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Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.

ACS medicinal chemistry letters

Lopez-Tapia F, Brotherton-Pleiss C, Yue P, Murakami H, Costa Araujo AC, Reis Dos Santos B, Ichinotsubo E, Rabkin A, Shah R, Lantz M, Chen S, Tius MA, Turkson J.
PMID: 29541369
ACS Med Chem Lett. 2018 Feb 16;9(3):250-255. doi: 10.1021/acsmedchemlett.7b00544. eCollection 2018 Mar 08.

The molecular determinants for the activities of the reported benzoic acid (SH4-54), salicylic acid (BP-1-102), and benzohydroxamic acid (SH5-07)-based STAT3 inhibitors were investigated to design optimized analogues. All three leads are based on an

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Lopez-Tapia F, Brotherton-Pleiss C, Yue P, et al. Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors. ACS Med Chem Lett. 2018;9(3):250-255doi: 10.1021/acsmedchemlett.7b00544.
Lopez-Tapia, F., Brotherton-Pleiss, C., Yue, P., Murakami, H., Costa Araujo, A. C., Reis Dos Santos, B., Ichinotsubo, E., Rabkin, A., Shah, R., Lantz, M., Chen, S., Tius, M. A., & Turkson, J. (2018). Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors. ACS medicinal chemistry letters, 9(3), 250-255. https://doi.org/10.1021/acsmedchemlett.7b00544
Lopez-Tapia, Francisco, et al. "Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors." ACS medicinal chemistry letters vol. 9,3 (2018): 250-255. doi: https://doi.org/10.1021/acsmedchemlett.7b00544
Lopez-Tapia F, Brotherton-Pleiss C, Yue P, Murakami H, Costa Araujo AC, Reis Dos Santos B, Ichinotsubo E, Rabkin A, Shah R, Lantz M, Chen S, Tius MA, Turkson J. Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors. ACS Med Chem Lett. 2018 Feb 16;9(3):250-255. doi: 10.1021/acsmedchemlett.7b00544. eCollection 2018 Mar 08. PMID: 29541369; PMCID: PMC5846032.
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Cavity ring-down spectroscopy system for the evaluation of negative hydrogen ion density at the ELISE test facility.

The Review of scientific instruments

Mimo A, Nakano H, Wimmer C, Wünderlich D, Fantz U, Tsumori K.
PMID: 32012532
Rev Sci Instrum. 2020 Jan 01;91(1):013510. doi: 10.1063/1.5129341.

The large RF negative hydrogen (deuterium) ion source at the ELISE test facility (half of the ITER-NBI source size) has been equipped with a Cavity Ring-Down Spectroscopy (CRDS) system, in order to measure the negative hydrogen (deuterium) ion density...

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Mimo A, Nakano H, Wimmer C, et al. Cavity ring-down spectroscopy system for the evaluation of negative hydrogen ion density at the ELISE test facility. Rev Sci Instrum. 2020;91(1):013510doi: 10.1063/1.5129341.
Mimo, A., Nakano, H., Wimmer, C., Wünderlich, D., Fantz, U., & Tsumori, K. (2020). Cavity ring-down spectroscopy system for the evaluation of negative hydrogen ion density at the ELISE test facility. The Review of scientific instruments, 91(1), 013510. https://doi.org/10.1063/1.5129341
Mimo, A, et al. "Cavity ring-down spectroscopy system for the evaluation of negative hydrogen ion density at the ELISE test facility." The Review of scientific instruments vol. 91,1 (2020): 013510. doi: https://doi.org/10.1063/1.5129341
Mimo A, Nakano H, Wimmer C, Wünderlich D, Fantz U, Tsumori K. Cavity ring-down spectroscopy system for the evaluation of negative hydrogen ion density at the ELISE test facility. Rev Sci Instrum. 2020 Jan 01;91(1):013510. doi: 10.1063/1.5129341. PMID: 32012532.
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Three-Cornered Hat and Groslambert Covariance: A First Attempt to Assess the Uncertainty Domains.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control

Vernotte F, Lantz E.
PMID: 30596574
IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Mar;66(3):643-653. doi: 10.1109/TUFFC.2018.2889703. Epub 2018 Dec 25.

