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Showing 121 to 130 of 130 entries
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Treatment of Thoracic Endometriosis Syndrome: A Meta-Analysis and Review.

The Annals of thoracic surgery

Ciriaco P, Muriana P, Lembo R, Carretta A, Negri G.
PMID: 33345783
Ann Thorac Surg. 2020 Dec 18; doi: 10.1016/j.athoracsur.2020.09.064. Epub 2020 Dec 18.

BACKGROUND: Thoracic endometriosis syndrome (TES) is a rare disorder characterized by the presence of functional endometrial tissue within the chest cavity. Up to 80% of women with TES present with concomitant pelvic endometriosis. The diagnostic-curative path is defined by...

Continuous Melt Granulation for Taste-Masking of Ibuprofen.

Pharmaceutics

Forster SP, Lebo DB.
PMID: 34208288
Pharmaceutics. 2021 Jun 11;13(6). doi: 10.3390/pharmaceutics13060863.

Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be challenging and require complex manufacturing approaches. The objective of this study was to produce taste-masked ibuprofen granules using a novel process, twin-screw melt granulation (TSMG). TSMG is...

Association of GSTM1 Deletion With Progression of CKD in Children: Findings From the Chronic Kidney Disease in Children (CKiD) Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Levy RV, Reidy KJ, Le TH, David V, Winkler C, Xu Y, Warady B, Furth S, Kaskel F, Melamed ML.
PMID: 34871703
Am J Kidney Dis. 2021 Dec 03; doi: 10.1053/j.ajkd.2021.10.007. Epub 2021 Dec 03.

RATIONALE AND OBJECTIVE: Loss of function of the product of the GSTM1 gene has been implicated in rapid progression of adult CKD. Its role in pediatric CKD has not been previously described.STUDY DESIGN: The study is a secondary analysis...

Optimizing immunoPET imaging of tumor PD-L1 expression: pharmacokinetics, biodistribution and dosimetric comparisons of .

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Bouleau A, Nozach H, Dubois S, Kereselidze D, Chevaleyre C, Wang CI, Evans MJ, Lebon V, Maillere B, Truillet C.
PMID: 34933891
J Nucl Med. 2021 Dec 21; doi: 10.2967/jnumed.121.262967. Epub 2021 Dec 21.

Positron emission tomography (PET) imaging of programmed cell death ligand 1 (PD-L1) may help to non-invasively predict and monitor responses to anti-PD-1/anti-PD-L1 immunotherapies. In this study, we compared the imaging characteristics of three radioligands, derived from the anti-PD-L1 IgG1...

A Novel XGBoost Method to Infer the Primary Lesion of 20 Solid Tumor Types From Gene Expression Data.

Frontiers in genetics

Chen S, Zhou W, Tu J, Li J, Wang B, Mo X, Tian G, Lv K, Huang Z.
PMID: 33613644
Front Genet. 2021 Feb 03;12:632761. doi: 10.3389/fgene.2021.632761. eCollection 2021.

PURPOSE: Establish a suitable machine learning model to identify its primary lesions for primary metastatic tumors in an integrated learning approach, making it more accurate to improve primary lesions' diagnostic efficiency.METHODS: After deleting the features whose expression level is...

Recurrent Stress Cardiomyopathy: A Rare Variant in a Young Patient with Undiagnosed Pheochromocytoma.

Case reports in cardiology

Lembo R, Wesley P, Calkins JB.
PMID: 34188960
Case Rep Cardiol. 2021 Jun 01;2021:5518578. doi: 10.1155/2021/5518578. eCollection 2021.

Biventricular stress cardiomyopathy is one of several known anatomical variants of reversible cardiomyopathies to occur. We present a case of a young patient with recurrent stress cardiomyopathy complicated by cardiogenic shock in the perioperative period. The cardiomyopathy observed was...

Returning actionable genomic results in a research biobank: Analytic validity, clinical implementation, and resource utilization.

American journal of human genetics

Blout Zawatsky CL, Shah N, Machini K, Perez E, Christensen KD, Zouk H, Steeves M, Koch C, Uveges M, Shea J, Gold N, Krier J, Boutin N, Mahanta L, Rehm HL, Weiss ST, Karlson EW, Smoller JW, Lebo MS, Green RC.
PMID: 34752750
Am J Hum Genet. 2021 Dec 02;108(12):2224-2237. doi: 10.1016/j.ajhg.2021.10.005. Epub 2021 Nov 08.

Over 100 million research participants around the world have had research array-based genotyping (GT) or genome sequencing (GS), but only a small fraction of these have been offered return of actionable genomic findings (gRoR). Between 2017 and 2021, we...

Systemic corticosteroids for COVID-19.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

Lu K, Leno RW, Brewster SR.
PMID: 34942049
Acad Emerg Med. 2021 Dec 23; doi: 10.1111/acem.14432. Epub 2021 Dec 23.

No abstract available.

ANCA-Negative Pauci-Immune Necrotizing Glomerulonephritis: A Case Series and a New Clinical Classification.

American journal of kidney diseases : the official journal of the National Kidney Foundation

Ronsin C, Georges M, Chapelet-Debout A, Augusto JF, Audard V, Lebourg L, Rubin S, Quemeneur T, Bataille P, Karras A, Daugas E, Titeca-Beauport D, Boffa JJ, Vigneau C, Halimi JM, Isnard-Bagnis C, Durault S, Renaudineau E, Bridoux F, Testa A, Le Quintrec M, Renaudin K, Fakhouri F.
PMID: 34119564
Am J Kidney Dis. 2021 Jun 11; doi: 10.1053/j.ajkd.2021.03.027. Epub 2021 Jun 11.

RATIONALE & OBJECTIVE: Pauci-immune necrotizing glomerulonephritis (PING) is usually associated with the presence of antineutrophil cytoplasmic antibodies (ANCA). However, a minority (2%-3%) of patients with PING do not have detectable ANCA. We assessed the clinical spectrum and outcome of...

Genetic Basis of Antimicrobial Resistant Gram-Negative Bacteria Isolated From Bloodstream in Brazil.

Frontiers in medicine

Silveira MC, Rocha-de-Souza CM, de Oliveira Santos IC, Pontes LDS, Oliveira TRTE, Tavares-Teixeira CB, Cossatis NA, Pereira NF, da Conceição-Neto OC, da Costa BS, Rodrigues DCS, Albano RM, da Silva FAB, Marques EA, Leão RS, Carvalho-Assef APD.
PMID: 33791325
Front Med (Lausanne). 2021 Mar 15;8:635206. doi: 10.3389/fmed.2021.635206. eCollection 2021.

Multidrug-resistant microorganisms are a well-known global problem, and gram-negative bacilli are top-ranking. When these pathogens are associated with bloodstream infections (BSI), outcomes become even worse. Here we applied whole-genome sequencing to access information about clonal distribution, resistance mechanism diversity...

Showing 121 to 130 of 130 entries