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Showing 193 to 198 of 198 entries
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CRISPR-to-Kill (C2K)-Employing the Bacterial Immune System to Kill Cancer Cells.

Cancers

Głów D, Maire CL, Schwarze LI, Lamszus K, Fehse B.
PMID: 34944926
Cancers (Basel). 2021 Dec 15;13(24). doi: 10.3390/cancers13246306.

CRISPR/Cas9 was described as a bacterial immune system that uses targeted introduction of DNA double-strand breaks (DSBs) to destroy invaders. We hypothesized that we can analogously employ CRISPR/Cas9 nucleases to kill cancer cells by inducing maximal numbers of DSBs...

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Głów D, Maire CL, Schwarze LI, et al. CRISPR-to-Kill (C2K)-Employing the Bacterial Immune System to Kill Cancer Cells. Cancers (Basel). 2021;13(24)doi: 10.3390/cancers13246306.
Głów, D., Maire, C. L., Schwarze, L. I., Lamszus, K., & Fehse, B. (2021). CRISPR-to-Kill (C2K)-Employing the Bacterial Immune System to Kill Cancer Cells. Cancers, 13(24), . https://doi.org/10.3390/cancers13246306
Głów, Dawid, et al. "CRISPR-to-Kill (C2K)-Employing the Bacterial Immune System to Kill Cancer Cells." Cancers vol. 13,24 (2021). doi: https://doi.org/10.3390/cancers13246306
Głów D, Maire CL, Schwarze LI, Lamszus K, Fehse B. CRISPR-to-Kill (C2K)-Employing the Bacterial Immune System to Kill Cancer Cells. Cancers (Basel). 2021 Dec 15;13(24). doi: 10.3390/cancers13246306. PMID: 34944926; PMCID: PMC8699370.
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Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.

Nature communications

Park S, Supek F, Lehner B.
PMID: 34862370
Nat Commun. 2021 Dec 03;12(1):7051. doi: 10.1038/s41467-021-27242-3.

The classic two-hit model posits that both alleles of a tumor suppressor gene (TSG) must be inactivated to cause cancer. In contrast, for some oncogenes and haploinsufficient TSGs, a single genetic alteration can suffice to increase tumor fitness. Here,...

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Park S, Supek F, Lehner B. Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers. Nat Commun. 2021;12(1):7051doi: 10.1038/s41467-021-27242-3.
Park, S., Supek, F., & Lehner, B. (2021). Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers. Nature communications, 12(1), 7051. https://doi.org/10.1038/s41467-021-27242-3
Park, Solip, et al. "Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers." Nature communications vol. 12,1 (2021): 7051. doi: https://doi.org/10.1038/s41467-021-27242-3
Park S, Supek F, Lehner B. Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers. Nat Commun. 2021 Dec 03;12(1):7051. doi: 10.1038/s41467-021-27242-3. PMID: 34862370.
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Human gut-associated lymphoid tissues (GALT); diversity, structure, and function.

Mucosal immunology

Mörbe UM, Jørgensen PB, Fenton TM, von Burg N, Riis LB, Spencer J, Agace WW.
PMID: 33753873
Mucosal Immunol. 2021 Jul;14(4):793-802. doi: 10.1038/s41385-021-00389-4. Epub 2021 Mar 22.

Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's patches of the ileum, the vermiform appendix, and the numerous isolated lymphoid follicles (ILF) which...