The three-cornered hat method and the Groslambert covariance are very often used to estimate the frequency stability of each individual oscillator in a set of three oscillators by comparing them in pairs. However, no rigorous method to assess the...

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Vernotte F, Lantz E. Three-Cornered Hat and Groslambert Covariance: A First Attempt to Assess the Uncertainty Domains. IEEE Trans Ultrason Ferroelectr Freq Control. 2018;66(3):643-653doi: 10.1109/TUFFC.2018.2889703.
Vernotte, F., & Lantz, E. (2019). Three-Cornered Hat and Groslambert Covariance: A First Attempt to Assess the Uncertainty Domains. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 66(3), 643-653. https://doi.org/10.1109/TUFFC.2018.2889703
Vernotte, Francois, and Lantz, Eric. "Three-Cornered Hat and Groslambert Covariance: A First Attempt to Assess the Uncertainty Domains." IEEE transactions on ultrasonics, ferroelectrics, and frequency control vol. 66,3 (2019): 643-653. doi: https://doi.org/10.1109/TUFFC.2018.2889703
Vernotte F, Lantz E. Three-Cornered Hat and Groslambert Covariance: A First Attempt to Assess the Uncertainty Domains. IEEE Trans Ultrason Ferroelectr Freq Control. 2019 Mar;66(3):643-653. doi: 10.1109/TUFFC.2018.2889703. Epub 2018 Dec 25. PMID: 30596574.
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Coupling between a Charge Density Wave and Magnetism in an Heusler Material.

Physical review letters

Lantz G, Neugebauer MJ, Kubli M, Savoini M, Abreu E, Tasca K, Dornes C, Esposito V, Rittmann J, Windsor YW, Beaud P, Ingold G, Johnson SL.
PMID: 29286787
Phys Rev Lett. 2017 Dec 01;119(22):227207. doi: 10.1103/PhysRevLett.119.227207. Epub 2017 Nov 29.

The prototypical magnetic memory shape alloy Ni_{2}MnGa undergoes various phase transitions as a function of the temperature, pressure, and doping. In the low-temperature phases below 260 K, an incommensurate structural modulation occurs along the [110] direction which is thought...

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Lantz G, Neugebauer MJ, Kubli M, et al. Coupling between a Charge Density Wave and Magnetism in an Heusler Material. Phys Rev Lett. 2017;119(22):227207doi: 10.1103/PhysRevLett.119.227207.
Lantz, G., Neugebauer, M. J., Kubli, M., Savoini, M., Abreu, E., Tasca, K., Dornes, C., Esposito, V., Rittmann, J., Windsor, Y. W., Beaud, P., Ingold, G., & Johnson, S. L. (2017). Coupling between a Charge Density Wave and Magnetism in an Heusler Material. Physical review letters, 119(22), 227207. https://doi.org/10.1103/PhysRevLett.119.227207
Lantz, G, et al. "Coupling between a Charge Density Wave and Magnetism in an Heusler Material." Physical review letters vol. 119,22 (2017): 227207. doi: https://doi.org/10.1103/PhysRevLett.119.227207
Lantz G, Neugebauer MJ, Kubli M, Savoini M, Abreu E, Tasca K, Dornes C, Esposito V, Rittmann J, Windsor YW, Beaud P, Ingold G, Johnson SL. Coupling between a Charge Density Wave and Magnetism in an Heusler Material. Phys Rev Lett. 2017 Dec 01;119(22):227207. doi: 10.1103/PhysRevLett.119.227207. Epub 2017 Nov 29. PMID: 29286787.
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Pattern formation in convection of rotating fluids with broken vertical symmetry.

Physical review. A, Atomic, molecular, and optical physics

Bestehorn M, Fantz M, Friedrich R, Pérez-García C, Rodríguez JM.
PMID: 9908691
Phys Rev A. 1992 Oct 15;46(8):4729-4735. doi: 10.1103/physreva.46.4729.

