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Showing 9985 to 9996 of 16916 entries
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Beyond hydrophilic polymers in amphiphilic polymer-based self-assembled NanoCarriers: Small hydrophilic carboxylate-capped disulfide drug delivery system and its multifunctionality and multispatial targetability.

Biomaterials

Choi YS, Cho H, Choi WG, Lee SS, Huh KM, Shim MS, Park IS, Cho YY, Lee JY, Lee HS, Kang HC.
PMID: 34894582
Biomaterials. 2021 Dec 06;280:121307. doi: 10.1016/j.biomaterials.2021.121307. Epub 2021 Dec 06.

Due to increasing safety and intracellular delivery concerns about hydrophilic polymers in amphiphilic polymer-based nanoparticles (NPs), this study investigates small hydrophilic molecule-stabilized NPs for effective intracellular delivery with multiorganelle targetability and dual responsiveness to acidic pH/glutathione (GSH). In the...

Rising Early-onset Colorectal Cancer Incidence Is Not an Artifact of Increased Screening Colonoscopy Use in a Large, Diverse Healthcare System.

Gastroenterology

Lee JK, Merchant SA, Jensen CD, Murphy CC, Udaltsova N, Corley DA.
PMID: 34555382
Gastroenterology. 2022 Jan;162(1):325-327.e3. doi: 10.1053/j.gastro.2021.09.034. Epub 2021 Sep 20.

No abstract available.

Comparison of precutting endoscopic mucosal resection and endoscopic submucosal dissection for large (20-30 mm) flat colorectal lesions.

Journal of gastroenterology and hepatology

Oh CK, Cho YW, Choi IH, Lee HH, Lim CH, Kim JS, Lee BI, Cho YS.
PMID: 34845766
J Gastroenterol Hepatol. 2021 Nov 29; doi: 10.1111/jgh.15744. Epub 2021 Nov 29.

BACKGROUND AND AIM: The complete and safe removal of large (≥ 20 mm) colorectal lesions is an area of concern. Endoscopic submucosal dissection (ESD) effectively removes these lesions compared with endoscopic mucosal resection (EMR). However, ESD requires advanced techniques,...

Effect of TGF-β1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease.

PloS one

Choi Y, Sim S, Lee DH, Lee HR, Ban GY, Shin YS, Kim YK, Park HS.
PMID: 34437574
PLoS One. 2021 Aug 26;16(8):e0256237. doi: 10.1371/journal.pone.0256237. eCollection 2021.

Cysteinyl leukotriene (cysLT) overproduction and eosinophil activation are hallmarks of aspirin-exacerbated respiratory disease (AERD). However, pathogenic mechanisms of AERD remain to be clarified. Here, we aimed to find the significance of transforming growth factor beta 1 (TGF-β1) in association...

Induction of Peptide-specific CTL Activity and Inhibition of Tumor Growth Following Immunization with Nanoparticles Coated with Tumor Peptide-MHC-I Complexes.

Immune network

Kim SH, Park HE, Jeong SU, Moon JH, Lee YR, Kim JK, Kong H, Park CS, Lee CK.
PMID: 35036031
Immune Netw. 2021 Dec 22;21(6):e44. doi: 10.4110/in.2021.21.e44. eCollection 2021 Dec.

Tumor peptides associated with MHC class I molecules or their synthetic variants have attracted great attention for their potential use as vaccines to induce tumor-specific CTLs. However, the outcome of clinical trials of peptide-based tumor vaccines has been disappointing....

COVID-19 Impact on Interventional Pulmonology Training.

ATS scholar

Kalchiem-Dekel O, Schwalk AJ, Patel NM, Lin IH, Beattie JA, Husta BC, Chawla M, Sachdeva A, Akulian JA, Musani AI, Argento AC, Lee HJ, Mullon JJ, Desai NR, Hsia DW, Lee RP.
PMID: 34409418
ATS Sch. 2021 Apr 13;2(2):236-248. doi: 10.34197/ats-scholar.2020-0126OC. eCollection 2021 Jun.