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Mörbe UM, Jørgensen PB, Fenton TM, et al. Human gut-associated lymphoid tissues (GALT); diversity, structure, and function. Mucosal Immunol. 2021;14(4):793-802doi: 10.1038/s41385-021-00389-4.
Mörbe, U. M., Jørgensen, P. B., Fenton, T. M., von Burg, N., Riis, L. B., Spencer, J., & Agace, W. W. (2021). Human gut-associated lymphoid tissues (GALT); diversity, structure, and function. Mucosal immunology, 14(4), 793-802. https://doi.org/10.1038/s41385-021-00389-4
Mörbe, Urs M, et al. "Human gut-associated lymphoid tissues (GALT); diversity, structure, and function." Mucosal immunology vol. 14,4 (2021): 793-802. doi: https://doi.org/10.1038/s41385-021-00389-4
Mörbe UM, Jørgensen PB, Fenton TM, von Burg N, Riis LB, Spencer J, Agace WW. Human gut-associated lymphoid tissues (GALT); diversity, structure, and function. Mucosal Immunol. 2021 Jul;14(4):793-802. doi: 10.1038/s41385-021-00389-4. Epub 2021 Mar 22. PMID: 33753873.
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Efficient Pseudotyping of Different Retroviral Vectors Using a Novel, Codon-Optimized Gene for Chimeric GALV Envelope.

Viruses

Mirow M, Schwarze LI, Fehse B, Riecken K.
PMID: 34452336
Viruses. 2021 Jul 27;13(8). doi: 10.3390/v13081471.

The Gibbon Ape Leukemia Virus envelope protein (GALV-Env) mediates efficient transduction of human cells, particularly primary B and T lymphocytes, and is therefore of great interest in gene therapy. Using internal domains from murine leukemia viruses (MLV), chimeric GALV-Env...

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Mirow M, Schwarze LI, Fehse B, et al. Efficient Pseudotyping of Different Retroviral Vectors Using a Novel, Codon-Optimized Gene for Chimeric GALV Envelope. Viruses. 2021;13(8)doi: 10.3390/v13081471.
Mirow, M., Schwarze, L. I., Fehse, B., & Riecken, K. (2021). Efficient Pseudotyping of Different Retroviral Vectors Using a Novel, Codon-Optimized Gene for Chimeric GALV Envelope. Viruses, 13(8), . https://doi.org/10.3390/v13081471
Mirow, Manuela, et al. "Efficient Pseudotyping of Different Retroviral Vectors Using a Novel, Codon-Optimized Gene for Chimeric GALV Envelope." Viruses vol. 13,8 (2021). doi: https://doi.org/10.3390/v13081471
Mirow M, Schwarze LI, Fehse B, Riecken K. Efficient Pseudotyping of Different Retroviral Vectors Using a Novel, Codon-Optimized Gene for Chimeric GALV Envelope. Viruses. 2021 Jul 27;13(8). doi: 10.3390/v13081471. PMID: 34452336; PMCID: PMC8402753.
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Humoral and cellular immune responses to two and three doses of SARS-CoV-2 vaccines in rituximab-treated patients with rheumatoid arthritis: a prospective, cohort study.

The Lancet. Rheumatology

Jyssum I, Kared H, Tran TT, Tveter AT, Provan SA, Sexton J, Jørgensen KK, Jahnsen J, Kro GB, Warren DJ, Vaage EB, Kvien TK, Nissen-Meyer LH, Anderson AM, Grødeland G, Haavardsholm EA, Vaage JT, Mjaaland S, Syversen SW, Lund-Johansen F, Munthe LA, Goll GL.
PMID: 34977602
Lancet Rheumatol. 2021 Dec 23; doi: 10.1016/S2665-9913(21)00394-5. Epub 2021 Dec 23.

BACKGROUND: In rituximab-treated patients with rheumatoid arthritis, humoral and cellular immune responses after two or three doses of SARS-CoV-2 vaccines are not well characterised. We aimed to address this knowledge gap.METHODS: This prospective, cohort study (Nor-vaC) was done at...