No abstract available.

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Bestehorn M, Fantz M, Friedrich R, et al. Pattern formation in convection of rotating fluids with broken vertical symmetry. Phys Rev A. 1992;46(8):4729-4735doi: 10.1103/physreva.46.4729.
Bestehorn, M., Fantz, M., Friedrich, R., Pérez-García, C., & Rodríguez, J. M. (1992). Pattern formation in convection of rotating fluids with broken vertical symmetry. Physical review. A, Atomic, molecular, and optical physics, 46(8), 4729-4735. https://doi.org/10.1103/physreva.46.4729
Bestehorn, et al. "Pattern formation in convection of rotating fluids with broken vertical symmetry." Physical review. A, Atomic, molecular, and optical physics vol. 46,8 (1992): 4729-4735. doi: https://doi.org/10.1103/physreva.46.4729
Bestehorn M, Fantz M, Friedrich R, Pérez-García C, Rodríguez JM. Pattern formation in convection of rotating fluids with broken vertical symmetry. Phys Rev A. 1992 Oct 15;46(8):4729-4735. doi: 10.1103/physreva.46.4729. PMID: 9908691.
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In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4.

Science immunology

Sutra Del Galy A, Menegatti S, Fuentealba J, Lucibello F, Perrin L, Helft J, Darbois A, Saitakis M, Tosello J, Rookhuizen D, Deloger M, Gestraud P, Socié G, Amigorena S, Lantz O, Menger L.
PMID: 34860579
Sci Immunol. 2021 Dec 03;6(66):eabe8219. doi: 10.1126/sciimmunol.abe8219. Epub 2021 Dec 03.

[Figure: see text].

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Sutra Del Galy A, Menegatti S, Fuentealba J, et al. In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4. Sci Immunol. 2021;6(66):eabe8219doi: 10.1126/sciimmunol.abe8219.
Sutra Del Galy, A., Menegatti, S., Fuentealba, J., Lucibello, F., Perrin, L., Helft, J., Darbois, A., Saitakis, M., Tosello, J., Rookhuizen, D., Deloger, M., Gestraud, P., Socié, G., Amigorena, S., Lantz, O., & Menger, L. (2021). In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4. Science immunology, 6(66), eabe8219. https://doi.org/10.1126/sciimmunol.abe8219
Sutra Del Galy, Aurélien, et al. "In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4." Science immunology vol. 6,66 (2021): eabe8219. doi: https://doi.org/10.1126/sciimmunol.abe8219
Sutra Del Galy A, Menegatti S, Fuentealba J, Lucibello F, Perrin L, Helft J, Darbois A, Saitakis M, Tosello J, Rookhuizen D, Deloger M, Gestraud P, Socié G, Amigorena S, Lantz O, Menger L. In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4. Sci Immunol. 2021 Dec 03;6(66):eabe8219. doi: 10.1126/sciimmunol.abe8219. Epub 2021 Dec 03. PMID: 34860579.
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Community-Engaged Bidirectional Crisis and Emergency Risk Communication With Immigrant and Refugee Populations During the COVID-19 Pandemic.

Public health reports (Washington, D.C. : 1974)

Wieland ML, Asiedu GB, Njeru JW, Weis JA, Lantz K, Abbenyi A, Molina L, Ahmed Y, Osman A, Goodson M, Torres-Herbeck G, Nur O, Porraz Capetillo G, Mohamed AA, Sia IG.
PMID: 35023414
Public Health Rep. 2022 Jan 13;333549211065514. doi: 10.1177/00333549211065514. Epub 2022 Jan 13.

OBJECTIVES: This study was conducted to assess an intervention that was created by a community-academic partnership to address COVID-19 health inequities. We evaluated a community-engaged bidirectional pandemic crisis and emergency risk communication (CERC) framework with immigrant and refugee populations...

