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Showing 25 to 36 of 218 entries
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Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction.

Molecular metabolism

Gueddouri D, Caüzac M, Fauveau V, Benhamed F, Charifi W, Beaudoin L, Rouland M, Sicherre F, Lehuen A, Postic C, Boudry G, Burnol AF, Guilmeau S.
PMID: 35007789
Mol Metab. 2022 Jan 07;101438. doi: 10.1016/j.molmet.2022.101438. Epub 2022 Jan 07.

A common feature of metabolic diseases is their association with chronic low-grade inflammation. While enhanced gut permeability and systemic bacterial endotoxin translocation have been suggested as key players of this metaflammation, the mechanistic bases underlying these features upon the...

Metabolipidomic profiling reveals an age-related deficiency of skeletal muscle pro-resolving mediators that contributes to maladaptive tissue remodeling.

Aging cell

Markworth JF, Brown LA, Lim E, Castor-Macias JA, Larouche J, Macpherson PCD, Davis C, Aguilar CA, Maddipati KR, Brooks SV.
PMID: 34075679
Aging Cell. 2021 Jun;20(6):e13393. doi: 10.1111/acel.13393. Epub 2021 Jun 02.

Specialized pro-resolving mediators actively limit inflammation and support tissue regeneration, but their role in age-related muscle dysfunction has not been explored. We profiled the mediator lipidome of aging muscle via liquid chromatography-tandem mass spectrometry and tested whether treatment with...

Variant Reinterpretation in Survivors of Cardiac Arrest With Preserved Ejection Fraction (the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry) by Clinicians and Clinical Commercial Laboratories.

Circulation. Genomic and precision medicine

Davies B, Bartels K, Hathaway J, Xu F, Roberts JD, Tadros R, Green MS, Healey JS, Simpson CS, Sanatani S, Steinberg C, Gardner M, Angaran P, Talajic M, Hamilton R, Arbour L, Seifer C, Fournier A, Joza J, Krahn AD, Lehman A, Laksman ZWM.
PMID: 33960826
Circ Genom Precis Med. 2021 Jun;14(3):e003235. doi: 10.1161/CIRCGEN.120.003235. Epub 2021 May 07.

BACKGROUND: Following an unexplained cardiac arrest, clinical genetic testing is increasingly becoming standard of care. Periodic review of variant classification is required, as reinterpretation can change the diagnosis, prognosis, and management of patients and their relatives.METHODS: This study aimed...

Association of Hypotension During Thrombectomy and Outcomes Differs With the Posterior Communicating Artery Patency.

Stroke

Maïer B, Robichon E, Bourcier R, Dargazanli C, Labreuche J, Thion LA, Leguen M, Riem R, Desilles JP, Boulouis G, Delvoye F, Hebert S, Redjem H, Smajda S, Escalard S, Blanc R, Piotin M, Lapergue B, Mazighi M.
PMID: 34134507
Stroke. 2021 Aug;52(9):2964-2967. doi: 10.1161/STROKEAHA.121.034542. Epub 2021 Jun 17.

BACKGROUND AND PURPOSE: Hypotension during endovascular therapy for acute ischemic stroke is associated with worse functional outcomes (FO). Given its important role in intracranial hemodynamics, we investigated whether hypotension during endovascular therapy had the same effect on FO according...

Novel findings and expansion of phenotype in a mosaic RASopathy caused by somatic KRAS variants.

American journal of medical genetics. Part A

Chang CA, Perrier R, Kurek KC, Estrada-Veras J, Lehman A, Yip S, Hendson G, Diamond C, Pinchot JW, Tran JM, Arkin LM, Drolet BA, Napier MP, O'Neill SA, Balci TB, Keppler-Noreuil KM.
PMID: 34056834
Am J Med Genet A. 2021 Sep;185(9):2829-2845. doi: 10.1002/ajmg.a.62356. Epub 2021 May 30.

Mosaic KRAS variants and other RASopathy genes cause oculoectodermal, encephalo-cranio-cutaneous lipomatosis, and Schimmelpenning-Feuerstein-Mims syndromes, and a spectrum of vascular malformations, overgrowth and other associated anomalies, the latter of which are only recently being characterized. We describe eight individuals in...

Denervation and senescence markers data from old rats with intrinsic differences in responsiveness to aerobic training.

Data in brief

Brown LA, Judge JL, Macpherson PC, Koch LG, Qi NR, Britton SL, Brooks SV.
PMID: 31687430
Data Brief. 2019 Oct 10;27:104570. doi: 10.1016/j.dib.2019.104570. eCollection 2019 Dec.

The data described below is related to the manuscript "Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training" [1]. Rodents exhibit age-related declines in skeletal muscle function that...

Effect of Mineralocorticoid Receptor Antagonists in Heart Failure with Preserved Ejection Fraction and with Reduced Ejection Fraction - A Narrative Review.

Current vascular pharmacology

Mares A, Rodriguez T, Deoker A, Lehker A, Mukherjee D.
PMID: 34303331
Curr Vasc Pharmacol. 2022;20(1):46-51. doi: 10.2174/1570161119666210720120439.

