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Showing 13 to 24 of 32 entries
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Avoiding selection bias in metabolomics studies: a tutorial.

Metabolomics : Official journal of the Metabolomic Society

Boone SC, le Cessie S, van Dijk KW, de Mutsert R, Mook-Kanamori DO.
PMID: 30830435
Metabolomics. 2019 Jan 03;15(1):7. doi: 10.1007/s11306-018-1463-4.

BACKGROUND: Metabolomics techniques are increasingly applied in epidemiologic research. Many available assays are still relatively expensive and therefore measurements are often performed in small patient population studies such as case series or case-control designs with strong participant selection criteria....

Associations of metabolomic profiles with circulating vitamin E and urinary vitamin E metabolites in middle-aged individuals.

Nutrition (Burbank, Los Angeles County, Calif.)

Luo J, Hashimoto Y, Martens LG, Meulmeester FL, Ashrafi N, Mook-Kanamori DO, Rosendaal FR, Jukema JW, van Dijk KW, Mills K, le Cessie S, Noordam R, van Heemst D.
PMID: 34534944
Nutrition. 2022 Jan;93:111440. doi: 10.1016/j.nut.2021.111440. Epub 2021 Jul 29.

Vitamin E (α-tocopherol [α-TOH]) is transported in lipoprotein particles in blood, but little is known about the transportation of its oxidized metabolites. In the Netherlands Epidemiology of Obesity Study, we aimed to investigate the associations of 147 circulating metabolomic...

Metabolomics dissection of depression heterogeneity and related cardiometabolic risk.

Psychological medicine

Alshehri T, Mook-Kanamori DO, Willems van Dijk K, Dinga R, Penninx BWJH, Rosendaal FR, le Cessie S, Milaneschi Y.
PMID: 34078486
Psychol Med. 2021 Jun 03;1-10. doi: 10.1017/S0033291721001471. Epub 2021 Jun 03.

BACKGROUND: A recent hypothesis postulates the existence of an 'immune-metabolic depression' (IMD) dimension characterized by metabolic dysregulations. Combining data on metabolomics and depressive symptoms, we aimed to identify depressions associated with an increased risk of adverse metabolic alterations.METHOD: Clustering...

The Relation Between Adult Weight Gain, Adipocyte Volume, and the Metabolic Profile at Middle Age.

The Journal of clinical endocrinology and metabolism

Verkouter I, Noordam R, Loh NY, van Dijk KW, Zock PL, Mook-Kanamori DO, le Cessie S, Rosendaal FR, Karpe F, Christodoulides C, de Mutsert R.
PMID: 34181708
J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4438-e4447. doi: 10.1210/clinem/dgab477.

CONTEXT: Weight gain during adulthood increases cardiometabolic disease risk, possibly through adipocyte hypertrophy.OBJECTIVE: We aimed to study the specific metabolomic profile of adult weight gain, and to examine its association with adipocyte volume.METHODS: Nuclear magnetic resonance-based metabolomics were measured...

Exploring gender differences among couples with unexplained recurrent pregnancy loss regarding preferences for supportive care.

BMC pregnancy and childbirth

du Fossé NA, Lashley EELO, Treurniet TT, van Lith JMM, le Cessie S, Boosman H, van der Hoorn MLP.
PMID: 34847864
BMC Pregnancy Childbirth. 2021 Nov 30;21(1):796. doi: 10.1186/s12884-021-04277-4.

BACKGROUND: International guidelines recommend to offer supportive care during a next pregnancy to couples affected by recurrent pregnancy loss (RPL). In previous research, several options for supportive care have been identified and women's preferences have been quantified. Although it...

Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue.