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Wieland ML, Asiedu GB, Njeru JW, et al. Community-Engaged Bidirectional Crisis and Emergency Risk Communication With Immigrant and Refugee Populations During the COVID-19 Pandemic. Public Health Rep. 2022;333549211065514doi: 10.1177/00333549211065514.
Wieland, M. L., Asiedu, G. B., Njeru, J. W., Weis, J. A., Lantz, K., Abbenyi, A., Molina, L., Ahmed, Y., Osman, A., Goodson, M., Torres-Herbeck, G., Nur, O., Porraz Capetillo, G., Mohamed, A. A., & Sia, I. G. (2022). Community-Engaged Bidirectional Crisis and Emergency Risk Communication With Immigrant and Refugee Populations During the COVID-19 Pandemic. Public health reports (Washington, D.C. : 1974), 333549211065514. https://doi.org/10.1177/00333549211065514
Wieland, Mark L, et al. "Community-Engaged Bidirectional Crisis and Emergency Risk Communication With Immigrant and Refugee Populations During the COVID-19 Pandemic." Public health reports (Washington, D.C. : 1974) vol. (2022): 333549211065514. doi: https://doi.org/10.1177/00333549211065514
Wieland ML, Asiedu GB, Njeru JW, Weis JA, Lantz K, Abbenyi A, Molina L, Ahmed Y, Osman A, Goodson M, Torres-Herbeck G, Nur O, Porraz Capetillo G, Mohamed AA, Sia IG. Community-Engaged Bidirectional Crisis and Emergency Risk Communication With Immigrant and Refugee Populations During the COVID-19 Pandemic. Public Health Rep. 2022 Jan 13;333549211065514. doi: 10.1177/00333549211065514. Epub 2022 Jan 13. PMID: 35023414.
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Risk of Recurrent Disease 6 Years After Open or Robotic-assisted Radical Prostatectomy in the Prospective Controlled Trial LAPPRO.

European urology open science

Nyberg M, Akre O, Bock D, Carlsson SV, Carlsson S, Hugosson J, Lantz A, Steineck G, Stranne J, Tyritzis S, Wiklund P, Haglind E, Bjartell A.
PMID: 34337458
Eur Urol Open Sci. 2020 Aug 19;20:54-61. doi: 10.1016/j.euros.2020.06.005. eCollection 2020 Jul.

BACKGROUND: Conclusive evidence of superiority in oncological outcome for robot-assisted laparoscopic prostatectomy (RALP) over retropubic radical prostatectomy (RRP) is lacking.OBJECTIVE: To compare RALP and RRP regarding recurrent disease and to report the mortality rate 6 yr after surgery.DESIGN SETTING...

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Nyberg M, Akre O, Bock D, et al. Risk of Recurrent Disease 6 Years After Open or Robotic-assisted Radical Prostatectomy in the Prospective Controlled Trial LAPPRO. Eur Urol Open Sci. 2020;20:54-61doi: 10.1016/j.euros.2020.06.005.
Nyberg, M., Akre, O., Bock, D., Carlsson, S. V., Carlsson, S., Hugosson, J., Lantz, A., Steineck, G., Stranne, J., Tyritzis, S., Wiklund, P., Haglind, E., & Bjartell, A. (2020). Risk of Recurrent Disease 6 Years After Open or Robotic-assisted Radical Prostatectomy in the Prospective Controlled Trial LAPPRO. European urology open science, 2054-61. https://doi.org/10.1016/j.euros.2020.06.005
Nyberg, Martin, et al. "Risk of Recurrent Disease 6 Years After Open or Robotic-assisted Radical Prostatectomy in the Prospective Controlled Trial LAPPRO." European urology open science vol. 20 (2020): 54-61. doi: https://doi.org/10.1016/j.euros.2020.06.005
Nyberg M, Akre O, Bock D, Carlsson SV, Carlsson S, Hugosson J, Lantz A, Steineck G, Stranne J, Tyritzis S, Wiklund P, Haglind E, Bjartell A. Risk of Recurrent Disease 6 Years After Open or Robotic-assisted Radical Prostatectomy in the Prospective Controlled Trial LAPPRO. Eur Urol Open Sci. 2020 Aug 19;20:54-61. doi: 10.1016/j.euros.2020.06.005. eCollection 2020 Jul. PMID: 34337458; PMCID: PMC8317794.
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Replication of Streptococcus equi subspecies zooepidemicus infection in swine.

