy.3620. Epub 2021 Dec 22.

No abstract available.

Effect of Terlipressin on Renal Function in Liver Cirrhosis With Ascites: A Pilot Study.

Journal of clinical and experimental hepatology

An Y, Bai Z, Guo X, Qi X.
PMID: 33311900
J Clin Exp Hepatol. 2020 Nov-Dec;10(6):643-645. doi: 10.1016/j.jceh.2020.05.002. Epub 2020 May 11.

No abstract available.

Genome sequencing sheds light on the contribution of structural variants to Brassica oleracea diversification.

BMC biology

Guo N, Wang S, Gao L, Liu Y, Wang X, Lai E, Duan M, Wang G, Li J, Yang M, Zong M, Han S, Pei Y, Borm T, Sun H, Miao L, Liu D, Yu F, Zhang W, Ji H, Zhu C, Xu Y, Bonnema G, Li J, Fei Z, Liu F.
PMID: 33952264
BMC Biol. 2021 May 05;19(1):93. doi: 10.1186/s12915-021-01031-2.

BACKGROUND: Brassica oleracea includes several morphologically diverse, economically important vegetable crops, such as the cauliflower and cabbage. However, genetic variants, especially large structural variants (SVs), that underlie the extreme morphological diversity of B. oleracea remain largely unexplored.RESULTS: Here we...

A nomogram to predict stricture-free survival in patients with ureteral stricture after balloon dilation.

BMC urology

Hu J, Lai C, Gao M, Li K, He W, Zhu D, Xie W, Wu H, Xu M, Huang J, Han J.
PMID: 34530805
BMC Urol. 2021 Sep 16;21(1):129. doi: 10.1186/s12894-021-00896-3.

BACKGROUND: Balloon dilation is a commonly used minimally invasive endourological treatment of ureteral stricture, but the postoperative recurrence rate is relatively high. And factors contributing to recurrence after treatment are poorly understood. Herein, we sought to develop a novel...

Comparative analysis of five Salvia species using LC-DAD-QToF.

Journal of pharmaceutical and biomedical analysis

Avula B, Bae JY, Chittiboyina AG, Wang YH, Wang M, Srivedavyasasri R, Ali Z, Li J, Wu C, Khan IA.
PMID: 34915321
J Pharm Biomed Anal. 2021 Dec 05;209:114520. doi: 10.1016/j.jpba.2021.114520. Epub 2021 Dec 05.

Several Salvia species, commonly known as sage plants, are an integral part of various culinary and folklore preparations for the perceived wide range of effects from organoleptic to psychological. As a result, many of these species are an integral...

Correction to: Exploring the oxygenase function of Form II Rubisco for production of glycolate from CO.

AMB Express

Yang F, Zhang J, Cai Z, Zhou J, Li Y.
PMID: 34559321
AMB Express. 2021 Sep 24;11(1):132. doi: 10.1186/s13568-021-01293-7.

No abstract available.

Showing 9985 to 9996 of 10691 entries