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Showing 13 to 24 of 194 entries
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The Antifibrinolysin Test in Normal and Toxemic Pregnancy.

The Yale journal of biology and medicine

Leary DC, Welt LG.
PMID: 21434139
Yale J Biol Med. 1943 Dec;16(2):193-6.

No abstract available.

A global cline in a colour polymorphism suggests a limited contribution of gene flow towards the recovery of a heavily exploited marine mammal.

Royal Society open science

Hoffman JI, Bauer E, Paijmans AJ, Humble E, Beckmann LM, Kubetschek C, Christaller F, Kröcker N, Fuchs B, Moreras A, Shihlomule YD, Bester MN, Cleary AC, De Bruyn PJN, Forcada J, Goebel ME, Goldsworthy SD, Guinet C, Hoelzel AR, Lydersen C, Kovacs KM, Lowther A.
PMID: 30473858
R Soc Open Sci. 2018 Oct 17;5(10):181227. doi: 10.1098/rsos.181227. eCollection 2018 Oct.

Evaluating how populations are connected by migration is important for understanding species resilience because gene flow can facilitate recovery from demographic declines. We therefore investigated the extent to which migration may have contributed to the global recovery of the...

Renal toxicities associated with pembrolizumab.

Clinical kidney journal

Izzedine H, Mathian A, Champiat S, Picard C, Mateus C, Routier E, Varga A, Malka D, Leary A, Michels J, Michot JM, Marabelle A, Lambotte O, Amoura Z, Soria JC, Kaaki S, Quellard N, Goujon JM, Brocheriou I.
PMID: 30746132
Clin Kidney J. 2019 Feb;12(1):81-88. doi: 10.1093/ckj/sfy100. Epub 2018 Nov 09.

OBJECTIVE: Expanded clinical experience with patients treated by pembrolizumab has accumulated. However, renal toxicities associated with this anti-programmed cell death 1 agent are poorly described because kidney histology is rarely sought. As a nephrology referral centre, we aimed to...

Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα-dependent mechanism.

The Journal of pathology

Cluzet V, Devillers MM, Petit F, Pierre A, Giton F, Airaud E, L'Hôte D, Leary A, Genestie C, Treilleux I, Mayeur A, Katzenellenbogen JA, Kim SH, Cohen-Tannoudji J, Chauvin S, Guigon CJ.
PMID: 34860414
J Pathol. 2021 Dec 03; doi: 10.1002/path.5843. Epub 2021 Dec 03.

Granulosa cell tumor (GCT) is a form of ovarian tumor characterized by its tendency to recur years after surgical ablation. Little is known about the mechanisms involved in GCT development and progression. GCTs can produce estradiol (E2), but whether...

The author replies.

Surgical endoscopy

Saunders CJ, Leary BF.
PMID: 8703164
Surg Endosc. 1996 Sep;10(9):951. doi: 10.1007/BF00188496.

No abstract available.

Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the .

Drug metabolism and disposition: the biological fate of chemicals

Fowler S, Brink A, Cleary Y, Günther A, Heinig K, Husser C, Kletzl H, Kratochwil N, Mueller L, Savage M, Stillhart C, Tuerck D, Ullah M, Umehara K, Poirier A.
PMID: 34620695
Drug Metab Dispos. 2022 Jan;50(1):65-75. doi: 10.1124/dmd.121.000563. Epub 2021 Oct 07.

Small molecules that present complex absorption, distribution, metabolism, and elimination (ADME) properties can be challenging to investigate as potential therapeutics. Acquiring data through standard methods can yield results that are insufficient to describe the in vivo situation, which can...

The Impact of Income and Social Mobility on Colorectal Cancer Outcomes and Treatment: A Cross-sectional Study.

Annals of surgery

Poulson M, Geary AD, Annesi C, Dechert T, Kenzik K, Hall J.
PMID: 34954755
Ann Surg. 2021 Dec 23; doi: 10.1097/SLA.0000000000005347. Epub 2021 Dec 23.