Veterinary microbiology

Hau SJ, Lantz K, Stuart KL, Sitthicharoenchai P, Macedo N, Derscheid RJ, Burrough ER, Robbe-Austerman S, Brockmeier SL.
PMID: 34826647
Vet Microbiol. 2021 Nov 02;264:109271. doi: 10.1016/j.vetmic.2021.109271. Epub 2021 Nov 02.

Streptococcus equi subspecies zooepidemicus (SEZ) is a commensal bacterium of horses and causes infections in mammalian species, including humans. Historically, virulent strains of SEZ caused high mortality in pigs in China and Indonesia, while disease in the U.S. was...

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Hau SJ, Lantz K, Stuart KL, et al. Replication of Streptococcus equi subspecies zooepidemicus infection in swine. Vet Microbiol. 2021;264:109271doi: 10.1016/j.vetmic.2021.109271.
Hau, S. J., Lantz, K., Stuart, K. L., Sitthicharoenchai, P., Macedo, N., Derscheid, R. J., Burrough, E. R., Robbe-Austerman, S., & Brockmeier, S. L. (2021). Replication of Streptococcus equi subspecies zooepidemicus infection in swine. Veterinary microbiology, 264109271. https://doi.org/10.1016/j.vetmic.2021.109271
Hau, Samantha J, et al. "Replication of Streptococcus equi subspecies zooepidemicus infection in swine." Veterinary microbiology vol. 264 (2021): 109271. doi: https://doi.org/10.1016/j.vetmic.2021.109271
Hau SJ, Lantz K, Stuart KL, Sitthicharoenchai P, Macedo N, Derscheid RJ, Burrough ER, Robbe-Austerman S, Brockmeier SL. Replication of Streptococcus equi subspecies zooepidemicus infection in swine. Vet Microbiol. 2021 Nov 02;264:109271. doi: 10.1016/j.vetmic.2021.109271. Epub 2021 Nov 02. PMID: 34826647.
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Deep-learning in situ classification of HIV-1 virion morphology.

Computational and structural biotechnology journal

Rey JS, Li W, Bryer AJ, Beatson H, Lantz C, Engelman AN, Perilla JR.
PMID: 34765089
Comput Struct Biotechnol J. 2021 Oct 05;19:5688-5700. doi: 10.1016/j.csbj.2021.10.001. eCollection 2021.

Transmission electron microscopy (TEM) has a multitude of uses in biomedical imaging due to its ability to discern ultrastructure morphology at the nanometer scale. Through its ability to directly visualize virus particles, TEM has for several decades been an...

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Rey JS, Li W, Bryer AJ, et al. Deep-learning in situ classification of HIV-1 virion morphology. Comput Struct Biotechnol J. 2021;19:5688-5700doi: 10.1016/j.csbj.2021.10.001.
Rey, J. S., Li, W., Bryer, A. J., Beatson, H., Lantz, C., Engelman, A. N., & Perilla, J. R. (2021). Deep-learning in situ classification of HIV-1 virion morphology. Computational and structural biotechnology journal, 195688-5700. https://doi.org/10.1016/j.csbj.2021.10.001
Rey, Juan S, et al. "Deep-learning in situ classification of HIV-1 virion morphology." Computational and structural biotechnology journal vol. 19 (2021): 5688-5700. doi: https://doi.org/10.1016/j.csbj.2021.10.001
Rey JS, Li W, Bryer AJ, Beatson H, Lantz C, Engelman AN, Perilla JR. Deep-learning in situ classification of HIV-1 virion morphology. Comput Struct Biotechnol J. 2021 Oct 05;19:5688-5700. doi: 10.1016/j.csbj.2021.10.001. eCollection 2021. PMID: 34765089; PMCID: PMC8554174.
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A 4K score/MRI-based nomogram for predicting prostate cancer, clinically significant prostate cancer, and unfavorable prostate cancer.