American journal of epidemiology

Boone SC, van Smeden M, Rosendaal FR, le Cessie S, Groenwold RHH, Jukema JW, van Dijk KW, Lamb HJ, Greenland P, Neeland IJ, Allison MA, Criqui MH, Budoff MJ, Lind LL, Kullberg J, Ahlström H, Mook-Kanamori DO, de Mutsert R.
PMID: 35015809
Am J Epidemiol. 2022 Jan 06; doi: 10.1093/aje/kwab298. Epub 2022 Jan 06.

Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general...

Identification of distinct seminal plasma cytokine profiles associated with male age and lifestyle characteristics in unexplained recurrent pregnancy loss.

Journal of reproductive immunology

du Fossé NA, Lashley EELO, van Beelen E, Meuleman T, le Cessie S, van Lith JMM, Eikmans M, van der Hoorn MLP.
PMID: 34246867
J Reprod Immunol. 2021 Sep;147:103349. doi: 10.1016/j.jri.2021.103349. Epub 2021 Jul 08.

BACKGROUND: Seminal plasma contains a wide range of cytokines, chemokines and growth factors. Part of these signalling molecules assist in inducing a state of active maternal immune tolerance towards the fetus. Disbalances in seminal plasma content may contribute to...

Hidden analyses: a review of reporting practice and recommendations for more transparent reporting of initial data analyses.

BMC medical research methodology

Huebner M, Vach W, le Cessie S, Schmidt CO, Lusa L.
PMID: 32169053
BMC Med Res Methodol. 2020 Mar 13;20(1):61. doi: 10.1186/s12874-020-00942-y.

BACKGROUND: In the data pipeline from the data collection process to the planned statistical analyses, initial data analysis (IDA) typically takes place between the end of the data collection and do not touch the research questions. A systematic process...

Authors' reply: Who is afraid of non-normal data? Choosing between t-tests and non-parametric tests.

European journal of endocrinology

le Cessie S, Goeman JJ, Dekkers OM.
PMID: 32580153
Eur J Endocrinol. 2020 Aug;183(2):L5-L6. doi: 10.1530/EJE-20-0596.

No abstract available.

Correction: Prediction of recurrent venous thrombosis in all patients with a first venous thrombotic event: The Leiden Thrombosis Recurrence Risk Prediction model (L-TRRiP).

PLoS medicine

Timp JF, Braekkan SK, Lijfering WM, van Hylckama Vlieg A, Hansen JB, Rosendaal FR, le Cessie S, Cannegieter SC.
PMID: 33891592
PLoS Med. 2021 Apr 23;18(4):e1003612. doi: 10.1371/journal.pmed.1003612. eCollection 2021 Apr.

[This corrects the article DOI: 10.1371/journal.pmed.1002883.].

A Workflow for Missing Values Imputation of Untargeted Metabolomics Data.

Metabolites

Faquih T, van Smeden M, Luo J, le Cessie S, Kastenmüller G, Krumsiek J, Noordam R, van Heemst D, Rosendaal FR, van Hylckama Vlieg A, Willems van Dijk K, Mook-Kanamori DO.
PMID: 33256233
Metabolites. 2020 Nov 26;10(12). doi: 10.3390/metabo10120486.

Metabolomics studies have seen a steady growth due to the development and implementation of affordable and high-quality metabolomics platforms. In large metabolite panels, measurement values are frequently missing and, if neglected or sub-optimally imputed, can cause biased study results....

Evaluating the Effectiveness and Cost-Effectiveness of Seizure Dogs in Persons With Medically Refractory Epilepsy in the Netherlands: Study Protocol for a Stepped Wedge Randomized Controlled Trial (EPISODE).

Frontiers in neurology

Wester V, de Groot S, Kanters T, Wagner L, Ardesch J, Corro Ramos I, Enders-Slegers MJ, de Ruiter M, le Cessie S, Los J, Papageorgiou G, van Exel J, Versteegh M.
PMID: 32038471
Front Neurol. 2020 Jan 22;11:3. doi: 10.3389/fneur.2020.00003. eCollection 2020.

No abstract available.

Showing 13 to 24 of 32 entries