OBJECTIVE: To determine the impact of income mobility on racial disparities in colorectal cancer.BACKGROUND: There are well-documented disparities in colorectal cancer treatment and outcomes between Black and White patients. Socioeconomic status, insurance, and other patient-level factors have been shown...

Process Evaluation of a School-Based High-Intensity Interval Training Program for Older Adolescents: The Burn 2 Learn Cluster Randomised Controlled Trial.

Children (Basel, Switzerland)

Kennedy SG, Leahy AA, Smith JJ, Eather N, Hillman CH, Morgan PJ, Plotnikoff RC, Boyer J, Lubans DR.
PMID: 33339356
Children (Basel). 2020 Dec 16;7(12). doi: 10.3390/children7120299.

Process evaluations can help to optimise the implementation of school-based physical activity interventions. The purpose of this paper is to describe the process evaluation of a school-based high-intensity interval training (HIIT) program for older adolescent students, known as Burn...

Revision Anterior Cruciate Ligament Reconstruction after Surgical Management of Multiligament Knee Injury.

The journal of knee surgery

Worley JR, Brimmo O, Nuelle CW, Zitsch BP, Leary EV, Cook JL, Stannard JP.
PMID: 32544974
J Knee Surg. 2022 Jan;35(1):72-77. doi: 10.1055/s-0040-1712969. Epub 2020 Jun 16.

The purpose of this study is to determine factors associated with the need for revision anterior cruciate ligament reconstruction (ACLR) after multiligament knee injury (MLKI) and to report outcomes for patients undergoing revision ACLR after MLKI. This involves a...

Psychopathy and Occurrence of Gambling Problems: The Role of Gambling Protective Strategies and Urgency.

Psychological reports

Kramer MP, Peterson R, Leary AV, Wilborn DD, Magri T, Dvorak RD.
PMID: 34080886
Psychol Rep. 2021 Jun 03;332941211022998. doi: 10.1177/00332941211022998. Epub 2021 Jun 03.

BACKGROUND: Psychopathy has been an increasing area of clinical and personality research and is associated with numerous problematic outcomes, including pathological gambling, though this area of research is limited. The most common conceptualization of psychopathy is a two-factor model...

Tolerability of maintenance olaparib in newly diagnosed patients with advanced ovarian cancer and a BRCA mutation in the randomized phase III SOLO1 trial.

Gynecologic oncology

Colombo N, Moore K, Scambia G, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, Gourley C, Banerjee S, Oza A, González-Martín A, Aghajanian C, Bradley WH, Kim JW, Mathews C, Liu J, Lowe ES, Bloomfield R, DiSilvestro P.
PMID: 34353615
Gynecol Oncol. 2021 Oct;163(1):41-49. doi: 10.1016/j.ygyno.2021.07.016. Epub 2021 Aug 02.

OBJECTIVES: In the phase III SOLO1 trial (NCT01844986), maintenance olaparib provided a substantial progression-free survival benefit in patients with newly diagnosed, advanced ovarian cancer and a BRCA mutation who were in response after platinum-based chemotherapy. We analyzed the timing,...

Rucaparib maintenance treatment for recurrent ovarian carcinoma: the effects of progression-free interval and prior therapies on efficacy and safety in the randomized phase III trial ARIEL3.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Clamp AR, Lorusso D, Oza AM, Aghajanian C, Oaknin A, Dean A, Colombo N, Weberpals JI, Scambia G, Leary A, Holloway RW, Amenedo Gancedo M, Fong PC, Goh JC, O'Malley DM, Armstrong DK, Banerjee S, García-Donas J, Swisher EM, Cameron T, Goble S, Coleman RL, Ledermann JA.
PMID: 34103386
Int J Gynecol Cancer. 2021 Jul;31(7):949-958. doi: 10.1136/ijgc-2020-002240. Epub 2021 Jun 08.

INTRODUCTION: In ARIEL3 (NCT01968213), the poly(adenosine diphosphate-ribose) polymerase inhibitor rucaparib significantly improved progression-free survival versus placebo regardless of biomarker status when used as maintenance treatment for recurrent ovarian cancer. The aim of the current analyses was to evaluate the...

Showing 13 to 24 of 194 entries