No abstract available.

Accessory pathway-mediated cardiomyopathy: Left ventricular systolic dysfunction due to preexcitation.

HeartRhythm case reports

Lee HS, Sureddi R.
PMID: 32461893
HeartRhythm Case Rep. 2020 Feb 08;6(5):272-274. doi: 10.1016/j.hrcr.2020.01.012. eCollection 2020 May.

No abstract available.

Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1.

Science advances

Song YH, Hwang YS, Kim K, Lee HR, Kim JH, Maclachlan C, Dubois A, Jung MW, Petersen CCH, Knott G, Lee SH, Lee SH.
PMID: 32494634
Sci Adv. 2020 Apr 22;6(17):eaaz0517. doi: 10.1126/sciadv.aaz0517. eCollection 2020 Apr.

Somatostatin (SST) is a neuropeptide expressed in a major subtype of GABAergic interneurons in the cortex. Despite abundant expression of SST and its receptors, their modulatory function in cortical processing remains unclear. Here, we found that SST application in...

Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell-based cartilage tissue engineering.

Science advances

Lee J, Jeon O, Kong M, Abdeen AA, Shin JY, Lee HN, Lee YB, Sun W, Bandaru P, Alt DS, Lee K, Kim HJ, Lee SJ, Chaterji S, Shin SR, Alsberg E, Khademhosseini A.
PMID: 32494742
Sci Adv. 2020 May 22;6(21):eaaz5913. doi: 10.1126/sciadv.aaz5913. eCollection 2020 May.

Despite great progress in biomaterial design strategies for replacing damaged articular cartilage, prevention of stem cell-derived chondrocyte hypertrophy and resulting inferior tissue formation is still a critical challenge. Here, by using engineered biomaterials and a high-throughput system for screening...

Physicochemical properties and bioavailability of naturally formulated fat-soluble vitamins extracted from agricultural products for complementary use for natural vitamin supplements.

Food science & nutrition

Lee HJ, Shin C, Chun YS, Kim J, Jung H, Choung J, Shim SM.
PMID: 33133568
Food Sci Nutr. 2020 Sep 08;8(10):5660-5672. doi: 10.1002/fsn3.1804. eCollection 2020 Oct.

The purpose of the current study was to evaluate the physicochemical properties, digestive stability, storage stability, and intestinal absorption of formulated natural vitamins (FNV) by mixing fat-soluble vitamins extracted from agricultural products with their synthetic vitamin (SYNV) counterparts using...

The effects of social comparison orientation on psychological well-being in social networking sites: Serial mediation of perceived social support and self-esteem.

Current psychology (New Brunswick, N.J.)

Lee JK.
PMID: 33078053
Curr Psychol. 2020 Oct 14;1-13. doi: 10.1007/s12144-020-01114-3. Epub 2020 Oct 14.

This study investigates the effects of the social comparison orientation in social networking sites on psychological well-being. In particular, it examines the mediation effect of perceived social support and self-esteem in the relationship between social comparison orientation and psychological...

The dopaminergic alterations induced by 4-F-PCP and 4-Keto-PCP may enhance their drug-induced rewarding and reinforcing effects: Implications for abuse.

Addiction biology

Ortiz DM, Custodio RJP, Abiero A, Botanas CJ, Sayson LV, Kim M, Lee HJ, Kim HJ, Jeong Y, Yoon S, Lee YS, Cheong JH.
PMID: 33135332
Addict Biol. 2021 Jul;26(4):e12981. doi: 10.1111/adb.12981. Epub 2020 Nov 01.

Novel psychoactive substances remain the popular recreational drugs of use over the years. They continue to bypass government restrictions due to their synthesis and modifications. Recent additions to the lists are the 4-F-PCP and 4-Keto-PCP, analogs of the drug...

Showing 9985 to 9996 of 16916 entries