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Jyssum I, Kared H, Tran TT, et al. Humoral and cellular immune responses to two and three doses of SARS-CoV-2 vaccines in rituximab-treated patients with rheumatoid arthritis: a prospective, cohort study. Lancet Rheumatol. 2021;doi: 10.1016/S2665-9913(21)00394-5.
Jyssum, I., Kared, H., Tran, T. T., Tveter, A. T., Provan, S. A., Sexton, J., Jørgensen, K. K., Jahnsen, J., Kro, G. B., Warren, D. J., Vaage, E. B., Kvien, T. K., Nissen-Meyer, L. H., Anderson, A. M., Grødeland, G., Haavardsholm, E. A., Vaage, J. T., Mjaaland, S., Syversen, S. W., Lund-Johansen, F., Munthe, L. A., & Goll, G. L. (2021). Humoral and cellular immune responses to two and three doses of SARS-CoV-2 vaccines in rituximab-treated patients with rheumatoid arthritis: a prospective, cohort study. The Lancet. Rheumatology, . https://doi.org/10.1016/S2665-9913(21)00394-5
Jyssum, Ingrid, et al. "Humoral and cellular immune responses to two and three doses of SARS-CoV-2 vaccines in rituximab-treated patients with rheumatoid arthritis: a prospective, cohort study." The Lancet. Rheumatology vol. (2021). doi: https://doi.org/10.1016/S2665-9913(21)00394-5
Jyssum I, Kared H, Tran TT, Tveter AT, Provan SA, Sexton J, Jørgensen KK, Jahnsen J, Kro GB, Warren DJ, Vaage EB, Kvien TK, Nissen-Meyer LH, Anderson AM, Grødeland G, Haavardsholm EA, Vaage JT, Mjaaland S, Syversen SW, Lund-Johansen F, Munthe LA, Goll GL. Humoral and cellular immune responses to two and three doses of SARS-CoV-2 vaccines in rituximab-treated patients with rheumatoid arthritis: a prospective, cohort study. Lancet Rheumatol. 2021 Dec 23; doi: 10.1016/S2665-9913(21)00394-5. Epub 2021 Dec 23. PMID: 34977602; PMCID: PMC8700278.
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Quality of life, infection control, and complication rates using a novel custom-made articulating hip spacer during two-stage revision for periprosthetic joint infection.

Archives of orthopaedic and trauma surgery

Lunz A, Omlor GW, Schmidt G, Moradi B, Lehner B, Streit MR.
PMID: 34853867
Arch Orthop Trauma Surg. 2021 Dec 01; doi: 10.1007/s00402-021-04274-4. Epub 2021 Dec 01.

INTRODUCTION: Two-stage revision remains the gold standard treatment for most chronically infected and complex total hip arthroplasty infections. To improve patient outcome and reduce complication rates, we have developed a novel custom-made articulating hip spacer technique and present our...

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Lunz A, Omlor GW, Schmidt G, et al. Quality of life, infection control, and complication rates using a novel custom-made articulating hip spacer during two-stage revision for periprosthetic joint infection. Arch Orthop Trauma Surg. 2021;doi: 10.1007/s00402-021-04274-4.
Lunz, A., Omlor, G. W., Schmidt, G., Moradi, B., Lehner, B., & Streit, M. R. (2021). Quality of life, infection control, and complication rates using a novel custom-made articulating hip spacer during two-stage revision for periprosthetic joint infection. Archives of orthopaedic and trauma surgery, . https://doi.org/10.1007/s00402-021-04274-4
Lunz, Andre, et al. "Quality of life, infection control, and complication rates using a novel custom-made articulating hip spacer during two-stage revision for periprosthetic joint infection." Archives of orthopaedic and trauma surgery vol. (2021). doi: https://doi.org/10.1007/s00402-021-04274-4
Lunz A, Omlor GW, Schmidt G, Moradi B, Lehner B, Streit MR. Quality of life, infection control, and complication rates using a novel custom-made articulating hip spacer during two-stage revision for periprosthetic joint infection. Arch Orthop Trauma Surg. 2021 Dec 01; doi: 10.1007/s00402-021-04274-4. Epub 2021 Dec 01. PMID: 34853867.
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Showing 193 to 198 of 198 entries