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Showing 25 to 36 of 174 entries
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Assessing effective mask use by the public in two countries: an observational study.

BMJ open

Atzema CL, Mostarac I, Button D, Austin PC, Javidan AP, Wintraub L, Li A, Patel RV, Lee DD, Latham NP, Latham EA, Brown PCM, Somogyi RD, Chang A, Nguyen H, Buerk S, Chen B, Zimmerman T, Funari T, Colbert C, Kea B.
PMID: 34887270
BMJ Open. 2021 Dec 09;11(12):e049389. doi: 10.1136/bmjopen-2021-049389.

OBJECTIVES: During the COVID-19 pandemic wearing a mask in public has been recommended in some settings and mandated in others. How often this advice is followed, how well, and whether it inadvertently leads to more disease transmission opportunities due...

Stomatitis.

The Dental register

Latham VA.
PMID: 33700084
Dent Regist. 1891 Dec;45(12):605-616.

No abstract available.

A Series of Tattoo-associated .

The Journal of clinical and aesthetic dermatology

Schlesinger TE, Wilson AE, Trivedi L, Latham PJ, Ball R.
PMID: 34055187
J Clin Aesthet Dermatol. 2021 Apr;14(4):38-40. Epub 2021 Apr 01.

No abstract available.

Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing.

European urology oncology

Truong H, Sheikh R, Kotecha R, Kemel Y, Reisz PA, Lenis AT, Mehta NN, Khurram A, Joseph V, Mandelker D, Latham A, Ceyhan-Birsoy O, Ladanyi M, Shah NJ, Walsh MF, Voss MH, Lee CH, Russo P, Coleman JA, Hakimi AA, Feldman DR, Stadler ZK, Robson ME, Motzer RJ, Offit K, Patil S, Carlo MI.
PMID: 34654685
Eur Urol Oncol. 2021 Dec;4(6):993-1000. doi: 10.1016/j.euo.2021.09.005. Epub 2021 Oct 12.

BACKGROUND: Despite guidelines recommending genetic counseling for patients with early-onset renal cell carcinoma (RCC), studies interrogating the spectrum of germline mutations and clinical associations in patients with early-onset RCC are lacking.OBJECTIVE: To define the germline genetic spectrum and clinical...

A Mouse Model for Studying Post-Acute Arthritis of Chikungunya.

Microorganisms

Chang AY, Tritsch SR, Porzucek AJ, Schwartz AM, Seyler-Schmidt M, Glass A, Latham PS, Reid SP, Simon GL, Mores CN.
PMID: 34576893
Microorganisms. 2021 Sep 21;9(9). doi: 10.3390/microorganisms9091998.

Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of...

Consistent Force Field Captures Homologue-Resolved HP1 Phase Separation.

Journal of chemical theory and computation

Latham AP, Zhang B.
PMID: 33826337
J Chem Theory Comput. 2021 May 11;17(5):3134-3144. doi: 10.1021/acs.jctc.0c01220. Epub 2021 Apr 07.

Many proteins have been shown to function via liquid-liquid phase separation. Computational modeling could offer much needed structural details of protein condensates and reveal the set of molecular interactions that dictate their stability. However, the presence of both ordered...

Effectiveness of a surveillance program of upper endoscopy for upper gastrointestinal cancers in Lynch syndrome patients.

International journal of colorectal disease

Ceravolo AH, Yang JJ, Latham A, Markowitz AJ, Shia J, Mermelstein J, Calo D, Gerdes H, Ludwig E, Schattner MA, Stadler ZK, Kantor E, Du M, Mendelsohn RB.
PMID: 34698909
Int J Colorectal Dis. 2022 Jan;37(1):231-238. doi: 10.1007/s00384-021-04053-y. Epub 2021 Oct 26.

BACKGROUND AND AIMS: Lynch syndrome (LS) is the most common cause of hereditary colorectal cancer and is associated with an increased lifetime risk of gastric and duodenal cancers of 8-16% and 7%, respectively; therefore, we aim to describe an...

β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development.

Science translational medicine

Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L.
PMID: 34910547
Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi: 10.1126/scitranslmed.abk2267. Epub 2021 Dec 15.

[Figure: see text].

Downregulation of miR-375 contributes to ERBB2-mediated VEGFA overexpression in esophageal cancer.

Journal of Cancer

Ren S, Tan X, Fu MZ, Ren S, Wu X, Chen T, Latham PS, Lin P, Man YG, Fu SW.
PMID: 34729115
J Cancer. 2021 Oct 20;12(23):7138-7146. doi: 10.7150/jca.63836. eCollection 2021.

Esophageal cancer (EC) is a lethal cancer with an extremely aggressive nature and poor survival rate. However, the molecular mechanisms driving the occurrence and progression of EC are not well understood. MicroRNAs (miRNAs) are small RNA molecules that regulate...

Unifying coarse-grained force fields for folded and disordered proteins.

Current opinion in structural biology

Latham AP, Zhang B.
PMID: 34536913
Curr Opin Struct Biol. 2021 Sep 15;72:63-70. doi: 10.1016/j.sbi.2021.08.006. Epub 2021 Sep 15.

Liquid-liquid phase separation drives the formation of biological condensates that play essential roles in transcriptional regulation and signal sensing. Computational modeling could provide high-resolution structural characterizations of these condensates and help uncover physicochemical interactions that dictate their stability. However,...

Biosynthesis of the redox cofactor mycofactocin is controlled by the transcriptional regulator MftR and induced by long-chain acyl-CoA species.

The Journal of biological chemistry

Mendauletova A, Latham JA.
PMID: 34896395
J Biol Chem. 2021 Dec 09;298(1):101474. doi: 10.1016/j.jbc.2021.101474. Epub 2021 Dec 09.

Mycofactocin (MFT) is a ribosomally synthesized and post-translationally-modified redox cofactor found in pathogenic mycobacteria. While MFT biosynthetic proteins have been extensively characterized, the physiological conditions under which MFT biosynthesis is required are not well understood. To gain insights into...

Prospective pan-cancer germline testing using MSK-IMPACT informs clinical translation in 751 patients with pediatric solid tumors.

Nature cancer

Fiala EM, Jayakumaran G, Mauguen A, Kennedy JA, Bouvier N, Kemel Y, Fleischut MH, Maio A, Salo-Mullen EE, Sheehan M, Arnold AG, Latham A, Carlo MI, Cadoo K, Murkherjee S, Slotkin EK, Trippett T, Bender JG, Meyers PA, Wexler L, Dela Cruz FS, Cheung NK, Basu E, Kentsis A, Ortiz M, Francis JH, Dunkel IJ, Khakoo Y, Gilheeney S, Sait SF, Forlenza CJ, Sulis M, Karajannis M, Modak S, Gerstle JT, Heaton TE, Roberts S, Yang C, Jairam S, Vijai J, Topka S, Friedman DN, Stadler ZK, Robson M, Berger MF, Schultz N, Ladanyi M, O'Reilly RJ, Abramson DH, Ceyhan-Birsoy O, Zhang L, Mandelker D, Shukla NN, Kung AL, Offit K, Zehir A, Walsh MF.
PMID: 34308366
Nat Cancer. 2021 Mar;2:357-365. doi: 10.1038/s43018-021-00172-1. Epub 2021 Feb 15.

The spectrum of germline predisposition in pediatric cancer continues to be realized. Here we report 751 solid tumor patients who underwent prospective matched tumor-normal DNA sequencing and downstream clinical use (clinicaltrials.gov NCT01775072). Germline pathogenic and likely pathogenic (P/LP) variants...

Showing 25 to 36 of 174 entries