BACKGROUND: Heart failure is a major cause of morbidity and mortality globally. By the end of this decade, ~8 million Americans will have heart failure with an expenditure of $69.8 billion.OBJECTIVE: In this narrative review, we evaluate the benefits,...

Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders.

Genome medicine

Gillentine MA, Wang T, Hoekzema K, Rosenfeld J, Liu P, Guo H, Kim CN, De Vries BBA, Vissers LELM, Nordenskjold M, Kvarnung M, Lindstrand A, Nordgren A, Gecz J, Iascone M, Cereda A, Scatigno A, Maitz S, Zanni G, Bertini E, Zweier C, Schuhmann S, Wiesener A, Pepper M, Panjwani H, Torti E, Abid F, Anselm I, Srivastava S, Atwal P, Bacino CA, Bhat G, Cobian K, Bird LM, Friedman J, Wright MS, Callewaert B, Petit F, Mathieu S, Afenjar A, Christensen CK, White KM, Elpeleg O, Berger I, Espineli EJ, Fagerberg C, Brasch-Andersen C, Hansen LK, Feyma T, Hughes S, Thiffault I, Sullivan B, Yan S, Keller K, Keren B, Mignot C, Kooy F, Meuwissen M, Basinger A, Kukolich M, Philips M, Ortega L, Drummond-Borg M, Lauridsen M, Sorensen K, Lehman A, Lopez-Rangel E, Levy P, Lessel D, Lotze T, Madan-Khetarpal S, Sebastian J, Vento J, Vats D, Benman LM, Mckee S, Mirzaa GM, Muss C, Pappas J, Peeters H, Romano C, Elia M, Galesi O, Simon MEH, van Gassen KLI, Simpson K, Stratton R, Syed S, Thevenon J, Palafoll IV, Vitobello A, Bournez M, Faivre L, Xia K, Earl RK, Nowakowski T, Bernier RA, Eichler EE.
PMID: 33874999
Genome Med. 2021 Apr 19;13(1):63. doi: 10.1186/s13073-021-00870-6.

BACKGROUND: With the increasing number of genomic sequencing studies, hundreds of genes have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery far outpaces our understanding of genotype-phenotype correlations, with clinical characterization remaining a bottleneck for understanding...

Fournier's Gangrene in Females: Presentation and Management at a Tertiary Center.

Urology

Beecroft NJ, Jaeger CD, Rose JR, Becerra CMC, Shah NC, Palettas MS, Lehman A, Posid T, Jenkins LC, Baradaran N.
PMID: 32531467
Urology. 2021 May;151:113-117. doi: 10.1016/j.urology.2020.05.056. Epub 2020 Jun 09.

OBJECTIVE: To report and compare presentation and management of Fournier's Gangrene (FG) in female vs male patients at a single tertiary care center.METHODS: Patient demographics, clinical characteristics, treatments and outcomes were summarized and compared between males and females who...

Fish consumption is associated with school performance in children in a non-linear way: Results from the German cohort study KiGGS.

Evolution, medicine, and public health

Lehner A, Staub K, Aldakak L, Eppenberger P, Rühli F, Martin RD, Bender N.
PMID: 31976073
Evol Med Public Health. 2019 Dec 23;2020(1):2-11. doi: 10.1093/emph/eoz038. eCollection 2020.

INTRODUCTION: How the long-chain fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in the diet permitted human brain evolution, and how much our brains need today to function optimally are still hot topics for debate. DHA and EPA...

Outcomes of Resident Performed Hydrus, iStent, and Kahook Glaucoma Procedures in a Predominantly African-American Population.

Journal of glaucoma

Meer E, Liu T, Hua P, Ying GS, Miller E, Lehman A.
PMID: 34731870
J Glaucoma. 2021 Nov 03; doi: 10.1097/IJG.0000000000001958. Epub 2021 Nov 03.

PRECIS: This retrospective study characterized the efficacy and safety of three different microinvasive glaucoma surgery (MIGS) procedures in a predominantly African-American population at the Philadelphia Veterans Affairs Hospital (Hydrus, Kahook, iStent), demonstrating no significant difference in IOP and medication...

Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses.

Cancers

Da Gama Duarte J, Woods K, Quigley LT, Deceneux C, Tutuka C, Witkowski T, Ostrouska S, Hudson C, Tsao SC, Pasam A, Dobrovic A, Blackburn JM, Cebon J, Behren A.
PMID: 33918976
Cancers (Basel). 2021 Apr 09;13(8). doi: 10.3390/cancers13081805.

Antibodies that block immune regulatory checkpoints (programmed cell death 1, PD-1 and cytotoxic T-lymphocyte-associated antigen 4, CTLA-4) to mobilise immunity have shown unprecedented clinical efficacy against cancer, demonstrating the importance of antigen-specific tumour recognition. Despite this, many patients still...

Showing 25 to 36 of 218 entries