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Showing 13 to 24 of 124 entries
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Introduction to sample size determination and power analysis for clinical trials.

Controlled clinical trials

Lachin JM.
PMID: 7273794
Control Clin Trials. 1981 Jun;2(2):93-113. doi: 10.1016/0197-2456(81)90001-5.

The importance of sample size evaluation in clinical trials is reviewed and a general method is presented from which specific equations are derived for sample size determination or the analysis of power for a wide variety os statistical procedures....

Utility of using electrocardiogram measures of heart rate variability as a measure of cardiovascular autonomic neuropathy in type 1 diabetes patients.

Journal of diabetes investigation

Pop-Busui R, Backlund JC, Bebu I, Braffett BH, Lorenzi G, White NH, Lachin JM, Soliman EZ.
PMID: 34309223
J Diabetes Investig. 2022 Jan;13(1):125-133. doi: 10.1111/jdi.13635. Epub 2021 Aug 14.

AIMS/INTRODUCTION: Cardiovascular autonomic neuropathy (CAN) is a predictor of cardiovascular disease and mortality. Cardiovascular reflex tests (CARTs) are the gold standard for the diagnosis of CAN, but might not be feasible in large research cohorts or in clinical care....

Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model.

Antiviral research

Cochin M, Touret F, Driouich JS, Moureau G, Petit PR, Laprie C, Solas C, de Lamballerie X, Nougairède A.
PMID: 34838583
Antiviral Res. 2021 Nov 24;197:105212. doi: 10.1016/j.antiviral.2021.105212. Epub 2021 Nov 24.

Drug repositioning has been used extensively since the beginning of the COVID-19 pandemic in an attempt to identify antiviral molecules for use in human therapeutics. Hydroxychloroquine and azithromycin have shown inhibitory activity against SARS-CoV-2 replication in different cell lines....

Arabidopsis Growth-Promotion and Root Architecture Responses to the Beneficial Rhizobacterium .

Plants (Basel, Switzerland)

Kechid M, Desbrosses G, Gamet L, Castaings L, Varoquaux F, Djekoun A, Touraine B.
PMID: 35009131
Plants (Basel). 2022 Jan 04;11(1). doi: 10.3390/plants11010128.

No abstract available.

Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model.

Antiviral research

Cochin M, Touret F, Driouich JS, Moureau G, Petit PR, Laprie C, Solas C, de Lamballerie X, Nougairède A.
PMID: 34838583
Antiviral Res. 2021 Nov 24;197:105212. doi: 10.1016/j.antiviral.2021.105212. Epub 2021 Nov 24.

Drug repositioning has been used extensively since the beginning of the COVID-19 pandemic in an attempt to identify antiviral molecules for use in human therapeutics. Hydroxychloroquine and azithromycin have shown inhibitory activity against SARS-CoV-2 replication in different cell lines....

Shape decomposition algorithms for laser capture microdissection.

Algorithms for molecular biology : AMB

Selbach L, Kowalski T, Gerwert K, Buchin M, Mosig A.
PMID: 34238311
Algorithms Mol Biol. 2021 Jul 08;16(1):15. doi: 10.1186/s13015-021-00193-6.

BACKGROUND: In the context of biomarker discovery and molecular characterization of diseases, laser capture microdissection is a highly effective approach to extract disease-specific regions from complex, heterogeneous tissue samples. For the extraction to be successful, these regions have to...

Early-Onset Leptomeningeal Manifestation of G47R Hereditary Transthyretin Amyloidosis.

Neurology. Clinical practice

Cechin L, Gasmelseed J, Bashford J, Rowczenio D, Reilly MM, Gillmore JD, Coutinho E.
PMID: 34840900
Neurol Clin Pract. 2021 Oct;11(5):e757-e759. doi: 10.1212/CPJ.0000000000001054.

No abstract available.

Understanding Metabolic Memory: The Prolonged Influence of Glycemia During the Diabetes Control and Complications Trial (DCCT) on Future Risks of Complications During the Study of the Epidemiology of Diabetes Interventions and Complications (EDIC).

Diabetes care

Lachin JM, Nathan DM.
PMID: 34548284
Diabetes Care. 2021 Sep 21; doi: 10.2337/dc20-3097. Epub 2021 Sep 21.

The Diabetes Control and Complications Trial (DCCT, 1983-1993) showed that intensive therapy (mean HbA

Welcome to the One Electron World.

Chimia

Lachia M, Kolleth-Krieger A.
PMID: 32264998
Chimia (Aarau). 2020 Feb 26;74(1):8.

No abstract available.

Serum-deprived differentiated neuroblastoma F-11 cells express functional dorsal root ganglion neuron properties.

PeerJ

Pastori V, D'Aloia A, Blasa S, Lecchi M.
PMID: 31687277
PeerJ. 2019 Oct 30;7:e7951. doi: 10.7717/peerj.7951. eCollection 2019.

The isolation and culture of dorsal root ganglion (DRG) neurons cause adaptive changes in the expression and regulation of ion channels, with consequences on neuronal excitability. Considering that not all neurons survive the isolation and that DRG neurons are...

Magnesium alginate versus proton pump inhibitors for the treatment of laryngopharyngeal reflux: a non-inferiority randomized controlled trial.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Pizzorni N, Ambrogi F, Eplite A, Rama S, Robotti C, Lechien J, Schindler A.
PMID: 35032204
Eur Arch Otorhinolaryngol. 2022 Jan 15; doi: 10.1007/s00405-021-07219-0. Epub 2022 Jan 15.

PURPOSE: Proton pump inhibitors (PPIs) are commonly prescribed for laryngopharyngeal reflux (LPR), but their efficacy remains debated. Alginates is an option for the treatment of LPR with few adverse effects. The study aimed to investigate the non-inferiority of an...

Mediators of the improvement in heart failure outcomes with empagliflozin in the EMPA-REG OUTCOME trial.

ESC heart failure

Fitchett D, Inzucchi SE, Zinman B, Wanner C, Schumacher M, Schmoor C, Ohneberg K, Ofstad AP, Salsali A, George JT, Hantel S, Bluhmki E, Lachin JM, Zannad F.
PMID: 34605192
ESC Heart Fail. 2021 Oct 04; doi: 10.1002/ehf2.13615. Epub 2021 Oct 04.

AIMS: In the EMPA-REG OUTCOME trial, empagliflozin reduced risk of death from heart failure (HF) or hospitalization for heart failure (HHF) versus placebo in patients with type 2 diabetes mellitus (T2DM) and established cardiovascular (CV) disease. We evaluated post...

Showing 13 to 24 of 124 entries