Cancer reports (Hoboken, N.J.)

Wagaskar VG, Sobotka S, Ratnani P, Young J, Lantz A, Parekh S, Falagario UG, Li L, Lewis S, Haines K, Punnen S, Wiklund P, Tewari A.
PMID: 33661541
Cancer Rep (Hoboken). 2021 Aug;4(4):e1357. doi: 10.1002/cnr2.1357. Epub 2021 Mar 04.

BACKGROUND: The detection of prostate cancer requires histological confirmation in biopsy core. Currently, number of unnecessary prostate biopsies are being performed in the United States. This is due to the absence of appropriate biopsy decision-making protocol.AIM: To develop and...

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Wagaskar VG, Sobotka S, Ratnani P, et al. A 4K score/MRI-based nomogram for predicting prostate cancer, clinically significant prostate cancer, and unfavorable prostate cancer. Cancer Rep (Hoboken). 2021;4(4):e1357doi: 10.1002/cnr2.1357.
Wagaskar, V. G., Sobotka, S., Ratnani, P., Young, J., Lantz, A., Parekh, S., Falagario, U. G., Li, L., Lewis, S., Haines, K., Punnen, S., Wiklund, P., & Tewari, A. (2021). A 4K score/MRI-based nomogram for predicting prostate cancer, clinically significant prostate cancer, and unfavorable prostate cancer. Cancer reports (Hoboken, N.J.), 4(4), e1357. https://doi.org/10.1002/cnr2.1357
Wagaskar, Vinayak G, et al. "A 4K score/MRI-based nomogram for predicting prostate cancer, clinically significant prostate cancer, and unfavorable prostate cancer." Cancer reports (Hoboken, N.J.) vol. 4,4 (2021): e1357. doi: https://doi.org/10.1002/cnr2.1357
Wagaskar VG, Sobotka S, Ratnani P, Young J, Lantz A, Parekh S, Falagario UG, Li L, Lewis S, Haines K, Punnen S, Wiklund P, Tewari A. A 4K score/MRI-based nomogram for predicting prostate cancer, clinically significant prostate cancer, and unfavorable prostate cancer. Cancer Rep (Hoboken). 2021 Aug;4(4):e1357. doi: 10.1002/cnr2.1357. Epub 2021 Mar 04. PMID: 33661541; PMCID: PMC8388161.
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Emission spectroscopy of negative hydrogen ion sources: From VUV to IR.

The Review of scientific instruments

Wünderlich D, Briefi S, Friedl R, Fantz U.
PMID: 34972417
Rev Sci Instrum. 2021 Dec 01;92(12):123510. doi: 10.1063/5.0075491.

The target parameters of negative ion sources regarding the current of extracted negative ions, the current of co-extracted electrons, the pulse duration, the duty cycle, and the availability of the system can be rather strict. Knowledge of plasma parameters...

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Wünderlich D, Briefi S, Friedl R, et al. Emission spectroscopy of negative hydrogen ion sources: From VUV to IR. Rev Sci Instrum. 2021;92(12):123510doi: 10.1063/5.0075491.
Wünderlich, D., Briefi, S., Friedl, R., & Fantz, U. (2021). Emission spectroscopy of negative hydrogen ion sources: From VUV to IR. The Review of scientific instruments, 92(12), 123510. https://doi.org/10.1063/5.0075491
Wünderlich, D, et al. "Emission spectroscopy of negative hydrogen ion sources: From VUV to IR." The Review of scientific instruments vol. 92,12 (2021): 123510. doi: https://doi.org/10.1063/5.0075491
Wünderlich D, Briefi S, Friedl R, Fantz U. Emission spectroscopy of negative hydrogen ion sources: From VUV to IR. Rev Sci Instrum. 2021 Dec 01;92(12):123510. doi: 10.1063/5.0075491. PMID: 34972417.
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